DK54081A - Fremgangsmaade til fremstilling af insulinderivater - Google Patents

Fremgangsmaade til fremstilling af insulinderivater

Info

Publication number: DK54081A
Authority: DK; Denmark
Prior art keywords: insulin; salt; preparation; water; threonine
Prior art date: 1980-02-11

Application number

DK54081A

Other languages

English (en)

Other versions

DK147437B (da

DK147437C (da

Inventor

J Markussen

Original Assignee

Novo Industri As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-02-11

Filing date

1981-02-09

Publication date

1981-08-12

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8095095&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK54081(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1981-02-09 Application filed by Novo Industri As filed Critical Novo Industri As

1981-02-09 Priority to DK54081A priority Critical patent/DK147437C/da

1981-08-12 Publication of DK54081A publication Critical patent/DK54081A/da

1984-08-06 Publication of DK147437B publication Critical patent/DK147437B/da

1986-12-08 Application granted granted Critical

1986-12-08 Publication of DK147437C publication Critical patent/DK147437C/da

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 4
101000976075 Homo sapiens Insulin Proteins 0.000 abstract 3
PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 3
150000003839 salts Chemical class 0.000 abstract 3
102000004877 Insulin Human genes 0.000 abstract 2
108090001061 Insulin Proteins 0.000 abstract 2
AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 abstract 2
102000004142 Trypsin Human genes 0.000 abstract 2
108090000631 Trypsin Proteins 0.000 abstract 2
229940125396 insulin Drugs 0.000 abstract 2
-1 insulin compound Chemical class 0.000 abstract 2
239000012588 trypsin Substances 0.000 abstract 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 abstract 1
239000004473 Threonine Substances 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
239000011541 reaction mixture Substances 0.000 abstract 1
150000003588 threonines Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Endocrinology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Toxicology (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Diabetes (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Forklifts And Lifting Vehicles (AREA)

DK54081A 1980-02-11 1981-02-09 Fremgangsmaade til fremstilling af humaninsulin eller threoninb30estere af humaninsulin eller et salt eller kompleks deraf DK147437C (da)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
DK54081A DK147437C (da)	1980-02-11	1981-02-09	Fremgangsmaade til fremstilling af humaninsulin eller threoninb30estere af humaninsulin eller et salt eller kompleks deraf

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
DK57480		1980-02-11
DK57480A DK147109C (da)	1980-02-11	1980-02-11	Fremgangsmaade til fremstilling af humant insulin eller humane insulinestere eller et salt eller kompleks deraf
DK54081		1981-02-09
DK54081A DK147437C (da)	1980-02-11	1981-02-09	Fremgangsmaade til fremstilling af humaninsulin eller threoninb30estere af humaninsulin eller et salt eller kompleks deraf

Publications (3)

Publication Number	Publication Date
DK54081A true DK54081A (da)	1981-08-12
DK147437B DK147437B (da)	1984-08-06
DK147437C DK147437C (da)	1986-12-08

Family

ID=8095095

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
DK147437D DK147437A (en)	1980-02-11		Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof
DK57480A DK147109C (da)	1980-02-11	1980-02-11	Fremgangsmaade til fremstilling af humant insulin eller humane insulinestere eller et salt eller kompleks deraf
DK54081A DK147437C (da)	1980-02-11	1981-02-09	Fremgangsmaade til fremstilling af humaninsulin eller threoninb30estere af humaninsulin eller et salt eller kompleks deraf

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
DK147437D DK147437A (en)	1980-02-11		Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof
DK57480A DK147109C (da)	1980-02-11	1980-02-11	Fremgangsmaade til fremstilling af humant insulin eller humane insulinestere eller et salt eller kompleks deraf

Country Status (19)

Country	Link
JP (1)	JPS56135452A (da)
AR (1)	AR231277A1 (da)
AU (1)	AU541528B2 (da)
BE (1)	BE887480A (da)
CA (1)	CA1162868A (da)
CH (1)	CH655949A5 (da)
DE (1)	DE3104949C2 (da)
DK (3)	DK147109C (da)
ES (1)	ES8205858A1 (da)
FI (1)	FI77876C (da)
GB (1)	GB2069502B (da)
GR (1)	GR73844B (da)
IT (1)	IT1195038B (da)
NL (1)	NL178797C (da)
NO (1)	NO156247C (da)
NZ (1)	NZ196224A (da)
PT (1)	PT72485B (da)
SE (2)	SE451143B (da)
ZA (1)	ZA81898B (da)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4601852A (en) *	1981-01-17	1986-07-22	Hoechst Aktiengesellschaft	Process for the preparation of human or the derivatives thereof from pig insulin or the derivatives thereof

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK147437A (en)	1980-02-11	1900-01-01		Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof
EP0088117B1 (en) *	1981-09-15	1986-09-24	Nordisk Insulinlaboratorium	Process for preparing human insulin or b-30 esters thereof
DK149824C (da) *	1982-01-22	1987-03-16	Carlsberg Biotechnology Ltd	Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyrer i insuliner
WO1983002772A1 (en) *	1982-02-08	1983-08-18	Robin Ewart Offord	An improved method for preparing human insulin from non-human insulin
DE3209184A1 (de) *	1982-03-13	1983-09-15	Hoechst Ag, 6230 Frankfurt	Verfahren zur umwandlung von praeproinsulinanaloga zu insulinen
NL8201650A (nl) *	1982-04-21	1983-11-16	Akzo Nv	Semisynthetische bereiding van humane insuline.
EP0092829B1 (en) *	1982-04-23	1990-11-07	Wako Pure Chemical Industries, Ltd.	Process for semi-synthesis of human insulin and alkaline protease for use therein
DK55183D0 (da) *	1983-02-09	1983-02-09	Nordisk Insulinlab	Fremgangsmade til fremstilling af human insulin
DE3334407A1 (de) *	1983-09-23	1985-04-04	Hoechst Ag, 6230 Frankfurt	In position b 30 modifizierte insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
DK119785D0 (da) *	1985-03-15	1985-03-15	Nordisk Gentofte	Insulinpraeparat
US5157021A (en) *	1985-03-15	1992-10-20	Novo Nordisk A/S	Insulin derivatives and pharmaceutical preparations containing these derivatives
SE449472B (sv) *	1985-10-15	1987-05-04	Mth Gruppen Ab	Utrustning vid facklager
DE3880346T2 (de) *	1987-02-25	1993-07-29	Novonordisk As	Insulinderivate.
DK134189D0 (da) *	1989-03-20	1989-03-20	Nordisk Gentofte	Insulinforbindelser
FI96503C (fi) *	1994-08-26	1996-07-10	Hymatic Ltd Oy	Menetelmä ja laitteisto maston ohjaamiseksi
CA2553392A1 (en)	2004-01-16	2005-08-11	Biodel Inc	Sublingual drug delivery device
US20080090753A1 (en)	2004-03-12	2008-04-17	Biodel, Inc.	Rapid Acting Injectable Insulin Compositions
US8084420B2 (en)	2005-09-29	2011-12-27	Biodel Inc.	Rapid acting and long acting insulin combination formulations
US7713929B2 (en)	2006-04-12	2010-05-11	Biodel Inc.	Rapid acting and long acting insulin combination formulations
JP2009533471A (ja)	2006-04-12	2009-09-17	バイオデル，インコーポレイテッド	即効型および長時間作用型組合せインスリン製剤
US9060927B2 (en)	2009-03-03	2015-06-23	Biodel Inc.	Insulin formulations for rapid uptake

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NO153061C (no) *	1979-04-13	1986-01-08	Shionogi & Co	Fremgangsmaate for fremstilling av et b30-threonininsulin
DK147437A (en)	1980-02-11	1900-01-01		Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof
DE3101382A1 (de) *	1981-01-17	1982-09-02	Hoechst Ag, 6000 Frankfurt	"verfahren zur herstellung von humanisulin oder dessen derivaten aus schweineinsulin oder dessen derivaten"

0
- DK DK147437D patent/DK147437A/da unknown
1980
- 1980-02-11 DK DK57480A patent/DK147109C/da not_active IP Right Cessation
1981
- 1981-02-09 ES ES499238A patent/ES8205858A1/es not_active Expired
- 1981-02-09 DK DK54081A patent/DK147437C/da not_active IP Right Cessation
- 1981-02-10 AR AR284258A patent/AR231277A1/es active
- 1981-02-10 FI FI810385A patent/FI77876C/fi not_active IP Right Cessation
- 1981-02-10 NO NO810443A patent/NO156247C/no unknown
- 1981-02-10 CA CA000370483A patent/CA1162868A/en not_active Expired
- 1981-02-10 SE SE8100928A patent/SE451143B/sv not_active IP Right Cessation
- 1981-02-10 IT IT19620/81A patent/IT1195038B/it active
- 1981-02-10 SE SE8100926A patent/SE427025B/sv not_active IP Right Cessation
- 1981-02-10 PT PT72485A patent/PT72485B/pt not_active IP Right Cessation
- 1981-02-10 NZ NZ196224A patent/NZ196224A/en unknown
- 1981-02-10 NL NLAANVRAGE8100624,A patent/NL178797C/xx not_active IP Right Cessation
- 1981-02-10 GB GB8104114A patent/GB2069502B/en not_active Expired
- 1981-02-10 JP JP1758081A patent/JPS56135452A/ja active Granted
- 1981-02-11 ZA ZA00810898A patent/ZA81898B/xx unknown
- 1981-02-11 CH CH910/81A patent/CH655949A5/de not_active IP Right Cessation
- 1981-02-11 AU AU67180/81A patent/AU541528B2/en not_active Ceased
- 1981-02-11 BE BE6/47396A patent/BE887480A/fr not_active IP Right Cessation
- 1981-02-11 DE DE3104949A patent/DE3104949C2/de not_active Expired
- 1981-02-11 GR GR64097A patent/GR73844B/el unknown

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4601852A (en) *	1981-01-17	1986-07-22	Hoechst Aktiengesellschaft	Process for the preparation of human or the derivatives thereof from pig insulin or the derivatives thereof

Also Published As

Publication number	Publication date
SE427025B (sv)	1983-02-28
IT1195038B (it)	1988-09-28
ES499238A0 (es)	1982-08-01
AU541528B2 (en)	1985-01-10
NO810443L (no)	1981-08-12
NL178797C (nl)	1986-05-16
IT8119620A1 (it)	1982-08-10
IT8119620A0 (it)	1981-02-10
DK147109C (da)	1986-12-08
DK57480A (da)	1981-08-12
NZ196224A (en)	1984-08-24
DK147109B (da)	1984-04-09
FI77876C (fi)	1989-05-10
SE451143B (sv)	1987-09-07
DK147437B (da)	1984-08-06
NO156247C (no)	1987-08-19
DE3104949A1 (de)	1981-11-26
ES8205858A1 (es)	1982-08-01
PT72485A (en)	1981-03-01
JPH0211240B2 (da)	1990-03-13
AU6718081A (en)	1981-08-20
ZA81898B (en)	1982-03-31
DK147437A (en)	1900-01-01
GB2069502A (en)	1981-08-26
FI810385L (fi)	1981-08-12
JPS56135452A (en)	1981-10-22
BE887480A (fr)	1981-08-11
NL8100624A (nl)	1981-09-01
DE3104949C2 (de)	1984-04-26
CA1162868A (en)	1984-02-28
GB2069502B (en)	1984-08-08
DK147437C (da)	1986-12-08
SE8100928L (sv)	1981-08-12
PT72485B (en)	1982-10-14
FI77876B (fi)	1989-01-31
NO156247B (no)	1987-05-11
CH655949A5 (de)	1986-05-30
GR73844B (da)	1984-05-07
NL178797B (nl)	1985-12-16
AR231277A1 (es)	1984-10-31
SE8100926L (sv)	1982-08-11

Legal Events

Date	Code	Title	Description
1999-09-27	PBP	Patent lapsed

Publication	Publication Date	Title
JPS53116314A (en)	1978-10-11	Separation of acetic acid and water
JPS5266551A (en)	1977-06-02	Stabilizer for plastics
SE8100928L (sv)	1981-08-12	Forfarande for framstellning av insulinderivat
SE8204627L (sv)	1983-02-11	Forfarande for framstellning av insulinderivat
DE3662100D1 (en)	1989-03-23	Use of solvents in the production of s-triazine derivatives and method for the production of s-triazine derivatives
DK32684A (da)	1984-01-25	Fremgangsmaade til fremstilling af 26,26,26,27,27,27-hexafluor-1alfa,25-dihydroxycholesterol og mellemprodukter til brug herfor
ES8205750A1 (es)	1982-06-16	Un procedimiento para la preparacion de nuevos derivados de fenetilamina.
JPS52128288A (en)	1977-10-27	Glucose isomerase solution
JPS5545648A (en)	1980-03-31	2-formyldibenzazepin derivative and its preparation
KR840000235A (ko)	1984-02-18	치환 히드록시벤젠류에 의한 2-레노일메르캅토프로피온일글리신의 에스테르 제조방법 및 이를 함유한 약제조성물
JPS56166189A (en)	1981-12-21	Thiazolidine-4-carboxylic derivative and its preparation
ES8207179A1 (es)	1982-09-01	Nuevo procedimiento de fabricacion de derivados de 5,6,7,7atetrahidro-4h-tieno(3,2-c)piridin-2-ona .
JPS5579395A (en)	1980-06-14	Novel germanium compound
ES452351A2 (es)	1977-12-16	Procedimiento para la preparacion de nuevos derivados de bi-fenililo.
JPS5241593A (en)	1977-03-31	Dissolved oxygen system
SE8107514L (sv)	1982-08-10	Forfarande for framstellning av estrar av omettade syror
JPS5283413A (en)	1977-07-12	Preparation of 3,3-dimethyl-4-pentenoic acid or its esters
JPS5673081A (en)	1981-06-17	Preparation of tocopherol acetate
DK346682A (da)	1983-02-11	Fremgangsmaade til fremstilling af polypeptidderivater
DK157400C (da)	1990-05-21	Fremgangsmaade til fremstilling af 3-hydroxy-5-methylisoxazol
NO147272C (no)	1983-03-09	Fremgangsmaate for fremstilling av diacetoksybuten ved omsetning av 1,3-butadien med oksygen og eddiksyre
JPS51143645A (en)	1976-12-10	Process for preparation of 3,3-dimethyl- 2-(2,2-dihalo)cyclopropanecar boxylic acid ester
JPS5353638A (en)	1978-05-16	Alpha-acetyl cinnamic acid ester derivatives, their preparation and theirherbicides containing the same
DK103781A (da)	1981-09-09	Alfa-ketocarboxylsyre-n-acylamider samt fremgangsmaade til deres fremstilling
JPS5439042A (en)	1979-03-24	Preparation of 2-(4-iso butylphenyl)-propionic acid

DK54081A - Fremgangsmaade til fremstilling af insulinderivater - Google Patents

Info

Links

Classifications

Landscapes

Priority Applications (1)

Applications Claiming Priority (4)

Publications (3)

Family

ID=8095095

Family Applications (3)

Family Applications Before (2)

Country Status (19)

Cited By (1)

Families Citing this family (21)

Family Cites Families (3)

Cited By (1)

Also Published As

Similar Documents

Legal Events