ES551203A0 - Procedimiento para preparar 17 beta-acetoxi-8,13-expoxi-ialfa.6beta,9alfa-trihidroxilabol-14-en-11-ona,sus compuestos analogos y derivados. - Google Patents
Procedimiento para preparar 17 beta-acetoxi-8,13-expoxi-ialfa.6beta,9alfa-trihidroxilabol-14-en-11-ona,sus compuestos analogos y derivados.Info
- Publication number
- ES551203A0 ES551203A0 ES551203A ES551203A ES551203A0 ES 551203 A0 ES551203 A0 ES 551203A0 ES 551203 A ES551203 A ES 551203A ES 551203 A ES551203 A ES 551203A ES 551203 A0 ES551203 A0 ES 551203A0
- Authority
- ES
- Spain
- Prior art keywords
- dsm
- compound
- formula
- strain
- see diagramm
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 title abstract 18
- 238000000034 method Methods 0.000 title abstract 2
- 239000000758 substrate Substances 0.000 abstract 4
- 150000004160 forskolin derivatives Chemical class 0.000 abstract 2
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 235000015097 nutrients Nutrition 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Ophthalmology & Optometry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pyrane Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19853502685 DE3502685A1 (de) | 1985-01-26 | 1985-01-26 | Forskolin, seine analoge und derivate, verfahren zu deren herstellung mittels mikrobieller umwandlungen und die anwendung dieser verbindungen als arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES551203A0 true ES551203A0 (es) | 1987-05-16 |
| ES8705873A1 ES8705873A1 (es) | 1987-05-16 |
Family
ID=6260903
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES551203A Expired ES8705873A1 (es) | 1985-01-26 | 1986-01-24 | Procedimiento para preparar 17 beta-acetoxi-8,13-expoxi-ialfa.6beta,9alfa-trihidroxilabol-14-en-11-ona,sus compuestos analogos y derivados. |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0189801B1 (es) |
| JP (1) | JPS61180782A (es) |
| AT (1) | ATE40362T1 (es) |
| DE (2) | DE3502685A1 (es) |
| DK (1) | DK37586A (es) |
| ES (1) | ES8705873A1 (es) |
| GR (1) | GR860206B (es) |
| PT (1) | PT81900B (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4963537A (en) * | 1985-03-01 | 1990-10-16 | Hoechst-Roussel Pharmaceuticals Inc. | Labdane compounds, pharmaceutical compositions and use |
| IN163242B (es) | 1985-05-03 | 1988-08-27 | Hoechst India | |
| US5247097A (en) * | 1986-08-28 | 1993-09-21 | Hoechst-Roussel Pharmaceuticals Incorporated | Oxolabdanes |
| US4740522A (en) * | 1986-08-28 | 1988-04-26 | Hoechst-Roussel Pharmaceuticals Inc. | Oxolabdanes useful as pharmaceuticals for reducing intraocular pressure |
| US4920146A (en) * | 1986-12-29 | 1990-04-24 | Hoechst Roussel Pharmaceuticals Inc. | Carbamoyloxylabdane compounds useful in reducing intraocular pressure |
| US5646175A (en) * | 1987-12-28 | 1997-07-08 | Hoechst Marion Roussel, Inc. | Carbamoyloxylabdane compounds |
| IN166900B (es) * | 1987-06-03 | 1990-08-04 | Hoechst India | |
| AT389114B (de) * | 1987-10-08 | 1989-10-25 | Hoechst Ag | 7-acyloxy-6-aminoacyloxypolyoxylabdane und verfahren zu ihrer herstellung |
| US4883793A (en) * | 1988-05-09 | 1989-11-28 | Hoechst-Roussel Pharmaceuticals Inc. | Hydrazinocarbonyloxylabdanes for treating cardiac failure |
| US5177207A (en) * | 1989-01-11 | 1993-01-05 | Hoechst-Roussel Pharmaceuticals, Inc. | 7-aryl and heteroaryl ethers of desacetylforskolin |
| US4999351A (en) * | 1989-01-11 | 1991-03-12 | Hoechst-Roussel Pharmaceuticals, Inc. | 7-aryl and heteroaryl ethers of desacetylforskolin |
| US5145855A (en) * | 1989-07-06 | 1992-09-08 | Hoechst Roussel Pharmaceuticals, Inc. | 6- and 7-deoxyforskolin and derivatives thereof |
| US5093336A (en) * | 1989-07-06 | 1992-03-03 | Hoechat-Roussel Pharmaceuticals, Inc. | 6- and 7-deoxyforskolin and derivatives thereof |
| US5629345A (en) * | 1993-07-23 | 1997-05-13 | Vide Pharmaceuticals | Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure |
| US5965620A (en) * | 1993-07-23 | 1999-10-12 | Vide Pharmaceuticals | Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure |
| JP5933419B2 (ja) * | 2012-11-26 | 2016-06-08 | 株式会社シャローム | ジテルペン化合物、美白剤およびジテルペン化合物の製造方法 |
| JP5933420B2 (ja) * | 2012-11-26 | 2016-06-08 | 株式会社シャローム | 新規化合物、美白剤および前記化合物の製造方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2557784C2 (de) * | 1975-12-22 | 1986-04-17 | Hoechst Ag, 6230 Frankfurt | Forskolin, Verfahren zu dessen Gewinnung und diese Verbindung enthaltende pharmazeutische Präparate |
| DE2654796A1 (de) * | 1976-12-03 | 1978-06-08 | Hoechst Ag | Polyoxygenierte labdan-derivate |
| US4517200A (en) * | 1982-12-27 | 1985-05-14 | Schering-Plough Corporation | Method for treating allergic reactions with forskolin |
| DE3314999A1 (de) * | 1983-04-26 | 1985-03-14 | Behringwerke Ag, 3550 Marburg | Verwendung des diterpen-derivates forskolin zur immunstimulation |
| US4476140A (en) * | 1983-05-16 | 1984-10-09 | Yale University | Composition and method for treatment of glaucoma |
| WO1985002616A1 (en) * | 1983-12-14 | 1985-06-20 | Brown University Research Foundation | Treatment of metastasis |
-
1985
- 1985-01-26 DE DE19853502685 patent/DE3502685A1/de not_active Withdrawn
-
1986
- 1986-01-18 DE DE8686100633T patent/DE3661915D1/de not_active Expired
- 1986-01-18 AT AT86100633T patent/ATE40362T1/de not_active IP Right Cessation
- 1986-01-18 EP EP86100633A patent/EP0189801B1/de not_active Expired
- 1986-01-24 JP JP61012303A patent/JPS61180782A/ja active Pending
- 1986-01-24 DK DK37586A patent/DK37586A/da not_active Application Discontinuation
- 1986-01-24 ES ES551203A patent/ES8705873A1/es not_active Expired
- 1986-01-24 PT PT81900A patent/PT81900B/pt not_active IP Right Cessation
- 1986-01-24 GR GR860206A patent/GR860206B/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GR860206B (en) | 1986-05-21 |
| DK37586D0 (da) | 1986-01-24 |
| DE3502685A1 (de) | 1986-09-04 |
| PT81900B (pt) | 1988-07-01 |
| JPS61180782A (ja) | 1986-08-13 |
| DE3661915D1 (en) | 1989-03-02 |
| DK37586A (da) | 1986-07-27 |
| EP0189801A1 (de) | 1986-08-06 |
| ATE40362T1 (de) | 1989-02-15 |
| ES8705873A1 (es) | 1987-05-16 |
| EP0189801B1 (de) | 1989-01-25 |
| PT81900A (de) | 1986-02-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970401 |