ES535027A0 - Procedimiento para preparar derivados de 1-piperazinacarboxamida - Google Patents

Procedimiento para preparar derivados de 1-piperazinacarboxamida

Info

Publication number: ES535027A0
Authority: ES; Spain
Prior art keywords: hydrogen; different; lower alkyl; derivatives; same
Prior art date: 1983-08-10
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

ES535027A

Other languages

English (en)

Other versions

ES8705411A1 (es

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pharmacia Animal Health Inc

Original Assignee

Ferrosan AB

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-08-10

Filing date

1984-08-09

Publication date

1987-05-01

1984-08-09 Application filed by Ferrosan AB filed Critical Ferrosan AB

1987-05-01 Publication of ES8705411A1 publication Critical patent/ES8705411A1/es

1987-05-01 Publication of ES535027A0 publication Critical patent/ES535027A0/es

Status Expired legal-status Critical Current

Links

229910052739 hydrogen Inorganic materials 0.000 abstract 6
239000001257 hydrogen Substances 0.000 abstract 6
125000000217 alkyl group Chemical group 0.000 abstract 5
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
241001465754 Metazoa Species 0.000 abstract 2
230000016571 aggressive behavior Effects 0.000 abstract 2
125000003342 alkenyl group Chemical group 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
230000001914 calming effect Effects 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
IVXQBCUBSIPQGU-UHFFFAOYSA-N piperazine-1-carboxamide Chemical compound NC(=O)N1CCNCC1 IVXQBCUBSIPQGU-UHFFFAOYSA-N 0.000 abstract 1
208000020016 psychiatric disease Diseases 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
239000011593 sulfur Substances 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/21—Radicals derived from sulfur analogues of carbonic acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/28—Radicals substituted by nitrogen atoms

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)

ES535027A 1983-08-10 1984-08-09 Procedimiento para preparar derivados de 1-piperazinacarboxamida Expired ES8705411A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE8304361A SE8304361D0 (sv)	1983-08-10	1983-08-10	Novel 1-acylpiperazine derivatives novel 1-acylpiperazine derivatives

Publications (2)

Publication Number	Publication Date
ES8705411A1 ES8705411A1 (es)	1987-05-01
ES535027A0 true ES535027A0 (es)	1987-05-01

Family

ID=20352166

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
ES535027A Expired ES8705411A1 (es)	1983-08-10	1984-08-09	Procedimiento para preparar derivados de 1-piperazinacarboxamida
ES552001A Expired ES8704917A1 (es)	1983-08-10	1986-02-14	Procedimiento para prepararar derivados de 1-piperazinacarboximida.
ES556989A Expired ES8802039A1 (es)	1983-08-10	1986-08-01	Procedimiento par preparar derivados de 1-piperazinacarboxamida

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
ES552001A Expired ES8704917A1 (es)	1983-08-10	1986-02-14	Procedimiento para prepararar derivados de 1-piperazinacarboximida.
ES556989A Expired ES8802039A1 (es)	1983-08-10	1986-08-01	Procedimiento par preparar derivados de 1-piperazinacarboxamida

Country Status (16)

Country	Link
US (1)	US4935419A (es)
EP (1)	EP0136274B1 (es)
JP (1)	JPH0723364B2 (es)
AT (1)	ATE47850T1 (es)
AU (1)	AU569537B2 (es)
CA (1)	CA1253148A (es)
DE (1)	DE3480395D1 (es)
DK (1)	DK157864C (es)
ES (3)	ES8705411A1 (es)
FI (1)	FI80449C (es)
HU (1)	HU196977B (es)
IE (1)	IE58065B1 (es)
IL (1)	IL72563A (es)
NZ (1)	NZ209166A (es)
SE (1)	SE8304361D0 (es)
WO (1)	WO1985000811A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE8500573D0 (sv) *	1985-02-08	1985-02-08	Ferrosan Ab	Novel piperazinecarboxamides having a phenoxyalkyl or thiophenoxyalkyl side chain
GB8713240D0 (en) *	1987-06-05	1987-07-08	Proteus Biotech Ltd	Hormones
US5070089A (en) *	1988-01-26	1991-12-03	Nippon Chemiphar Co., Ltd.	Therapeutic agent for liver disease and piperazine derivatives
US5719156A (en) *	1995-05-02	1998-02-17	Schering Corporation	Piperazino derivatives as neurokinin antagonists
US5795894A (en) *	1995-05-02	1998-08-18	Schering Corporation	Piperazino derivatives as neurokinn antagonists
US5892039A (en) *	1995-08-31	1999-04-06	Schering Corporation	Piperazino derivatives as neurokinin antagonists
US5869488A (en) *	1996-05-01	1999-02-09	Schering Corporation	Piperazino derivatives as neurokinin antagonists
US5968929A (en) *	1996-10-30	1999-10-19	Schering Corporation	Piperazino derivatives as neurokinin antagonists
EP1158983A4 (en)	1999-03-03	2003-05-21	Merck & Co Inc	Prenyl protein transferase inhibitors
JP2012505906A (ja) *	2008-10-15	2012-03-08	日東電工株式会社	ポリグルタメートコンジュゲートの調製方法
JP2013514443A (ja) *	2009-12-16	2013-04-25	日東電工株式会社	ポリグルタミン酸の制御された合成
KR20140146192A (ko) *	2012-04-14	2014-12-24	인트라-셀룰라 써래피스, 인코퍼레이티드.	유기 화합물
PL3838274T3 (pl)	2016-01-26	2024-04-02	Intra-Cellular Therapies, Inc.	Pochodna pirydo[3',4':4,5]pirolo[1,2,3-DE]chinoksaliny do zastosowania w leczeniu zaburzeń OUN
WO2018126140A1 (en)	2016-12-29	2018-07-05	Intra-Cellular Therapies, Inc.	Organic compounds
EP3562484B1 (en)	2016-12-29	2021-08-25	Intra-Cellular Therapies, Inc.	Pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline derivatives useful in the treatment of cns disorders
CN112040940A (zh)	2018-03-23	2020-12-04	细胞内治疗公司	有机化合物

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3000892A (en) *	1959-11-16	1961-09-19	Paul A J Janssen	1-aroylalkyl-4-aroylpiperazines
GB1150245A (en) *	1966-03-04	1969-04-30	Chinoin Gyogyszer Es Vegyeszet	New Piperazine Derivatives and a Process for the Preparation thereof.
GB1143882A (es) *	1966-06-21
GB1186495A (en) *	1968-02-20	1970-04-02	Delalande Sa	0-[3-(4-Fluorobenzoyl) Proplyl]-4-Substituted Piperazines, their Acid Addition Salts and their method of preparation
FR2262521A1 (en) *	1973-08-08	1975-09-26	Delalande Sa	3-(3,4,5-Trimethoxyphenyl)piperazines - with coronary vasodilator, hypotensive, antiinflammatory, analgesic, and antiulcer activity
JPS5143772A (en) *	1974-09-26	1976-04-14	Kyorin Seiyaku Kk	11 * 33 fuenirupuropiru * 44 furoirupiperajinjudotaino seizoho
AR207031A1 (es) *	1974-03-06	1976-09-09	Kyorin Seiyaku Kk	Procedimiento para preparacion de nuevos derivados de 1-(3-fenilpropil)-4-furoilpiperacina
JPS50131974A (es) *	1974-03-06	1975-10-18
JPS518283A (en) *	1974-07-09	1976-01-23	Kyorin Seiyaku Kk	11 * 33 fuenirupuropiru * 44 karubamoirupiperajinjudotaino seizoho
JPS5346988A (en) *	1976-10-07	1978-04-27	Kyorin Seiyaku Kk	Piperadine derivative
NO154582C (no) *	1978-10-20	1986-11-05	Ferrosan Ab	Analogifremgangsmaate for fremstilling av terapeutisk aktive difenyl-dibutylpiperazinkarboksamider.
EP0042366B1 (en) *	1980-06-16	1984-11-07	AB Ferrosan	Diphenylbutyl-1-acylpiperazines
ATE28327T1 (de) *	1981-12-02	1987-08-15	Ferrosan Ab	1-piperazinocarboxylate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.

1983
- 1983-08-10 SE SE8304361A patent/SE8304361D0/xx unknown
1984
- 1984-08-01 IL IL72563A patent/IL72563A/xx not_active IP Right Cessation
- 1984-08-02 WO PCT/SE1984/000269 patent/WO1985000811A1/en not_active Ceased
- 1984-08-02 DE DE8484850237T patent/DE3480395D1/de not_active Expired
- 1984-08-02 JP JP59503010A patent/JPH0723364B2/ja not_active Expired - Lifetime
- 1984-08-02 AU AU32111/84A patent/AU569537B2/en not_active Expired
- 1984-08-02 EP EP84850237A patent/EP0136274B1/en not_active Expired
- 1984-08-02 HU HU843341A patent/HU196977B/hu unknown
- 1984-08-02 AT AT84850237T patent/ATE47850T1/de not_active IP Right Cessation
- 1984-08-09 ES ES535027A patent/ES8705411A1/es not_active Expired
- 1984-08-09 NZ NZ209166A patent/NZ209166A/en unknown
- 1984-08-09 IE IE205084A patent/IE58065B1/en not_active IP Right Cessation
- 1984-08-09 CA CA000460595A patent/CA1253148A/en not_active Expired
1985
- 1985-04-03 FI FI851350A patent/FI80449C/fi not_active IP Right Cessation
- 1985-04-09 DK DK157485A patent/DK157864C/da not_active IP Right Cessation
1986
- 1986-02-14 ES ES552001A patent/ES8704917A1/es not_active Expired
- 1986-08-01 ES ES556989A patent/ES8802039A1/es not_active Expired
1988
- 1988-07-29 US US07/227,420 patent/US4935419A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
ATE47850T1 (de)	1989-11-15
IE58065B1 (en)	1993-06-30
ES8705411A1 (es)	1987-05-01
ES8802039A1 (es)	1988-03-16
HU196977B (en)	1989-02-28
DK157864C (da)	1990-07-23
JPH0723364B2 (ja)	1995-03-15
IL72563A0 (en)	1984-11-30
HUT37415A (en)	1985-12-28
IE842050L (en)	1985-02-10
CA1253148A (en)	1989-04-25
ES556989A0 (es)	1988-03-16
FI80449C (fi)	1990-06-11
FI851350L (fi)	1985-04-03
ES8704917A1 (es)	1987-04-16
IL72563A (en)	1988-10-31
DE3480395D1 (en)	1989-12-14
DK157864B (da)	1990-02-26
NZ209166A (en)	1987-07-31
FI80449B (fi)	1990-02-28
DK157485D0 (da)	1985-04-09
US4935419A (en)	1990-06-19
SE8304361D0 (sv)	1983-08-10
JPS60501956A (ja)	1985-11-14
FI851350A0 (fi)	1985-04-03
WO1985000811A1 (en)	1985-02-28
ES552001A0 (es)	1987-04-16
AU3211184A (en)	1985-03-12
DK157485A (da)	1985-04-09
EP0136274A1 (en)	1985-04-03
AU569537B2 (en)	1988-02-04
EP0136274B1 (en)	1989-11-08

Legal Events

Date	Code	Title	Description
2002-08-01	PC1A	Transfer granted
2006-11-01	FD1A	Patent lapsed	Effective date: 20050124

Publication	Publication Date	Title
ES552001A0 (es)	1987-04-16	Procedimiento para prepararar derivados de 1-piperazinacarboximida.
HU9301585D0 (en)	1993-09-28	Methods for producing phenyl-imidazolydine derivatives as well as medical preparatives containing said compounds
DK165833C (da)	1993-06-21	Analogifremgangsmaade til fremstilling af diazabicyclo-(3,3,1)-nonaner
ZA878696B (en)	1988-05-19	Process for preparing mono-,bi-and tricyclic amino acids,intermediates of this process,and a process for preparing same
DK420682A (da)	1983-03-25	Fremgangsmaade til fremstilling af triazoloquinazoloner eller salte deraf
ES546366A0 (es)	1986-03-01	Procedimiento para preparar derivados de 1,6-naftiridina
ES523120A0 (es)	1984-03-16	"porcedimiento de preparar nuevos derivados de oxazinobenzotiazina-6,6-dioxido".
ATE38665T1 (de)	1988-12-15	Verfahren zur herstellung von 5-perfluoralkyl-5,6-dihydrouracyl-derivaten und verwendbare zwischenprodukte.
ES442119A1 (es)	1977-06-16	Procedimiento para la preparacion de compuestos tetracicli- cos sustituidos en el grupo amino.
ES2040744T3 (es)	1993-11-01	Un procedimiento para preparar derivados de 1,2,4-triazinona.
ES2135383T3 (es)	1999-11-01	Pirido(3,4-b)pirrolo(1,2-e)(1,4,5)oxadiazepinas y compuestos analogos relacionados, un procedimiento para su preparacion y su uso como medicamentos.
ES2036600T3 (es)	1993-06-01	Procedimiento para preparar 1-(3-(2-dialquilaminoetoxi)-2-tienil)-3-fenil-1-propanonas.
ES483275A1 (es)	1980-09-01	Un procedimiento para la preparacion de derivados de benzo- diacepina
ES2101269T3 (es)	1997-07-01	Nuevos derivados de 1-fenil-biciclo-(2.2.2)-octano, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.
ES432918A1 (es)	1976-11-01	Un procedimiento de preparacion de fenilalquilaralquilami- nas.