ES8307218A1 - Proceso de fabricacion de los nuevos derivados de la amidinopiperadina. - Google Patents

Proceso de fabricacion de los nuevos derivados de la amidinopiperadina.

Info

Publication number
ES8307218A1
ES8307218A1 ES512519A ES512519A ES8307218A1 ES 8307218 A1 ES8307218 A1 ES 8307218A1 ES 512519 A ES512519 A ES 512519A ES 512519 A ES512519 A ES 512519A ES 8307218 A1 ES8307218 A1 ES 8307218A1
Authority
ES
Spain
Prior art keywords
compound
amidinopiperadine
group
manufacturing process
pyridyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES512519A
Other languages
English (en)
Other versions
ES512519A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Chemiphar Co Ltd
Original Assignee
Nippon Chemiphar Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP56078142A external-priority patent/JPS57193457A/ja
Priority claimed from JP7814381A external-priority patent/JPS57193456A/ja
Priority claimed from JP13085681A external-priority patent/JPS5832865A/ja
Application filed by Nippon Chemiphar Co Ltd filed Critical Nippon Chemiphar Co Ltd
Publication of ES512519A0 publication Critical patent/ES512519A0/es
Publication of ES8307218A1 publication Critical patent/ES8307218A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCESO DE FABRICACION DE LOS NUEVOS DERIVADOS DE LA AMIDINOPIPERADINA. CONSTA DE LAS SIGUIENTES ETAPAS: 1 ) REACCION DE UN COMPUESTO (II) O UNA SAL ACIDA DEL MISMO CON UN ALQUILO ISOUREA O ALQUILO ISOTIOUREA; SE OBTIENE EL COMPUESTO (III) QUE EN UNA FASE. 2 ) SE HACE REACCIONAR CON R -A-H, DONDE R ES UN GRUPO NAFTILO, INDANILO, TETRAHIDRONAFTILO O PIRIDILO O UN GRUPO FENILO. EL COMPUESTO OBTENIDO, PUEDE HIDROGENARSE CON HIDROGENO ACTIVADO CATALITICAMENTE CON LO QUE SE TRANSFORMA EL SUSTITUYENTE R EN R , SIENDO ESTE NAFTILO, INDANILO, TETRAHIDRONAFTILO O PIRIDILO O UN GRUPO DE FENILO. SE OBTIENE EL COMPUESTO (I) EN QUE R ES UN ATOMO DE HIDROGENO, UN GRUPO NAFTILO, INDANILO, TETRAHIDRONAFTILO O PIRIDILO O BIEN UN GRUPO FENILO.
ES512519A 1981-05-25 1982-05-25 Proceso de fabricacion de los nuevos derivados de la amidinopiperadina. Expired ES8307218A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP56078142A JPS57193457A (en) 1981-05-25 1981-05-25 Amidinopiperidine derivative and its preparation
JP7814381A JPS57193456A (en) 1981-05-25 1981-05-25 Novel amidinopiperidine derivative and its preparation
JP13085681A JPS5832865A (ja) 1981-08-22 1981-08-22 新規なアミジノピペリジン誘導体およびその製造法

Publications (2)

Publication Number Publication Date
ES512519A0 ES512519A0 (es) 1983-07-01
ES8307218A1 true ES8307218A1 (es) 1983-07-01

Family

ID=27302625

Family Applications (1)

Application Number Title Priority Date Filing Date
ES512519A Expired ES8307218A1 (es) 1981-05-25 1982-05-25 Proceso de fabricacion de los nuevos derivados de la amidinopiperadina.

Country Status (12)

Country Link
US (1) US4433152A (es)
KR (1) KR880002273B1 (es)
AR (1) AR242560A1 (es)
BR (1) BR8203060A (es)
CA (1) CA1188302A (es)
CH (1) CH654298A5 (es)
DE (1) DE3219614A1 (es)
ES (1) ES8307218A1 (es)
FR (1) FR2506306B1 (es)
IT (1) IT1157014B (es)
MX (1) MX158198A (es)
NL (1) NL8202109A (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59139357A (ja) * 1983-01-28 1984-08-10 Torii Yakuhin Kk アミジン誘導体
FR2603583B1 (fr) * 1986-09-05 1988-12-09 Andre Buzas Derives de la benzhydryloxyethyl-piperidine, procede d'obtention et compositions pharmaceutiques les contenant
IT1231238B (it) * 1987-09-21 1991-11-26 Angeli Inst Spa Derivati ammidinici
TW201303B (es) * 1990-07-05 1993-03-01 Hoffmann La Roche
JPH07501063A (ja) * 1991-11-14 1995-02-02 グラクソ、グループ、リミテッド フィブリノーゲン依存性血小板凝集阻害剤としてのピペリジン酢酸誘導体
WO1993014077A1 (en) * 1992-01-21 1993-07-22 Glaxo Group Limited Piperidineacetic acid derivatives as inhibitors of fibrinogen-dependent blood platelet aggregation
TW223629B (es) * 1992-03-06 1994-05-11 Hoffmann La Roche
TW394760B (en) * 1993-09-07 2000-06-21 Hoffmann La Roche Novel Carboxamides, process for their preparation and pharmaceutical composition containing the same
US5637599A (en) * 1994-06-17 1997-06-10 Corvas International, Inc. Arginine mimic derivatives as enzyme inhibitors
US5932733A (en) * 1994-06-17 1999-08-03 Corvas International, Inc. 3-amino-2-oxo-1-piperidineacetic derivatives containing an arginine mimic as enzyme inhibitors
US5658930A (en) * 1994-12-13 1997-08-19 Corvas International, Inc. Aromatic heterocyclic derivatives as enzyme inhibitors
HUP9802764A3 (en) * 1995-09-29 2000-03-28 Dimensional Pharm Inc Guanidino protease inhibitors
US5792769A (en) * 1995-09-29 1998-08-11 3-Dimensional Pharmaceuticals, Inc. Guanidino protease inhibitors
CA2256309C (en) * 1995-12-29 2006-08-15 3-Dimensional Pharmaceuticals, Inc. Amidino protease inhibitors
US6756389B2 (en) * 1996-08-09 2004-06-29 Cambridge Neuroscience, Inc. Pharmaceutically active compounds and methods of use
JP4247415B2 (ja) 1996-10-07 2009-04-02 広栄化学工業株式会社 γ―（ピペリジル）酪酸の酸塩の製造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3189601A (en) * 1964-01-10 1965-06-15 Ciba Geigy Corp N, n-alkylene-imino-lower alkanoamidine compounds
US3933797A (en) * 1972-02-22 1976-01-20 Pfizer Inc. 6-[α-(ω-QUANIDINOALKANOYLAMIDO)ACYLAMIDO]PENICILLANIC ACIDS
US3979398A (en) * 1973-02-08 1976-09-07 Smith Kline & French Laboratories Limited Sulphoxides
US3972872A (en) * 1974-09-23 1976-08-03 Pfizer Inc. 6-[α-(ω-Guanidinoalkanoylamido)acylamido]penicillanic acids

Also Published As

Publication number Publication date
DE3219614C2 (es) 1990-10-04
FR2506306B1 (fr) 1985-12-06
IT8267668A1 (it) 1984-01-14
IT1157014B (it) 1987-02-11
IT8267668A0 (it) 1982-05-24
KR880002273B1 (ko) 1988-10-21
NL8202109A (nl) 1982-12-16
MX158198A (es) 1989-01-16
CA1188302A (en) 1985-06-04
DE3219614A1 (de) 1982-12-23
AR242560A1 (es) 1993-04-30
US4433152A (en) 1984-02-21
BR8203060A (pt) 1983-05-10
KR830010072A (ko) 1983-12-26
ES512519A0 (es) 1983-07-01
FR2506306A1 (fr) 1982-11-26
CH654298A5 (fr) 1986-02-14

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19971201