ES8604199A1 - Procedimiento para la preparacion de nuevos bencimidazoles sustituidos. - Google Patents

Procedimiento para la preparacion de nuevos bencimidazoles sustituidos.

Info

Publication number
ES8604199A1
ES8604199A1 ES517167A ES517167A ES8604199A1 ES 8604199 A1 ES8604199 A1 ES 8604199A1 ES 517167 A ES517167 A ES 517167A ES 517167 A ES517167 A ES 517167A ES 8604199 A1 ES8604199 A1 ES 8604199A1
Authority
ES
Spain
Prior art keywords
formula
salts
substituted benzimidazoles
preparation
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES517167A
Other languages
English (en)
Other versions
ES517167A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Byk Gulden Lomberg Chemische Fabrik GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chemische Fabrik GmbH filed Critical Byk Gulden Lomberg Chemische Fabrik GmbH
Publication of ES517167A0 publication Critical patent/ES517167A0/es
Publication of ES8604199A1 publication Critical patent/ES8604199A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/68—One oxygen atom attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE BENCIMIDAZOLES SUSTITUIDOS Y DE SUS SALES, DE FORMULA (I), EN LA QUE R1 Y R2 REPRESENTAN HIDROGENO O METILO; Y N VALE 0. CONSISTE EN LA REACCION DE MERCAPTOBENCIMIDAZOLES DE FORMULA (II), O SUS SALES, CON DERIVADOS DE PICOLINA DE FORMULA (III), O SUS SALES, EN LAS QUE Z1 REPRESENTA UN GRUPO SALIENTE ACTIVO Y R1 Y R2 TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE EFECTUA EN UN DISOLVENTE ORGANICO POLAR, CON ADICION O SIN ADICION DE AGUA, EN PRESENCIA DE UN ACEPTOR DE PROTONES, A UNA TEMPERATURA COMPRENDIDA ENTRE 50JC Y 100JC. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE ENFERMEDADES BASADAS EN AFECCIONES DE ESTOMAGO Y DE LOS INTESTINOS.
ES517167A 1981-11-05 1982-11-05 Procedimiento para la preparacion de nuevos bencimidazoles sustituidos. Expired ES8604199A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH708081 1981-11-05
CH708181 1981-11-05

Publications (2)

Publication Number Publication Date
ES517167A0 ES517167A0 (es) 1986-02-01
ES8604199A1 true ES8604199A1 (es) 1986-02-01

Family

ID=25700722

Family Applications (2)

Application Number Title Priority Date Filing Date
ES517167A Expired ES8604199A1 (es) 1981-11-05 1982-11-05 Procedimiento para la preparacion de nuevos bencimidazoles sustituidos.
ES526899A Granted ES526899A0 (es) 1981-11-05 1983-10-28 Procedimiento para la preparacion de nuevos bencimidazoles substituidos

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES526899A Granted ES526899A0 (es) 1981-11-05 1983-10-28 Procedimiento para la preparacion de nuevos bencimidazoles substituidos

Country Status (11)

Country Link
US (1) US4472409A (es)
EP (1) EP0080602A1 (es)
AU (1) AU544288B2 (es)
DE (1) DE3240248A1 (es)
DK (1) DK491682A (es)
ES (2) ES8604199A1 (es)
FI (1) FI823787A7 (es)
GR (1) GR77370B (es)
HU (1) HU187521B (es)
NO (1) NO823691L (es)
PT (1) PT75805B (es)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL66340A (en) * 1981-08-13 1986-08-31 Haessle Ab Pharmaceutical compositions comprising pyridylmethyl-thiobenzimidazole derivatives,certain such novel derivatives and their preparation
SE8204879D0 (sv) * 1982-08-26 1982-08-26 Haessle Ab Novel chemical intermediates
SE8300736D0 (sv) * 1983-02-11 1983-02-11 Haessle Ab Novel pharmacologically active compounds
SE8301182D0 (sv) * 1983-03-04 1983-03-04 Haessle Ab Novel compounds
HU191756B (en) * 1983-05-03 1987-04-28 Byk Gulden Lomberg Chem Fab Process for preparing new fluoro-alkoxy-benzimidazole derivatives
CA1259070A (en) * 1983-07-01 1989-09-05 Upjohn Company (The) Substituted 2-¬monoannelated(3,4-,4,5-, and 5,6-)- pyridylalkylenesulfinyl|-benzimidazoles
DE3333314A1 (de) * 1983-09-15 1985-03-28 Hoechst Ag, 6230 Frankfurt Substituierte pyrido(1,2-c)imidazo(1,2-a)benzimidazole, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen
US4575554A (en) * 1983-12-05 1986-03-11 The Upjohn Company Substituted 2-pyridylmethylthio- and sulfinyl-benzimidazoles as gastric antisecretory agents
ZW4585A1 (en) * 1984-04-19 1985-11-20 Hoffmann La Roche Imidazole derivatives
IL75400A (en) * 1984-06-16 1988-10-31 Byk Gulden Lomberg Chem Fab Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same
CA1341314C (en) * 1984-07-06 2001-11-06 David Cox Derivatives of benzimidazole, benzothiazole and benzoxazole
SE8404065D0 (sv) * 1984-08-10 1984-08-10 Haessle Ab Novel biologically active compounds
JPS6150979A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
JPS6150978A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
IL76839A (en) * 1984-10-31 1988-08-31 Byk Gulden Lomberg Chem Fab Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
SE8405588D0 (sv) * 1984-11-08 1984-11-08 Haessle Ab New compounds
GB8526154D0 (en) * 1985-02-06 1985-11-27 Kotobuki Seiyaku Co Ltd 2-substituted cyclo-heptoimidazoles
US4743609A (en) * 1985-02-12 1988-05-10 Banyu Pharmaceutical Co., Ltd. Indole derivatives having gastric and antisecretory and cytoprotective properties, and pharmaceutical preparations containing same
AU5768886A (en) 1985-05-24 1986-11-27 G.D. Searle & Co. 2-((1-h-benzimidazol-2-ylsulfinyl)methyl)benzenamines
US5869513A (en) * 1985-05-24 1999-02-09 G. D. Searle & Co. 2- (1H-benzimidazol-2-ylsulfinyl)methyl!benzenamines
US4738975A (en) * 1985-07-02 1988-04-19 Takeda Chemical Industries, Ltd. Pyridine derivatives, and use as anti-ulcer agents
DK337086A (da) * 1985-08-12 1987-02-13 Hoffmann La Roche Benzimidazolderivater
AR243167A1 (es) 1985-08-24 1993-07-30 Hoechst Ag Procedimiento para la preparacion de toluidinas sustituidas.
US5433959A (en) * 1986-02-13 1995-07-18 Takeda Chemical Industries, Ltd. Stabilized pharmaceutical composition
CA1327010C (en) * 1986-02-13 1994-02-15 Tadashi Makino Stabilized solid pharmaceutical composition containing antiulcer benzimidazole compound and its production
US6749864B2 (en) 1986-02-13 2004-06-15 Takeda Chemical Industries, Ltd. Stabilized pharmaceutical composition
ES2032394T3 (es) * 1986-02-20 1993-02-16 Hoechst Aktiengesellschaft Procedimiento para preparar derivados de tienoimidazol sustituidos.
JPS62201884A (ja) * 1986-02-28 1987-09-05 Tokyo Tanabe Co Ltd ベンズイミダゾール誘導体及びその製造法
WO1987005296A1 (en) * 1986-03-07 1987-09-11 Pfizer Inc. 2-[(2-pyridyl)methylsulfinyl]thienoimidazoles and related compounds as antiulcer agents
GB2189699A (en) * 1986-04-30 1987-11-04 Haessle Ab Coated acid-labile medicaments
GB2189698A (en) * 1986-04-30 1987-11-04 Haessle Ab Coated omeprazole tablets
US4687775A (en) * 1986-07-17 1987-08-18 G. D. Searle & Co. 2-[(Imidazo[1,2-a]pyridinylmethyl)sulfinyl]-1H-benzimidazoles
US4772619A (en) * 1986-07-17 1988-09-20 G. D. Searle & Co. [(1H-benzimidazol-2-ylsulfinyl)methyl]-2-pyridinamines
US4721718A (en) * 1986-08-18 1988-01-26 G. D. Searle & Co. 2-[(imidazo[1,2-a]pyridin-3-ylmethyl)sulfinyl]-1H-benzimidazoles useful in the treatment and prevention of ulcers
DE3639926A1 (de) * 1986-11-22 1988-06-01 Hoechst Ag Substituierte thienoimidazoltoluidin-derivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung als magensaeuresekretionshemmer
DE3723327A1 (de) * 1987-07-15 1989-02-02 Hoechst Ag Substituierte thienoimidazol-derivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung als magensaeuresekretionshemmer, magenschutzmittel sowie als medikament gegen intestinale entzuendungen
DK171989B1 (da) * 1987-08-04 1997-09-08 Takeda Chemical Industries Ltd Fremgangsmåde til fremstilling af 2-(2-pyridylmethylsulfinyl)-benzimidazoler
AU617721B2 (en) * 1987-10-30 1991-12-05 Aktiebolaget Hassle 2-pyridinylmethyl (sulfinyl or thio) benzimidazoles for treatment of diseases related to bone loss
KR890701580A (ko) * 1987-10-30 1989-12-21 앤더스 베딘 골(骨)손실에 관련된 질병 치료용 2-피리디닐메틸(술피닐 또는 티오) 벤즈이미다졸
US5223515A (en) * 1988-08-18 1993-06-29 Takeda Chemical Industries, Ltd. Injectable solution containing a pyridyl methylsulfinylbenzimidazole
AT391693B (de) * 1988-11-15 1990-11-12 Cl Pharma Verfahren zur herstellung von 3-5-dimethyl-4methoxypyridinderivaten sowie neues zwischenprodukt hierfuer
HU203736B (en) * 1989-04-06 1991-09-30 Gyogyszerkutato Intezet Process for producing new thiouracil-derivatives and pharmaceutical compositions containing them
AT394368B (de) * 1990-08-07 1992-03-25 Byk Gulden Lomberg Chem Fab Verfahren zur herstellung von 3,4-dialkoxypyridinen
DE69132082T2 (de) * 1990-10-17 2000-08-31 Takeda Chemical Industries, Ltd. Pyridin-Derivate, Verfahren zu deren Herstellung und Anwendung
CA2138787A1 (en) * 1992-07-08 1994-01-20 Clifton Augustus Baile Alleviating stomach ulcers in swine
SG52479A1 (en) * 1992-07-28 1998-09-28 Astra Ab Injection and injection kit containing omeprazole and its analogs
TW280770B (es) 1993-10-15 1996-07-11 Takeda Pharm Industry Co Ltd
KR950014611A (ko) * 1993-11-11 1995-06-16 이헌조 고풍량 횡류펜 익근차
WO1995029897A1 (en) * 1994-04-29 1995-11-09 G.D. Searle & Co. METHOD OF USING (H+/K+) ATPase INHIBITORS AS ANTIVIRAL AGENTS
CN1045773C (zh) * 1994-06-23 1999-10-20 沈阳药科大学 吡啶衍生物的制备方法
US5824339A (en) * 1995-09-08 1998-10-20 Takeda Chemical Industries, Ltd Effervescent composition and its production
ATE286394T1 (de) * 1995-09-21 2005-01-15 Pharma Pass Ii Llc Ein säurelabile omeprazol enthaltende arzneizusammensetzung und verfahren zu deren herstellung
US6699885B2 (en) * 1996-01-04 2004-03-02 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and methods of using same
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US6489346B1 (en) * 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US6645988B2 (en) * 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
SI20019A (sl) * 1998-07-13 2000-02-29 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Izboljšan postopek sinteze 5-metoksi -2-/(4-metoksi-3,5-dimetil-2-piridil)metil/ sulfinil-1H-benzimidazola
AU1054899A (en) * 1998-11-06 2000-05-29 Dong-A Pharmaceutical Co., Ltd. Method of preparing sulfide derivatives
US6544556B1 (en) 2000-09-11 2003-04-08 Andrx Corporation Pharmaceutical formulations containing a non-steroidal antiinflammatory drug and a proton pump inhibitor
WO2002026210A2 (en) * 2000-09-29 2002-04-04 Geneva Pharmaceuticals Inc. Proton pump inhibitor formulation
WO2003063840A2 (en) * 2002-01-25 2003-08-07 Santarus, Inc. Transmucosal delivery of proton pump inhibitors
US20030228363A1 (en) * 2002-06-07 2003-12-11 Patel Mahendra R. Stabilized pharmaceutical compositons containing benzimidazole compounds
TWI367759B (en) * 2003-02-20 2012-07-11 Santarus Inc A novel formulation, omeprazole antacid complex-immediate release, for rapid and sustained suppression of gastric acid
WO2004101533A1 (en) * 2003-05-12 2004-11-25 Janssen Pharmaceutica, N.V. 1, 3, 4-benzotriazepin-2-one salts and their use as cck receptor ligands
US8993599B2 (en) 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
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CN101648907B (zh) * 2009-09-14 2011-08-03 南京第一农药集团有限公司 2-氯甲基-4-甲氧基-3,5-二甲基吡啶盐酸盐的纯化方法
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EA201591338A1 (ru) 2013-01-15 2016-01-29 Айронвуд Фармасьютикалз, Инк. Гастроретентивная лекарственная форма секвестранта желчных кислот с замедленным высвобождением для перорального применения
JP6377334B2 (ja) * 2013-10-25 2018-08-22 東洋鋼鈑株式会社 非線形光学色素、フォトリフラクティブ材料組成物、フォトリフラクティブ基材およびホログラム記録媒体
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US20170042806A1 (en) 2015-04-29 2017-02-16 Dexcel Pharma Technologies Ltd. Orally disintegrating compositions
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KR102471278B1 (ko) * 2016-09-14 2022-11-25 바이엘 크롭사이언스 악티엔게젤샤프트 할로겐화 바이사이클릭 화합물의 제조 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4045564A (en) * 1974-02-18 1977-08-30 Ab Hassle Benzimidazole derivatives useful as gastric acid secretion inhibitors
SE416649B (sv) * 1974-05-16 1981-01-26 Haessle Ab Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US4359465A (en) * 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
IL66340A (en) * 1981-08-13 1986-08-31 Haessle Ab Pharmaceutical compositions comprising pyridylmethyl-thiobenzimidazole derivatives,certain such novel derivatives and their preparation

Also Published As

Publication number Publication date
DE3240248A1 (de) 1983-06-01
DK491682A (da) 1983-05-06
PT75805A (en) 1982-12-01
ES517167A0 (es) 1986-02-01
EP0080602A1 (de) 1983-06-08
FI823787L (fi) 1983-05-06
FI823787A7 (fi) 1983-05-06
HU187521B (en) 1986-01-28
FI823787A0 (fi) 1982-11-04
ES8504140A1 (es) 1985-05-01
US4472409A (en) 1984-09-18
ES526899A0 (es) 1985-05-01
GR77370B (es) 1984-09-11
PT75805B (en) 1989-07-03
AU544288B2 (en) 1985-05-23
NO823691L (no) 1983-05-06
AU9019582A (en) 1983-05-12

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