ES8506082A1 - Procedimiento para la inactivacion de germenes patogenos, capaces de reproducirse - Google Patents

Procedimiento para la inactivacion de germenes patogenos, capaces de reproducirse

Info

Publication number
ES8506082A1
ES8506082A1 ES532075A ES532075A ES8506082A1 ES 8506082 A1 ES8506082 A1 ES 8506082A1 ES 532075 A ES532075 A ES 532075A ES 532075 A ES532075 A ES 532075A ES 8506082 A1 ES8506082 A1 ES 8506082A1
Authority
ES
Spain
Prior art keywords
pathogens
proteins
preparation
ammonium sulfate
inactivation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES532075A
Other languages
English (en)
Other versions
ES532075A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oesterreichisches Institut fuer Haemoderivate
Original Assignee
Immuno AG
Immuno AG fuer Chemisch Medizinische Produkte
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AT0159183A external-priority patent/AT376882B/de
Priority claimed from AT0159383A external-priority patent/AT376884B/de
Priority claimed from AT0159283A external-priority patent/AT376883B/de
Priority claimed from AT0159083A external-priority patent/AT376881B/de
Application filed by Immuno AG, Immuno AG fuer Chemisch Medizinische Produkte filed Critical Immuno AG
Publication of ES532075A0 publication Critical patent/ES532075A0/es
Publication of ES8506082A1 publication Critical patent/ES8506082A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/16—Blood plasma; Blood serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A61L2/04—Heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2103/00—Materials or objects being the target of disinfection or sterilisation
    • A61L2103/05—Living organisms or biological materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Peptides Or Proteins (AREA)

Abstract

PROCEDIMIENTO PARA LA INACTIVACION DE GERMENES PATOGENOS, CAPACES DE REPRODUCIRSE, EN PREPARADOS QUE CONTIENEN ENZIMAS Y PROENZIMAS PLASMATICAS, FACTORES DE COAGULACION ACTIVADOS O NO ACTIVADOS, Y PREPARADOS DE COMPLEJOS DE PROTROMBINA, INHIBIDORES PLASMATICOS E INMUNOGLOBULINAS U OTROS PRODUCTOS SANGUINEOS.CONSISTE EN LLEVAR EL PREPARADO, POR ADICION DE SULFATO AMONICO, A UNA CONCENTRACION EN SAL SUPERIOR A 0,5 MOLAR Y EN SOMETERLA A UN TRATAMIENTO TERMICO, ELIMINANDO A CONTINUACION LA SAL DEL PREPARADO.
ES532075A 1983-05-02 1984-04-30 Procedimiento para la inactivacion de germenes patogenos, capaces de reproducirse Expired ES8506082A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
AT0159183A AT376882B (de) 1983-05-02 1983-05-02 Verfahren zur inaktivierung von vermehrungsfaehigen krankheitserregern
AT0159383A AT376884B (de) 1983-05-02 1983-05-02 Verfahren zur inaktivierung von vermehrungsfaehigen krankeitserregern
AT0159283A AT376883B (de) 1983-05-02 1983-05-02 Verfahren zur inaktivierung von vermehrungsfaehigen krankheitserregern
AT0159083A AT376881B (de) 1983-05-02 1983-05-02 Verfahren zur inaktivierung von vermehrungsfaehigen krankheitserregern

Publications (2)

Publication Number Publication Date
ES532075A0 ES532075A0 (es) 1985-06-16
ES8506082A1 true ES8506082A1 (es) 1985-06-16

Family

ID=27421575

Family Applications (1)

Application Number Title Priority Date Filing Date
ES532075A Expired ES8506082A1 (es) 1983-05-02 1984-04-30 Procedimiento para la inactivacion de germenes patogenos, capaces de reproducirse

Country Status (5)

Country Link
US (1) US4687664A (es)
EP (1) EP0124506B1 (es)
AT (1) ATE36457T1 (es)
DE (1) DE3473407D1 (es)
ES (1) ES8506082A1 (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0669961B2 (ja) * 1984-09-25 1994-09-07 株式会社ミドリ十字 免疫グロブリンの加熱処理方法
JPH0825902B2 (ja) * 1985-02-21 1996-03-13 株式会社ミドリ十字 γ−グロブリンの加熱処理方法
DK595285D0 (da) * 1985-12-20 1985-12-20 Nordisk Gentofte Injicerbart og varmebehandet igg-praeparat og fremgangsmaade til fremstilling af samme
JPH0662436B2 (ja) * 1986-05-19 1994-08-17 株式会社ミドリ十字 静注用免疫グロブリン製剤の製造方法
US5248767A (en) * 1986-06-11 1993-09-28 Behringwerke Aktiengesellschaft Process for the preparation of a pasteurized immunoglobulin preparation using ethanol
DE3619565A1 (de) * 1986-06-11 1987-12-17 Behringwerke Ag Verfahren zur herstellung einer pasteurisierten immunglobulinpraeparation
AT391808B (de) * 1986-11-03 1990-12-10 Immuno Ag Verfahren zur herstellung einer faktor viii (ahf)-haeltigen fraktion
GB8628104D0 (en) * 1986-11-25 1986-12-31 Connaught Lab Pasteurization of immunoglobin solutions
US6022742A (en) * 1986-11-26 2000-02-08 Kopf; Henry B. Culture device and method
DE3816139A1 (de) * 1987-10-17 1989-04-27 Bayer Ag Verfahren zur herstellung von paramunitaetsinducern
ATE195877T1 (de) 1991-03-01 2000-09-15 Rhone Poulenc Rorer Int Herstellung von faktor-ix
AT402891B (de) * 1991-06-20 1997-09-25 Immuno Ag Verfahren zur herstellung eines inaktivierten blutproduktes
US5792835A (en) * 1991-09-05 1998-08-11 Baxter International Inc. Method of preparing a topical fibrinogen complex
AT399818B (de) * 1992-04-24 1995-07-25 Immuno Ag Verfahren zur herstellung einer hochgereinigten virussicheren faktor viii-präparation
DE4240103A1 (de) * 1992-05-26 1993-12-02 Behringwerke Ag Verfahren zur Inaktivierung von Viren in Präparationen von Proteinen
WO1994013329A1 (de) * 1992-12-16 1994-06-23 Immuno Aktiengesellschaft Verfahren zur herstellung eines virussicheren biologischen präparates
DE4320294A1 (de) * 1993-06-18 1994-12-22 Immuno Ag Verwendung von humanem Protein C zur Verhinderung und Behandlung von Thrombozytenablagerungen
DE4325872C1 (de) * 1993-08-02 1994-08-04 Immuno Ag Virusinaktivierte Faktor Xa-Präparation
HRP940645A2 (en) * 1993-10-06 1996-12-31 Immuno Ag Process for virus deactivation in the presence of polyalkylene glycol and the pharmaceutical preparation thus obtained
DE19506633A1 (de) * 1995-02-25 1996-08-29 Octapharma Ag Verfahren zur Herstellung von Faktor IX aus biologischen Quellen
DE19531637A1 (de) * 1995-08-28 1997-03-06 Immuno Ag Pharmazeutische Zusammensetzung zur Behandlung von Blutgerinnungsstörugnen, Verfahren zur Herstellung derselben und deren Verwendung
WO1998009660A1 (en) * 1996-09-06 1998-03-12 Epic Therapeutics, Inc. Viral inactivation of biological fluids with biomolecule activity retention
AT405608B (de) * 1997-04-08 1999-10-25 Immuno Ag Verfahren zur inaktivierung von pathogenen, insbesondere von viren, in einem biologischen material
DE19856443A1 (de) * 1998-12-08 2000-06-21 Centeon Pharma Gmbh Stabilisiertes Antithrombin III-Präparat
DE19923027C2 (de) * 1999-05-19 2002-09-19 Aventis Behring Gmbh Verfahren zur Inaktivierung von Viren
US6586574B1 (en) * 1999-08-17 2003-07-01 Nn A/S Stabilization of freeze-dried cake
DE102004037805B3 (de) * 2004-08-03 2006-03-23 Zlb Behring Gmbh Verfahren zur Hitzebehandlung fibrinogenhaltiger pharmazeutischer Zubereitungen
AU2008286361B2 (en) 2007-08-13 2013-09-26 Takeda Pharmaceutical Company Limited IVIG modulation of chemokines for treatment of multiple sclerosis, Alzheimer's disease, and Parkinson's disease
DK2820042T3 (da) 2012-02-29 2019-10-28 Baxalta GmbH Igg-stimuleret remyelinisering af perifere nerver
JP7110360B2 (ja) 2017-10-09 2022-08-01 テルモ ビーシーティー バイオテクノロジーズ，エルエルシー 凍結乾燥方法
CN113614477B (zh) 2019-03-14 2023-04-28 泰尔茂比司特生物技术有限公司 冷冻干燥装载托盘组件及系统
DE102020201285A1 (de) 2020-02-03 2021-08-05 Beiersdorf Aktiengesellschaft Behälter für Mehrkomponentenzubereitungen
DE202020001666U1 (de) 2020-04-21 2020-06-08 Walther Enßlin Imprägnierung der Oberfläche von Kleidung, Schutzkleidung, Gewebehandschuhen gegen Viren aus den Tröpfchen der Atemluft

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3100737A (en) * 1958-02-05 1963-08-13 Auerswald Wilhelm Method of preparing a plasma protein solution free of active hepatitis virus and product produced thereby
US3227626A (en) * 1961-09-18 1966-01-04 Merck & Co Inc Plasminogen heat sterilization
US3203865A (en) * 1962-11-30 1965-08-31 Dow Chemical Co Hog serum antibody concentrate
US4137307A (en) * 1973-11-15 1979-01-30 The Green Cross Corporation Process for preparing haptoglobin aqueous solution using strong anion exchanger
US3973002A (en) * 1974-04-12 1976-08-03 E. R. Squibb & Sons, Inc. Antihemophilic factor
JPS6029687B2 (ja) * 1978-11-07 1985-07-12 株式会社ミドリ十字 ヒト胎盤由来血液凝固第１０３因子の濃縮液の製造方法
AT359646B (de) * 1979-04-19 1980-11-25 Immuno Ag Verfahren zur herstellung von nebenwirkungs- freien plasmafraktionen
DE2916711A1 (de) * 1979-04-25 1980-11-06 Behringwerke Ag Blutgerinnungsfaktoren und verfahren zu ihrer herstellung
US4440679A (en) * 1980-03-05 1984-04-03 Cutter Laboratories, Inc. Pasteurized therapeutically active protein compositions
EP0035204B2 (en) * 1980-03-05 1991-05-22 Miles Inc. Pasteurized therapeutically active protein compositions
AT368883B (de) * 1980-07-22 1982-11-25 Immuno Ag Verfahren zur herstellung einer neuen blutgerinnungsfoerdernden praeparation auf basis von humanproteinen
DE3045153A1 (de) * 1980-11-29 1982-07-08 Behringwerke Ag, 3550 Marburg Verfahren zur herstellung von blutgerinnungsfaktoren und danach hergestellte praeparation der faktoren ix und x
US4495278A (en) * 1981-04-27 1985-01-22 Baxter Travenol Laboratories, Inc. Process for making novel blood clotting enzyme compositions
US4379085A (en) * 1982-05-14 1983-04-05 American National Red Cross Heat stabilization of plasma proteins
US4470968A (en) * 1983-01-13 1984-09-11 Miles Laboratories, Inc. Pasteurized therapeutically active blood coagulation factor concentrates
US4534972A (en) * 1983-03-29 1985-08-13 Miles Laboratories, Inc. Protein compositions substantially free from infectious agents

Also Published As

Publication number Publication date
DE3473407D1 (en) 1988-09-22
US4687664A (en) 1987-08-18
EP0124506A3 (en) 1985-07-03
EP0124506B1 (de) 1988-08-17
ES532075A0 (es) 1985-06-16
ATE36457T1 (de) 1988-09-15
EP0124506A2 (de) 1984-11-07

Similar Documents

Publication Publication Date Title
ES8506082A1 (es) Procedimiento para la inactivacion de germenes patogenos, capaces de reproducirse
FR2679251B1 (fr) Procede de preparation d'un concentre de thrombine humaine destine a un usage therapeutique.
ES540919A0 (es) Procedimiento para la inactivacion de germenes patogenos filtrables,capaces de reproducirse,en productos sanguineos
DE69328685D1 (de) Verfahren zur inaktivierung von bakterien in blutpräparaten mit hilfe von methoxypsoralen
Ogston The physiology of hemostasis
ATE242960T1 (de) Vorrichtung und verfahren zur photoaktivierung
EP0182579B2 (en) Method for stabilizing immobilized fibrinolytic enzyme
DE68903558D1 (de) Verfahren zur inaktivierung von viren.
ATE57474T1 (de) Ozonentkeimung von blut und blutprodukten.
DE69328777D1 (de) Dekontaminierung von Plättchen mit 8-Methoxypsoralen
DE58902313D1 (de) Verfahren zur sterilisation von blut, plasma, blut- und plasmaderivaten, zellsuspensionen oder dgl.
ATE413182T1 (de) Gerät und verfahren zur herstellung von stabilem langzeitigem thrombin aus plasma sowie so hergestelltes thrombin
KR900012615A (ko) 저온살균되고 정제된 폰 빌레브란트 인자 농축물 및 이의 제조방법
DE3869230D1 (de) Verfahren zur herstellung einer loesung hoher spezifischer volumenaktivitaet von einem protein mit gewebe-plasminogenaktivator (t-pa)-aktivitaet, loesung, enthaltend protein mit t-pa-aktivitaet und verwendung der loesung in der human- und veterinaermedizin.
ATE56146T1 (de) Steriles plasmaaustauschmittel.
AU568849B2 (en) Inactivation of viruses in virus containing protein samples
SE9403831D0 (sv) A storage stable water solution for infusion I
PL306671A1 (en) Method of minimising degradation of activated protein c and pharmaceutical agent
KR890701732A (ko) 개량형 조직 플라스미노겐 활성화 인자
Honig et al. Some properties of the anticoagulant factor of aged pooled plasma

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20040601