ES8400744A1 - Procedimiento para la preparacion de benzotriazoles. - Google Patents

Procedimiento para la preparacion de benzotriazoles.

Info

Publication number
ES8400744A1
ES8400744A1 ES519351A ES519351A ES8400744A1 ES 8400744 A1 ES8400744 A1 ES 8400744A1 ES 519351 A ES519351 A ES 519351A ES 519351 A ES519351 A ES 519351A ES 8400744 A1 ES8400744 A1 ES 8400744A1
Authority
ES
Spain
Prior art keywords
formula
benzotriazoles
procedure
preparation
anticipants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES519351A
Other languages
English (en)
Other versions
ES519351A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES519351A0 publication Critical patent/ES519351A0/es
Publication of ES8400744A1 publication Critical patent/ES8400744A1/es
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D237/00Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/16Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D249/18Benzotriazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE BENZOTRIAZOLES Y DE SUS SALES DE ADICION DE ACIDOS FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R2 ES HIDROGENO O ALCOHILO C1-3; Y R1 PUEDE SER UNO DE VARIOS TIPOS DE RADICALES.CONSISTE EN LA REACCION DE CONDENSACION CICLICA DE HIDRAZINA CON UN ACIDO CARBOXILICO, SU ANHIDRIDO, ESTER, TIOESTER, AMIDA, IMIDAZOLIDA O HALOGENURO, DE FORMULA (II), EN LA QUE R1 Y R2 TIENEN LOS MISMOS SIGNIFICADOS QUE EN LA FORMULA (I), EN UN DISOLVENTE INERTE, A UNA TEMPERATURA COMPRENDIDA ENTRE 0JC Y 200JC.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PORSUS EFECTOS CARDIOTONICOS, HIPOTENSORES SANGUINEOS Y/O ANTITROMBOTICOS.
ES519351A 1981-07-25 1983-01-28 Procedimiento para la preparacion de benzotriazoles. Expired ES8400744A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813129447 DE3129447A1 (de) 1981-07-25 1981-07-25 "neue benztriazole, ihre herstellung und ihre verwendung als arzneimittel"

Publications (2)

Publication Number Publication Date
ES519351A0 ES519351A0 (es) 1983-11-01
ES8400744A1 true ES8400744A1 (es) 1983-11-01

Family

ID=6137768

Family Applications (2)

Application Number Title Priority Date Filing Date
ES514274A Expired ES8308325A1 (es) 1981-07-25 1982-07-23 "procedimiento para la preparacion de benzotriazoles".
ES519351A Expired ES8400744A1 (es) 1981-07-25 1983-01-28 Procedimiento para la preparacion de benzotriazoles.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES514274A Expired ES8308325A1 (es) 1981-07-25 1982-07-23 "procedimiento para la preparacion de benzotriazoles".

Country Status (27)

Country Link
US (1) US4616018A (es)
EP (1) EP0071102B1 (es)
JP (1) JPS5824582A (es)
KR (1) KR880001476B1 (es)
AR (1) AR230631A1 (es)
AT (1) ATE16184T1 (es)
AU (1) AU554184B2 (es)
CA (1) CA1189076A (es)
CS (1) CS226747B2 (es)
DD (1) DD202564A5 (es)
DE (2) DE3129447A1 (es)
DK (1) DK331282A (es)
ES (2) ES8308325A1 (es)
FI (1) FI73994C (es)
GB (1) GB2107703B (es)
GR (1) GR76230B (es)
HU (1) HU188585B (es)
IE (1) IE53664B1 (es)
IL (1) IL66385A (es)
NO (1) NO159273C (es)
NZ (1) NZ201364A (es)
PH (1) PH19512A (es)
PL (1) PL130643B1 (es)
PT (1) PT75313B (es)
SU (1) SU1179927A3 (es)
YU (1) YU42783B (es)
ZA (1) ZA825275B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8320005D0 (en) * 1983-07-25 1983-08-24 Fujisawa Pharmaceutical Co Benzothiazoline derivatives
DE3511110A1 (de) * 1985-03-27 1986-10-02 Dr. Karl Thomae Gmbh, 7950 Biberach Neue pyridazinone, ihre herstellung und diese verbindungen enthaltende arzneimittel
DE3734083A1 (de) * 1987-10-08 1989-04-20 Heumann Pharma Gmbh & Co Benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
ES2080064T3 (es) * 1988-07-11 1996-02-01 Akzo Nobel Nv Derivados de piridazinona.
DE3934436A1 (de) * 1989-06-01 1991-04-18 Thomae Gmbh Dr K 2-hydroxy-n-propylamine, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
PT794184E (pt) * 1994-11-21 2001-09-28 Dainippon Pharmaceutical Co Derivados de 6-metoxi-1h-benzotriazolo-5-carboxamida seus processos de producao e composicoes farmaceuticas que os contem
AU2002345796A1 (en) * 2001-06-26 2003-03-03 Beth Israel Deaconess Medical Center Compositions and methods for inhibiting platelet activation and thrombosis
GB201321740D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2516040C2 (de) * 1974-06-10 1984-12-20 Dr. Karl Thomae Gmbh, 7950 Biberach Benzimidazole, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
ES482789A0 (es) * 1978-08-25 1980-12-01 Thomae Gmbh Dr K Procedimiento para la preparacion de nuevos bencimidazoles sustituidos en posicion 5 o 6 con un anillo de piridazinona
US4258185A (en) * 1978-10-17 1981-03-24 Yoshitomi Pharmaceutical Industries, Ltd. Pyridazinone compounds
DE2845220A1 (de) * 1978-10-17 1980-04-30 Yoshitomi Pharmaceutical Pyridazinon-derivate, ihre salze mit saeuren, verfahren zu ihrer herstellung und ihre verwendung bei der behandlung von thrombosen und hypertonie

Also Published As

Publication number Publication date
FI73994C (fi) 1987-12-10
PL237601A1 (en) 1983-05-09
HU188585B (en) 1986-04-28
CA1189076A (en) 1985-06-18
AU8637782A (en) 1983-02-03
ES514274A0 (es) 1983-08-16
NO159273C (no) 1988-12-14
NO822119L (no) 1983-01-26
PL130643B1 (en) 1984-08-31
ZA825275B (en) 1984-03-28
EP0071102A1 (de) 1983-02-09
JPS5824582A (ja) 1983-02-14
YU159782A (en) 1984-08-31
IE821781L (en) 1983-01-25
YU42783B (en) 1988-12-31
SU1179927A3 (ru) 1985-09-15
DD202564A5 (de) 1983-09-21
KR880001476B1 (ko) 1988-08-13
IL66385A (en) 1985-11-29
NZ201364A (en) 1986-01-24
PT75313A (de) 1982-08-01
DK331282A (da) 1983-01-26
DE3129447A1 (de) 1983-02-10
KR840000530A (ko) 1984-02-25
PT75313B (de) 1985-11-29
ES519351A0 (es) 1983-11-01
CS226747B2 (en) 1984-04-16
GB2107703B (en) 1985-06-12
EP0071102B1 (de) 1985-10-23
GB2107703A (en) 1983-05-05
FI822549L (fi) 1983-01-26
FI822549A0 (fi) 1982-07-20
AU554184B2 (en) 1986-08-14
FI73994B (fi) 1987-08-31
ATE16184T1 (de) 1985-11-15
IL66385A0 (en) 1982-11-30
PH19512A (en) 1986-05-14
NO159273B (no) 1988-09-05
ES8308325A1 (es) 1983-08-16
US4616018A (en) 1986-10-07
AR230631A1 (es) 1984-05-31
GR76230B (es) 1984-08-04
IE53664B1 (en) 1989-01-04
DE3267020D1 (en) 1985-11-28

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