ES8507496A1 - Un procedimiento para preparar nuevas amino y aroilamino-n-fenilpiridinaminas - Google Patents

Un procedimiento para preparar nuevas amino y aroilamino-n-fenilpiridinaminas

Info

Publication number
ES8507496A1
ES8507496A1 ES531221A ES531221A ES8507496A1 ES 8507496 A1 ES8507496 A1 ES 8507496A1 ES 531221 A ES531221 A ES 531221A ES 531221 A ES531221 A ES 531221A ES 8507496 A1 ES8507496 A1 ES 8507496A1
Authority
ES
Spain
Prior art keywords
aroylamino
nitro
amino
phenylpyridinamines
benzodiazapines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES531221A
Other languages
English (en)
Other versions
ES531221A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AH Robins Co Inc
Original Assignee
AH Robins Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AH Robins Co Inc filed Critical AH Robins Co Inc
Publication of ES531221A0 publication Critical patent/ES531221A0/es
Publication of ES8507496A1 publication Critical patent/ES8507496A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE AMINO Y AROILAMINO-N-FENILPIRIDINAMINAS, DE FORMULA GENERAL (I), EN LA QUE Q SE SELECCIONA ENTRE HIDROGENO O HALOGENO; R1 Y R2 SIGNIFICAN ALCOHILO INFERIOR O TOMADOS JUNTOS FORMAN CON EL ATOMO DE NITROGENO ADYACENTE, UN RESTO HETEROCICLICO; R3 SIGNIFICA AMINO O AROILAMINO; AR SIGNIFICA FENILO O FENILO SUSTITUIDO; ALC1 ES UNA CADENA DE HIDROCARBURO RECTA O RAMIFICADA; Z ES HIDROGENO, HALOGENO O ALCOHILO INFERIOR; E Y SIGNIFICA HIDROGENO O ALCOXI INFERIOR, Y SUS SALES DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLES.CONSISTE EN SOMETER A UNA REACCION DE REDUCCION UN COMPUESTO DE FORMULA (II), PARA CONVERTIR EL GRUPO NITRO EN UN GRUPO AMINO Y OBTENER UN COMPUESTO DE FORMULA (III), Y EN HACER REACCIONAR DICHO COMPUESTO DE FORMULA (III) CON UN HALURO DE AROILO, PARA OBTENER UNA AROILAMINO-N-SUSTITUIDO-N-FENILPIRIDINAMINA.DE APLICACION COMO AGENTE ANTIDEPRESIVO.
ES531221A 1982-07-02 1984-04-02 Un procedimiento para preparar nuevas amino y aroilamino-n-fenilpiridinaminas Expired ES8507496A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/394,551 US4558132A (en) 1982-07-02 1982-07-02 Nitro, amino and aroylamino-N-phenylpyridinamines in a process for preparing pyrido[1,4]benzodiazepines

Publications (2)

Publication Number Publication Date
ES531221A0 ES531221A0 (es) 1985-09-01
ES8507496A1 true ES8507496A1 (es) 1985-09-01

Family

ID=23559432

Family Applications (2)

Application Number Title Priority Date Filing Date
ES518376A Granted ES518376A0 (es) 1982-07-02 1982-12-20 Un procedimiento para preparar nuevas nitro-n-fenilpiridinaminas
ES531221A Expired ES8507496A1 (es) 1982-07-02 1984-04-02 Un procedimiento para preparar nuevas amino y aroilamino-n-fenilpiridinaminas

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES518376A Granted ES518376A0 (es) 1982-07-02 1982-12-20 Un procedimiento para preparar nuevas nitro-n-fenilpiridinaminas

Country Status (20)

Country Link
US (1) US4558132A (es)
EP (1) EP0099614A3 (es)
JP (1) JPS597166A (es)
KR (1) KR880001282B1 (es)
AU (1) AU550950B2 (es)
CA (1) CA1198424A (es)
DK (1) DK547782A (es)
ES (2) ES518376A0 (es)
FI (1) FI78076C (es)
GR (1) GR77822B (es)
HU (2) HU194175B (es)
IE (1) IE54618B1 (es)
IL (1) IL67508A (es)
IN (1) IN156481B (es)
NO (1) NO158062C (es)
NZ (1) NZ202800A (es)
PH (1) PH21401A (es)
PL (4) PL144137B1 (es)
PT (1) PT76093B (es)
ZA (1) ZA829155B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3409237A1 (de) * 1984-03-14 1985-09-19 Dr. Karl Thomae Gmbh, 7950 Biberach Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3626095A1 (de) * 1986-07-31 1988-02-11 Thomae Gmbh Dr K Neue substituierte pyrido(2,3-b)(1,4)benzodiazepin-6-one, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US4749788A (en) * 1987-04-13 1988-06-07 A. H. Robins Company, Incorporated Process for the preparation of aryl-pyrido(1,4) benzodiazepines

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2785172A (en) * 1953-06-17 1957-03-12 Searle & Co Dialkylaminoalkylphenetidinopyridine
GB907646A (en) * 1959-01-23 1962-10-10 Wander S A A Method of production of new derivatives of diazepin
FR8363M (es) * 1967-02-01 1971-02-15
GB1192995A (en) * 1967-04-12 1970-05-28 Egyt Gyogyszervegyeszeti Gyar Formimino Ethers
GB1268772A (en) * 1968-03-15 1972-03-29 Glaxo Lab Ltd NOVEL alpha-CARBOLINE DERIVATIVES, THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME
AT327200B (de) * 1972-09-06 1976-01-26 Degussa Verfahren zur herstellung von neuen aza-10,11-dihydro-5h-dibenzo (b,e)-(1,4) diazepinen sowie deren salzen
AT325052B (de) * 1972-12-07 1975-10-10 Degussa Verfahren zur herstellung von neuen 6-azabenzo-1,5-diazepinen und ihren salzen
SE7605398L (sv) * 1975-05-28 1976-11-29 Merck & Co Inc 3h-1,2,3-trizol(4,5-b)pyridiner

Also Published As

Publication number Publication date
IE54618B1 (en) 1989-12-20
FI78076C (fi) 1989-06-12
HU191837B (en) 1987-04-28
HUT34477A (en) 1985-03-28
US4558132A (en) 1985-12-10
ES531221A0 (es) 1985-09-01
EP0099614A2 (en) 1984-02-01
NZ202800A (en) 1987-07-31
FI824247L (fi) 1984-01-03
ES8406441A1 (es) 1984-08-01
PL250096A1 (en) 1985-09-10
PL250095A1 (en) 1985-09-10
IE822918L (en) 1984-01-02
IN156481B (es) 1985-08-10
NO158062B (no) 1988-03-28
FI824247A0 (fi) 1982-12-10
AU550950B2 (en) 1986-04-10
EP0099614A3 (en) 1985-05-29
PL141485B1 (en) 1987-07-31
KR880001282B1 (ko) 1988-07-18
IL67508A (en) 1986-02-28
ES518376A0 (es) 1984-08-01
JPS597166A (ja) 1984-01-14
CA1198424A (en) 1985-12-24
PL143959B1 (en) 1988-03-31
KR840002837A (ko) 1984-07-21
ZA829155B (en) 1983-09-28
HU194175B (en) 1988-01-28
PL241785A1 (en) 1985-02-27
NO158062C (no) 1988-07-06
PL144138B1 (en) 1988-04-30
PL144137B1 (en) 1988-04-30
FI78076B (fi) 1989-02-28
HUT40420A (en) 1986-12-28
PT76093B (en) 1986-01-09
PH21401A (en) 1987-10-15
DK547782A (da) 1984-01-03
PL250097A1 (en) 1985-09-10
AU9163382A (en) 1984-01-05
PT76093A (en) 1983-02-01
NO824115L (no) 1984-01-03
GR77822B (es) 1984-09-25

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