ES550302A0 - Un procedimiento para preparar compuestos de acido difosforico. - Google Patents
Un procedimiento para preparar compuestos de acido difosforico.Info
- Publication number
- ES550302A0 ES550302A0 ES550302A ES550302A ES550302A0 ES 550302 A0 ES550302 A0 ES 550302A0 ES 550302 A ES550302 A ES 550302A ES 550302 A ES550302 A ES 550302A ES 550302 A0 ES550302 A0 ES 550302A0
- Authority
- ES
- Spain
- Prior art keywords
- acid compounds
- preparing
- procedure
- diphosphoric acid
- pharmaceutical compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/650905—Six-membered rings having the nitrogen atoms in the positions 1 and 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Output Control And Ontrol Of Special Type Engine (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68454384A | 1984-12-21 | 1984-12-21 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8707543A1 ES8707543A1 (es) | 1987-08-01 |
| ES550302A0 true ES550302A0 (es) | 1987-08-01 |
Family
ID=24748488
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES000550302D Expired - Lifetime ES8707543B9 (es) | 1984-12-21 | 1985-12-20 | Un procedimiento para preparar compuestos de acido difosforico. |
| ES550302A Expired ES8707543A1 (es) | 1984-12-21 | 1985-12-20 | Un procedimiento para preparar compuestos de acido difosforico. |
| ES557322D Expired - Lifetime ES8802428B9 (en) | 1984-12-21 | 1987-01-16 | Pharmaceutical compositions containing geminal diphosphonates. |
| ES557322A Expired ES8802428A1 (es) | 1984-12-21 | 1987-01-16 | Un procedimiento para preparar compuestos de acido difosfonico |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES000550302D Expired - Lifetime ES8707543B9 (es) | 1984-12-21 | 1985-12-20 | Un procedimiento para preparar compuestos de acido difosforico. |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES557322D Expired - Lifetime ES8802428B9 (en) | 1984-12-21 | 1987-01-16 | Pharmaceutical compositions containing geminal diphosphonates. |
| ES557322A Expired ES8802428A1 (es) | 1984-12-21 | 1987-01-16 | Un procedimiento para preparar compuestos de acido difosfonico |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5583122A (es) |
| EP (1) | EP0186405B1 (es) |
| AT (1) | ATE61370T1 (es) |
| DE (2) | DE3582033D1 (es) |
| DK (1) | DK168754B1 (es) |
| ES (4) | ES8707543B9 (es) |
| IE (1) | IE58749B1 (es) |
| IL (1) | IL77243A (es) |
| LU (1) | LU90669I2 (es) |
| NL (1) | NL300031I2 (es) |
| ZA (1) | ZA859694B (es) |
Families Citing this family (127)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4902679A (en) * | 1985-12-13 | 1990-02-20 | Norwich Eaton Pharmaceuticals, Inc. | Methods of treating diseases with certain geminal diphosphonates |
| DE10199052I1 (de) * | 1986-11-21 | 2002-01-10 | Novartis Ag | Neue substituierte Alkandiphosphonsaeuren |
| ES2039259T3 (es) * | 1986-11-21 | 1993-09-16 | Ciba-Geigy Ag | Procedimiento para la obtencion de acidos azacicloalquil alcandifosfonicos aromaticamente substituidos. |
| ES2038693T3 (es) * | 1986-11-21 | 1993-08-01 | Ciba-Geigy Ag | Nuevos acidos aminometanodifosfonicos substituidos. |
| US5057505A (en) * | 1986-11-21 | 1991-10-15 | Ciba-Geigy Corporation | Substituted aminomethanediphosphonic acids and use in medicaments |
| DE3640938A1 (de) * | 1986-11-29 | 1988-06-01 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindung enthaltende arzneimittel |
| IL84731A0 (en) * | 1986-12-19 | 1988-05-31 | Norwich Eaton Pharma | Heterocycle-substituted diphosphonic acids and salts and esters and pharmaceutical compositions containing them |
| FR2611203B1 (fr) * | 1987-02-20 | 1989-06-09 | Sturtz Georges | Analogues gem-diphosphoniques d'amethopterine (methotrexate) et de derives deaza-n-10 amethopterine. leur preparation et les compositions pharmaceutiques qui les contiennent |
| US4973576A (en) * | 1987-03-10 | 1990-11-27 | Yamanouchi Pharmaceutical Co., Ltd. | Bisphophonic acid derivatives and pharmaceutical compositions containing the same |
| KR880011136A (ko) * | 1987-03-11 | 1988-10-26 | 모리오까 시게오 | 아졸- 아미노메틸렌 비스포스폰산 유도체 |
| IL86951A (en) * | 1987-07-06 | 1996-07-23 | Procter & Gamble Pharma | Methylene phosphonoalkylphosphinates and pharmaceutical preparations containing them |
| EP0317505A1 (de) * | 1987-11-13 | 1989-05-24 | Ciba-Geigy Ag | Neue Azacycloalkylalkandiphosphonsäuren |
| US5190930A (en) * | 1987-12-11 | 1993-03-02 | Ciba-Geigy Corporation | Araliphatylaminoalkanediphosphonic acids |
| ATE90353T1 (de) * | 1987-12-11 | 1993-06-15 | Ciba Geigy Ag | Araliphatylaminoalkandiphosphonsaeuren. |
| US5110807A (en) * | 1988-12-01 | 1992-05-05 | Ciba-Geigy Corporation | Araliphatylaminoalkanediphosphonic acids |
| US4933472A (en) * | 1988-04-08 | 1990-06-12 | Yamanouchi Pharmaceutical Co., Ltd. | Substituted aminomethylenebis(phosphonic acid) derivatives |
| DE3822650A1 (de) * | 1988-07-05 | 1990-02-01 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| TW198039B (es) * | 1988-11-28 | 1993-01-11 | Ciba Geigy Ag | |
| ATE96321T1 (de) * | 1988-12-14 | 1993-11-15 | Pfizer | Derivate von 5-hydroxy- und 5-methoxy-2-aminopyrimidin als inhibitoren der interleukin-1produktion. |
| PH26923A (en) * | 1989-03-08 | 1992-12-03 | Ciba Geigy | N-substituted amino alkanediphosphonic acids |
| FI83421C (fi) * | 1989-06-21 | 1991-07-10 | Huhtamaeki Oy | Foerfarande foer framstaellning av farmakologiskt anvaendbara metylenbisfosfonsyraderivat. |
| US5139786A (en) * | 1989-07-07 | 1992-08-18 | Ciba-Geigy Corporation | Topical formulations |
| MX21452A (es) * | 1989-07-07 | 1994-01-31 | Ciba Geigy Ag | Preparaciones farmaceuticas que se administran en forma topica. |
| FI89366C (fi) * | 1990-12-20 | 1993-09-27 | Leiras Oy | Foerfarande foer framstaellning av nya farmakologiskt anvaendbara metylenbisfosfonsyraderivat |
| JPH06508365A (ja) * | 1991-06-19 | 1994-09-22 | ジ・アップジョン・カンパニー | 抗炎症剤としてのりん酸ジアルキル（ジアルコキシホスフィニル）メチル類 |
| JPH05194563A (ja) * | 1991-07-12 | 1993-08-03 | Hoechst Ag | 置換アミノエタン−１，１−ビスホスホン酸およびアミノエタン−１，１−アルキルホスフィノホスホン酸 |
| US6096342A (en) * | 1997-03-12 | 2000-08-01 | The Procter & Gamble Company | Dosage forms of risedronate |
| AU661080B2 (en) * | 1991-11-22 | 1995-07-13 | Warner Chilcott Company, Llc | Risedronate delayed-release compositions |
| TW222637B (es) * | 1991-12-12 | 1994-04-21 | Hoechst Ag | |
| DE4141928A1 (de) * | 1991-12-19 | 1993-06-24 | Boehringer Mannheim Gmbh | Neue phosphonobernsteinsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| US5283057A (en) * | 1992-04-24 | 1994-02-01 | The Procter & Gamble Company | Risedronate in oral compositions |
| IL119243A (en) * | 1992-05-29 | 2002-11-10 | Procter & Gamble Pharma | Phosphonocarboxylate compounds and pharmaceutical compositions containing them |
| SG47603A1 (en) * | 1992-05-29 | 1998-04-17 | Procter & Gamble Pharma | Thio-substitute nitrogen containing heterocyclic phosphonate compounds for treating abnormal calcium and phosphate metabolism |
| EP0646119B1 (en) * | 1992-05-29 | 1998-07-15 | PROCTER & GAMBLE PHARMACEUTICALS, INC. | Quaternary nitrogen-containing phosphonate compounds for treating abnormal calcium and phosphate metabolism as well as dental calculus and plaque |
| US5760021A (en) * | 1992-05-29 | 1998-06-02 | The Procter & Gamble Company | Phosphonocarboxylate compounds pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism |
| US5763611A (en) * | 1992-05-29 | 1998-06-09 | The Procter & Gamble Company | Thio-substituted cyclic phosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism |
| NZ253523A (en) * | 1992-05-29 | 1997-01-29 | Procter & Gamble Pharma | Phosphonosulphate derivatives and medicaments (for treating abnormal calcium and phosphate metabolism) |
| US5391743A (en) * | 1992-05-29 | 1995-02-21 | Procter & Gamble Pharmaceuticals, Inc. | Quaternary nitrogen-containing phosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism and methods of treating and preventing dental calculus and plaque |
| WO1993024496A1 (en) * | 1992-05-29 | 1993-12-09 | Procter & Gamble Pharmaceuticals, Inc. | Sulfur-containing phosponate compounds for treating abnormal calcium and phosphate metabolism |
| US5753634A (en) * | 1992-05-29 | 1998-05-19 | The Procter & Gamble Company | Quaternary nitrogen containing phosphonate compounds, pharmaceutical compostions, and methods for treating abnormal calcium and phosphate metabolism |
| US5731299A (en) * | 1992-05-29 | 1998-03-24 | The Procter & Gamble Company | Phosphonosulfonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism |
| ATE179329T1 (de) * | 1992-06-30 | 1999-05-15 | Procter & Gamble Pharma | Arzneimitteln zur behandlung von arthritis die phosphonate und nsaids enthalten |
| HUT70210A (en) * | 1992-06-30 | 1995-09-28 | Procter & Gamble Pharma | Use of phosphonates for the treatment of osteoporosis |
| US5635495A (en) * | 1992-10-09 | 1997-06-03 | The Upjohn Company | Pyrimidine bisphosphonate esters and (alkoxymethylphosphinyl)alkyl phosphonic acids as anti-inflammatories |
| DE59309360D1 (de) * | 1992-12-02 | 1999-03-18 | Hoechst Ag | Guanidinalkyl-1, 1-bisphosphonsäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung |
| CN1043423C (zh) * | 1993-01-02 | 1999-05-19 | 曼海姆泊灵格股份公司 | 新膦酰基琥珀酸衍生物及其制备方法和含这些化合物的药物组合物 |
| FR2703590B1 (fr) * | 1993-04-05 | 1995-06-30 | Sanofi Elf | Utilisation de derives d'acide bisphosphonique pour la preparation de medicaments destines a favoriser la reparation osseuse . |
| JPH06298779A (ja) * | 1993-04-15 | 1994-10-25 | Hoechst Japan Ltd | ヘテロ環イミノビスメチレンビスホスホン酸誘導体 |
| US5451401A (en) * | 1993-09-29 | 1995-09-19 | The Procter & Gamble Company | Diphosphonic acid esters as tartar control agents |
| US5728650A (en) * | 1993-10-07 | 1998-03-17 | Zeneca Limited | Herbicidal aza bisphosphonic acids and compositions containing the same |
| US20010007863A1 (en) * | 1998-06-18 | 2001-07-12 | Merck & Co., Inc. | Wet granulation formulation for bisphosphonic acids |
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| US5880111A (en) * | 1995-06-07 | 1999-03-09 | Farcasiu; Dan | Therapeutic derivations of diphosphonates |
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| JP5354858B2 (ja) * | 2006-05-09 | 2013-11-27 | 株式会社Ａｄｅｋａ | スルホンアミド化合物の金属塩を含有するポリエステル樹脂組成物 |
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-
1985
- 1985-12-05 IL IL7724385A patent/IL77243A/en not_active IP Right Cessation
- 1985-12-06 US US06/806,155 patent/US5583122A/en not_active Expired - Lifetime
- 1985-12-16 EP EP85309140A patent/EP0186405B1/en not_active Expired - Lifetime
- 1985-12-16 DE DE8585309140T patent/DE3582033D1/de not_active Expired - Lifetime
- 1985-12-16 DE DE2000175030 patent/DE10075030I2/de active Active
- 1985-12-16 AT AT85309140T patent/ATE61370T1/de active
- 1985-12-19 ZA ZA859694A patent/ZA859694B/xx unknown
- 1985-12-20 ES ES000550302D patent/ES8707543B9/es not_active Expired - Lifetime
- 1985-12-20 ES ES550302A patent/ES8707543A1/es not_active Expired
- 1985-12-20 DK DK599685A patent/DK168754B1/da not_active IP Right Cessation
- 1985-12-21 IE IE328685A patent/IE58749B1/en not_active IP Right Cessation
-
1987
- 1987-01-16 ES ES557322D patent/ES8802428B9/es not_active Expired - Lifetime
- 1987-01-16 ES ES557322A patent/ES8802428A1/es not_active Expired
-
2000
- 2000-11-10 LU LU90669C patent/LU90669I2/fr unknown
- 2000-12-01 NL NL300031C patent/NL300031I2/nl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US5583122A (en) | 1996-12-10 |
| EP0186405B1 (en) | 1991-03-06 |
| IE853286L (en) | 1986-06-21 |
| EP0186405A2 (en) | 1986-07-02 |
| ATE61370T1 (de) | 1991-03-15 |
| ZA859694B (en) | 1986-08-27 |
| ES8802428A1 (es) | 1988-06-01 |
| ES8707543A1 (es) | 1987-08-01 |
| DK599685D0 (da) | 1985-12-20 |
| DK599685A (da) | 1986-06-22 |
| NL300031I1 (nl) | 2001-02-01 |
| DE10075030I1 (de) | 2000-12-21 |
| ES8707543B9 (es) | 2013-05-08 |
| IL77243A (en) | 1996-11-14 |
| ES8802428B9 (en) | 2011-08-25 |
| DE10075030I2 (de) | 2004-01-29 |
| DK168754B1 (da) | 1994-06-06 |
| IE58749B1 (en) | 1993-11-03 |
| ES557322A0 (es) | 1988-06-01 |
| LU90669I2 (fr) | 2001-01-10 |
| EP0186405A3 (en) | 1987-10-28 |
| NL300031I2 (nl) | 2001-03-01 |
| DE3582033D1 (de) | 1991-04-11 |
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