ES8106889A1 - Procedimiento para la obtencion de acido (1-(4-clorobenzoil)-5-metoxi-2-metil-3-indol)acetoxiacetico - Google Patents

Procedimiento para la obtencion de acido (1-(4-clorobenzoil)-5-metoxi-2-metil-3-indol)acetoxiacetico

Info

Publication number
ES8106889A1
ES8106889A1 ES496249A ES496249A ES8106889A1 ES 8106889 A1 ES8106889 A1 ES 8106889A1 ES 496249 A ES496249 A ES 496249A ES 496249 A ES496249 A ES 496249A ES 8106889 A1 ES8106889 A1 ES 8106889A1
Authority
ES
Spain
Prior art keywords
acid
formula
chlorobenzoil
indol
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES496249A
Other languages
English (en)
Other versions
ES496249A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Troponwerke GmbH
Original Assignee
Troponwerke GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Troponwerke GmbH filed Critical Troponwerke GmbH
Publication of ES496249A0 publication Critical patent/ES496249A0/es
Publication of ES8106889A1 publication Critical patent/ES8106889A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DEL ACIDO [1-(4-CLOROBENZOIL)-5-METOXI-2-METIL-3-INDOL]ACETOXIACETICO. SE HACE REACCIONAR, A TEMPERATURA DE 20G-60GC, EN PRESENCIA DE ACIDO ACETICO GLACIAL COMO DISOLVENTE, UN HIDROCLORURO DE ALFA-(4-CLOROBENZOIL)-4-METOXI-FENILHIDRAZINA DE FORMULA (I) O SU SULFONATO CORRESPONDIENTE, CON ACIDO LEVULINOILOXIACETICO LIBRE DE FORMULA (II), OBTENIDO POR HIDROGENACION CATALITICA DEL ESTER DE BENCILO DEL ACIDO LEVOLINOILOXIACETICO. LA HIDRAZONA DE FORMULA (III) RESULTANTE SE CICLIZA A INDOL POR CALENTAMIENTO DE 40G A 80GC, EN ATMOSFERA DE GAS INERTE, BAJO DISOCIACION DE AMONIACO. DE APLICACION COMO AGENTE ANTIFLOGISTICO EN PREPARADOS FARMACEUTICOS. *FORMULA*
ES496249A 1979-10-25 1980-10-24 Procedimiento para la obtencion de acido (1-(4-clorobenzoil)-5-metoxi-2-metil-3-indol)acetoxiacetico Expired ES8106889A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19792943125 DE2943125A1 (de) 1979-10-25 1979-10-25 Verfahren zur herstellung von 1-(4-chlorbenzoyl)-5-methoxy-2-methyl-3-indol acetoxyessigsaeure

Publications (2)

Publication Number Publication Date
ES496249A0 ES496249A0 (es) 1981-09-16
ES8106889A1 true ES8106889A1 (es) 1981-09-16

Family

ID=6084363

Family Applications (1)

Application Number Title Priority Date Filing Date
ES496249A Expired ES8106889A1 (es) 1979-10-25 1980-10-24 Procedimiento para la obtencion de acido (1-(4-clorobenzoil)-5-metoxi-2-metil-3-indol)acetoxiacetico

Country Status (13)

Country Link
US (1) US4332727A (es)
EP (1) EP0027956A1 (es)
JP (1) JPS5668667A (es)
AU (1) AU532859B2 (es)
CA (1) CA1148540A (es)
DE (1) DE2943125A1 (es)
DK (1) DK452480A (es)
ES (1) ES8106889A1 (es)
FI (1) FI803320A7 (es)
GR (1) GR70767B (es)
IL (1) IL61328A (es)
PT (1) PT71921B (es)
ZA (1) ZA806544B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH653326A5 (de) * 1981-12-28 1985-12-31 Siegfried Ag Verfahren zur herstellung eines indolderivates.
DE3206889A1 (de) * 1982-02-26 1983-09-15 Troponwerke GmbH & Co KG, 5000 Köln Verfahren zur herstellung von 1-(4-chlorbenzoyl)-5-methoxy-2-methyl-3-indolacetoxyessigsaeure
DE3206885A1 (de) * 1982-02-26 1983-09-15 Troponwerke GmbH & Co KG, 5000 Köln Indolderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
WO1997048694A1 (en) * 1996-06-20 1997-12-24 Board Of Regents, The University Of Texas System Compounds and methods for providing pharmacologically active preparations and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT290523B (de) * 1962-01-05 1971-06-11 Merck & Co Inc Verfahren zur Herstellung neuer α-(3-Indolyl)-carbonsäuren
DE2234651C3 (de) * 1972-07-14 1978-11-09 Troponwerke Gmbh & Co Kg, 5000 Koeln Eckige Klammer auf l-(p-Chlorbenzoyl)-5-methoxy-2-methyl-3-indol] -acetoxj essigsaure, ihre Salze mit Basen, Verfahren zu ihrer Herstellung sowie pharmakologische Zubereitungen
DE2413125C2 (de) * 1974-03-15 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen Indolylacetylaminosäurederivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneipräparate
JPS52156862A (en) * 1976-06-22 1977-12-27 Hisamitsu Pharmaceut Co Inc Novel indoleacetic acid ester derivatives
DE2740852A1 (de) * 1977-09-10 1979-03-29 Troponwerke Gmbh & Co Kg Basische 1-acylindol-3-acetocyessigsaeureester, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE2740836A1 (de) * 1977-09-10 1979-03-22 Troponwerke Gmbh & Co Kg Anellierte indolderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE2752361A1 (de) * 1977-11-24 1979-06-07 Troponwerke Gmbh & Co Kg Neue indolderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Also Published As

Publication number Publication date
PT71921B (de) 1981-08-31
DK452480A (da) 1981-04-26
JPS5668667A (en) 1981-06-09
EP0027956A1 (de) 1981-05-06
CA1148540A (en) 1983-06-21
GR70767B (es) 1983-03-16
IL61328A (en) 1983-06-15
IL61328A0 (en) 1980-12-31
PT71921A (de) 1980-11-01
ES496249A0 (es) 1981-09-16
US4332727A (en) 1982-06-01
FI803320L (fi) 1981-04-26
DE2943125A1 (de) 1981-05-14
FI803320A7 (fi) 1981-04-26
AU532859B2 (en) 1983-10-13
ZA806544B (en) 1981-11-25

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