ES8606338A1 - Un procedimiento de preparar un nuevo azabiciclo (3.3.1)- nonano - Google Patents

Un procedimiento de preparar un nuevo azabiciclo (3.3.1)- nonano

Info

Publication number
ES8606338A1
ES8606338A1 ES548112A ES548112A ES8606338A1 ES 8606338 A1 ES8606338 A1 ES 8606338A1 ES 548112 A ES548112 A ES 548112A ES 548112 A ES548112 A ES 548112A ES 8606338 A1 ES8606338 A1 ES 8606338A1
Authority
ES
Spain
Prior art keywords
iii
arrhythmic
hydroxy group
azabicyclic compounds
platinum
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES548112A
Other languages
English (en)
Other versions
ES548112A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of ES8606338A1 publication Critical patent/ES8606338A1/es
Publication of ES548112A0 publication Critical patent/ES548112A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO DE PREPARAR UN NUEVO AZABICICLO (3.3.1)-NONANO. COMPRENDE: A) HACER REACCIONAR A UN DERIVADO DE TETRAHIDROPIRIDINA D.F. (IV) CON ACROLINA, P.O A UN C.D.F. (III); B) REDUCIR A (III) CON HIDROGENO EN PRESENCIA DE UN ALCOHOL PLATINO METALICO SOBRE UN SOPORTE COMO NI RANEY U OXIDO DE PLATINO, P.O A UN C.D.F. (I) (R4FGRUPO HIDROXI) Y C) TRATAR A (I) CON UN ACIDO CARBOXILICO D.F. (II) P.O UN C.D.F. (I) (R4FUN GRUPO HIDROXI ESTERIFICADO COMO -COOR6), SUS ESTEROISOMEROS Y SUS SALES DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLES. SIENDO: R1, R2 Y R3 IGUALES O DIFERENTES BENCILO O ALQUILOS DE C 1 A 4, R6 UN GRUPO ALQUILO DE C 1 A 8 O UN GRUPO CICLOALQUILO DE C 3 A 6; D.F. DE FORMULA Y P.O PARA OBTENER. SE UTILIZAN COMO ANTIARRITMICOS.
ES548112A 1983-11-30 1985-10-22 Un procedimiento de preparar un nuevo azabiciclo (3.3.1)- nonano Expired ES8606338A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU834096A HU190511B (en) 1983-11-30 1983-11-30 Process for preparing new azabicyclic compounds

Publications (2)

Publication Number Publication Date
ES8606338A1 true ES8606338A1 (es) 1986-04-01
ES548112A0 ES548112A0 (es) 1986-04-01

Family

ID=10966876

Family Applications (2)

Application Number Title Priority Date Filing Date
ES538069A Expired ES8604579A1 (es) 1983-11-30 1984-11-29 Un procedimiento de preparar un nuevo azabiciclo (3.3.1)-nonano
ES548112A Expired ES8606338A1 (es) 1983-11-30 1985-10-22 Un procedimiento de preparar un nuevo azabiciclo (3.3.1)- nonano

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES538069A Expired ES8604579A1 (es) 1983-11-30 1984-11-29 Un procedimiento de preparar un nuevo azabiciclo (3.3.1)-nonano

Country Status (31)

Country Link
US (1) US4769373A (es)
JP (1) JPS60185766A (es)
AR (1) AR241492A1 (es)
AT (1) AT388730B (es)
AU (1) AU570285B2 (es)
BE (1) BE901174A (es)
CA (1) CA1280751C (es)
CH (1) CH663615A5 (es)
CS (1) CS273602B2 (es)
DD (1) DD231073A1 (es)
DE (1) DE3442365A1 (es)
DK (1) DK568584A (es)
EG (1) EG16845A (es)
ES (2) ES8604579A1 (es)
FI (1) FI80445C (es)
FR (1) FR2555580B1 (es)
GB (1) GB2150558B (es)
GR (1) GR81084B (es)
HU (1) HU190511B (es)
IL (1) IL73421A (es)
IT (1) IT1178638B (es)
MX (1) MX157611A (es)
NL (1) NL8403634A (es)
NO (1) NO165292C (es)
PH (1) PH19659A (es)
PL (2) PL142604B1 (es)
PT (1) PT79568B (es)
SE (1) SE460418B (es)
SU (1) SU1395141A3 (es)
YU (1) YU45681B (es)
ZA (1) ZA848721B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0525672D0 (en) * 2005-12-16 2006-01-25 Novartis Ag Organic compounds
CN111187210B (zh) * 2020-01-08 2022-05-03 成都中医药大学 一种热解型二萜生物碱化合物及其制备方法和用途
CN113149906B (zh) * 2021-02-24 2022-05-17 成都中医药大学 一种抗心律失常药物及其制备方法
CN113149905B (zh) * 2021-02-24 2022-04-29 成都中医药大学 一种抗心律失常的化合物及其制药用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1195746A (en) * 1967-06-07 1970-06-24 Yoshitomi Pharmaceutical 3-Azabicyclo [3,3,1] Nonane Derivatives
US3740408A (en) * 1967-09-11 1973-06-19 Upjohn Co Oxygenated 3-aza bicyclo(3,3,1)nonanes
GB1393253A (en) * 1971-09-10 1975-05-07 Wyeth John & Brother Ltd 3-azabicyclo-3,3,1-nonanes

Also Published As

Publication number Publication date
GB2150558B (en) 1987-10-14
NL8403634A (nl) 1985-06-17
DK568584A (da) 1985-05-31
ES538069A0 (es) 1986-02-01
ES8604579A1 (es) 1986-02-01
SE8406046L (sv) 1985-05-31
PL144546B1 (en) 1988-06-30
YU45681B (sh) 1992-07-20
US4769373A (en) 1988-09-06
FI80445C (fi) 1990-06-11
FR2555580B1 (fr) 1988-10-28
GR81084B (en) 1985-03-29
GB2150558A (en) 1985-07-03
FI844480L (fi) 1985-05-31
BE901174A (fr) 1985-05-30
AU570285B2 (en) 1988-03-10
PT79568A (en) 1984-12-01
CA1280751C (en) 1991-02-26
ATA352184A (de) 1989-01-15
NO165292C (no) 1991-01-23
SE460418B (sv) 1989-10-09
CS920184A2 (en) 1990-08-14
HUT35647A (en) 1985-07-29
DD231073A1 (de) 1985-12-18
PH19659A (en) 1986-06-09
AU3602984A (en) 1985-06-06
HU190511B (en) 1986-09-29
YU200684A (en) 1987-10-31
PL254457A1 (en) 1987-03-23
IT1178638B (it) 1987-09-09
CH663615A5 (de) 1987-12-31
SU1395141A3 (ru) 1988-05-07
SE8406046D0 (sv) 1984-11-29
EG16845A (en) 1990-12-30
PL142604B1 (en) 1987-11-30
FI80445B (fi) 1990-02-28
MX157611A (es) 1988-12-05
IL73421A (en) 1987-12-31
ZA848721B (en) 1985-06-26
IT8423805A1 (it) 1986-05-29
JPS60185766A (ja) 1985-09-21
NO844750L (no) 1985-05-31
ES548112A0 (es) 1986-04-01
CS273602B2 (en) 1991-03-12
IT8423805A0 (it) 1984-11-29
AT388730B (de) 1989-08-25
FI844480A0 (fi) 1984-11-15
AR241492A1 (es) 1992-07-31
PT79568B (en) 1986-09-11
DK568584D0 (da) 1984-11-29
GB8428143D0 (en) 1984-12-12
PL250635A1 (en) 1985-11-05
DE3442365A1 (de) 1985-06-05
NO165292B (no) 1990-10-15
FR2555580A1 (fr) 1985-05-31

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Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960506