ES8505200A1 - Un procedimiento para la preparacion de nuevos derivados de 2-propanol - Google Patents
Un procedimiento para la preparacion de nuevos derivados de 2-propanolInfo
- Publication number
- ES8505200A1 ES8505200A1 ES531872A ES531872A ES8505200A1 ES 8505200 A1 ES8505200 A1 ES 8505200A1 ES 531872 A ES531872 A ES 531872A ES 531872 A ES531872 A ES 531872A ES 8505200 A1 ES8505200 A1 ES 8505200A1
- Authority
- ES
- Spain
- Prior art keywords
- procedure
- preparation
- hydrogen
- new
- propanol derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical class CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- -1 LOWER ALKYL Chemical class 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 229940125692 cardiovascular agent Drugs 0.000 abstract 1
- 239000002327 cardiovascular agent Substances 0.000 abstract 1
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical group [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 229910000029 sodium carbonate Inorganic materials 0.000 abstract 1
- IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
PROCEDIMIENTO DE PREPARACION DE DERIVADOS DE 2-PROPANOL DE FORMULA (I), DONDE W ES HALOGENO O HIDROXILO; R ES HIDROGENO O OFC-L CON L SELECCIONADO ENTRE ALQUILO C1-10, FENILO, SUSTITUIDO O FENALQUILO; Y G ES EL RADICAL (II) SIENDO R, R, A Y B HIDROGENO O ALQUILO INFERIOR Y C UN SUSTITUYENTE SELECCIONADO ENTRE HIDROGENO, ALQUILO INFERIOR, HALOGENO, ALCOXI INFE RIOR O HIDROXI.MEDIANTE REACCION DE UN COMPUESTO DE FORMULA (III), DONDE R, R, A, B Y C SON LOS YA INDICADOS, CON 3-CLORO-1,2-PROPANODIOL, EN ALCOHOL A REFLUJO Y EN PRESENCIA DE UNA BASE, PREFERIBLEMENTE CARBONATO SODICO.DE APLICACION COMO AGENTES CARDIOVASCULARES.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41474882A | 1982-09-03 | 1982-09-03 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8505200A1 true ES8505200A1 (es) | 1985-05-16 |
| ES531872A0 ES531872A0 (es) | 1985-05-16 |
Family
ID=23642783
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES525243A Granted ES525243A0 (es) | 1982-09-03 | 1983-08-30 | Un procedimiento de preparacion de nuevos derivados de 2-propanol. |
| ES531872A Granted ES531872A0 (es) | 1982-09-03 | 1984-04-25 | Un procedimiento para la preparacion de nuevos derivados de 2-propanol |
| ES547110A Expired ES8604930A1 (es) | 1982-09-03 | 1985-09-19 | Un procedimiento de preparacion de nuevos derivados de 2- propanol |
| ES547111A Expired ES8604931A1 (es) | 1982-09-03 | 1985-09-19 | Un procedimiento de preparacion de nuevos derivados de 2- propanol |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES525243A Granted ES525243A0 (es) | 1982-09-03 | 1983-08-30 | Un procedimiento de preparacion de nuevos derivados de 2-propanol. |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES547110A Expired ES8604930A1 (es) | 1982-09-03 | 1985-09-19 | Un procedimiento de preparacion de nuevos derivados de 2- propanol |
| ES547111A Expired ES8604931A1 (es) | 1982-09-03 | 1985-09-19 | Un procedimiento de preparacion de nuevos derivados de 2- propanol |
Country Status (28)
| Country | Link |
|---|---|
| JP (1) | JPS5965087A (es) |
| KR (1) | KR870001019B1 (es) |
| AT (1) | AT387385B (es) |
| AU (4) | AU567112B2 (es) |
| BE (1) | BE897671A (es) |
| CA (1) | CA1236834A (es) |
| CH (2) | CH668593A5 (es) |
| CY (1) | CY1521A (es) |
| DE (1) | DE3331612A1 (es) |
| DK (1) | DK399783A (es) |
| ES (4) | ES525243A0 (es) |
| FI (1) | FI79709C (es) |
| FR (1) | FR2543952B1 (es) |
| GB (1) | GB2126230B (es) |
| GR (1) | GR79061B (es) |
| HK (1) | HK17490A (es) |
| HU (2) | HU192862B (es) |
| IE (1) | IE56201B1 (es) |
| IL (1) | IL69618A (es) |
| IT (1) | IT1169459B (es) |
| LU (1) | LU84986A1 (es) |
| NL (1) | NL8303038A (es) |
| NO (1) | NO161258C (es) |
| NZ (1) | NZ205466A (es) |
| PT (1) | PT77282B (es) |
| SE (2) | SE460419B (es) |
| YU (2) | YU45150B (es) |
| ZA (1) | ZA836469B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2543952B1 (fr) * | 1982-09-03 | 1986-02-21 | Bristol Myers Co | Composes hydrocarbones heterocycliques appartenant aux series indoliques et leur application pharmacologique |
| DE3721260A1 (de) * | 1987-06-27 | 1989-01-12 | Beiersdorf Ag | Neue indolylpropanole, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen |
| US5030640A (en) * | 1989-01-05 | 1991-07-09 | Merck & Co., Inc. | Novel β-adrenergic agonists and pharmaceutical compositions thereof |
| MXPA03003688A (es) * | 2000-10-25 | 2003-08-07 | Smithkline Beecham Corp | Compuestos calciliticos. |
| KR100457857B1 (ko) * | 2002-05-23 | 2004-11-18 | (주) 비엔씨바이오팜 | 2-[2-(3-인돌릴)에틸아미노]피리딘 유도체, 그 제조방법및 이를 포함하는 항바이러스용 약학적 조성물 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4144343A (en) * | 1978-01-04 | 1979-03-13 | Merck & Co., Inc. | Heterocycle substituted (3-loweralkylamino-2-R1 O-propoxy)pyridines |
| FR2463765A1 (fr) * | 1979-08-17 | 1981-02-27 | Clin Midy | Nouveaux derives de l'indole actifs sur le systeme cardiovasculaire |
| FR2543952B1 (fr) * | 1982-09-03 | 1986-02-21 | Bristol Myers Co | Composes hydrocarbones heterocycliques appartenant aux series indoliques et leur application pharmacologique |
| CA1241660A (en) * | 1984-06-25 | 1988-09-06 | Yvan Guindon | Indole-2-alkanoic acids |
-
1983
- 1983-08-26 FR FR8313793A patent/FR2543952B1/fr not_active Expired
- 1983-08-30 ES ES525243A patent/ES525243A0/es active Granted
- 1983-08-30 GR GR72336A patent/GR79061B/el unknown
- 1983-08-31 NL NL8303038A patent/NL8303038A/nl not_active Application Discontinuation
- 1983-08-31 FI FI833102A patent/FI79709C/fi not_active IP Right Cessation
- 1983-08-31 AU AU18592/83A patent/AU567112B2/en not_active Ceased
- 1983-08-31 ZA ZA836469A patent/ZA836469B/xx unknown
- 1983-09-01 IL IL69618A patent/IL69618A/xx unknown
- 1983-09-01 DE DE19833331612 patent/DE3331612A1/de not_active Withdrawn
- 1983-09-01 PT PT77282A patent/PT77282B/pt not_active IP Right Cessation
- 1983-09-01 DK DK399783A patent/DK399783A/da not_active Application Discontinuation
- 1983-09-01 CA CA000435880A patent/CA1236834A/en not_active Expired
- 1983-09-01 NO NO833128A patent/NO161258C/no unknown
- 1983-09-02 NZ NZ205466A patent/NZ205466A/en unknown
- 1983-09-02 HU HU833064A patent/HU192862B/hu not_active IP Right Cessation
- 1983-09-02 GB GB08323641A patent/GB2126230B/en not_active Expired
- 1983-09-02 AT AT0315583A patent/AT387385B/de not_active IP Right Cessation
- 1983-09-02 KR KR1019830004140A patent/KR870001019B1/ko not_active Expired
- 1983-09-02 IE IE2063/83A patent/IE56201B1/en unknown
- 1983-09-02 HU HU864311A patent/HU194164B/hu not_active IP Right Cessation
- 1983-09-02 LU LU84986A patent/LU84986A1/fr unknown
- 1983-09-02 IT IT22765/83A patent/IT1169459B/it active
- 1983-09-02 BE BE211466A patent/BE897671A/fr unknown
- 1983-09-02 SE SE8304751A patent/SE460419B/sv not_active IP Right Cessation
- 1983-09-02 JP JP58160596A patent/JPS5965087A/ja active Pending
- 1983-09-05 CH CH4390/86A patent/CH668593A5/fr not_active IP Right Cessation
- 1983-09-05 YU YU1803/83A patent/YU45150B/xx unknown
- 1983-09-05 CH CH4855/83A patent/CH661512A5/fr not_active IP Right Cessation
-
1984
- 1984-04-25 ES ES531872A patent/ES531872A0/es active Granted
-
1985
- 1985-09-19 ES ES547110A patent/ES8604930A1/es not_active Expired
- 1985-09-19 ES ES547111A patent/ES8604931A1/es not_active Expired
-
1986
- 1986-12-25 YU YU2247/86A patent/YU44940B/xx unknown
-
1987
- 1987-10-30 AU AU80559/87A patent/AU613589B2/en not_active Ceased
- 1987-10-30 AU AU80557/87A patent/AU609067B2/en not_active Ceased
- 1987-10-30 AU AU80558/87A patent/AU609068B2/en not_active Ceased
-
1988
- 1988-06-16 SE SE8802265A patent/SE8802265L/xx not_active Application Discontinuation
-
1990
- 1990-03-08 HK HK174/90A patent/HK17490A/xx unknown
- 1990-11-16 CY CY1521A patent/CY1521A/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970401 |