ES557516A0 - Procedimiento para la obtencion del acido 2,6-dicloro-5-fluor-piridin-3-carboxilico - Google Patents

Procedimiento para la obtencion del acido 2,6-dicloro-5-fluor-piridin-3-carboxilico

Info

Publication number
ES557516A0
ES557516A0 ES557516A ES557516A ES557516A0 ES 557516 A0 ES557516 A0 ES 557516A0 ES 557516 A ES557516 A ES 557516A ES 557516 A ES557516 A ES 557516A ES 557516 A0 ES557516 A0 ES 557516A0
Authority
ES
Spain
Prior art keywords
carboxilico
piridin
fluor
dichloro
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES557516A
Other languages
English (en)
Other versions
ES8800222A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES557516A0 publication Critical patent/ES557516A0/es
Publication of ES8800222A1 publication Critical patent/ES8800222A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/76—Nitrogen atoms to which a second hetero atom is attached
    • C07D213/77—Hydrazine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
ES557516A 1985-01-10 1987-04-29 Procedimiento para la obtencion del acido 2,6-dicloro-5-fluor-piridin-3-carboxilico Expired ES8800222A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3500562 1985-01-10
DE19853508816 DE3508816A1 (de) 1985-01-10 1985-03-13 6,7-disubstituierte 1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphtyridin-3-carbonsaeuren

Publications (2)

Publication Number Publication Date
ES557516A0 true ES557516A0 (es) 1987-10-16
ES8800222A1 ES8800222A1 (es) 1987-10-16

Family

ID=25828438

Family Applications (5)

Application Number Title Priority Date Filing Date
ES550767A Expired ES8802520A1 (es) 1985-01-10 1986-01-09 Procedimiento para la obtencion de acidos 1-ciclopropil-1,4-dihidro-4-oxo-1,8 naftiridin-3-carboxilicos.
ES557514A Expired ES8801919A1 (es) 1985-01-10 1987-04-29 Procedimiento para la obtencion de acidos 1-ciclopropil-1,4-dihidro-4-oxo-1,8-naftiridin-3-carboxilicos
ES557516A Expired ES8800222A1 (es) 1985-01-10 1987-04-29 Procedimiento para la obtencion del acido 2,6-dicloro-5-fluor-piridin-3-carboxilico
ES557515A Expired ES8801796A1 (es) 1985-01-10 1987-04-29 Procedimiento para la obtencion de derivados del acido piridin-3-carboxilico
ES557785A Expired ES8802225A1 (es) 1985-01-10 1987-12-15 Procedimiento para la obtencion de acidos 1-ciclopropil-1,4-dihidro-4-oxo-1,8-naftiridein-3-carboxilicos

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES550767A Expired ES8802520A1 (es) 1985-01-10 1986-01-09 Procedimiento para la obtencion de acidos 1-ciclopropil-1,4-dihidro-4-oxo-1,8 naftiridin-3-carboxilicos.
ES557514A Expired ES8801919A1 (es) 1985-01-10 1987-04-29 Procedimiento para la obtencion de acidos 1-ciclopropil-1,4-dihidro-4-oxo-1,8-naftiridin-3-carboxilicos

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES557515A Expired ES8801796A1 (es) 1985-01-10 1987-04-29 Procedimiento para la obtencion de derivados del acido piridin-3-carboxilico
ES557785A Expired ES8802225A1 (es) 1985-01-10 1987-12-15 Procedimiento para la obtencion de acidos 1-ciclopropil-1,4-dihidro-4-oxo-1,8-naftiridein-3-carboxilicos

Country Status (21)

Country Link
US (1) US4840954A (es)
EP (1) EP0187376B1 (es)
JP (1) JPH0653741B2 (es)
KR (1) KR910002645B1 (es)
CN (1) CN1003236B (es)
AT (1) ATE76076T1 (es)
AU (3) AU574550B2 (es)
CA (2) CA1339373C (es)
DE (2) DE3508816A1 (es)
DK (1) DK168439B1 (es)
ES (5) ES8802520A1 (es)
FI (2) FI86721C (es)
GR (1) GR860031B (es)
HU (1) HU193623B (es)
IE (1) IE58412B1 (es)
IL (2) IL77538A (es)
NO (2) NO163331C (es)
NZ (2) NZ214746A (es)
PH (2) PH25055A (es)
PL (2) PL148191B1 (es)
PT (1) PT81810B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5153204A (en) * 1986-03-01 1992-10-06 Bayer Aktiengesellschaft 7-(1-Pyrrolidinyl)-quinolonecarboxylic acid derivatives
US5262417A (en) * 1988-12-06 1993-11-16 The Upjohn Company Antibacterial quinolone compounds
FR2650276B1 (fr) * 1989-07-28 1991-10-18 Bellon Labor Sa Roger Nouveaux derives de benzonaphtyridine-1,8 leur preparation et les compositions qui les contiennent
EP0449445A3 (en) * 1990-03-27 1993-08-25 Pfizer Inc. Preparation of beta-ketoesters useful in preparing quinolone antibiotics
US5290794A (en) * 1992-10-27 1994-03-01 Warner Lambert Co. Soluble calcium lactate antibacterial complexes as non-irritating parenteral forms
ATE217309T1 (de) * 1993-10-14 2002-05-15 Abbott Lab Verbindungen des chinolizinon-typs
WO1996037493A1 (de) * 1995-05-26 1996-11-28 Bayer Aktiengesellschaft Pyridyl-thiazole und deren verwendung zum schutz von pflanzen gegen befall durch mikroorganismen
US5739342A (en) * 1997-03-03 1998-04-14 Abbott Laboratories Process for the preparation of nicotinic acids
CA2285352A1 (en) * 1998-01-29 1999-08-05 Suntory Limited 1-cycloalkyl-1,8-naphthyridin-4-one derivatives with phosphodiesterase iv inhibitory activity
KR100364226B1 (ko) * 1998-03-18 2003-01-24 주식회사 엘지생명과학 7-할로-1-시클로프로필-6-플루오로-4-옥소-1,4-디히드로-[1.8]나프티리딘-3-카복실레이트의 제조방법
BR0212829A (pt) * 2001-09-26 2004-08-03 Bayer Pharmaceuticals Corp Derivados de 1,8-naftiridina e seu uso para tratar diabetes e distúrbios relacionados
JP4147190B2 (ja) * 2001-10-15 2008-09-10 エルジー・ライフ・サイエンシーズ・リミテッド β−ケトエステル化合物の製造方法
AR096135A1 (es) 2013-05-02 2015-12-09 Actelion Pharmaceuticals Ltd Derivados de la quinolona
JOP20190045A1 (ar) 2016-09-14 2019-03-14 Bayer Ag مركبات أميد حمض 1- أريل-نفثيريدين-3-كربوكسيليك مستبدلة في الموضع 7 واستخدامها.
EP3296298A1 (de) 2016-09-14 2018-03-21 Bayer Pharma Aktiengesellschaft 7-substituierte 1-aryl-naphthyridin-3-carbonsäureamide und ihre verwendung
CN109206424A (zh) * 2018-09-18 2019-01-15 佳木斯大学 依诺沙星-邻苯二甲酸药物盐单晶体及其制备方法
CN115784988B (zh) * 2022-12-13 2025-10-21 湖北省生物农药工程研究中心 一种多取代含氮杂环衍生物及其制备方法与应用

Family Cites Families (31)

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Publication number Priority date Publication date Assignee Title
CA1175836A (en) * 1977-09-20 1984-10-09 Marcel Pesson Production of 1,4-dihydroquinoline-3-carboxylic acid derivatives
DE2808070A1 (de) * 1978-02-24 1979-08-30 Bayer Ag Verfahren zur herstellung von 4-pyridon-3-carbonsaeuren und/oder deren derivaten
AR223983A1 (es) * 1978-08-25 1981-10-15 Dainippon Pharmaceutical Co Un procedimiento para-preparar derivados de acido 6-halogeno-4-oxo-7-(1-piperazinil)-1,8-naftiridin-3-carboxilico
JPS5531042A (en) * 1978-08-25 1980-03-05 Dainippon Pharmaceut Co Ltd 1,8-naphthylidine derivative and its salt
JPS5845426B2 (ja) * 1978-09-29 1983-10-08 杏林製薬株式会社 置換キノリンカルボン酸誘導体
JPS5649382A (en) * 1979-09-28 1981-05-02 Dainippon Pharmaceut Co Ltd 6-fluoro-7-cyclic amino-1,8-naphthylidine derivative and its salt
DE3142854A1 (de) * 1981-10-29 1983-05-11 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-piperazino-chinolin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3033157A1 (de) * 1980-09-03 1982-04-01 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-naphthyridin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3037417A1 (de) * 1980-10-03 1982-05-06 Vdo Adolf Schindling Ag, 6000 Frankfurt Einrichtung zur ermittlung des wegspezifischen kraftstoffverbrauchs
JPS57106681A (en) * 1980-12-24 1982-07-02 Dainippon Pharmaceut Co Ltd 1,8-naphthyridine derivative and its salt
US4665079A (en) * 1984-02-17 1987-05-12 Warner-Lambert Company Antibacterial agents
IE55898B1 (en) * 1982-09-09 1991-02-14 Warner Lambert Co Antibacterial agents
DE3248506A1 (de) * 1982-12-29 1984-07-05 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7(alkyl-1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3248507A1 (de) * 1982-12-29 1984-07-05 Bayer Ag, 5090 Leverkusen Mikrobizide mittel auf chinoloncarbonsaeure basis
DE3306771A1 (de) * 1983-02-25 1984-08-30 Bayer Ag, 5090 Leverkusen Chinoloncarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
JPS6028978A (ja) * 1983-07-27 1985-02-14 Dainippon Pharmaceut Co Ltd １，８−ナフチリジン誘導体
CS274601B2 (en) * 1983-07-27 1991-09-15 Dainippon Pharmaceutical Co Method of 1,8-naphthyridine derivative production
JPS6032790A (ja) * 1983-08-01 1985-02-19 Dainippon Pharmaceut Co Ltd １，８−ナフチリジン類
JPS6089480A (ja) * 1983-10-21 1985-05-20 Dainippon Pharmaceut Co Ltd ピリドンカルボン酸誘導体
JPS60126284A (ja) * 1983-12-09 1985-07-05 Dainippon Pharmaceut Co Ltd ピリドンカルボン酸誘導体およびその塩
US4616019A (en) * 1984-01-26 1986-10-07 Abbott Laboratories Naphthyridine antibacterial compounds
CA1285279C (en) * 1984-02-17 1991-06-25 Joseph P. Sanchez 7-amine derivatives of 1-cyclopropyl-6,8-difluoro-1,4- dihydro-4-oxo-3-quinolinecarboxylic acids and 1-cyclopropyl-1,4-dihydro-6-fluoro-4-oxo-1,8-naphthyridine- 3-carboxylic acidsas antibacterial agents
ZA85853B (en) * 1984-02-17 1986-09-24 Warner Lambert Co Antibacterial agents
DE3574380D1 (en) * 1984-02-17 1989-12-28 Daiichi Seiyaku Co 1,8-naphthyridine derivatives
JPS60172981A (ja) * 1984-02-17 1985-09-06 Dai Ichi Seiyaku Co Ltd １，８−ナフチリジン誘導体
JPS60197686A (ja) * 1984-03-19 1985-10-07 Dai Ichi Seiyaku Co Ltd １，８−ナフチリジン誘導体
US4571396A (en) * 1984-04-16 1986-02-18 Warner-Lambert Company Antibacterial agents
JPS6172753A (ja) * 1984-09-18 1986-04-14 Dainippon Pharmaceut Co Ltd ピリジルケトン誘導体
US4663457A (en) * 1985-01-23 1987-05-05 Warner-Lambert Company 1-cyclopropyl-6,7-dihalo-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid and their esters, useful as intermediates for preparing the 7-amine substituted naphthyridines
DE3525108A1 (de) * 1985-06-07 1986-12-11 Bayer Ag, 5090 Leverkusen Antibakteriell wirksame chinoloncarbonsaeureester
ATE75740T1 (de) * 1985-06-26 1992-05-15 Daiichi Seiyaku Co Pyridoncarbonsaeurederivate.

Also Published As

Publication number Publication date
AU576449B2 (en) 1988-08-25
US4840954A (en) 1989-06-20
PL148191B1 (en) 1989-09-30
GR860031B (en) 1986-04-29
DK9186A (da) 1986-07-11
IL89168A0 (en) 1989-09-10
JPH0653741B2 (ja) 1994-07-20
JPS61161284A (ja) 1986-07-21
ES8801796A1 (es) 1988-02-16
AU1835988A (en) 1988-09-15
HUT40126A (en) 1986-11-28
FI892675A0 (fi) 1989-06-01
PH24769A (en) 1990-10-01
CA1320206C (en) 1993-07-13
AU7311887A (en) 1987-09-10
DK168439B1 (da) 1994-03-28
ES557785A0 (es) 1988-04-16
FI860073A7 (fi) 1986-07-11
ATE76076T1 (de) 1992-05-15
PL148759B1 (en) 1989-11-30
ES8800222A1 (es) 1987-10-16
CN1003236B (zh) 1989-02-08
ES550767A0 (es) 1988-06-16
EP0187376B1 (de) 1992-05-13
ES8802225A1 (es) 1988-04-16
NO860199L (no) 1986-07-11
AU5216486A (en) 1987-01-22
PL264565A1 (en) 1988-01-07
IE860062L (en) 1986-07-10
CA1339373C (en) 1997-08-26
PH25055A (en) 1991-01-28
NZ229861A (en) 1989-10-27
PT81810A (en) 1986-02-01
DE3508816A1 (de) 1986-07-10
FI892675A7 (fi) 1989-06-01
NO163331B (no) 1990-01-29
FI86721B (fi) 1992-06-30
AU574550B2 (en) 1988-07-07
DK9186D0 (da) 1986-01-09
ES8801919A1 (es) 1988-03-01
FI860073A0 (fi) 1986-01-08
KR910002645B1 (ko) 1991-04-27
FI892675L (fi) 1989-06-01
EP0187376A3 (en) 1988-05-04
CN86100126A (zh) 1986-07-09
PL257419A1 (en) 1987-07-27
NO855134L (no) 1986-07-11
IE58412B1 (en) 1993-09-22
DE3586048D1 (en) 1992-06-17
FI86721C (fi) 1992-10-12
EP0187376A2 (de) 1986-07-16
ES557515A0 (es) 1988-02-16
ES8802520A1 (es) 1988-06-16
NZ214746A (en) 1989-10-27
ES557514A0 (es) 1988-03-01
IL77538A (en) 1992-05-25
PT81810B (pt) 1988-05-27
KR860005818A (ko) 1986-08-13
HU193623B (en) 1987-11-30
NO163331C (no) 1990-05-09

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