ES8105262A1 - Un procedimiento para la preparacion de 1, 1'-bifenil-2-il- alquilamina. - Google Patents
Un procedimiento para la preparacion de 1, 1'-bifenil-2-il- alquilamina.Info
- Publication number
- ES8105262A1 ES8105262A1 ES489469A ES489469A ES8105262A1 ES 8105262 A1 ES8105262 A1 ES 8105262A1 ES 489469 A ES489469 A ES 489469A ES 489469 A ES489469 A ES 489469A ES 8105262 A1 ES8105262 A1 ES 8105262A1
- Authority
- ES
- Spain
- Prior art keywords
- biphenyl
- production
- preparations containing
- containing same
- cardiovascular preparations
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 1,1'-Biphenyl-2-yl alkylamine Chemical class 0.000 title 1
- 230000002526 effect on cardiovascular system Effects 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 239000007818 Grignard reagent Substances 0.000 abstract 1
- 238000002512 chemotherapy Methods 0.000 abstract 1
- 150000004795 grignard reagents Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
PROCEDIMIENTO DE OBTENCION DE DERIVADOS DE 1,1''BIFENIL-2-IL-ALQUILAMINA. CONSISTE EN HACER REACCIONAR UNA CETONA DE FORMULA GENERAL (II) CON UN REACTIVO DE GRIGNARD DE FORMULA (III), OBTENIENDOSE DERIVADOS DE FORMULA GENERAL (I), EN QUE X ES HIDROGENO, R'' ES HIDROXI, R ELEVADO A 2 ES HIDROGENO O ALQUILO, Z ES -(CH2)N Y R ELEVADO A 4, R ELEVADO A 3 SON HIDROGENO, ALQUILO, CH2-ALQUENILO, FENILALQUILO. *FORMULA* QUIMIOTERAPIA DE ALTERACIONES CARDIOVASCULARES. R
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1953479A | 1979-03-12 | 1979-03-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8105262A1 true ES8105262A1 (es) | 1981-05-16 |
| ES489469A0 ES489469A0 (es) | 1981-05-16 |
Family
ID=21793713
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES489469A Granted ES489469A0 (es) | 1979-03-12 | 1980-03-12 | Un procedimiento para la preparacion de 1, 1'-bifenil-2-il- alquilamina. |
| ES497209A Expired ES8201528A1 (es) | 1979-03-12 | 1980-11-27 | Un procedimiento para la preparacion de nuevos derivados de 1,1'-bifenil-2-il-alquilamina |
| ES497207A Granted ES497207A0 (es) | 1979-03-12 | 1980-11-27 | Un procedimiento para la preparacion de nuevos derivados de 1,1'-binefil-2-il-alquilamina |
| ES497210A Granted ES497210A0 (es) | 1979-03-12 | 1980-11-27 | Un procedimiento para la preparacion de nuevos derivados de 1-1'-bifenil-2-il-alquilamina |
| ES497206A Granted ES497206A0 (es) | 1979-03-12 | 1980-11-27 | Un procedimiento para la preparacion de nuevos derivados de 1,1'-bifenil-2-il-alquilamina |
| ES497208A Expired ES8201527A1 (es) | 1979-03-12 | 1980-11-27 | Un procedimiento para las preparaciones de nuevos derivados de 1,1'-bifenil-2-il-alquilamina |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES497209A Expired ES8201528A1 (es) | 1979-03-12 | 1980-11-27 | Un procedimiento para la preparacion de nuevos derivados de 1,1'-bifenil-2-il-alquilamina |
| ES497207A Granted ES497207A0 (es) | 1979-03-12 | 1980-11-27 | Un procedimiento para la preparacion de nuevos derivados de 1,1'-binefil-2-il-alquilamina |
| ES497210A Granted ES497210A0 (es) | 1979-03-12 | 1980-11-27 | Un procedimiento para la preparacion de nuevos derivados de 1-1'-bifenil-2-il-alquilamina |
| ES497206A Granted ES497206A0 (es) | 1979-03-12 | 1980-11-27 | Un procedimiento para la preparacion de nuevos derivados de 1,1'-bifenil-2-il-alquilamina |
| ES497208A Expired ES8201527A1 (es) | 1979-03-12 | 1980-11-27 | Un procedimiento para las preparaciones de nuevos derivados de 1,1'-bifenil-2-il-alquilamina |
Country Status (31)
| Country | Link |
|---|---|
| EP (1) | EP0015776B1 (es) |
| JP (1) | JPS55127347A (es) |
| KR (1) | KR840000103B1 (es) |
| AR (1) | AR228852A1 (es) |
| AT (1) | AT367395B (es) |
| AU (1) | AU528060B2 (es) |
| BE (1) | BE882167A (es) |
| CA (1) | CA1144926A (es) |
| CH (1) | CH644094A5 (es) |
| CS (1) | CS215052B2 (es) |
| DD (1) | DD149664A5 (es) |
| DE (1) | DE3060611D1 (es) |
| DK (1) | DK103480A (es) |
| ES (6) | ES489469A0 (es) |
| FI (1) | FI800736A7 (es) |
| FR (1) | FR2451363A1 (es) |
| GB (1) | GB2046256B (es) |
| GR (1) | GR68036B (es) |
| HU (1) | HU180334B (es) |
| IE (1) | IE49552B1 (es) |
| IL (1) | IL59557A (es) |
| IT (1) | IT1140773B (es) |
| LU (1) | LU82237A1 (es) |
| MX (1) | MX6219E (es) |
| NZ (1) | NZ193079A (es) |
| PH (1) | PH14749A (es) |
| PL (1) | PL121662B1 (es) |
| PT (1) | PT70928A (es) |
| RO (1) | RO79906A (es) |
| SU (2) | SU940645A3 (es) |
| ZA (1) | ZA801421B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100470454B1 (ko) * | 2002-05-14 | 2005-02-05 | 대한민국 | 돼지 사료공급을 위한 자동조절급이기 |
| CN101035756A (zh) * | 2004-06-17 | 2007-09-12 | 南卡罗来纳州医科大学研究发展基金会 | 非天然氨基酸 |
| ES2742261T3 (es) * | 2011-04-15 | 2020-02-13 | Hivih | Inhibidores de la replicación viral, su proceso de preparación y sus usos terapéuticos |
| EP2821104A1 (en) | 2013-07-05 | 2015-01-07 | Laboratoire Biodim | Inhibitors of viral replication, their process of preparation and their therapeutical uses |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES236010A1 (es) * | 1956-06-29 | 1957-12-16 | Lab Pharmaceutica Dr C Janssen | UN PROCEDIMIENTO PARA PREPARAR NUEVOS DERIVADOS PARASIMPATICOLiTICAMENTE ACTIVOS DE ALFAS-DEFENIL PROPANO |
| US3433836A (en) * | 1966-01-14 | 1969-03-18 | Rexall Drug Chemical | Alpha-diaryl alpha,omega-alkylene glycol-dilower-alkylamines |
| GB1475314A (en) * | 1973-11-02 | 1977-06-01 | Cm Ind | Phenyl-propylamine derivatives |
| IL48319A0 (en) * | 1974-10-26 | 1975-12-31 | Merck Patent Gmbh | Araliphatic nitrogen compounds and a process for their preparation |
| GB1523655A (en) * | 1975-02-10 | 1978-09-06 | Armour Pharma | 4-(4-biphenylyl) butylamines and treatment of the animal organism therewith |
-
1980
- 1980-03-09 IL IL59557A patent/IL59557A/xx unknown
- 1980-03-10 PT PT70928A patent/PT70928A/pt unknown
- 1980-03-10 CA CA000347365A patent/CA1144926A/en not_active Expired
- 1980-03-10 CH CH186880A patent/CH644094A5/fr not_active IP Right Cessation
- 1980-03-10 NZ NZ193079A patent/NZ193079A/xx unknown
- 1980-03-10 PH PH23743A patent/PH14749A/en unknown
- 1980-03-10 FR FR8005311A patent/FR2451363A1/fr active Granted
- 1980-03-10 GR GR61387A patent/GR68036B/el unknown
- 1980-03-10 RO RO80100427A patent/RO79906A/ro unknown
- 1980-03-10 LU LU82237A patent/LU82237A1/fr unknown
- 1980-03-10 HU HU8080563A patent/HU180334B/hu unknown
- 1980-03-10 AU AU56302/80A patent/AU528060B2/en not_active Ceased
- 1980-03-11 GB GB8008170A patent/GB2046256B/en not_active Expired
- 1980-03-11 PL PL1980222601A patent/PL121662B1/pl unknown
- 1980-03-11 JP JP3256880A patent/JPS55127347A/ja active Pending
- 1980-03-11 AT AT0134580A patent/AT367395B/de not_active IP Right Cessation
- 1980-03-11 FI FI800736A patent/FI800736A7/fi not_active Application Discontinuation
- 1980-03-11 CS CS801665A patent/CS215052B2/cs unknown
- 1980-03-11 IT IT20503/80A patent/IT1140773B/it active
- 1980-03-11 BE BE1/9747A patent/BE882167A/fr not_active IP Right Cessation
- 1980-03-11 ZA ZA00801421A patent/ZA801421B/xx unknown
- 1980-03-11 EP EP80300744A patent/EP0015776B1/en not_active Expired
- 1980-03-11 IE IE493/80A patent/IE49552B1/en unknown
- 1980-03-11 DE DE8080300744T patent/DE3060611D1/de not_active Expired
- 1980-03-11 DK DK103480A patent/DK103480A/da not_active Application Discontinuation
- 1980-03-12 AR AR280280A patent/AR228852A1/es active
- 1980-03-12 KR KR1019800001023A patent/KR840000103B1/ko not_active Expired
- 1980-03-12 DD DD80219615A patent/DD149664A5/de unknown
- 1980-03-12 MX MX808706U patent/MX6219E/es unknown
- 1980-03-12 ES ES489469A patent/ES489469A0/es active Granted
- 1980-03-12 SU SU802892804A patent/SU940645A3/ru active
- 1980-11-27 ES ES497209A patent/ES8201528A1/es not_active Expired
- 1980-11-27 ES ES497207A patent/ES497207A0/es active Granted
- 1980-11-27 ES ES497210A patent/ES497210A0/es active Granted
- 1980-11-27 ES ES497206A patent/ES497206A0/es active Granted
- 1980-11-27 ES ES497208A patent/ES8201527A1/es not_active Expired
-
1981
- 1981-01-14 SU SU813229052A patent/SU1022655A3/ru active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19980202 |