ES8308560A1 - Procedimiento para preparar 6-fluoro-3-(3-(1-heterociclo)-propil)-1,2-benzoisoxazoles. - Google Patents

Procedimiento para preparar 6-fluoro-3-(3-(1-heterociclo)-propil)-1,2-benzoisoxazoles.

Info

Publication number
ES8308560A1
ES8308560A1 ES516828A ES516828A ES8308560A1 ES 8308560 A1 ES8308560 A1 ES 8308560A1 ES 516828 A ES516828 A ES 516828A ES 516828 A ES516828 A ES 516828A ES 8308560 A1 ES8308560 A1 ES 8308560A1
Authority
ES
Spain
Prior art keywords
heterocyclo
fluoro
propyl
benzisoxazoles
medicaments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES516828A
Other languages
English (en)
Other versions
ES516828A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Roussel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharmaceuticals Inc filed Critical Hoechst Roussel Pharmaceuticals Inc
Publication of ES8308560A1 publication Critical patent/ES8308560A1/es
Publication of ES516828A0 publication Critical patent/ES516828A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR 6-FLUORO-3-(3-1-HETEROCICLO-PROPIL)-1,2-BENZOISOXAZOLES. SE HACE REACCIONAR EL COMPUESTO (II) CON EL (III) EN PRESENCIA DE UN ACEPTOR DE ACIDO, UN AGENTE FAVORECEDOR DEL DESPLAZAMIENTO Y UN DISOLVENTE, A UNA TEMPERATURA COMPRENDIDA ENTRE 50 Y 150 C. SE OBTIENE EL COMPUESTO (I). COMO ACEPTORES DE ACIDO SE EMPLEAN CARBONATOS DE METALES ALCALINOS Y BICARBONATOS DE METALES ALCALINOS. COMO AGENTES FAVORECEDORES DEL DESPLAZAMIENTO SE EMPLEAN HALOGENUROS DE LOS METALES ALCALINOS MENCIONADOS. ENTRE LOS DISOLVENTES SE EMPLEAN POR EJEMPLO DIMETILFORMAMIDA, DIMETILACETAMIDA Y HEXAMETILFOSFORAMIDA. LA TEMPERATURA PREFERIDA OSCILA ENTRE 70 Y 110 C.
ES516828A 1982-04-09 1982-10-26 Procedimiento para preparar 6-fluoro-3-(3-(1-heterociclo)-propil)-1,2-benzoisoxazoles. Granted ES516828A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/366,245 US4458075A (en) 1982-04-09 1982-04-09 6-Fluoro-3-[3-(1-heterocyclo)propyl]-1,2-benzisoxazoles

Publications (2)

Publication Number Publication Date
ES8308560A1 true ES8308560A1 (es) 1983-09-16
ES516828A0 ES516828A0 (es) 1983-09-16

Family

ID=23442245

Family Applications (1)

Application Number Title Priority Date Filing Date
ES516828A Granted ES516828A0 (es) 1982-04-09 1982-10-26 Procedimiento para preparar 6-fluoro-3-(3-(1-heterociclo)-propil)-1,2-benzoisoxazoles.

Country Status (18)

Country Link
US (1) US4458075A (es)
EP (1) EP0091512B1 (es)
JP (1) JPS58177981A (es)
AT (1) ATE34172T1 (es)
AU (1) AU560513B2 (es)
CA (1) CA1189858A (es)
DE (1) DE3278472D1 (es)
DK (1) DK474582A (es)
ES (1) ES516828A0 (es)
FI (1) FI823434A7 (es)
GR (1) GR77705B (es)
HU (1) HU191076B (es)
IL (1) IL66868A (es)
NO (1) NO823557L (es)
NZ (1) NZ202045A (es)
PH (1) PH18365A (es)
PT (1) PT75728B (es)
ZA (1) ZA827814B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4894461A (en) * 1981-04-27 1990-01-16 Hoechst-Roussel Pharmaceuticals, Inc. 3-(γ-chloropropyl)-6-fluoro-1,2-benzisoxazole
US4980365A (en) * 1987-07-13 1990-12-25 Hoechst-Roussel Pharmaceuticals Inc. N-substituted-5,6-dimethoxy-1,2-benzisoxazole-3-propanamine and related compounds as analgesic and hypotensive agents
US4914204A (en) * 1988-03-14 1990-04-03 Hoechst-Roussel Pharmaceuticals Incorporated 4-Pentafluorophenoxypiperidines
US4954511A (en) * 1988-03-14 1990-09-04 Hoechst-Roussell Pharmaceuticals Inc. 4-pentafluorophenoxypiperidines
US4861889A (en) * 1988-03-14 1989-08-29 Hoechst-Roussel Pharmaceuticals, Inc. 3-(2,3,4,5,6-pentafluorophenoxy)-8-azabicyclo[3.2.1]octanes
US5114936A (en) * 1990-08-23 1992-05-19 Hoechst-Roussel Pharmaceuticals Incorporated 6,7-dihydro-3-phenyl-1,2-benzisoxazol-4(5h)-ones and -ols, compositions and pharmaceutical use
US5750542A (en) 1993-09-28 1998-05-12 Pfizer Benzisoxazole and benzisothizole derivatives as cholinesterase inhibitors
EP1535912A1 (en) * 2000-04-28 2005-06-01 Arcadia Pharmaceuticals Inc. Muscarinic agonists
TWI310035B (en) 2000-04-28 2009-05-21 Acadia Pharm Inc Muscarinic agonists
DE102019103847A1 (de) 2019-02-15 2020-08-20 Vetron Typical Europe Gmbh Nähmaschine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4970963A (es) * 1972-11-09 1974-07-09
GB1488003A (en) * 1973-10-23 1977-10-05 Lilly Industries Ltd 1,2-benzisoxazole derivatives processes for their preparation and their use as pharmaceuticals
FI60390C (fi) * 1975-03-05 1982-01-11 Sumitomo Chemical Co Foerfarande foer framstaellning av neuroleptiska butyrofenoner
JPS51136666A (en) * 1975-05-19 1976-11-26 Dainippon Pharmaceut Co Ltd Process for preparing 3-aminoalkyl-1,2-benzisoxazole derivatives.
JPS6043064B2 (ja) * 1979-11-28 1985-09-26 ウェルファイド株式会社 新規イソオキサゾ−ル誘導体

Also Published As

Publication number Publication date
JPS58177981A (ja) 1983-10-18
GR77705B (es) 1984-09-25
CA1189858A (en) 1985-07-02
FI823434L (fi) 1983-10-10
AU560513B2 (en) 1987-04-09
NZ202045A (en) 1986-03-14
PH18365A (en) 1985-06-13
DE3278472D1 (en) 1988-06-16
EP0091512B1 (en) 1988-05-11
DK474582A (da) 1983-10-10
PT75728A (en) 1982-11-01
AU8977782A (en) 1983-10-13
NO823557L (no) 1983-10-10
ZA827814B (en) 1983-08-31
IL66868A (en) 1987-07-31
PT75728B (en) 1985-11-11
ATE34172T1 (de) 1988-05-15
FI823434A7 (fi) 1983-10-10
US4458075A (en) 1984-07-03
EP0091512A3 (en) 1984-12-12
HU191076B (en) 1987-01-28
FI823434A0 (fi) 1982-10-08
ES516828A0 (es) 1983-09-16
IL66868A0 (en) 1982-12-31
EP0091512A2 (en) 1983-10-19

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