ES8303392A1 - Procedimiento para la obtencion de la n-2(5-dimetilamino) metil-2-furanil) metil tio etil-n-(2-etanol)-2-nitro-1,1-etenodiamina. - Google Patents

Procedimiento para la obtencion de la n-2(5-dimetilamino) metil-2-furanil) metil tio etil-n-(2-etanol)-2-nitro-1,1-etenodiamina.

Info

Publication number
ES8303392A1
ES8303392A1 ES511896A ES511896A ES8303392A1 ES 8303392 A1 ES8303392 A1 ES 8303392A1 ES 511896 A ES511896 A ES 511896A ES 511896 A ES511896 A ES 511896A ES 8303392 A1 ES8303392 A1 ES 8303392A1
Authority
ES
Spain
Prior art keywords
methyl
therapy
manufacture
addition salts
drug composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES511896A
Other languages
English (en)
Other versions
ES511896A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Inke SA
Original Assignee
Inke SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inke SA filed Critical Inke SA
Priority to ES511896A priority Critical patent/ES511896A0/es
Publication of ES8303392A1 publication Critical patent/ES8303392A1/es
Publication of ES511896A0 publication Critical patent/ES511896A0/es
Priority to PT76557A priority patent/PT76557B/pt
Priority to ZA831977A priority patent/ZA831977B/xx
Priority to US06/478,052 priority patent/US4515806A/en
Priority to AU12801/83A priority patent/AU551113B2/en
Priority to NZ203698A priority patent/NZ203698A/en
Priority to FI831053A priority patent/FI831053L/fi
Priority to IL68253A priority patent/IL68253A0/xx
Priority to KR1019830001273A priority patent/KR840004097A/ko
Priority to GB08309645A priority patent/GB2118551B/en
Priority to CA000425480A priority patent/CA1185611A/en
Priority to NL8301269A priority patent/NL8301269A/nl
Priority to FR8305870A priority patent/FR2525221B1/fr
Priority to SE8302045A priority patent/SE8302045L/xx
Priority to IT20588/83A priority patent/IT1164174B/it
Priority to GR71082A priority patent/GR78560B/el
Priority to DE19833313603 priority patent/DE3313603A1/de
Priority to BE0/210550A priority patent/BE896462A/fr
Priority to NO831343A priority patent/NO831343L/no
Priority to DK165583A priority patent/DK165583A/da
Priority to CH2037/83A priority patent/CH655721A5/fr
Priority to JP58067664A priority patent/JPS58213768A/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE LA N- 2- (5- (DIMETILAMINO)METIL -2-FURANIL)METIL TIO ETIL -N''-(2-ETANOL)-2-NITRO-1,1-ETENODIAMINA. CONSISTE EN LA REACCION DE LA 2- (5-DIMETILAMINO)METIL-2-FURANIL METIL TIO ETANOAMINA CON UN EXCESO ENTRE 10 Y 20% DE N,N''-BIS(2-ETANOL)-2-NITRO-1,1-ETENODIAMINA. LA REACCION SE LLEVA A CABO EN DISOLUCION ACUOSA, A TEMPERATURAS COMPRENDIDAS ENTRE 90 C Y 110 C. EL PRODUCTO OBTENIDO SE SEPARA Y PURIFICA SIGUIENDO METODOS CONVENCIONALES. ESTE COMPUESTO TIENE APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE LA ULCERA GASTRODUODENAL Y DE LOS SINTOMAS SOSTENIDOS O ACOMPAÑADOS POR SECRECCION ACIDA.
ES511896A 1982-04-16 1982-04-16 Procedimiento para la obtencion de la n-2(5-dimetilamino) metil-2-furanil) metil tio etil-n-(2-etanol)-2-nitro-1,1-etenodiamina. Granted ES511896A0 (es)

Priority Applications (22)

Application Number Priority Date Filing Date Title
ES511896A ES511896A0 (es) 1982-04-16 1982-04-16 Procedimiento para la obtencion de la n-2(5-dimetilamino) metil-2-furanil) metil tio etil-n-(2-etanol)-2-nitro-1,1-etenodiamina.
PT76557A PT76557B (en) 1982-04-16 1983-03-14 Process for preparing furan derivatives and addition salts thereof and of pharmaceutical compositions containing the same
ZA831977A ZA831977B (en) 1982-04-16 1983-03-22 Furan derivatives and addition salts thereof,processes for the preparation thereof,pharmaceutical compositions and the therapeutical applications thereof
US06/478,052 US4515806A (en) 1982-04-16 1983-03-23 Furan derivatives and addition salts thereof pharmaceutical compositions and the therapeutical applications thereof
AU12801/83A AU551113B2 (en) 1982-04-16 1983-03-24 Dimethyl amino methyl furans
NZ203698A NZ203698A (en) 1982-04-16 1983-03-25 Furan derivatives and pharmaceutical compositions
IL68253A IL68253A0 (en) 1982-04-16 1983-03-28 Furan derivatives,processes for the preparation thereof,and pharmaceutical compositions containing the same
FI831053A FI831053L (fi) 1982-04-16 1983-03-28 Furanderivat och deras additionssalter, foerfaranden foer deras framstaellning, dessa innehaollandefarmaceutiska kompositioner och deras terapeutiska anvaendningsmoejligheter
KR1019830001273A KR840004097A (ko) 1982-04-16 1983-03-29 푸란 유도체의 제조방법
GB08309645A GB2118551B (en) 1982-04-16 1983-04-08 Furan derivatives and pharmaceutical compositions containing them
CA000425480A CA1185611A (en) 1982-04-16 1983-04-08 Furan derivatives and addition salts thereof and processes for the preparation thereof
NL8301269A NL8301269A (nl) 1982-04-16 1983-04-11 Werkwijze ter bereiding van nieuwe furanderivaten.
FR8305870A FR2525221B1 (fr) 1982-04-16 1983-04-11 Derives du furanne et sels d'addition de ces derives, leurs procedes de preparation et leurs applications en therapeutique
SE8302045A SE8302045L (sv) 1982-04-16 1983-04-13 Furanderivat
IT20588/83A IT1164174B (it) 1982-04-16 1983-04-14 Derivati del furano e relativi sali di addizione,procedimenti per la loro preparazione,composti farmaceutici e loro applicazioni terapeutiche
GR71082A GR78560B (es) 1982-04-16 1983-04-14
DE19833313603 DE3313603A1 (de) 1982-04-16 1983-04-14 Furanderivate, verfahren zu deren herstellung und diese enthaltende arzneimittel
BE0/210550A BE896462A (fr) 1982-04-16 1983-04-14 Derives du furanne et sels d'addition de ces derives, leurs procedes de preparation et leur applications en therapeutique
NO831343A NO831343L (no) 1982-04-16 1983-04-15 Furanderivater og fremgangsmaate til deres fremstilling
DK165583A DK165583A (da) 1982-04-16 1983-04-15 Fremgangsmaade til fremstilling af furanderivater
CH2037/83A CH655721A5 (fr) 1982-04-16 1983-04-15 Derives du furanne et sels d'addition de ces derives leurs procedes de preparation et composition pharmaceutique les contenant.
JP58067664A JPS58213768A (ja) 1982-04-16 1983-04-16 フラン誘導体およびそれらの付加塩、それらの製法、薬剤組成物、ならびにそれらの治療への使用

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES511896A ES511896A0 (es) 1982-04-16 1982-04-16 Procedimiento para la obtencion de la n-2(5-dimetilamino) metil-2-furanil) metil tio etil-n-(2-etanol)-2-nitro-1,1-etenodiamina.

Publications (2)

Publication Number Publication Date
ES8303392A1 true ES8303392A1 (es) 1983-02-01
ES511896A0 ES511896A0 (es) 1983-02-01

Family

ID=8484092

Family Applications (1)

Application Number Title Priority Date Filing Date
ES511896A Granted ES511896A0 (es) 1982-04-16 1982-04-16 Procedimiento para la obtencion de la n-2(5-dimetilamino) metil-2-furanil) metil tio etil-n-(2-etanol)-2-nitro-1,1-etenodiamina.

Country Status (5)

Country Link
JP (1) JPS58213768A (es)
KR (1) KR840004097A (es)
BE (1) BE896462A (es)
ES (1) ES511896A0 (es)
ZA (1) ZA831977B (es)

Also Published As

Publication number Publication date
JPS58213768A (ja) 1983-12-12
BE896462A (fr) 1983-08-01
JPS616069B2 (es) 1986-02-24
KR840004097A (ko) 1984-10-06
ES511896A0 (es) 1983-02-01
ZA831977B (en) 1983-11-30

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970612