SE8304751L - Substituerade 1-pyridyloxi-3-indolylalkylamino-2-propanoler, deras framstellning och anvendning - Google Patents

Substituerade 1-pyridyloxi-3-indolylalkylamino-2-propanoler, deras framstellning och anvendning

Info

Publication number: SE8304751L
Authority: SE; Sweden
Prior art keywords: propanols; indolylalkylamino; coupling; pyridinyloxy; substituted
Prior art date: 1982-09-03

Application number

SE8304751A

Other languages

English (en)

Other versions

SE8304751D0 (sv

SE460419B (sv

Inventor

W E Kreighbaum

Original Assignee

Bristol Myers Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-09-03

Filing date

1983-09-02

Publication date

1984-03-04

1983-09-02 Application filed by Bristol Myers Co filed Critical Bristol Myers Co

1983-09-02 Publication of SE8304751D0 publication Critical patent/SE8304751D0/sv

1984-03-04 Publication of SE8304751L publication Critical patent/SE8304751L/sv

1989-10-09 Publication of SE460419B publication Critical patent/SE460419B/sv

Links

230000008878 coupling Effects 0.000 abstract 5
238000010168 coupling process Methods 0.000 abstract 5
238000005859 coupling reaction Methods 0.000 abstract 5
230000008570 general process Effects 0.000 abstract 2
JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
150000001408 amides Chemical class 0.000 abstract 1
102000012740 beta Adrenergic Receptors Human genes 0.000 abstract 1
108010079452 beta Adrenergic Receptors Proteins 0.000 abstract 1
230000000903 blocking effect Effects 0.000 abstract 1
239000002327 cardiovascular agent Substances 0.000 abstract 1
229940125692 cardiovascular agent Drugs 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
-1 hydroxyl-substituted propanol Chemical class 0.000 abstract 1
BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 abstract 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
150000003222 pyridines Chemical class 0.000 abstract 1
IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 abstract 1
229940124549 vasodilator Drugs 0.000 abstract 1
239000003071 vasodilator agent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

SE8304751A 1982-09-03 1983-09-02 Substituerade 1-pyridyloxi-3-indolylalkylamino-2-propanoler, foerfarande foer framstaellning av dessa och en farmaceutisk komposition SE460419B (sv)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US41474882A	1982-09-03	1982-09-03

Publications (3)

Publication Number	Publication Date
SE8304751D0 SE8304751D0 (sv)	1983-09-02
SE8304751L true SE8304751L (sv)	1984-03-04
SE460419B SE460419B (sv)	1989-10-09

Family

ID=23642783

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
SE8304751A SE460419B (sv)	1982-09-03	1983-09-02	Substituerade 1-pyridyloxi-3-indolylalkylamino-2-propanoler, foerfarande foer framstaellning av dessa och en farmaceutisk komposition
SE8802265A SE8802265L (sv)	1982-09-03	1988-06-16	Pyridyloxi-glycidoler och pyridyloxi-indolylalkyloxazolidiner

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
SE8802265A SE8802265L (sv)	1982-09-03	1988-06-16	Pyridyloxi-glycidoler och pyridyloxi-indolylalkyloxazolidiner

Country Status (28)

Country	Link
JP (1)	JPS5965087A (sv)
KR (1)	KR870001019B1 (sv)
AT (1)	AT387385B (sv)
AU (4)	AU567112B2 (sv)
BE (1)	BE897671A (sv)
CA (1)	CA1236834A (sv)
CH (2)	CH668593A5 (sv)
CY (1)	CY1521A (sv)
DE (1)	DE3331612A1 (sv)
DK (1)	DK399783A (sv)
ES (4)	ES525243A0 (sv)
FI (1)	FI79709C (sv)
FR (1)	FR2543952B1 (sv)
GB (1)	GB2126230B (sv)
GR (1)	GR79061B (sv)
HK (1)	HK17490A (sv)
HU (2)	HU192862B (sv)
IE (1)	IE56201B1 (sv)
IL (1)	IL69618A (sv)
IT (1)	IT1169459B (sv)
LU (1)	LU84986A1 (sv)
NL (1)	NL8303038A (sv)
NO (1)	NO161258C (sv)
NZ (1)	NZ205466A (sv)
PT (1)	PT77282B (sv)
SE (2)	SE460419B (sv)
YU (2)	YU45150B (sv)
ZA (1)	ZA836469B (sv)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2543952B1 (fr) *	1982-09-03	1986-02-21	Bristol Myers Co	Composes hydrocarbones heterocycliques appartenant aux series indoliques et leur application pharmacologique
DE3721260A1 (de) *	1987-06-27	1989-01-12	Beiersdorf Ag	Neue indolylpropanole, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen
US5030640A (en) *	1989-01-05	1991-07-09	Merck & Co., Inc.	Novel β-adrenergic agonists and pharmaceutical compositions thereof
MXPA03003688A (es) *	2000-10-25	2003-08-07	Smithkline Beecham Corp	Compuestos calciliticos.
KR100457857B1 (ko) *	2002-05-23	2004-11-18	(주) 비엔씨바이오팜	2-[2-(3-인돌릴)에틸아미노]피리딘 유도체, 그 제조방법및 이를 포함하는 항바이러스용 약학적 조성물

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4144343A (en) *	1978-01-04	1979-03-13	Merck & Co., Inc.	Heterocycle substituted (3-loweralkylamino-2-R1 O-propoxy)pyridines
FR2463765A1 (fr) *	1979-08-17	1981-02-27	Clin Midy	Nouveaux derives de l'indole actifs sur le systeme cardiovasculaire
FR2543952B1 (fr) *	1982-09-03	1986-02-21	Bristol Myers Co	Composes hydrocarbones heterocycliques appartenant aux series indoliques et leur application pharmacologique
CA1241660A (en) *	1984-06-25	1988-09-06	Yvan Guindon	Indole-2-alkanoic acids

1983
- 1983-08-26 FR FR8313793A patent/FR2543952B1/fr not_active Expired
- 1983-08-30 ES ES525243A patent/ES525243A0/es active Granted
- 1983-08-30 GR GR72336A patent/GR79061B/el unknown
- 1983-08-31 NL NL8303038A patent/NL8303038A/nl not_active Application Discontinuation
- 1983-08-31 FI FI833102A patent/FI79709C/sv not_active IP Right Cessation
- 1983-08-31 AU AU18592/83A patent/AU567112B2/en not_active Ceased
- 1983-08-31 ZA ZA836469A patent/ZA836469B/xx unknown
- 1983-09-01 IL IL69618A patent/IL69618A/xx unknown
- 1983-09-01 DE DE19833331612 patent/DE3331612A1/de not_active Withdrawn
- 1983-09-01 PT PT77282A patent/PT77282B/pt not_active IP Right Cessation
- 1983-09-01 DK DK399783A patent/DK399783A/da not_active Application Discontinuation
- 1983-09-01 CA CA000435880A patent/CA1236834A/en not_active Expired
- 1983-09-01 NO NO833128A patent/NO161258C/no unknown
- 1983-09-02 NZ NZ205466A patent/NZ205466A/en unknown
- 1983-09-02 HU HU833064A patent/HU192862B/hu not_active IP Right Cessation
- 1983-09-02 GB GB08323641A patent/GB2126230B/en not_active Expired
- 1983-09-02 AT AT0315583A patent/AT387385B/de not_active IP Right Cessation
- 1983-09-02 KR KR1019830004140A patent/KR870001019B1/ko not_active Expired
- 1983-09-02 IE IE2063/83A patent/IE56201B1/en unknown
- 1983-09-02 HU HU864311A patent/HU194164B/hu not_active IP Right Cessation
- 1983-09-02 LU LU84986A patent/LU84986A1/fr unknown
- 1983-09-02 IT IT22765/83A patent/IT1169459B/it active
- 1983-09-02 BE BE211466A patent/BE897671A/fr unknown
- 1983-09-02 SE SE8304751A patent/SE460419B/sv not_active IP Right Cessation
- 1983-09-02 JP JP58160596A patent/JPS5965087A/ja active Pending
- 1983-09-05 CH CH4390/86A patent/CH668593A5/fr not_active IP Right Cessation
- 1983-09-05 YU YU1803/83A patent/YU45150B/xx unknown
- 1983-09-05 CH CH4855/83A patent/CH661512A5/fr not_active IP Right Cessation
1984
- 1984-04-25 ES ES531872A patent/ES531872A0/es active Granted
1985
- 1985-09-19 ES ES547110A patent/ES8604930A1/es not_active Expired
- 1985-09-19 ES ES547111A patent/ES8604931A1/es not_active Expired
1986
- 1986-12-25 YU YU2247/86A patent/YU44940B/xx unknown
1987
- 1987-10-30 AU AU80559/87A patent/AU613589B2/en not_active Ceased
- 1987-10-30 AU AU80557/87A patent/AU609067B2/en not_active Ceased
- 1987-10-30 AU AU80558/87A patent/AU609068B2/en not_active Ceased
1988
- 1988-06-16 SE SE8802265A patent/SE8802265L/sv not_active Application Discontinuation
1990
- 1990-03-08 HK HK174/90A patent/HK17490A/xx unknown
- 1990-11-16 CY CY1521A patent/CY1521A/en unknown

Also Published As

Publication number	Publication date
DK399783D0 (da)	1983-09-01
DE3331612A1 (de)	1984-03-08
ES547111A0 (es)	1986-02-16
KR870001019B1 (ko)	1987-05-23
AU8055787A (en)	1988-02-18
IL69618A (en)	1987-02-27
ES8505200A1 (es)	1985-05-16
SE8304751D0 (sv)	1983-09-02
ES531872A0 (es)	1985-05-16
FR2543952A1 (fr)	1984-10-12
ES8604930A1 (es)	1986-02-16
SE460419B (sv)	1989-10-09
PT77282A (en)	1983-10-01
NO833128L (no)	1984-03-05
BE897671A (fr)	1984-03-02
ES8604931A1 (es)	1986-02-16
PT77282B (en)	1986-04-28
CY1521A (en)	1990-11-16
AU567112B2 (en)	1987-11-12
NO161258C (no)	1989-07-26
NL8303038A (nl)	1984-04-02
FI833102A0 (fi)	1983-08-31
YU224786A (en)	1987-10-31
SE8802265D0 (sv)	1988-06-16
AU8055887A (en)	1988-02-18
HU194164B (en)	1988-01-28
YU44940B (en)	1991-04-30
ZA836469B (en)	1984-04-25
AU1859283A (en)	1984-03-08
CH668593A5 (fr)	1989-01-13
FI833102L (fi)	1984-03-04
IL69618A0 (en)	1983-12-30
ES8507537A1 (es)	1985-09-01
GR79061B (sv)	1984-10-02
IT1169459B (it)	1987-05-27
CA1236834A (en)	1988-05-17
HU192862B (en)	1987-07-28
JPS5965087A (ja)	1984-04-13
GB2126230B (en)	1987-01-14
HK17490A (en)	1990-03-16
FI79709B (fi)	1989-10-31
FI79709C (sv)	1990-02-12
DK399783A (da)	1984-03-04
FR2543952B1 (fr)	1986-02-21
IE56201B1 (en)	1991-05-22
IT8322765A0 (it)	1983-09-02
IE832063L (en)	1984-03-03
YU45150B (en)	1992-03-10
ES547110A0 (es)	1986-02-16
LU84986A1 (fr)	1984-04-24
AU613589B2 (en)	1991-08-08
KR840006235A (ko)	1984-11-22
GB2126230A (en)	1984-03-21
ATA315583A (de)	1988-06-15
SE8802265L (sv)	1988-06-16
NO161258B (no)	1989-04-17
AU8055987A (en)	1988-02-18
AT387385B (de)	1989-01-10
ES525243A0 (es)	1985-09-01
CH661512A5 (fr)	1987-07-31
AU609068B2 (en)	1991-04-26
YU180383A (en)	1988-06-30
GB8323641D0 (en)	1983-10-05
AU609067B2 (en)	1991-04-26
NZ205466A (en)	1986-12-05

Legal Events

Date

Code

Title

Description

1995-01-31

NUG

Patent has lapsed

Ref document number: 8304751-4

Effective date: 19940410

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IT1174184B (it)	1987-07-01	Procentimento per l'incollaggio di trucioli di legno e simili mediante colla liquida ed apparecchiatura per l'esecuzione del procentimento stresso
GB1422650A (en)	1976-01-28	Azo dyes having 2,6-diaminopyridine derivatives as coupling components
ES8301920A1 (es)	1982-11-16	Un procedimiento para preparar un derivado de piridina .
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ES537666A0 (es)	1985-09-16	Procedimiento para preparar nuevos derivados de 1, 3-dihidro-6-metilfuro-(3, 4-c)-piridina
DK159114C (da)	1991-02-11	Benzyldihydrofuropyridinderivater og praeparater indeholdende disse forbindelser
BG41822A3 (en)	1987-08-14	Method for preparing pyridyl derivatives
SE8304751D0 (sv)	1983-09-02	Substituerade 1-pyridyloxi-3-indolylalkylamino-2-propanoler, deras framstellning och anvendning
BE876685A (fr)	1979-11-30	Procede pour preparer des granules de pigments ou de colorants ne formant pas de poussiere
BE855761A (fr)	1977-12-16	Derives n-aminoalkyles d'indoles et procedes pour les preparer
BR8004058A (pt)	1981-01-21	Aparelho para tratamento de material fluente pela irradiaco do mesmo
BG35042A3 (en)	1983-01-16	Method for preparing benzodiazepinic compounds
MY102963A (en)	1993-03-31	Substituted 1-pyridyloxy-3-indolylalky lamino -2-propanols, preparation, and use thereof
DE3173396D1 (en)	1986-02-13	Tridecapeptide, process for its preparation and its use
IT7947515A0 (it)	1979-01-03	Procedimento per la preparazione di (3-inferioralchilammino-2-r1o-pro possi)piridine eterociclo sostituite e prodotto ottenuto
GB1260352A (en)	1972-01-19	New derivatives of benzoxazolin-2-one and methods for producing the same
BG41129A3 (en)	1987-04-15	Method for preparing acetamide derivatives
JPS5395961A (en)	1978-08-22	Tetrahydrophthalimide derivatives process for their preparation and herbicides containing the same
SE7407296L (sv)	1974-12-16
ES8603458A1 (es)	1985-12-16	Un procedimiento para preparar una 3-r1-4-r2-5-q-6-r-2(1h)-piridinona
PT71427A (en)	1980-07-01	Process for the preparation of 5-(4-pyridinyl)-2 (1h) pyridinones useful as cardiotonic agents
ES8601148A1 (es)	1985-11-16	Procedimiento de obtencion de nuevos derivados imidazoliletoxiindanicos.
BE777882A (fr)	1972-07-10	Derives d'acide isocyanurique, et procedes pour les preparer
BE850130A (fr)	1977-05-02	Nouveaux derives de 4,5,6,7-tetrahydro-imidazo-(4,5-c)-pyridine et procede pour les preparer