ES8606372A1 - Procedimiento para preparar derivados diacilicos de glice- rilfosforilcolina opticamente activa o racemica - Google Patents

Procedimiento para preparar derivados diacilicos de glice- rilfosforilcolina opticamente activa o racemica

Info

Publication number
ES8606372A1
ES8606372A1 ES549645A ES549645A ES8606372A1 ES 8606372 A1 ES8606372 A1 ES 8606372A1 ES 549645 A ES549645 A ES 549645A ES 549645 A ES549645 A ES 549645A ES 8606372 A1 ES8606372 A1 ES 8606372A1
Authority
ES
Spain
Prior art keywords
optically active
rilphosphorylcholine
racemical
diacilic
glyc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES549645A
Other languages
English (en)
Other versions
ES549645A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neopharmed Gentili SpA
Original Assignee
Neopharmed SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neopharmed SRL filed Critical Neopharmed SRL
Publication of ES549645A0 publication Critical patent/ES549645A0/es
Publication of ES8606372A1 publication Critical patent/ES8606372A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C07F9/106—Adducts, complexes, salts of phosphatides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

METODO DE OBTENCION DE ESTERES BIS(PIRIDIL-3-CARBOXILATOS) DE GLICERILFOSFORILCOLINA L (ALFA) OPTICAMENTE ACTIVA O D,L (ALFA) RACEMICA Y SUS RESPECTIVOS COMPLEJOS DE FORMULA (I); DONDE Y ES UN RADICAL PIRIDIL-CARBOXILATO; M PUEDE SER CA, MG, AL O ZN; X REPRESENTA UN HALOGENO; N ES 2 O 3 Y M TOMA EL VALOR 0 O 1. CONSISTE EN UTILIZAR COMO REACTANTE A ESTERIFICAR UN COMPLEJO DE GLICERILFOSFORILCOLINA CON CLORURO DE CALCIO O ZINC DE FORMULA (II) DONDE Z REPRESENTA CA O ZN Y N PUEDE TOMAR UNO DE LOS VALORES SIGUIENTES: 0,5; 0,75; 1,25; 1,5; EL REACTIVO DE ACILACION UTILIZADO ES EL ANHIDRIDO DE ACIDO PIRIDIN-3-CARBOXILICO. LA REACCION SE LLEVA A CABO EN PRESENCIA DE UNA AMINA TERCIARIA Y ES CATALIZADA POR 4-DIMETILAMINOPIRIDINA. DE APLICACION TERAPEUTICA, COMO AGENTES ANTIDISLIPEMICOS Y CEREBROACTIVOS.
ES549645A 1984-12-05 1985-12-05 Procedimiento para preparar derivados diacilicos de glice- rilfosforilcolina opticamente activa o racemica Expired ES8606372A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT23896/84A IT1178709B (it) 1984-12-05 1984-12-05 Diacilderivati della glicerilfosforilcolina ad attivita'terapeutica, procedimento per la loro preparazione e relative composizioni farmaceutiche

Publications (2)

Publication Number Publication Date
ES549645A0 ES549645A0 (es) 1986-04-16
ES8606372A1 true ES8606372A1 (es) 1986-04-16

Family

ID=11210716

Family Applications (1)

Application Number Title Priority Date Filing Date
ES549645A Expired ES8606372A1 (es) 1984-12-05 1985-12-05 Procedimiento para preparar derivados diacilicos de glice- rilfosforilcolina opticamente activa o racemica

Country Status (9)

Country Link
US (2) US4699901A (es)
EP (1) EP0186803B1 (es)
JP (1) JPS61171490A (es)
AT (1) ATE46517T1 (es)
CA (1) CA1300152C (es)
DE (1) DE3573121D1 (es)
ES (1) ES8606372A1 (es)
IT (1) IT1178709B (es)
PT (1) PT81621B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1178709B (it) * 1984-12-05 1987-09-16 Neopharmed Spa Diacilderivati della glicerilfosforilcolina ad attivita'terapeutica, procedimento per la loro preparazione e relative composizioni farmaceutiche
IT1201477B (it) * 1985-10-04 1989-02-02 Istituto Chemioterapico Procedimento per la preparazione di l-alfa-glicerilfosforilcolina,l-alfa-glicerilfosforiletanolommina e l-alfa-glicerilfosforilinositolo da lecitine grezze e/o deoleate
EP0329053A1 (en) * 1988-02-15 1989-08-23 MAGIS FARMACEUTICI S.p.A. Choline esters of glycerophosphoric acids
IT1216535B (it) * 1988-03-28 1990-03-08 Magis Farmaceutici O_(1,2_di_0_acetilglicero_3_fosforil)etanolamina, procedimento per la sua preparazione e suo uso terapeutico.
JPH0745507B2 (ja) * 1988-06-02 1995-05-17 和光純薬工業株式会社 ホスファチジルコリン誘導体の製造方法
US4983592A (en) * 1988-12-19 1991-01-08 American Cyanamid Co. Bis-arylphosphate ester antagonists of platelet activating factor
US20110015154A1 (en) * 2009-07-20 2011-01-20 Kellermann Gottfried H Supporting acetylcholine function
US20110098265A1 (en) * 2009-10-28 2011-04-28 Neuroscience, Inc. Methods for reducing cravings and impulses associated with addictive and compulsive behaviors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2864848A (en) * 1954-07-19 1958-12-16 Ca Nat Research Council Method of producing l-alpha-glycerylphosphorylcholine
DK104583A (da) * 1982-03-22 1983-09-23 Fujisawa Pharmaceutical Co Fremgangsmaade til fremstilling af phospholipider
IT1178709B (it) * 1984-12-05 1987-09-16 Neopharmed Spa Diacilderivati della glicerilfosforilcolina ad attivita'terapeutica, procedimento per la loro preparazione e relative composizioni farmaceutiche

Also Published As

Publication number Publication date
US4699901A (en) 1987-10-13
EP0186803A3 (en) 1987-06-16
ES549645A0 (es) 1986-04-16
PT81621B (pt) 1987-10-20
IT8423896A0 (it) 1984-12-05
IT1178709B (it) 1987-09-16
EP0186803B1 (en) 1989-09-20
DE3573121D1 (en) 1989-10-26
US4824978A (en) 1989-04-25
EP0186803A2 (en) 1986-07-09
ATE46517T1 (de) 1989-10-15
PT81621A (en) 1986-01-02
IT8423896A1 (it) 1986-06-05
JPS61171490A (ja) 1986-08-02
CA1300152C (en) 1992-05-05

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970203