ES8404683A1 - Un procedimiento para la preparacion de antagonistas de los receptores hidrogeno de la histamina. - Google Patents

Un procedimiento para la preparacion de antagonistas de los receptores hidrogeno de la histamina.

Info

Publication number
ES8404683A1
ES8404683A1 ES520982A ES520982A ES8404683A1 ES 8404683 A1 ES8404683 A1 ES 8404683A1 ES 520982 A ES520982 A ES 520982A ES 520982 A ES520982 A ES 520982A ES 8404683 A1 ES8404683 A1 ES 8404683A1
Authority
ES
Spain
Prior art keywords
thiadiazoles
substituted diamino
formula
substituted
diamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES520982A
Other languages
English (en)
Other versions
ES520982A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ES8404683A1 publication Critical patent/ES8404683A1/es
Publication of ES520982A0 publication Critical patent/ES520982A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE ANTAGONISTAS DE LOS RECEPTORES H2 DE LA HISTAMINA, DE FORMULA GENERAL (I), EN LA QUE R ES HIDROGENO, ALQUILO INFERIOR O PROPARGILO; M ES 0, 1 O 2; N ES 2, 3,, 4, 5; Z ES OXIGENO, AZUFRE O METILENO; Y A ES UN RADICAL, Y SUS SALES NOTOXICAS, FARMACEUTICAMENTE ACEPTABLES.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON AL MENOS UN EQUIVALENTE MOLAR, PREFERIBLEMENTE CON UN EXCESO MOLAR, DE DICLORURO DE AZUFRE, MONOCLORURO DE AZUFRE O DE UN EQUIVALENTE QUIMICO DE LOS MISMOS, EN PRESENCIA DE UN DISOLVENTEORGANICO INERTE A LA REACCION.DE APLICACION EN EL TRATAMIENTO DE LAS ULCERAS PEPTICAS.
ES520982A 1982-03-29 1983-03-25 Un procedimiento para la preparacion de antagonistas de los receptores hidrogeno de la histamina. Granted ES520982A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US36320782A 1982-03-29 1982-03-29

Publications (2)

Publication Number Publication Date
ES8404683A1 true ES8404683A1 (es) 1984-05-16
ES520982A0 ES520982A0 (es) 1984-05-16

Family

ID=23429274

Family Applications (3)

Application Number Title Priority Date Filing Date
ES520982A Granted ES520982A0 (es) 1982-03-29 1983-03-25 Un procedimiento para la preparacion de antagonistas de los receptores hidrogeno de la histamina.
ES527685A Expired ES8505977A1 (es) 1982-03-29 1983-11-30 Un procedimiento para la preparacion de antagonistas de los receptores hidrogeno de la histamina
ES527686A Granted ES527686A0 (es) 1982-03-29 1983-11-30 Un procedimiento para la preparacion de antagonistas de los receptores hidrogeno de la histamina.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES527685A Expired ES8505977A1 (es) 1982-03-29 1983-11-30 Un procedimiento para la preparacion de antagonistas de los receptores hidrogeno de la histamina
ES527686A Granted ES527686A0 (es) 1982-03-29 1983-11-30 Un procedimiento para la preparacion de antagonistas de los receptores hidrogeno de la histamina.

Country Status (30)

Country Link
JP (2) JPS58180477A (es)
KR (1) KR880002209B1 (es)
AT (1) AT386599B (es)
AU (2) AU557577B2 (es)
BE (1) BE896291A (es)
CH (2) CH655111A5 (es)
CS (2) CS250240B2 (es)
DD (2) DD210909A5 (es)
DE (1) DE3311281A1 (es)
DK (2) DK166677B1 (es)
ES (3) ES520982A0 (es)
FR (2) FR2542741B1 (es)
GB (2) GB2117769B (es)
GR (1) GR78524B (es)
HU (2) HU188742B (es)
IE (1) IE55596B1 (es)
IL (1) IL68259A0 (es)
IT (1) IT1164633B (es)
LU (1) LU84716A1 (es)
MY (1) MY8700942A (es)
NL (1) NL8301063A (es)
NO (1) NO163055C (es)
NZ (1) NZ203726A (es)
OA (1) OA07356A (es)
PT (1) PT76459B (es)
SE (2) SE461040B (es)
SU (2) SU1419518A3 (es)
YU (1) YU44849B (es)
ZA (1) ZA832154B (es)
ZW (1) ZW7683A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2222083A (en) * 1982-12-14 1984-06-21 Smith Kline & French Laboratories Limited Pyridine derivatives
US4593039A (en) * 1984-04-02 1986-06-03 Merck & Co., Inc. 1-aryloxy-3-(substituted aminoalkylamino)-2-propanols
US4644006A (en) * 1984-06-22 1987-02-17 Bristol-Myers Company Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H2 -receptor antagonist activity
JPH0622828B2 (ja) * 1986-06-30 1994-03-30 フアナツク株式会社 直圧式型締機構
EP4196793A1 (en) 2020-08-11 2023-06-21 Université de Strasbourg H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3018289A (en) * 1960-02-10 1962-01-23 Wyandotte Chemicals Corp Process for preparing oxamidines
GB1595291A (en) * 1976-09-21 1981-08-12 Smith Kline French Lab Pyrimidone and thiopyrimidone derivatives
DK160611C (da) * 1979-09-04 1991-09-16 Bristol Myers Squibb Co Analogifremgangsmaade til fremstilling af 3,4-disubstituerede 1,2,5-thiadiazol-1-oxider og -1,1-dioxider
DE3175201D1 (en) * 1980-04-30 1986-10-02 Merck & Co Inc Aminothiadiazoles as gastric secretion inhibitors
AU2222083A (en) * 1982-12-14 1984-06-21 Smith Kline & French Laboratories Limited Pyridine derivatives

Also Published As

Publication number Publication date
DK81192A (da) 1992-06-18
GB2149406B (en) 1986-01-02
DK166677B1 (da) 1993-06-28
FR2542741B1 (fr) 1989-12-08
FR2597867A1 (fr) 1987-10-30
AT386599B (de) 1988-09-12
SE461040B (sv) 1989-12-18
GB2149406A (en) 1985-06-12
GB2117769B (en) 1985-08-29
ES527685A0 (es) 1985-06-16
SE8301725D0 (sv) 1983-03-28
HU196386B (en) 1988-11-28
KR840004095A (ko) 1984-10-06
JPH06135925A (ja) 1994-05-17
KR880002209B1 (ko) 1988-10-18
NZ203726A (en) 1986-05-09
ZW7683A1 (en) 1984-01-04
GB8432809D0 (en) 1985-02-06
SE8704689L (sv) 1987-11-25
SE8301725L (sv) 1983-11-25
JPS58180477A (ja) 1983-10-21
OA07356A (fr) 1984-08-31
JPH0568472B2 (es) 1993-09-29
FR2597867B1 (fr) 1989-12-08
AU557577B2 (en) 1986-12-24
CS250240B2 (en) 1987-04-16
NO831100L (no) 1983-09-30
GR78524B (es) 1984-09-27
ES8505978A1 (es) 1985-06-16
PT76459B (en) 1986-03-11
NO163055B (no) 1989-12-18
NL8301063A (nl) 1983-10-17
FR2542741A1 (fr) 1984-09-21
YU44849B (en) 1991-04-30
SE464302B (sv) 1991-04-08
GB8308518D0 (en) 1983-05-05
DD219768A5 (de) 1985-03-13
HU188742B (en) 1986-05-28
CH660880A5 (de) 1987-05-29
DK141383D0 (da) 1983-03-28
DD210909A5 (de) 1984-06-27
LU84716A1 (fr) 1983-12-05
ES8505977A1 (es) 1985-06-16
DK141383A (da) 1983-09-30
NO163055C (no) 1990-03-28
CS250229B2 (en) 1987-04-16
BE896291A (fr) 1983-09-28
IL68259A0 (en) 1983-06-15
SU1419518A3 (ru) 1988-08-23
PT76459A (en) 1983-04-01
IT8348005A0 (it) 1983-03-28
IE55596B1 (en) 1990-11-21
AU1290783A (en) 1983-10-06
AU586037B2 (en) 1989-06-29
DE3311281A1 (de) 1983-11-24
IT1164633B (it) 1987-04-15
CH655111A5 (de) 1986-03-27
AU6327286A (en) 1987-01-08
SU1355123A3 (ru) 1987-11-23
ATA111083A (de) 1988-02-15
IE830686L (en) 1983-09-29
DK81192D0 (da) 1992-06-18
ZA832154B (en) 1983-12-28
SE8704689D0 (sv) 1987-11-25
ES527686A0 (es) 1985-06-16
ES520982A0 (es) 1984-05-16
YU74483A (en) 1986-02-28
MY8700942A (en) 1987-12-31
GB2117769A (en) 1983-10-19

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19991108