ES8500060A1 - Un metodo de producir una solucion de insulina. - Google Patents

Un metodo de producir una solucion de insulina.

Info

Publication number
ES8500060A1
ES8500060A1 ES519533A ES519533A ES8500060A1 ES 8500060 A1 ES8500060 A1 ES 8500060A1 ES 519533 A ES519533 A ES 519533A ES 519533 A ES519533 A ES 519533A ES 8500060 A1 ES8500060 A1 ES 8500060A1
Authority
ES
Spain
Prior art keywords
insulin
solutions
hexamer
insulin preparations
stabilized insulin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES519533A
Other languages
English (en)
Other versions
ES519533A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Industri AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Industri AS filed Critical Novo Industri AS
Publication of ES8500060A1 publication Critical patent/ES8500060A1/es
Publication of ES519533A0 publication Critical patent/ES519533A0/es
Granted legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
    • H05K13/00—Apparatus or processes specially adapted for manufacturing or adjusting assemblages of electric components
    • H05K13/06—Wiring by machine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Manufacturing & Machinery (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

METODO DE PREPARACION DE DISOLUCIONES DE INSULINA, QUE TIENE APLICACIONES PARA EL SUMINISTRO CONTINUO DE INSULINA.CONSISTE EN DISOLVER INSULINA EN AGUA QUE CONTIENE ACIDO, AN/ADIR UNA DISOLUCION ACUOSA DE UNA SAL DE CINC IONIZADA, QUE CONTIENE IONES CINCICOS A DISPOSICION DE LA INSULINA EN CONCENTRACION MAYOR QUE 4 ZN2B/ INSULINA HEXAMERA; AN/ADIR UN AGENTE DE CONSERVACION, UN AGENTE QUE HACE LA DISOLUCION ISOTONICA UN TAMPON Y UN AGENTE FORMADOR DE COMPLEJOS CON EL CINC.
ES519533A 1982-02-05 1983-02-04 Un metodo de producir una solucion de insulina. Granted ES519533A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK49182 1982-02-05

Publications (2)

Publication Number Publication Date
ES8500060A1 true ES8500060A1 (es) 1984-10-16
ES519533A0 ES519533A0 (es) 1984-10-16

Family

ID=8094159

Family Applications (1)

Application Number Title Priority Date Filing Date
ES519533A Granted ES519533A0 (es) 1982-02-05 1983-02-04 Un metodo de producir una solucion de insulina.

Country Status (22)

Country Link
US (1) US4476118A (es)
JP (1) JPS58192818A (es)
AT (1) AT382780B (es)
AU (1) AU549981B2 (es)
BE (1) BE895832A (es)
CA (1) CA1203476A (es)
CH (1) CH657530A5 (es)
DE (1) DE3303860A1 (es)
ES (1) ES519533A0 (es)
FI (1) FI78616C (es)
FR (1) FR2521009B1 (es)
GB (1) GB2114573B (es)
GR (1) GR77388B (es)
IE (1) IE54548B1 (es)
IT (1) IT1178455B (es)
LU (1) LU84632A1 (es)
NL (1) NL187269C (es)
NO (1) NO161204C (es)
NZ (1) NZ203189A (es)
PT (1) PT76195B (es)
SE (1) SE460948B (es)
ZA (1) ZA83742B (es)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
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ATE50502T1 (de) * 1984-06-09 1990-03-15 Hoechst Ag Insulinzubereitungen, verfahren zu deren herstellung und deren verwendung.
JP2520262B2 (ja) * 1987-08-21 1996-07-31 春幸 川原 パツチテスト材料
US4789660A (en) * 1987-09-10 1988-12-06 American Home Products Corporation Insulin administration using methyl and propyl paraben
US5130298A (en) * 1989-05-16 1992-07-14 Ethicon, Inc. Stabilized compositions containing epidermal growth factor
US5534488A (en) * 1993-08-13 1996-07-09 Eli Lilly And Company Insulin formulation
US5474978A (en) * 1994-06-16 1995-12-12 Eli Lilly And Company Insulin analog formulations
AR002976A1 (es) * 1995-03-31 1998-05-27 Lilly Co Eli Formulaciones farmaceuticas parenterales de efecto prolongado de insulina; cristales de dichos analogos aplicables en dichas formulaciones yprocedimiento de las formulaciones mencionadas
AU7678196A (en) * 1995-11-13 1997-06-05 Minimed, Inc. Methods and compositions for the delivery of monomeric proteins
JP2000507812A (ja) * 1996-03-12 2000-06-27 ライフ テクノロジーズ，インコーポレイテッド 造血細胞培養栄養補充成分
DE59711533D1 (de) * 1996-07-26 2004-05-27 Aventis Pharma Gmbh Insulinderivate mit erhöhter Zinkbindung
SI0884053T1 (en) * 1997-06-13 2003-02-28 Eli Lilly And Company Stable insulin formulations
ZA984697B (en) 1997-06-13 1999-12-01 Lilly Co Eli Stable insulin formulations.
WO1999024015A1 (en) * 1997-11-12 1999-05-20 Alza Corporation Buffered drug formulations for transdermal electrotransport delivery
DE19825447A1 (de) 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh Neue Insulinanaloga mit erhöhter Zinkbildung
DE69920767T2 (de) * 1998-10-16 2006-02-02 Novo Nordisk A/S Stabile konzentrierte Insulin Präparationen zur pulmonaren Verabreichung
DE19930676B4 (de) * 1999-07-02 2006-01-19 Sanofi-Aventis Deutschland Gmbh Verfahren zur Stabilisierung von Insulin, Insulinderivaten und/oder deren Vorläufer in komplexen Mischungen bei deren Lagerung in wäßrigen Lösungsmitteln
DK1265630T3 (da) * 2000-03-24 2006-10-09 Genentech Inc Anvendelse af insulin til behandling af brusksygdomme
JP4147234B2 (ja) * 2004-09-27 2008-09-10 キヤノン株式会社 吐出用液体、吐出方法、カートリッジ及び吐出装置
WO2003094956A1 (en) 2002-05-07 2003-11-20 Novo Nordisk A/S Soluble formulations comprising monomeric insulin and acylated insulin
US20050065066A1 (en) * 2002-12-20 2005-03-24 Kaarsholm Niels Christian Stabilised insulin compositions
JP2006516966A (ja) * 2002-12-20 2006-07-13 ノボ　ノルディスク　アクティーゼルスカブ 安定化されたインスリン組成物
WO2004096266A1 (en) * 2003-05-02 2004-11-11 Novo Nordisk A/S Improved physical stability of insulin formulations
EP2107069B1 (en) * 2003-08-05 2013-01-16 Novo Nordisk A/S Novel insulin derivatives
CN103223160B (zh) 2004-07-19 2015-02-18 比奥孔有限公司 胰岛素-低聚物共轭物,制剂及其用途
US20090074882A1 (en) 2005-12-28 2009-03-19 Novo Nordisk A/S Insulin compositions and method of making a composition
US20090136538A1 (en) * 2006-05-22 2009-05-28 Jan Jezek Stable vaccine formulation
GB0700523D0 (en) * 2007-01-11 2007-02-21 Insense Ltd The Stabilisation Of Proteins
WO2008112706A1 (en) 2007-03-13 2008-09-18 Nutrition 21, Inc. Methods and compositions for the sustained release of chromium
JP5552046B2 (ja) * 2007-06-13 2014-07-16 ノボ・ノルデイスク・エー／エス インスリン誘導体を含有する薬学的製剤
WO2009002867A2 (en) 2007-06-26 2008-12-31 Nutrition 21, Inc. Multiple unit dosage form having a therapeutic agents in combination with a nutritional supplement
WO2009063072A2 (en) * 2007-11-16 2009-05-22 Novo Nordisk A/S Pharmaceutical compositions containing insulin and an insulinotropic peptide
EP2341940A1 (en) * 2008-07-16 2011-07-13 Arecor Limited The stabilisation of proteins
EP2328607A1 (en) * 2008-07-16 2011-06-08 Arecor Limited Stable formulation of a therapeutic protein
KR20110085985A (ko) * 2008-10-30 2011-07-27 노보 노르디스크 에이/에스 하루 한번 주사 빈도보다 적은 인슐린 주사를 사용한 진성 당뇨병의 치료
US9060927B2 (en) 2009-03-03 2015-06-23 Biodel Inc. Insulin formulations for rapid uptake
BR112013010345A2 (pt) 2010-10-27 2017-07-25 Novo Nordisk As tratamento de diabetes melitus usando as injeções de insulina administradas com intervalos de variação da injeção
ES2927800T3 (es) 2011-03-01 2022-11-11 Nutrition 21 Llc Composición de insulina y cromo para el tratamiento y la prevención de diabetes, hipoglicemia y trastornos relacionados
ES2670969T3 (es) 2012-11-13 2018-06-04 Adocia Formulación de acción rápida de insulina que comprende un compuesto aniónico sustituido
MX360420B (es) * 2012-12-19 2018-10-31 Wockhardt Ltd Una composicion acuosa estable que comprende insulina humana o un analogo o derivado de la misma.
BR112015013223A2 (pt) 2012-12-26 2017-07-11 Wockhardt Ltd composição farmacêutica
TWI641381B (zh) * 2013-02-04 2018-11-21 法商賽諾菲公司 胰島素類似物及／或胰島素衍生物之穩定化醫藥調配物
JP2016519127A (ja) 2013-04-30 2016-06-30 ノヴォ ノルディスク アー／エス 新規投与レジメン
WO2015084694A2 (en) * 2013-12-04 2015-06-11 Merck Sharp & Dohme Corp. Method for preparing crystalline insulin
TW201630622A (zh) 2014-12-16 2016-09-01 美國禮來大藥廠 速效胰島素組合物
JO3749B1 (ar) 2015-08-27 2021-01-31 Lilly Co Eli تركيبات إنسولين سريعة المفعول
GB2564295A (en) 2016-02-11 2019-01-09 Nutrition 21 Llc Chromium containing compositions for improving health and fitness
EP3518893A1 (en) 2016-09-29 2019-08-07 Arecor Limited Novel formulations
KR20190140048A (ko) 2017-06-01 2019-12-18 일라이 릴리 앤드 캄파니 신속-작용 인슐린 조성물
US10335464B1 (en) 2018-06-26 2019-07-02 Novo Nordisk A/S Device for titrating basal insulin
US12343383B2 (en) 2019-07-12 2025-07-01 Novo Nordisk A/S High concentration insulin formulation
CN114887039B (zh) * 2022-05-13 2026-01-30 西北工业大学 一种锌离子介导的自组装胰岛素纳米药物、制备方法和应用
CN120142500B (zh) * 2025-02-28 2025-10-10 中国计量科学研究院 一种具有互换性的活性人胰岛素溶液标准物质及其制备方法和应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2882202A (en) * 1950-04-05 1959-04-14 Novo Terapeutisk Labor As Insulin crystal preparations and methods of producing them
US2787575A (en) * 1950-11-22 1957-04-02 Organon Zinc-glycine-insulin composition and production thereof
US2882203A (en) * 1951-06-26 1959-04-14 Novo Terapeutisk Labor As Injectable insulin preparation with protracted effect
DE1044360B (de) * 1953-08-19 1958-11-20 Roskilde Medical Company Ltd R Verfahren zur Herstellung von Zinkinsulin mit erhoehtem Zinkgehalt
DE956098C (de) * 1954-02-18 1957-01-10 Dr Dr Guenther Weitzel Verfahren zur Herstellung zinkreicher Insulin-Komplexverbindungen
US3058885A (en) * 1957-06-08 1962-10-16 Novo Terapeutisk Labor As Process for treatment of insulin crystals and for production of insulin preparationstherefrom
US3014842A (en) * 1957-08-10 1961-12-26 Novo Terapeutish Lab A S Injectable bovine insulin crystal suspensions and process of producing same
US3091573A (en) * 1958-05-12 1963-05-28 Novo Terapeutisk Labor As Quick acting insulin preparation
FR1263220A (fr) * 1958-08-01 1961-06-09 Novo Terapeutisk Labor As Procédé de production d'une préparation d'insuline à action rapide
DK116527B (da) * 1967-03-01 1970-01-19 Nordisk Insulinlab Fremgangsmåde til fremstilling af en hurtigtvirkende, holdbar, neutral opløsning af rent krystallinsk okseinsulin eller okseinsulin, der ved tilsætning af Zn er krystalliserbart i vand, eller blandinger af okseinsulin og insulin af anden oprindelse.
GB1285023A (en) * 1968-08-09 1972-08-09 Novo Terapeutisk Labor As Improvements in or relating to injectable insulin preparations
US3657425A (en) * 1969-03-12 1972-04-18 Burroughs Wellcome Co Beef insulin preparations
DE2459515C3 (de) * 1974-12-17 1982-02-11 Hoechst Ag, 6000 Frankfurt Arzneimittelzubereitungen mit antidiabetischer Wirkung
EP0018609B1 (de) * 1979-04-30 1983-09-21 Hoechst Aktiengesellschaft Gegen Denaturierung beständige, wässrige Protein-Lösungen, Verfahren zu ihrer Herstellung und ihre Verwendung
DK80781A (da) * 1980-02-29 1981-08-30 Hospital For Sick Children Oploesninger af polypeptider
WO1983003054A1 (en) * 1982-03-03 1983-09-15 Johansen, Kristian, Betton A proces for producing an insulin preparation

Also Published As

Publication number Publication date
AT382780B (de) 1987-04-10
BE895832A (fr) 1983-08-04
NL8300440A (nl) 1983-09-01
IE54548B1 (en) 1989-11-08
NL187269C (nl) 1991-08-01
GB2114573B (en) 1985-05-01
DE3303860A1 (de) 1983-08-18
SE8300598L (sv) 1983-08-06
NO161204C (no) 1989-07-19
IT8319420A0 (it) 1983-02-04
NO830385L (no) 1983-08-08
LU84632A1 (fr) 1983-09-08
NL187269B (nl) 1991-03-01
AU1113683A (en) 1983-08-11
ATA38983A (de) 1986-09-15
US4476118A (en) 1984-10-09
IT1178455B (it) 1987-09-09
IE830220L (en) 1983-08-05
PT76195A (en) 1983-03-01
FR2521009B1 (fr) 1987-07-17
ZA83742B (en) 1983-11-30
NZ203189A (en) 1985-07-31
PT76195B (en) 1986-01-27
GB2114573A (en) 1983-08-24
GR77388B (es) 1984-09-11
FI78616C (fi) 1989-09-11
CH657530A5 (de) 1986-09-15
DE3303860C2 (es) 1989-12-28
JPH0367056B2 (es) 1991-10-21
SE8300598D0 (sv) 1983-02-04
SE460948B (sv) 1989-12-11
FI830375L (fi) 1983-08-06
FI830375A0 (fi) 1983-02-03
NO161204B (no) 1989-04-10
ES519533A0 (es) 1984-10-16
FI78616B (fi) 1989-05-31
GB8303133D0 (en) 1983-03-09
CA1203476A (en) 1986-04-22
AU549981B2 (en) 1986-02-20
FR2521009A1 (fr) 1983-08-12
JPS58192818A (ja) 1983-11-10

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