ES8106157A1 - Un procedimiento para la preparacion de acido clavulanico - Google Patents

Un procedimiento para la preparacion de acido clavulanico

Info

Publication number
ES8106157A1
ES8106157A1 ES494431A ES494431A ES8106157A1 ES 8106157 A1 ES8106157 A1 ES 8106157A1 ES 494431 A ES494431 A ES 494431A ES 494431 A ES494431 A ES 494431A ES 8106157 A1 ES8106157 A1 ES 8106157A1
Authority
ES
Spain
Prior art keywords
preparation
clavulanic acid
amine salt
salt
tertiary
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES494431A
Other languages
English (en)
Other versions
ES494431A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10507413&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8106157(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES8106157A1 publication Critical patent/ES8106157A1/es
Publication of ES494431A0 publication Critical patent/ES494431A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PURIFICACION DE ACIDO CLAVULANICO DE FORMULA (I) Y SALES Y ESTERES FARMACEUTICAMENTE ACEPTABLES DEL MISMO. SE PONE EN CONTACTO EL ACIDO CLAVULANICO IMPURO EN UN DISOLVENTE ORGANICO CON TERC-BUTILAMINA DEL ACIDO CLAVULANICO. SE CONVIERTE LA SAL DE TERC-BUTILAMINA ASI FORMADA EN EL ACIDO CLAVULANICO O EN UNA SAL O ESTER FARMACEUTICAMENTE ACEPTABLE DEL MISMO. *FORMULA*
ES494431A 1979-08-24 1980-08-22 Un procedimiento para la preparacion de acido clavulanico Granted ES494431A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7929544 1979-08-24

Publications (2)

Publication Number Publication Date
ES8106157A1 true ES8106157A1 (es) 1981-07-16
ES494431A0 ES494431A0 (es) 1981-07-16

Family

ID=10507413

Family Applications (1)

Application Number Title Priority Date Filing Date
ES494431A Granted ES494431A0 (es) 1979-08-24 1980-08-22 Un procedimiento para la preparacion de acido clavulanico

Country Status (20)

Country Link
US (1) US4647659A (es)
EP (1) EP0026044B1 (es)
JP (2) JPS5634685A (es)
KR (1) KR860000343B1 (es)
AU (1) AU535198B2 (es)
CA (1) CA1157862A (es)
DE (1) DE3063683D1 (es)
DK (1) DK156069C (es)
ES (1) ES494431A0 (es)
FI (1) FI67222C (es)
GR (1) GR69870B (es)
HK (1) HK1086A (es)
HU (1) HU185619B (es)
IE (1) IE50047B1 (es)
IL (1) IL60885A (es)
MY (1) MY8500999A (es)
NO (1) NO165241C (es)
NZ (1) NZ194703A (es)
PL (1) PL139811B1 (es)
ZA (1) ZA805206B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2058029A1 (es) * 1992-03-10 1994-10-16 Biochemie Gmbh Proceso para la produccion de sales del acido clavulanico.

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2200355B (en) 1987-01-29 1990-08-01 Beecham Group Plc Potassium clavulanate
ES2010143A6 (es) † 1989-03-01 1989-10-16 Pharma Mar S A Pharmar Un nuevo procedimiento de obtencion del acido z(2r,5r)-3-(2-hiadroxietiliden)-7- oxo-4-oxa-1-azabiciclo(3,2,0) -heptano-2-carboxilico y de sales estares farmaceutiacamente aceptables del mismo,a partir de caldos de fermentacion de streptomyces, sp.
JPH0457085U (es) * 1990-09-14 1992-05-15
JPH0569557U (ja) * 1992-02-26 1993-09-21 東京電機工業株式會社 固体蓄熱装置
AT399155B (de) * 1992-03-26 1995-03-27 Lek Tovarna Farmacevtskih Neue alkylendiammonium-diclavulanat-derivate, verfahren zu deren herstellung sowie deren verwendung
AT1447U1 (de) * 1992-06-11 1997-05-26 Smithkline Beecham Plc Neue salze von clavulansäure
AT475U1 (de) * 1992-06-11 1995-11-27 Smithkline Beecham Plc Verfahren zur herstellung von clavulansaeure
GB9222841D0 (en) * 1992-10-31 1992-12-16 Smithkline Beecham Plc Novel process
SI9300296B (sl) * 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline
GB2282810B (en) * 1992-06-11 1997-02-26 Smithkline Beecham Plc Preparation or purification of clavulanic acid
SI9200139A (en) * 1992-07-08 1994-03-31 Lek Tovarna Farmacevtskih New inclusion complex of clavulanic acid with hydrophylyc and hydropholyc beta-cyclodextrin derivates for production of them
KR100200239B1 (ko) * 1992-10-21 1999-06-15 김충환 클라불란산 칼륨염의 제조방법
AT1446U1 (de) * 1992-10-31 1997-05-26 Smithkline Beecham Plc Verfahren zur herstellung und/oder reinigung von clavulansäure
GB9305565D0 (en) * 1993-03-18 1993-05-05 Smithkline Beecham Plc Novel compounds and processes
US5760218A (en) * 1993-03-26 1998-06-02 Gist-Brocades N.V. Diamine salts of clavulanic acid
US5821364A (en) * 1993-03-26 1998-10-13 Gist-Brocades N.V. Diamine salts of clavulanic acid
CZ284855B6 (cs) * 1993-03-26 1999-03-17 Dsm N.V. Soli klavulanové kyseliny s diaminy, způsob jejich výroby, farmaceutické přípravky na jejich bázi, použití těchto solí pro výrobu kyseliny klavulanové nebo jejích farmaceuticky vhodných solí nebo esterů a způsob čištění posledně uvedených látek
DE4318916A1 (de) * 1993-06-07 1994-12-08 Bayer Ag Cyclobutylazole
EP0658558B1 (en) 1993-11-17 2001-01-24 Biochemie Gesellschaft M.B.H. Separation of cephalosporin isomers
GB9401969D0 (en) * 1994-02-02 1994-03-30 Smithkline Beecham Plc Process
GB9426261D0 (en) * 1994-12-24 1995-02-22 Spurcourt Ltd Clavulanic acid salts
GB9500977D0 (en) 1995-01-19 1995-03-08 Smithkline Beecham Plc Novel process
CZ266697A3 (en) * 1995-02-25 1997-11-12 Spurcourt Ltd Salts of clavulanic acid
SI9500134B (sl) 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
KR100200242B1 (ko) * 1995-05-16 1999-06-15 김충환 클라불란산염의 제조 방법
GB9515809D0 (en) * 1995-08-02 1995-10-04 Smithkline Beecham Plc Process
JPH09152148A (ja) * 1995-09-29 1997-06-10 Tokyo Denki Kogyo Kk 蓄熱式空調装置
US6414142B1 (en) * 1996-06-13 2002-07-02 Smithkline Beecham Corporation Process for preparing potassium clavulanate
AT404728B (de) * 1996-11-27 1999-02-25 Biochemie Gmbh Verfahren zur herstellung von clavulansäure-aminsalzen
AU5409799A (en) * 1998-07-03 2000-01-24 Dsm N.V. Fermentation process to produce clavulanic acid at a low concentration of free amino acids
AU6089699A (en) * 1998-09-29 2000-04-17 Dsm N.V. Fermentation of clavulanic acid at a controlled level of ammonia
GB0003305D0 (en) 2000-02-15 2000-04-05 Zeneca Ltd Pyrimidine derivatives
ES2177391B1 (es) * 2000-04-19 2004-08-16 Felipe Lopez Oliva Muñoz Protesis de disco cervical.
BRPI0110774B8 (pt) * 2000-05-13 2021-05-25 Smithkline Beecham Plc processo para purificação de um sal de ácido clavulânico
CN105384758B (zh) * 2015-12-01 2018-05-01 国药集团威奇达药业有限公司 克拉维酸胺盐的制备方法
CN109305978A (zh) * 2017-07-26 2019-02-05 山东睿鹰先锋制药有限公司 一种制备克拉维酸盐的新方法
CN108822134B (zh) * 2018-04-25 2021-06-25 国药集团威奇达药业有限公司 克拉维酸叔丁胺盐的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1508977A (en) * 1974-04-20 1978-04-26 Beecham Group Ltd Beta-lactam antibiotic from streptomyces clavuligerus
IE41109B1 (en) * 1974-04-20 1979-10-24 Beecham Group Ltd Novel -lactam antibiotic from streptomyces clavuligerus
GB1543563A (en) * 1975-02-07 1979-04-04 Glaxo Lab Ltd Beta-lactam antibiotic in purified form
YU40452B (en) * 1975-02-07 1986-02-28 Beecham Group Plc Process for the elimination of contaminating impurities from clavulinic acid
GB1578739A (en) * 1976-07-23 1980-11-05 Beecham Group Ltd Amine salts of clavulanic acid methods for their preparation and compositions containing them
GB1572912A (en) * 1977-01-19 1980-08-06 Beecham Group Ltd Clavulanic acid esters
US4255332A (en) * 1977-09-01 1981-03-10 Beecham Group Limited Process for the preparation of potassium clavulanate from lithium clavulanate

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2058029A1 (es) * 1992-03-10 1994-10-16 Biochemie Gmbh Proceso para la produccion de sales del acido clavulanico.

Also Published As

Publication number Publication date
JPH0234954B2 (es) 1990-08-07
AU535198B2 (en) 1984-03-08
FI67222B (fi) 1984-10-31
GR69870B (es) 1982-07-20
HK1086A (en) 1986-01-10
US4647659A (en) 1987-03-03
CA1157862A (en) 1983-11-29
PL139811B1 (en) 1987-02-28
DK156069B (da) 1989-06-19
JPH02167286A (ja) 1990-06-27
JPH0415234B2 (es) 1992-03-17
ZA805206B (en) 1981-08-26
JPS5634685A (en) 1981-04-06
EP0026044B1 (en) 1983-06-08
DE3063683D1 (en) 1983-07-14
NO165241C (no) 1991-01-16
IE50047B1 (en) 1986-02-05
MY8500999A (en) 1985-12-31
DK156069C (da) 1989-12-04
IE801777L (en) 1981-02-24
AU6163280A (en) 1981-04-09
ES494431A0 (es) 1981-07-16
FI67222C (fi) 1985-02-11
NZ194703A (en) 1983-09-02
NO802498L (no) 1981-02-25
HU185619B (en) 1985-03-28
IL60885A (en) 1983-11-30
FI802590A7 (fi) 1981-02-25
KR830003492A (ko) 1983-06-20
NO165241B (no) 1990-10-08
PL226397A1 (es) 1981-05-22
DK363080A (da) 1981-02-25
KR860000343B1 (ko) 1986-04-12
IL60885A0 (en) 1980-10-26
EP0026044A1 (en) 1981-04-01

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Legal Events

Date Code Title Description
GD1A Contractual licences

Effective date: 19961009

FD1A Patent lapsed

Effective date: 20010407