ES8401058A1 - Un procedimiento para la preparacion de un derivado carbostirilo. - Google Patents

Un procedimiento para la preparacion de un derivado carbostirilo.

Info

Publication number
ES8401058A1
ES8401058A1 ES514992A ES514992A ES8401058A1 ES 8401058 A1 ES8401058 A1 ES 8401058A1 ES 514992 A ES514992 A ES 514992A ES 514992 A ES514992 A ES 514992A ES 8401058 A1 ES8401058 A1 ES 8401058A1
Authority
ES
Spain
Prior art keywords
formula
carbostirile
reaction
derivative
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES514992A
Other languages
English (en)
Other versions
ES514992A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP56137984A external-priority patent/JPS5838258A/ja
Priority claimed from JP56210368A external-priority patent/JPS58110568A/ja
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of ES8401058A1 publication Critical patent/ES8401058A1/es
Publication of ES514992A0 publication Critical patent/ES514992A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE CARBOSTIRILO, DE FORMULA (I), EN LA QUE A ES ALQUILENO INFERIOR; R1 Y R2 PUEDEN SER VARIOS TIPOS DE RADICALES; Y LA LINEA DISCONTINUA REPRESENTA DOS ATOMOS DE HIDROGENO O UN ENLACE.CONSISTE EN LA REACCION DE UN DERIVADO DE CARBOSTIRILO, DE FORMULA (II), CON UN ACIDO CARBOXILICO O UN DERIVADO ACTIVO DEL MISMO, DE FORMULA HOR2, EN LAS QUE TODOS LOS SIMBOLOS TIENEN LOS MISMOS SIGNIFICADOS QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE, A UNA TEMPERATURA COMPRENDIDA ENTRE -20JC Y 180JC.ESTOSCOMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES CARDIOTONICOS.
ES514992A 1981-09-01 1982-08-13 Un procedimiento para la preparacion de un derivado carbostirilo. Granted ES514992A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP56137984A JPS5838258A (ja) 1981-09-01 1981-09-01 カルボスチリル誘導体
JP56210368A JPS58110568A (ja) 1981-12-25 1981-12-25 カルボスチリル誘導体

Publications (2)

Publication Number Publication Date
ES8401058A1 true ES8401058A1 (es) 1983-11-16
ES514992A0 ES514992A0 (es) 1983-11-16

Family

ID=26471144

Family Applications (5)

Application Number Title Priority Date Filing Date
ES514992A Granted ES514992A0 (es) 1981-09-01 1982-08-13 Un procedimiento para la preparacion de un derivado carbostirilo.
ES521472A Granted ES521472A0 (es) 1981-09-01 1983-04-14 Un procedimiento para la preparacion de un derivado de carbostirilo.
ES521471A Expired ES8500933A1 (es) 1981-09-01 1983-04-14 Un procedimiento para la preparacion de un derivado de carbostirilo.
ES521473A Expired ES8405001A1 (es) 1981-09-01 1983-04-14 Un procedimiento para la preparacion de un derivado de carbostirilo.
ES536982A Granted ES536982A0 (es) 1981-09-01 1984-10-22 Un procedimiento para la preparacion de un derivado de carbostirilo

Family Applications After (4)

Application Number Title Priority Date Filing Date
ES521472A Granted ES521472A0 (es) 1981-09-01 1983-04-14 Un procedimiento para la preparacion de un derivado de carbostirilo.
ES521471A Expired ES8500933A1 (es) 1981-09-01 1983-04-14 Un procedimiento para la preparacion de un derivado de carbostirilo.
ES521473A Expired ES8405001A1 (es) 1981-09-01 1983-04-14 Un procedimiento para la preparacion de un derivado de carbostirilo.
ES536982A Granted ES536982A0 (es) 1981-09-01 1984-10-22 Un procedimiento para la preparacion de un derivado de carbostirilo

Country Status (21)

Country Link
US (1) US4514401A (es)
KR (1) KR860000135B1 (es)
AR (2) AR241905A1 (es)
AT (1) AT383592B (es)
AU (1) AU532361B2 (es)
BE (1) BE894105A (es)
CA (1) CA1205807A (es)
CH (1) CH650783A5 (es)
DE (1) DE3230209C2 (es)
DK (1) DK166877B1 (es)
ES (5) ES514992A0 (es)
FI (1) FI78688C (es)
FR (1) FR2512019B1 (es)
GB (1) GB2108109B (es)
IT (1) IT1156490B (es)
NL (1) NL8203225A (es)
NO (1) NO159591C (es)
PH (1) PH18055A (es)
PT (1) PT75424B (es)
SE (1) SE452984B (es)
SU (1) SU1356962A3 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH17194A (en) * 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
FR2557570B1 (fr) * 1984-01-04 1986-04-18 Adir Nouveaux derives de la quinoleine, leur procede de preparation et les compositions pharmaceutiques les renfermant
DE3423003A1 (de) * 1984-06-22 1986-01-02 Beiersdorf Ag, 2000 Hamburg Benzo(c)(1,8)naphthyridine, verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen
DE3431303A1 (de) * 1984-08-25 1986-02-27 Goedecke Ag 1,6-naphthyridin-derivate, verfahren zu deren herstellung und deren verwendung
JPH0696555B2 (ja) * 1986-07-31 1994-11-30 大塚製薬株式会社 カルボスチリル誘導体
EP0255134B1 (en) * 1986-07-31 1993-03-03 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and salts thereof, process for preparing them, and cardiotonic composition containing same
US5098477A (en) * 1988-12-14 1992-03-24 Ciba-Geigy Corporation Inks, particularly for ink printing
JP2686887B2 (ja) * 1992-08-11 1997-12-08 キッセイ薬品工業株式会社 ピペリジノ−３，４−ジヒドロカルボスチリル誘導体
ES2565581T3 (es) * 2003-12-10 2016-04-05 Janssen Pharmaceutica Nv 2-Quinolinonas/2-quinoxalinonas 6-(hetero)ciclohexilalquil sustituidas como inhibidores de poli(ADP-ribosa) polimerasa
PT2445502T (pt) 2009-06-25 2017-09-22 Alkermes Pharma Ireland Ltd Compostos heterocíclicos para o tratamento de distúrbios neurológicos e psicológicos
JP5857040B2 (ja) 2010-05-04 2016-02-10 アルカーメス ファーマ アイルランド リミテッド 酸化ラクタム化合物の合成方法
RU2448698C2 (ru) * 2010-06-21 2012-04-27 Государственное образовательное учреждение высшего профессионального образования "Нижегородская государственная медицинская академия Федерального Агентства по здравоохранению и социальному развитию" (ГОУ ВПО НижГМА Росздрава) Способ восстановления синусового ритма при трепетании предсердий i типа
NZ604423A (en) 2010-06-24 2015-01-30 Alkermes Pharma Ireland Ltd Prodrugs of nh-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5118771A (ja) * 1974-08-07 1976-02-14 Akimitsu Takeya Bantaioshigatanitaisuru keshoshiitotenchakuho
US4081447A (en) * 1975-04-09 1978-03-28 Abbott Laboratories 5-[2-Hydroxy-3-(3,4-dimethoxy phenethylamino)]-propoxy-3,4-dihydro carbostyril and pharmaceutically acceptable salts thereof
JPS597707B2 (ja) * 1975-06-23 1984-02-20 オオツカセイヤク カブシキガイシヤ カルボスチリルユウドウタイノ セイゾウホウ
JPS52283A (en) * 1975-06-23 1977-01-05 Otsuka Pharmaceut Co Ltd Process for preparation of carbostyril derivatives
GB1589871A (en) * 1976-07-19 1981-05-20 Conder Group Serv Ltd Tank construction
JPS5416478A (en) * 1977-07-08 1979-02-07 Otsuka Pharmaceut Co Ltd 3,4-dihydrocarbostyril herivative
DE2853996A1 (de) * 1978-12-14 1980-07-03 Hoechst Ag Neue substituierte phenylpiperazinderivate und verfahren zu deren herstellung
JPS5585520A (en) * 1978-12-22 1980-06-27 Otsuka Pharmaceut Co Ltd Remedy for peptic ulcer
DE2928583A1 (de) * 1979-07-14 1981-01-29 Thomae Gmbh Dr K Verfahren zur herstellung von carbostyrilderivaten
PH17194A (en) * 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
FI77852C (fi) * 1981-02-17 1989-05-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av nya, saosom hjaertmediciner anvaendbara substituerade amid- och (maettad heterocykel)karbonylkarbostyrilderivat.

Also Published As

Publication number Publication date
ES521471A0 (es) 1984-11-01
DK361982A (da) 1983-03-02
SE8204677L (sv) 1983-03-02
CH650783A5 (de) 1985-08-15
ES521473A0 (es) 1984-05-16
SU1356962A3 (ru) 1987-11-30
FI822803A0 (fi) 1982-08-11
ES8405000A1 (es) 1984-05-16
DE3230209A1 (de) 1983-03-10
US4514401A (en) 1985-04-30
FI78688C (fi) 1989-09-11
FI822803L (fi) 1983-03-02
IT8268020A1 (it) 1984-02-16
FR2512019A1 (fr) 1983-03-04
NO159591C (no) 1989-01-18
ES8500933A1 (es) 1984-11-01
AU532361B2 (en) 1983-09-29
PT75424A (en) 1982-09-01
GB2108109A (en) 1983-05-11
KR840001157A (ko) 1984-03-28
NL8203225A (nl) 1983-04-05
FI78688B (fi) 1989-05-31
FR2512019B1 (fr) 1986-01-03
DK166877B1 (da) 1993-07-26
IT1156490B (it) 1987-02-04
CA1205807A (en) 1986-06-10
ES8506302A1 (es) 1985-07-01
AT383592B (de) 1987-07-27
PH18055A (en) 1985-03-18
AR241905A1 (es) 1993-01-29
AU8698082A (en) 1983-04-14
ES8405001A1 (es) 1984-05-16
AR240918A1 (es) 1991-03-27
NO822749L (no) 1983-03-02
GB2108109B (en) 1985-05-09
ES514992A0 (es) 1983-11-16
AR240918A2 (es) 1991-03-27
ATA310682A (de) 1986-12-15
PT75424B (en) 1985-01-04
BE894105A (fr) 1983-02-14
SE452984B (sv) 1988-01-04
ES521472A0 (es) 1984-05-16
KR860000135B1 (ko) 1986-02-26
NO159591B (no) 1988-10-10
ES536982A0 (es) 1985-07-01
IT8268020A0 (it) 1982-08-16
SE8204677D0 (sv) 1982-08-13
DE3230209C2 (de) 1985-08-22

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20040601