ES538238A0 - Un procedimiento para preparar derivados de adenosina. - Google Patents

Un procedimiento para preparar derivados de adenosina.

Info

Publication number
ES538238A0
ES538238A0 ES538238A ES538238A ES538238A0 ES 538238 A0 ES538238 A0 ES 538238A0 ES 538238 A ES538238 A ES 538238A ES 538238 A ES538238 A ES 538238A ES 538238 A0 ES538238 A0 ES 538238A0
Authority
ES
Spain
Prior art keywords
procedure
adenosine derivatives
preparing adenosine
preparing
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES538238A
Other languages
English (en)
Other versions
ES8602033A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of ES538238A0 publication Critical patent/ES538238A0/es
Publication of ES8602033A1 publication Critical patent/ES8602033A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
ES538238A 1983-12-05 1984-12-04 Un procedimiento para preparar derivados de adenosina. Expired ES8602033A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/558,144 US4501735A (en) 1983-12-05 1983-12-05 N6-(1- and 2-benzocycloalkyl) adenosines

Publications (2)

Publication Number Publication Date
ES538238A0 true ES538238A0 (es) 1985-11-01
ES8602033A1 ES8602033A1 (es) 1985-11-01

Family

ID=24228400

Family Applications (1)

Application Number Title Priority Date Filing Date
ES538238A Expired ES8602033A1 (es) 1983-12-05 1984-12-04 Un procedimiento para preparar derivados de adenosina.

Country Status (18)

Country Link
US (1) US4501735A (es)
EP (1) EP0144235A3 (es)
JP (1) JPS60136592A (es)
KR (1) KR850004484A (es)
AU (1) AU562690B2 (es)
CA (1) CA1230595A (es)
DK (1) DK573484A (es)
ES (1) ES8602033A1 (es)
FI (1) FI77667C (es)
GR (1) GR81144B (es)
HU (1) HUT36482A (es)
IL (1) IL73700A (es)
NO (1) NO159384C (es)
NZ (1) NZ210428A (es)
OA (1) OA07883A (es)
PH (1) PH21367A (es)
PT (1) PT79613B (es)
ZA (1) ZA849337B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1239397A (en) * 1983-08-01 1988-07-19 James A. Bristol N.sup.6-substituted adenosines
DE3406533A1 (de) * 1984-02-23 1985-08-29 Boehringer Mannheim Gmbh, 6800 Mannheim Verwendung von adenosin-derivaten als antiallergica und arzneimittel, die diese enthalten
US4683223A (en) * 1985-09-09 1987-07-28 Warner-Lambert Company N6 -Benzopyrano-and benzothiopyrano adenosines and methods of use
CA1255297A (en) * 1984-10-26 1989-06-06 Bharat Trivedi N.sup.6-benzopyrano and benzothiopyrano adenosines
US4693996A (en) * 1985-12-23 1987-09-15 Warner-Lambert Company Method of treating heart failure and medicaments therefor
US4833273A (en) * 1986-02-03 1989-05-23 Warner-Lambert Company Process for the resolution of 1-aminoindanes
AU618723B2 (en) * 1986-10-06 1992-01-09 University Of Virginia Alumni Patents Foundation, The Use of an adenosine, hypoxanthine and ribose-containing solution for improved protection of the heart during surgery
US4954504A (en) * 1986-11-14 1990-09-04 Ciba-Geigy Corporation N9 -cyclopentyl-substituted adenine derivatives having adenosine-2 receptor stimulating activity
US5063233A (en) * 1986-11-14 1991-11-05 Ciba-Geigy Corporation N9 -cyclopentyl-substituted adenine derivatives useful as adenosine receptor agonists
US4968697A (en) * 1987-02-04 1990-11-06 Ciba-Geigy Corporation 2-substituted adenosine 5'-carboxamides as antihypertensive agents
PT86660B (pt) * 1987-02-04 1992-02-28 Ciba Geigy Ag Processo para a preparacao de derivados de adenosina-5'-carboxamida
US4837207A (en) * 1987-05-13 1989-06-06 Warner-Lambert Company Diastereoisomers of n6 -endo-bicyclo[2.2.1]heptyladenosine as antihypertensives with selective action
US5410019A (en) * 1987-09-24 1995-04-25 The Administrators Of The Tulane-Educational Fund Therapeutic peptides
US5034381A (en) * 1988-01-07 1991-07-23 Ciba-Geigy Corporation 2-(substituted amino) adenosines as antihypertensives
JPH0725785B2 (ja) * 1989-01-11 1995-03-22 日本臓器製薬株式会社 アデノシン誘導体及び該化合物を有効成分として含有する医薬組成物
ES2095960T3 (es) * 1990-09-25 1997-03-01 Rhone Poulenc Rorer Int Compuestos que tienen propiedades antihipertensivas y antiisquemicas.
US5561134A (en) * 1990-09-25 1996-10-01 Rhone-Poulenc Rorer Pharmaceuticals Inc. Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties
ES2219033T3 (es) 1998-07-22 2004-11-16 Daiichi Suntory Pharma Co., Ltd. Inhibidores de nf-kappa b que contienen derivados de indano como ingrediente activo.
JP2015172077A (ja) * 2015-06-24 2015-10-01 中国医学科学院葯物研究所 Ｎ６−置換アデノシン誘導体とｎ６−置換アデニン誘導体の鎮静、催眠、抗うつ、抗痙攣、抗てんかん、抗パーキンソン病と認知証予防・治療の用途

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670175A1 (de) * 1966-12-21 1970-11-05 Boehringer Mannheim Gmbh Verfahren zur Herstellung von Adenosin-Derivaten
DE1670265A1 (de) * 1967-08-25 1971-01-28 Boehringer Mannheim Gmbh 2-Amino-Adenosinderivate und Verfahren zu deren Herstellung
JPS4826038B1 (es) * 1970-09-25 1973-08-03
DE2059922A1 (de) * 1970-12-05 1972-06-15 Boehringer Mannheim Gmbh Neue N(6)-Aralkyl-adenosin-Derivate und Verfahren zur Herstellung derselben
DE2136624A1 (de) * 1971-07-22 1973-02-08 Boehringer Mannheim Gmbh N (6)-substituierte adenosin-derivate und verfahren zur herstellung derselben
BE788958A (fr) * 1971-09-18 1973-03-19 Schering Ag Derives d'adenosine et leur procede de preparation
US4090021A (en) * 1971-10-08 1978-05-16 Schering Aktiengesellschaft Process for the production of N6 -substituted adenosine nucleotides and products resulting therefrom
DE2230160A1 (de) * 1972-06-21 1974-01-31 Merck Patent Gmbh Adenosinderivat
US3922261A (en) * 1972-06-21 1975-11-25 Merck Patent Gmbh Adenosine derivative
JPS5046689A (es) * 1972-07-24 1975-04-25
DE2249397A1 (de) * 1972-10-09 1974-05-02 Merck Patent Gmbh Adenosinester und -aether
DE2406587A1 (de) * 1974-02-12 1975-08-21 Klinge Co Chem Pharm Fab Hypolipaemisch wirksame adenosinderivate
DE3019322A1 (de) * 1980-05-21 1981-12-03 Merck Patent Gmbh, 6100 Darmstadt Psychopharmakon sowie verwendung von adenosinderivaten
US4388308A (en) * 1980-06-09 1983-06-14 G.D. Searle & Co. N6 -[(2-Hydroxypropyl)aryl]adenosines
JPS57171998A (en) * 1981-04-15 1982-10-22 Fujisawa Pharmaceut Co Ltd Adenosine derivative and its salt, preparation thereof and medicinal composition containing the same
DE3406533A1 (de) * 1984-02-23 1985-08-29 Boehringer Mannheim Gmbh, 6800 Mannheim Verwendung von adenosin-derivaten als antiallergica und arzneimittel, die diese enthalten

Also Published As

Publication number Publication date
FI77667C (fi) 1989-04-10
DK573484A (da) 1985-06-06
NO844830L (no) 1985-06-06
JPS60136592A (ja) 1985-07-20
FI77667B (fi) 1988-12-30
FI844750A0 (fi) 1984-12-03
FI844750L (fi) 1985-06-06
IL73700A0 (en) 1985-02-28
DK573484D0 (da) 1984-12-03
GR81144B (en) 1985-04-04
PT79613B (en) 1986-12-12
PH21367A (en) 1987-10-15
NO159384C (no) 1988-12-21
KR850004484A (ko) 1985-07-15
EP0144235A3 (en) 1986-07-30
ES8602033A1 (es) 1985-11-01
US4501735A (en) 1985-02-26
NZ210428A (en) 1989-05-29
EP0144235A2 (en) 1985-06-12
CA1230595A (en) 1987-12-22
OA07883A (en) 1986-11-20
AU562690B2 (en) 1987-06-18
PT79613A (en) 1985-01-01
HUT36482A (en) 1985-09-30
AU3621684A (en) 1985-06-13
IL73700A (en) 1988-09-30
NO159384B (no) 1988-09-12
ZA849337B (en) 1986-07-30

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