ES8201527A1 - Un procedimiento para las preparaciones de nuevos derivados de 1,1'-bifenil-2-il-alquilamina - Google Patents

Un procedimiento para las preparaciones de nuevos derivados de 1,1'-bifenil-2-il-alquilamina

Info

Publication number
ES8201527A1
ES8201527A1 ES497208A ES497208A ES8201527A1 ES 8201527 A1 ES8201527 A1 ES 8201527A1 ES 497208 A ES497208 A ES 497208A ES 497208 A ES497208 A ES 497208A ES 8201527 A1 ES8201527 A1 ES 8201527A1
Authority
ES
Spain
Prior art keywords
carbon atoms
formula
biphenyl
production
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES497208A
Other languages
English (en)
Other versions
ES497208A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES8201527A1 publication Critical patent/ES8201527A1/es
Publication of ES497208A0 publication Critical patent/ES497208A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE 1,1''-BIFENIL-2-IL-ALQUILAMINA, DE FORMULA GENERAL (I), DONDE X ES HIDROGENO O UN SUSTITUYENTE HALOGENO EN CUALQUIER POSICION DEL ANILLO DE FENILO; R1 ES CN, CONH2 O COOH; R2 ES HIDROGENO O ALQUILO DE 1 A 3 ATOMOS DE CARBONO; Z ES -(CH2)N-, EN DONDE N ES 2, 3 O 4; R3 Y R4 INDEPENDIENTEMENTE SON HIDROGENO, ALQUILO DE 1 A 6 ATOMOS DE CARBONO, CH2-ALQUENILO DE 2 A 5 ATOMOS DE CARBONO, O FENILALQUILO DE 1 A 3 ATOMOS DE CARBONO, CH2-ALQUENILO DE 2 A 5 ATOMOS DE CARBONO, O FENILALQUILO DE 1 A 3 ATOMOS DE CARBONO; Y SUS SALES DE ADICION FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN HACER REACCIONAR UN NITRILO DE FORMULA (II), CON UN AGENTE DE MINOALQUILACION DE FORMULA (III), DONDE A ES UN GRUPO SALIENTE, Y R3, R4 Y N TIENEN LOS SIGNIFICADOS YA INDICADOS, PARA PRODUCIR UN COMPUESTO DE FORMULA (I), DONDE R1 ES -CN. OPCIONALMENTE SE SOMETE A UNA REACCION DE HIDROLISIS EL COMPUESTO PROCEDENTE DE LA ETAPA ANTERIOR, PARA OBTENER LOS COMPUESTOS DE FORMULA (I), DONDE R1 ES -CONH2 O -COOH.
ES497208A 1979-03-12 1980-11-27 Un procedimiento para las preparaciones de nuevos derivados de 1,1'-bifenil-2-il-alquilamina Granted ES497208A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1953479A 1979-03-12 1979-03-12

Publications (2)

Publication Number Publication Date
ES8201527A1 true ES8201527A1 (es) 1981-12-16
ES497208A0 ES497208A0 (es) 1981-12-16

Family

ID=21793713

Family Applications (6)

Application Number Title Priority Date Filing Date
ES489469A Expired ES8105262A1 (es) 1979-03-12 1980-03-12 Un procedimiento para la preparacion de 1, 1'-bifenil-2-il- alquilamina.
ES497209A Expired ES8201528A1 (es) 1979-03-12 1980-11-27 Un procedimiento para la preparacion de nuevos derivados de 1,1'-bifenil-2-il-alquilamina
ES497206A Expired ES8201525A1 (es) 1979-03-12 1980-11-27 Un procedimiento para la preparacion de nuevos derivados de 1,1'-bifenil-2-il-alquilamina
ES497207A Expired ES8201526A1 (es) 1979-03-12 1980-11-27 Un procedimiento para la preparacion de nuevos derivados de 1,1'-binefil-2-il-alquilamina
ES497210A Granted ES497210A0 (es) 1979-03-12 1980-11-27 Un procedimiento para la preparacion de nuevos derivados de 1-1'-bifenil-2-il-alquilamina
ES497208A Granted ES497208A0 (es) 1979-03-12 1980-11-27 Un procedimiento para las preparaciones de nuevos derivados de 1,1'-bifenil-2-il-alquilamina

Family Applications Before (5)

Application Number Title Priority Date Filing Date
ES489469A Expired ES8105262A1 (es) 1979-03-12 1980-03-12 Un procedimiento para la preparacion de 1, 1'-bifenil-2-il- alquilamina.
ES497209A Expired ES8201528A1 (es) 1979-03-12 1980-11-27 Un procedimiento para la preparacion de nuevos derivados de 1,1'-bifenil-2-il-alquilamina
ES497206A Expired ES8201525A1 (es) 1979-03-12 1980-11-27 Un procedimiento para la preparacion de nuevos derivados de 1,1'-bifenil-2-il-alquilamina
ES497207A Expired ES8201526A1 (es) 1979-03-12 1980-11-27 Un procedimiento para la preparacion de nuevos derivados de 1,1'-binefil-2-il-alquilamina
ES497210A Granted ES497210A0 (es) 1979-03-12 1980-11-27 Un procedimiento para la preparacion de nuevos derivados de 1-1'-bifenil-2-il-alquilamina

Country Status (31)

Country Link
EP (1) EP0015776B1 (es)
JP (1) JPS55127347A (es)
KR (1) KR840000103B1 (es)
AR (1) AR228852A1 (es)
AT (1) AT367395B (es)
AU (1) AU528060B2 (es)
BE (1) BE882167A (es)
CA (1) CA1144926A (es)
CH (1) CH644094A5 (es)
CS (1) CS215052B2 (es)
DD (1) DD149664A5 (es)
DE (1) DE3060611D1 (es)
DK (1) DK103480A (es)
ES (6) ES8105262A1 (es)
FI (1) FI800736A7 (es)
FR (1) FR2451363A1 (es)
GB (1) GB2046256B (es)
GR (1) GR68036B (es)
HU (1) HU180334B (es)
IE (1) IE49552B1 (es)
IL (1) IL59557A (es)
IT (1) IT1140773B (es)
LU (1) LU82237A1 (es)
MX (1) MX6219E (es)
NZ (1) NZ193079A (es)
PH (1) PH14749A (es)
PL (1) PL121662B1 (es)
PT (1) PT70928A (es)
RO (1) RO79906A (es)
SU (2) SU940645A3 (es)
ZA (1) ZA801421B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100470454B1 (ko) * 2002-05-14 2005-02-05 대한민국 돼지 사료공급을 위한 자동조절급이기
AU2005265164A1 (en) * 2004-06-17 2006-01-26 Musc Foundation For Research Development Non-natural amino acids
EP2511273B8 (en) * 2011-04-15 2019-06-26 Hivih Inhibitors of viral replication, their process of preparation and their therapeutical uses
EP2821104A1 (en) 2013-07-05 2015-01-07 Laboratoire Biodim Inhibitors of viral replication, their process of preparation and their therapeutical uses

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES236010A1 (es) * 1956-06-29 1957-12-16 Lab Pharmaceutica Dr C Janssen UN PROCEDIMIENTO PARA PREPARAR NUEVOS DERIVADOS PARASIMPATICOLiTICAMENTE ACTIVOS DE ALFAS-DEFENIL PROPANO
US3433836A (en) * 1966-01-14 1969-03-18 Rexall Drug Chemical Alpha-diaryl alpha,omega-alkylene glycol-dilower-alkylamines
GB1475314A (en) * 1973-11-02 1977-06-01 Cm Ind Phenyl-propylamine derivatives
IL48319A0 (en) * 1974-10-26 1975-12-31 Merck Patent Gmbh Araliphatic nitrogen compounds and a process for their preparation
GB1523655A (en) * 1975-02-10 1978-09-06 Armour Pharma 4-(4-biphenylyl) butylamines and treatment of the animal organism therewith

Also Published As

Publication number Publication date
PT70928A (en) 1980-04-01
IT8020503A0 (it) 1980-03-11
ES497209A0 (es) 1981-12-16
ES8201529A1 (es) 1981-12-16
DD149664A5 (de) 1981-07-22
IT1140773B (it) 1986-10-10
ES8201528A1 (es) 1981-12-16
HU180334B (en) 1983-02-28
SU1022655A3 (ru) 1983-06-07
JPS55127347A (en) 1980-10-02
ES497207A0 (es) 1981-12-16
FR2451363B1 (es) 1983-01-14
DK103480A (da) 1980-09-13
ES489469A0 (es) 1981-05-16
MX6219E (es) 1984-12-21
IL59557A (en) 1983-10-31
ES497206A0 (es) 1981-12-16
GB2046256B (en) 1983-04-20
LU82237A1 (fr) 1980-06-06
RO79906A (ro) 1982-10-11
SU940645A3 (ru) 1982-06-30
ES497210A0 (es) 1981-12-16
CH644094A5 (fr) 1984-07-13
ES8201525A1 (es) 1981-12-16
AU5630280A (en) 1980-09-18
EP0015776A1 (en) 1980-09-17
EP0015776B1 (en) 1982-06-30
AT367395B (de) 1982-06-25
ES497208A0 (es) 1981-12-16
ZA801421B (en) 1981-10-28
FR2451363A1 (fr) 1980-10-10
NZ193079A (en) 1982-05-31
PL121662B1 (en) 1982-05-31
CS215052B2 (en) 1982-07-30
GB2046256A (en) 1980-11-12
PH14749A (en) 1981-11-20
PL222601A1 (es) 1981-01-30
AR228852A1 (es) 1983-04-29
AU528060B2 (en) 1983-04-14
CA1144926A (en) 1983-04-19
ES8105262A1 (es) 1981-05-16
IE800493L (en) 1980-09-12
ATA134580A (de) 1981-11-15
DE3060611D1 (en) 1982-08-19
ES8201526A1 (es) 1981-12-16
FI800736A7 (fi) 1981-01-01
KR840000103B1 (ko) 1984-02-11
IE49552B1 (en) 1985-10-30
GR68036B (es) 1981-10-27
BE882167A (fr) 1980-09-11
KR830001854A (ko) 1983-05-19
IL59557A0 (en) 1980-06-30

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