ES8305698A1 - Un procedimiento para la preparacion de derivados de acidos-s-aminoacil-3-mercaptopropanoilos. - Google Patents

Un procedimiento para la preparacion de derivados de acidos-s-aminoacil-3-mercaptopropanoilos.

Info

Publication number
ES8305698A1
ES8305698A1 ES500254A ES500254A ES8305698A1 ES 8305698 A1 ES8305698 A1 ES 8305698A1 ES 500254 A ES500254 A ES 500254A ES 500254 A ES500254 A ES 500254A ES 8305698 A1 ES8305698 A1 ES 8305698A1
Authority
ES
Spain
Prior art keywords
formula
reacted
hydrogen
compound
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES500254A
Other languages
English (en)
Other versions
ES500254A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Miami
Original Assignee
University of Miami
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Miami filed Critical University of Miami
Publication of ES8305698A1 publication Critical patent/ES8305698A1/es
Publication of ES500254A0 publication Critical patent/ES500254A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C329/00—Thiocarbonic acids; Halides, esters or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE ACIDOS S MINOACIL-3-MERCAPTOPROPANOICOS DE FORMULA GENERAL (I), EN LA QUE R ES HIDROGENO, L-LISILO O T-BUTILOXICARBONILO; R ES HIDROGENO O METILO; R ES L-PROLINA O L-5-OXO-PROLINA; Y R ES FENILMETILO O METILO. COMPRENDE LAS SIGUIENTES ETAPAS: PRIMERA, SE HACE REACCIONAR UN DERIVADO DE UN AMINOACIDO DE FORMULA (II) CON UN COMPUESTO DE FORMULA: T-SH, DONDE T ES ALQUILO O ARILO; SEGUNDA, EL PRODUCTO OBTENIDO EN LA PRIMERA ETAPA SE HACE REACCIONAR CON UN COMPUESTO DE FORMULA: MHS, EN LA QUE M ES HIDROGENO O UN METAL ALCALINO; Y POR ULTIMO, SE HACE REACCIONAR EL PRODUCTO OBTENIDO EN LA SEGUNDA ETAPA CON UN COMPUESTO DE FORMULA (III), EN LA QUE R ES OH O R ; Y R Y R TIENEN LOS SIGNIFICADOS YA INDICADOS. DE APLICACION EN EL TRATAMIENTO DE LA HIPERTENSION.
ES500254A 1980-03-10 1981-03-10 Un procedimiento para la preparacion de derivados de acidos-s-aminoacil-3-mercaptopropanoilos. Granted ES500254A0 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12895380A 1980-03-10 1980-03-10
US15827880A 1980-06-10 1980-06-10
AU73631/81A AU7363181A (en) 1980-03-10 1981-07-31 Anti-ace peptide preparative methods

Publications (2)

Publication Number Publication Date
ES8305698A1 true ES8305698A1 (es) 1983-04-16
ES500254A0 ES500254A0 (es) 1983-04-16

Family

ID=27156035

Family Applications (5)

Application Number Title Priority Date Filing Date
ES500254A Granted ES500254A0 (es) 1980-03-10 1981-03-10 Un procedimiento para la preparacion de derivados de acidos-s-aminoacil-3-mercaptopropanoilos.
ES519567A Granted ES519567A0 (es) 1980-03-10 1983-02-04 Un procedimiento para la preparacion de derivados de aminoacido.
ES519564A Expired ES8403104A1 (es) 1980-03-10 1983-02-04 Un procedimiento para la preparacion de derivados de aminoacido.
ES519565A Granted ES519565A0 (es) 1980-03-10 1983-02-04 Un procedimiento para la preparacion de derivados de aminoacido.
ES519566A Granted ES519566A0 (es) 1980-03-10 1983-02-04 Un procedimiento para la preparacion de derivados de aminoacido.

Family Applications After (4)

Application Number Title Priority Date Filing Date
ES519567A Granted ES519567A0 (es) 1980-03-10 1983-02-04 Un procedimiento para la preparacion de derivados de aminoacido.
ES519564A Expired ES8403104A1 (es) 1980-03-10 1983-02-04 Un procedimiento para la preparacion de derivados de aminoacido.
ES519565A Granted ES519565A0 (es) 1980-03-10 1983-02-04 Un procedimiento para la preparacion de derivados de aminoacido.
ES519566A Granted ES519566A0 (es) 1980-03-10 1983-02-04 Un procedimiento para la preparacion de derivados de aminoacido.

Country Status (14)

Country Link
EP (1) EP0038117A1 (es)
JP (3) JPH0667903B2 (es)
KR (1) KR850001629B1 (es)
AU (1) AU7363181A (es)
CS (1) CS174581A2 (es)
DD (1) DD156805A5 (es)
DK (1) DK105981A (es)
ES (5) ES500254A0 (es)
FI (1) FI810725L (es)
GR (1) GR74795B (es)
NO (5) NO156695C (es)
PL (1) PL230076A1 (es)
PT (1) PT72635B (es)
SU (1) SU1567125A3 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7056935B2 (en) 1995-06-07 2006-06-06 Gpi Nil Holdings, Inc. Rotamase enzyme activity inhibitors
US5801187A (en) 1996-09-25 1998-09-01 Gpi-Nil Holdings, Inc. Heterocyclic esters and amides
CN111039838B (zh) * 2019-12-31 2022-04-05 杭州乐敦科技有限公司 一种3-乙酰巯基-2-甲基丙酸的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA802420B (en) * 1979-05-18 1981-04-29 Squibb & Sons Inc Aminoacyl derivatives of mercaptoacyl amino acids

Also Published As

Publication number Publication date
PT72635B (en) 1982-03-19
PT72635A (en) 1981-04-01
ES519564A0 (es) 1984-03-01
GR74795B (es) 1984-07-12
JPH0667901B2 (ja) 1994-08-31
FI810725A7 (fi) 1981-09-11
JPH0667903B2 (ja) 1994-08-31
SU1567125A3 (ru) 1990-05-23
ES8403448A1 (es) 1984-03-16
JPH02209865A (ja) 1990-08-21
ES519565A0 (es) 1984-03-16
ES8403104A1 (es) 1984-03-01
NO831111L (no) 1981-09-11
JPH01246257A (ja) 1989-10-02
NO831113L (no) 1981-09-11
NO831114L (no) 1981-09-11
KR830005133A (ko) 1983-08-03
ES8403450A1 (es) 1984-03-16
ES500254A0 (es) 1983-04-16
PL230076A1 (es) 1982-09-13
ES519567A0 (es) 1984-03-16
DK105981A (da) 1981-09-11
CS174581A2 (en) 1990-09-12
DD156805A5 (de) 1982-09-22
ES8403449A1 (es) 1984-03-16
AU7363181A (en) 1983-02-03
KR850001629B1 (ko) 1985-10-31
NO156695C (no) 1987-11-04
FI810725L (fi) 1981-09-11
NO156695B (no) 1987-07-27
NO810795L (no) 1981-09-11
EP0038117A1 (en) 1981-10-21
ES519566A0 (es) 1984-03-16
NO831112L (no) 1981-09-11
JPH01250344A (ja) 1989-10-05
JPH0667902B2 (ja) 1994-08-31

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970203