ES8600219A1 - Procedimiento para preparar dipeptidos alcohilados en n y sus esteres - Google Patents

Procedimiento para preparar dipeptidos alcohilados en n y sus esteres

Info

Publication number
ES8600219A1
ES8600219A1 ES535917A ES535917A ES8600219A1 ES 8600219 A1 ES8600219 A1 ES 8600219A1 ES 535917 A ES535917 A ES 535917A ES 535917 A ES535917 A ES 535917A ES 8600219 A1 ES8600219 A1 ES 8600219A1
Authority
ES
Spain
Prior art keywords
alkyl
aryl
carbon atoms
substituted
atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES535917A
Other languages
English (en)
Other versions
ES535917A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES535917A0 publication Critical patent/ES535917A0/es
Publication of ES8600219A1 publication Critical patent/ES8600219A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DIPEPTIDOS ALCOHILADOS EN N Y SUS ESTERES.SE HACEN REACCIONAR COMPUESTOS DE FORMULA II, DEFINIDA EN LA MEMORIA, EN PRESENCIA DE ANHIDRIDOS DE ACIDOS FOSFINICOS DE FORMULA III, CON COMPUESTOS DE LA FORMULA IV, DEFINIDA EN LA MEMORIA, EVENTUALMENTE SE DISOCIAN RADICALES INTRODUCIDOS PARA LA PROTECCION DE OTROS GRUPOS FUNCIONALES Y EVENTUALMENTE SE ESTERIFICAN GRUPOS CARBOXI LIBRES DE UNA MANERA EN SI CONOCIDA.
ES535917A 1983-09-16 1984-09-14 Procedimiento para preparar dipeptidos alcohilados en n y sus esteres Expired ES8600219A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19833333454 DE3333454A1 (de) 1983-09-16 1983-09-16 Verfahren zur herstellung von n-alkylierten dipeptiden und deren estern

Publications (2)

Publication Number Publication Date
ES535917A0 ES535917A0 (es) 1985-10-01
ES8600219A1 true ES8600219A1 (es) 1985-10-01

Family

ID=6209235

Family Applications (1)

Application Number Title Priority Date Filing Date
ES535917A Expired ES8600219A1 (es) 1983-09-16 1984-09-14 Procedimiento para preparar dipeptidos alcohilados en n y sus esteres

Country Status (21)

Country Link
US (1) US5068351A (es)
EP (1) EP0135182B1 (es)
JP (1) JPH0798835B2 (es)
KR (1) KR910007574B1 (es)
AT (1) ATE35997T1 (es)
AU (1) AU576782B2 (es)
CA (1) CA1338163C (es)
DE (2) DE3333454A1 (es)
DK (1) DK164939C (es)
ES (1) ES8600219A1 (es)
FI (1) FI80464C (es)
GR (1) GR80369B (es)
HU (1) HU201565B (es)
IE (1) IE57798B1 (es)
IL (1) IL72947A (es)
MA (1) MA20225A1 (es)
MX (1) MX172737B (es)
NO (1) NO167743C (es)
NZ (1) NZ209543A (es)
PT (1) PT79202B (es)
ZA (1) ZA847257B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3333456A1 (de) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von carbonsaeureamidgruppen enthaltenden verbindungen, insbesondere von peptiden
DE3333455A1 (de) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung n-alkylierter dipeptide und deren estern
DE3408923A1 (de) * 1984-03-12 1985-09-26 Hoechst Ag, 6230 Frankfurt Carboxyalkyldipeptidderivate, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung
KR900009154B1 (ko) * 1985-09-16 1990-12-22 쉐링 코포레이션 고혈압 치료제, 이를 포함하는 약제학적 조성물 및 이들의 제조방법
EP0331609A3 (de) * 1988-01-27 1992-07-01 Hoechst Aktiengesellschaft Angiotensin-Converting-Enzym-Hemmstoffe mit psychotroper Wirkung
FI91159C (fi) * 1988-12-07 1994-05-25 Tanabe Seiyaku Co Menetelmä imidatsolipitoisten peptidien ja niiden farmaseuttisesti sopivien suolojen valmistamiseksi
JP2581770Y2 (ja) * 1993-01-20 1998-09-24 川崎重工業 株式会社 航空機洗浄装置
ES2122941B1 (es) * 1997-05-29 1999-07-01 Esteve Quimica Sa Procedimiento para la obtencion de quinapril clorhidrato y solvatos utiles para el aislamiento y purificacion de quinapril clorhidrato.
CA2363658C (en) * 2001-11-21 2005-12-13 Brantford Chemicals Inc. Improved process for the preparation of ramipril
KR20070085754A (ko) * 2004-11-05 2007-08-27 킹 파머슈티칼스 리서치 앤드 디벨로프먼트 아이엔씨 안정화된 라미프릴 조성물 및 제조 방법

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5572169A (en) * 1978-11-27 1980-05-30 Tanabe Seiyaku Co Ltd Isoquinoline derivative and its preparation
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
DE2901843A1 (de) * 1979-01-18 1980-07-31 Hoechst Ag Verfahren zur herstellung von carbonsaeureamiden und peptiden
US4294832A (en) * 1979-04-28 1981-10-13 Tanabe Seiyaku Co., Ltd. Tetrahydroisoquinoline compounds and a pharmaceutical composition thereof
FR2491469A1 (fr) * 1980-10-02 1982-04-09 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
IE52663B1 (en) * 1980-04-02 1988-01-20 Warner Lambert Co Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids
US4350704A (en) * 1980-10-06 1982-09-21 Warner-Lambert Company Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
EP0046953B1 (de) * 1980-08-30 1989-12-06 Hoechst Aktiengesellschaft Aminosäurederivate, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung
IL63813A0 (en) * 1980-09-17 1981-12-31 Univ Miami Carboxyalkyl peptides and thioethers and ethers of peptides,antihypertensive compositions and methods for their use
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
ZA817261B (en) * 1980-10-23 1982-09-29 Schering Corp Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them
ATE20469T1 (de) * 1980-10-23 1986-07-15 Schering Corp Carboxyalkyl-dipeptide, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
US4374847A (en) * 1980-10-27 1983-02-22 Ciba-Geigy Corporation 1-Carboxyalkanoylindoline-2-carboxylic acids
GB2086390B (en) * 1980-11-03 1984-06-06 Ciba Geigy Ag 1-carboxy-azaalkanoylindoline-2-carboxylic acids process for their manufacture pharmaceutical preparations containing these compounds and their therapeutic application
DE3101427A1 (de) * 1981-01-17 1982-09-02 Hoechst Ag, 6000 Frankfurt "verfahren zur herstellung von carbonsaeureamidgruppen enthaltenden verbindungen, insbesondere von peptiden"
IN156096B (es) * 1981-03-19 1985-05-11 Usv Pharma Corp
US4820729A (en) * 1981-03-30 1989-04-11 Rorer Pharmaceutical Corporation N-substituted-amido-amino acids
DE3226768A1 (de) * 1981-11-05 1983-05-26 Hoechst Ag, 6230 Frankfurt Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
DE3210496A1 (de) * 1982-03-23 1983-10-06 Hoechst Ag Neue derivate bicyclischer aminsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung
DE3211676A1 (de) * 1982-03-30 1983-10-06 Hoechst Ag Neue derivate von cycloalka (c) pyrrol-carbonsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue cycloalka (c) pyrrol-carbonsaeuren als zwischenstufen und verfahren zu deren herstellung
DE3315464A1 (de) * 1983-04-28 1984-10-31 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von n-alkylierten dipeptiden und deren estern
DE3322530A1 (de) * 1983-06-23 1985-01-10 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von mono-, bi- und tricyclischen aminosaeuren
DE3333455A1 (de) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung n-alkylierter dipeptide und deren estern
DE3333456A1 (de) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von carbonsaeureamidgruppen enthaltenden verbindungen, insbesondere von peptiden

Also Published As

Publication number Publication date
ZA847257B (en) 1985-05-29
ATE35997T1 (de) 1988-08-15
US5068351A (en) 1991-11-26
KR910007574B1 (ko) 1991-09-28
KR850002251A (ko) 1985-05-10
FI843590A0 (fi) 1984-09-13
EP0135182B1 (de) 1988-07-27
FI80464B (fi) 1990-02-28
ES535917A0 (es) 1985-10-01
EP0135182A2 (de) 1985-03-27
IE842350L (en) 1985-03-16
FI80464C (fi) 1990-06-11
IL72947A0 (en) 1984-12-31
NO167743C (no) 1991-12-04
NO843662L (no) 1985-03-18
FI843590L (fi) 1985-03-17
JPS6089497A (ja) 1985-05-20
IE57798B1 (en) 1993-04-07
DK440584D0 (da) 1984-09-14
IL72947A (en) 1989-02-28
HUT36145A (en) 1985-08-28
PT79202B (de) 1986-09-10
MA20225A1 (fr) 1985-04-01
MX172737B (es) 1994-01-10
PT79202A (de) 1984-10-01
HU201565B (en) 1990-11-28
GR80369B (en) 1985-01-11
AU3307084A (en) 1985-03-21
JPH0798835B2 (ja) 1995-10-25
DK440584A (da) 1985-03-17
DE3333454A1 (de) 1985-04-11
CA1338163C (en) 1996-03-12
DK164939B (da) 1992-09-14
EP0135182A3 (en) 1986-03-05
AU576782B2 (en) 1988-09-08
NO167743B (no) 1991-08-26
DK164939C (da) 1993-02-01
NZ209543A (en) 1989-04-26
DE3472962D1 (en) 1988-09-01

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