ES8403473A1 - Procedimiento para la obtencion de derivados de n-(benzotiofenmetil)-n-metil-het-2-en-4-in-amina. - Google Patents

Procedimiento para la obtencion de derivados de n-(benzotiofenmetil)-n-metil-het-2-en-4-in-amina.

Info

Publication number
ES8403473A1
ES8403473A1 ES519477A ES519477A ES8403473A1 ES 8403473 A1 ES8403473 A1 ES 8403473A1 ES 519477 A ES519477 A ES 519477A ES 519477 A ES519477 A ES 519477A ES 8403473 A1 ES8403473 A1 ES 8403473A1
Authority
ES
Spain
Prior art keywords
methyl
procedure
obtaining
benzotiofenmetil
het
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES519477A
Other languages
English (en)
Other versions
ES519477A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES8403473A1 publication Critical patent/ES8403473A1/es
Publication of ES519477A0 publication Critical patent/ES519477A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
    • C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
    • C07C29/40—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing carbon-to-metal bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heat-Exchange Devices With Radiators And Conduit Assemblies (AREA)
  • Refuge Islands, Traffic Blockers, Or Guard Fence (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE UNA BENZOTIENILDIALQUILALILAMINA, DE FORMULA GENERAL (I), EN LA QUE R1 REPRESENTA HIDROGENO O METILO; R2 REPRESENTA METILO O ETILO; R3 REPRESENTA UN GRUPO ALQUILO TERCIARIO O UN GRUPO ALQUENILO; Y R3 Y R4 REPRESENTAN, CADA UNO, INDEPENDIENTEMENTE, HIDROGENO, HALOGENO, HIDROXI O CIANO, Y SUS SALES DE ADICION DE ACIDOS.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II), CON UN COMPUESTO DE FORMULA: A-CH2-CHFCH-CFC-R3, EN LAS QUE R1, R2, R3, R4 Y R5 TIENEN LOS SIGNIFICADOS YA MENCIONADOS; Y A REPRESENTA UN GRUPO SUSCEPTIBLE DE SERELIMINADO.DE APLICACION EN EL TRATAMIENTO DE ENFERMEDADES O DE INFECCIONES CAUSADAS POR MICETOS.
ES519477A 1982-02-03 1983-02-02 Procedimiento para la obtencion de derivados de n-(benzotiofenmetil)-n-metil-het-2-en-4-in-amina. Granted ES519477A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH656/82A CH653028A5 (de) 1982-02-03 1982-02-03 Benzthiophenallylamin-verbindungen und verfahren zu ihrer herstellung.

Publications (2)

Publication Number Publication Date
ES8403473A1 true ES8403473A1 (es) 1984-03-16
ES519477A0 ES519477A0 (es) 1984-03-16

Family

ID=4192086

Family Applications (1)

Application Number Title Priority Date Filing Date
ES519477A Granted ES519477A0 (es) 1982-02-03 1983-02-02 Procedimiento para la obtencion de derivados de n-(benzotiofenmetil)-n-metil-het-2-en-4-in-amina.

Country Status (28)

Country Link
US (2) US4474141A (es)
JP (1) JPS58146580A (es)
AT (1) AT391865B (es)
AU (1) AU569838B2 (es)
BE (1) BE895751A (es)
CA (1) CA1193271A (es)
CH (1) CH653028A5 (es)
CY (1) CY1485A (es)
DE (1) DE3302814A1 (es)
DK (1) DK160043C (es)
ES (1) ES519477A0 (es)
FI (1) FI80689C (es)
FR (1) FR2520741B1 (es)
GB (1) GB2116171B (es)
HK (1) HK47789A (es)
HU (1) HU190886B (es)
IE (1) IE55073B1 (es)
IL (1) IL67813A0 (es)
IT (1) IT1197565B (es)
KE (1) KE3877A (es)
MY (1) MY8700167A (es)
NL (1) NL8300350A (es)
NZ (1) NZ203144A (es)
PH (1) PH22625A (es)
PT (1) PT76175B (es)
SE (1) SE455095B (es)
SG (1) SG16289G (es)
ZA (1) ZA83733B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH672311A5 (es) * 1985-09-14 1989-11-15 Sandoz Ag
US5068359A (en) * 1989-06-20 1991-11-26 Ciba-Geigy Corporation Microbicidal compositions
CA2038633A1 (en) * 1990-03-20 1991-09-21 Yoshimi Tsuchiya Substituted amine derivatives having anti-hyperlipemia activity
FR2695930B1 (fr) * 1992-09-22 1994-12-23 Sanofi Elf Dérivé du 2-éthyl benzo[b]thiophène, son procédé de préparation et son utilisation comme intermédiaire de synthèse.
JP4759500B2 (ja) * 2001-02-22 2011-08-31 帝人株式会社 ベンゾ［ｂ］チオフェン誘導体、およびその製造方法
EP1947097A1 (en) * 2005-10-27 2008-07-23 Teijin Pharma Limited BENZOÝb¨THIOPHEN DERIVATIVE AND PROCESS FOR PRODUCTION THEREOF
CN102898314B (zh) * 2012-11-13 2014-09-03 山东铂源药业有限公司 一种盐酸特比萘芬的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1250019B (es) * 1963-07-19
CH442353A (de) * 1964-04-16 1967-08-31 Sandoz Ag Verfahren zur Herstellung von neuen Benzothiophen-Derivaten
US3930537A (en) * 1974-05-06 1976-01-06 The United States Of America As Represented By The United States Energy Research And Development Administration Heat exchanger
DE2862103D1 (en) * 1977-08-19 1982-11-18 Sandoz Ag Propenyl amines, processes for their production and pharmaceutical compositions containing them
ATE10272T1 (de) * 1979-08-22 1984-11-15 Sandoz Ag Propenylamine, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zusammensetzungen und ihre verwendung als arzneimittel.

Also Published As

Publication number Publication date
IE55073B1 (en) 1990-05-23
US4474141A (en) 1984-10-02
US4737516A (en) 1988-04-12
FI80689C (fi) 1990-07-10
IE830202L (en) 1983-08-03
CA1193271A (en) 1985-09-10
DE3302814A1 (de) 1983-08-11
DK40883D0 (da) 1983-02-01
PH22625A (en) 1988-10-28
CH653028A5 (de) 1985-12-13
HU190886B (en) 1986-12-28
FI80689B (fi) 1990-03-30
DK160043C (da) 1991-06-17
IT8347666A0 (it) 1983-02-03
SE8300535L (sv) 1983-08-04
CY1485A (en) 1989-12-08
JPS58146580A (ja) 1983-09-01
AU1089783A (en) 1983-08-11
NL8300350A (nl) 1983-09-01
FI830297L (fi) 1983-08-04
PT76175A (en) 1983-03-01
FI830297A0 (fi) 1983-01-27
FR2520741B1 (fr) 1986-03-21
GB2116171B (en) 1986-04-03
KE3877A (en) 1989-07-21
DK40883A (da) 1983-08-04
IL67813A0 (en) 1983-06-15
ZA83733B (en) 1984-09-26
HK47789A (en) 1989-06-23
SG16289G (en) 1989-07-07
ES519477A0 (es) 1984-03-16
DE3302814C2 (es) 1992-06-25
GB2116171A (en) 1983-09-21
AU569838B2 (en) 1988-02-25
SE8300535D0 (sv) 1983-02-01
PT76175B (en) 1986-01-15
IT1197565B (it) 1988-12-06
DK160043B (da) 1991-01-21
AT391865B (de) 1990-12-10
MY8700167A (en) 1987-12-31
JPH0446275B2 (es) 1992-07-29
BE895751A (fr) 1983-08-01
FR2520741A1 (fr) 1983-08-05
IT8347666A1 (it) 1984-08-03
ATA34983A (de) 1990-06-15
GB8302573D0 (en) 1983-03-02
SE455095B (sv) 1988-06-20
NZ203144A (en) 1985-12-13

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970612