IT8423896A1 - Diacilderivati della glicerilfosforilcolina ad attività terapeutica, procedimento per la loro preparazione e relative composizioni farmaceutiche. - Google Patents

Diacilderivati della glicerilfosforilcolina ad attività terapeutica, procedimento per la loro preparazione e relative composizioni farmaceutiche.

Info

Publication number: IT8423896A1
Authority: IT; Italy
Prior art keywords: glycerylphosphorylcholine; preparation; pharmaceutical compositions; therapeutic activity; related pharmaceutical
Prior art date: 1984-12-05

Application number

IT1984A23896A

Other languages

English (en)

Other versions

IT8423896A0 (it

IT1178709B (it

Original Assignee

Neopharmed Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-12-05

Filing date

1984-12-05

Publication date

1986-06-05

1984-12-05 Application filed by Neopharmed Spa filed Critical Neopharmed Spa

1984-12-05 Publication of IT8423896A0 publication Critical patent/IT8423896A0/it

1984-12-05 Priority to IT23896/84A priority Critical patent/IT1178709B/it

1985-12-02 Priority to US06/803,474 priority patent/US4699901A/en

1985-12-04 Priority to AT85115414T priority patent/ATE46517T1/de

1985-12-04 Priority to CA000496835A priority patent/CA1300152C/en

1985-12-04 Priority to EP85115414A priority patent/EP0186803B1/en

1985-12-04 Priority to DE8585115414T priority patent/DE3573121D1/de

1985-12-05 Priority to PT81621A priority patent/PT81621B/pt

1985-12-05 Priority to JP60272642A priority patent/JPS61171490A/ja

1985-12-05 Priority to ES549645A priority patent/ES8606372A1/es

1986-06-05 Publication of IT8423896A1 publication Critical patent/IT8423896A1/it

1987-07-07 Priority to US07/070,542 priority patent/US4824978A/en

1987-09-16 Application granted granted Critical

1987-09-16 Publication of IT1178709B publication Critical patent/IT1178709B/it

Links

SUHOQUVVVLNYQR-MRVPVSSYSA-O glycerylphosphorylcholine Chemical class C[N+](C)(C)CCO[P@](O)(=O)OC[C@H](O)CO SUHOQUVVVLNYQR-MRVPVSSYSA-O 0.000 title abstract 3
239000008194 pharmaceutical composition Substances 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1
239000008777 Glycerylphosphorylcholine Substances 0.000 abstract 2
229960004956 glycerylphosphorylcholine Drugs 0.000 abstract 2
JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 abstract 2
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
230000010933 acylation Effects 0.000 abstract 1
238000005917 acylation reaction Methods 0.000 abstract 1
150000008064 anhydrides Chemical class 0.000 abstract 1
229910052791 calcium Inorganic materials 0.000 abstract 1
239000011575 calcium Substances 0.000 abstract 1
239000001110 calcium chloride Substances 0.000 abstract 1
229910001628 calcium chloride Inorganic materials 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
239000000460 chlorine Substances 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
239000011592 zinc chloride Substances 0.000 abstract 1
235000005074 zinc chloride Nutrition 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/10—Phosphatides, e.g. lecithin
- C07F9/106—Adducts, complexes, salts of phosphatides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Hospice & Palliative Care (AREA)
Obesity (AREA)
Psychiatry (AREA)
Hematology (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

IT23896/84A 1984-12-05 1984-12-05 Diacilderivati della glicerilfosforilcolina ad attivita'terapeutica, procedimento per la loro preparazione e relative composizioni farmaceutiche IT1178709B (it)

Priority Applications (10)

Application Number	Priority Date	Filing Date	Title
IT23896/84A IT1178709B (it)	1984-12-05	1984-12-05	Diacilderivati della glicerilfosforilcolina ad attivita'terapeutica, procedimento per la loro preparazione e relative composizioni farmaceutiche
US06/803,474 US4699901A (en)	1984-12-05	1985-12-02	Diacyl derivatives of glycerylphosphorylcholine, their preparation, and antihyperlipidemic compositions
EP85115414A EP0186803B1 (en)	1984-12-05	1985-12-04	Diacylderivatives of glycerylphosphorylcholine having therapeutical activity, a process for their preparation and related pharmaceutical compositions
CA000496835A CA1300152C (en)	1984-12-05	1985-12-04	Diacylderivatives of glycerylphosphorylcholine having therapeutical activity, a process for their preparation and related pharmaceutical compositions
AT85115414T ATE46517T1 (de)	1984-12-05	1985-12-04	Diacylderivate von glycerylphosphorylcholin mit therapeutischen eigenschaften, verfahren zu ihrer herstellung und entsprechende pharmazeutische zusammensetzungen.
DE8585115414T DE3573121D1 (en)	1984-12-05	1985-12-04	Diacylderivatives of glycerylphosphorylcholine having therapeutical activity, a process for their preparation and related pharmaceutical compositions
PT81621A PT81621B (pt)	1984-12-05	1985-12-05	Processo para a preparacao de derivados da glicerilfosforilcolina possuindo actividade terapeutica e de suas composicoes farmaceuticas
JP60272642A JPS61171490A (ja)	1984-12-05	1985-12-05	グリセリルホスホリルコリンのジアシル誘導体
ES549645A ES8606372A1 (es)	1984-12-05	1985-12-05	Procedimiento para preparar derivados diacilicos de glice- rilfosforilcolina opticamente activa o racemica
US07/070,542 US4824978A (en)	1984-12-05	1987-07-07	Complexes of glycerylphosphorylcholine

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT23896/84A IT1178709B (it)	1984-12-05	1984-12-05	Diacilderivati della glicerilfosforilcolina ad attivita'terapeutica, procedimento per la loro preparazione e relative composizioni farmaceutiche

Publications (3)

Publication Number	Publication Date
IT8423896A0 IT8423896A0 (it)	1984-12-05
IT8423896A1 true IT8423896A1 (it)	1986-06-05
IT1178709B IT1178709B (it)	1987-09-16

Family

ID=11210716

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT23896/84A IT1178709B (it)	1984-12-05	1984-12-05	Diacilderivati della glicerilfosforilcolina ad attivita'terapeutica, procedimento per la loro preparazione e relative composizioni farmaceutiche

Country Status (9)

Country	Link
US (2)	US4699901A (it)
EP (1)	EP0186803B1 (it)
JP (1)	JPS61171490A (it)
AT (1)	ATE46517T1 (it)
CA (1)	CA1300152C (it)
DE (1)	DE3573121D1 (it)
ES (1)	ES8606372A1 (it)
IT (1)	IT1178709B (it)
PT (1)	PT81621B (it)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1178709B (it) *	1984-12-05	1987-09-16	Neopharmed Spa	Diacilderivati della glicerilfosforilcolina ad attivita'terapeutica, procedimento per la loro preparazione e relative composizioni farmaceutiche
IT1201477B (it) *	1985-10-04	1989-02-02	Istituto Chemioterapico	Procedimento per la preparazione di l-alfa-glicerilfosforilcolina,l-alfa-glicerilfosforiletanolommina e l-alfa-glicerilfosforilinositolo da lecitine grezze e/o deoleate
EP0329053A1 (en) *	1988-02-15	1989-08-23	MAGIS FARMACEUTICI S.p.A.	Choline esters of glycerophosphoric acids
IT1216535B (it) *	1988-03-28	1990-03-08	Magis Farmaceutici	O_(1,2_di_0_acetilglicero_3_fosforil)etanolamina, procedimento per la sua preparazione e suo uso terapeutico.
JPH0745507B2 (ja) *	1988-06-02	1995-05-17	和光純薬工業株式会社	ホスファチジルコリン誘導体の製造方法
US4983592A (en) *	1988-12-19	1991-01-08	American Cyanamid Co.	Bis-arylphosphate ester antagonists of platelet activating factor
US20110015154A1 (en) *	2009-07-20	2011-01-20	Kellermann Gottfried H	Supporting acetylcholine function
US20110098265A1 (en) *	2009-10-28	2011-04-28	Neuroscience, Inc.	Methods for reducing cravings and impulses associated with addictive and compulsive behaviors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2864848A (en) *	1954-07-19	1958-12-16	Ca Nat Research Council	Method of producing l-alpha-glycerylphosphorylcholine
DK104583A (da) *	1982-03-22	1983-09-23	Fujisawa Pharmaceutical Co	Fremgangsmaade til fremstilling af phospholipider
IT1178709B (it) *	1984-12-05	1987-09-16	Neopharmed Spa	Diacilderivati della glicerilfosforilcolina ad attivita'terapeutica, procedimento per la loro preparazione e relative composizioni farmaceutiche

1984
- 1984-12-05 IT IT23896/84A patent/IT1178709B/it active
1985
- 1985-12-02 US US06/803,474 patent/US4699901A/en not_active Expired - Fee Related
- 1985-12-04 DE DE8585115414T patent/DE3573121D1/de not_active Expired
- 1985-12-04 EP EP85115414A patent/EP0186803B1/en not_active Expired
- 1985-12-04 AT AT85115414T patent/ATE46517T1/de not_active IP Right Cessation
- 1985-12-04 CA CA000496835A patent/CA1300152C/en not_active Expired - Lifetime
- 1985-12-05 JP JP60272642A patent/JPS61171490A/ja active Pending
- 1985-12-05 PT PT81621A patent/PT81621B/pt not_active IP Right Cessation
- 1985-12-05 ES ES549645A patent/ES8606372A1/es not_active Expired
1987
- 1987-07-07 US US07/070,542 patent/US4824978A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US4699901A (en)	1987-10-13
EP0186803A3 (en)	1987-06-16
ES549645A0 (es)	1986-04-16
PT81621B (pt)	1987-10-20
IT8423896A0 (it)	1984-12-05
IT1178709B (it)	1987-09-16
EP0186803B1 (en)	1989-09-20
DE3573121D1 (en)	1989-10-26
US4824978A (en)	1989-04-25
ES8606372A1 (es)	1986-04-16
EP0186803A2 (en)	1986-07-09
ATE46517T1 (de)	1989-10-15
PT81621A (en)	1986-01-02
JPS61171490A (ja)	1986-08-02
CA1300152C (en)	1992-05-05

Publication	Publication Date	Title
NO177265C (no)	1995-08-16	Analogifremgangsmåte for fremstilling av terapeutisk aktive imidazoler
FI872379A7 (fi)	1987-11-30	Menetelmä farmakologisesti vaikuttavien 1,5-diaryyli-3-(w-substituoitu-alempi-alkyyli)-pyratsolien valmistamiseksi
NO880182D0 (no)	1988-01-18	Fremgangsmaate for fremstilling av terapeutisk aktive 1, 2-dihydro-3h-indazol-3h-indazol-3-on-derivater.
NO873125L (no)	1988-01-29	Fremgangsmaate for fremstilling av antibakterielle forbindelser.
NO880731D0 (no)	1988-02-19	Fremgangsmaate for fremstilling av farmasoeytisk aktive naftalenderivater.
ES2002053A6 (es)	1988-07-01	Procedimiento para la obtencion de peptidos inihiobidores de renina que contienen grupos hidroxi.
NO171412C (no)	1993-03-10	Analogifremgangsmaate for fremstilling av terapeutisk aktive 1,3-oksatiolan- eller 1,3-ditiolanderivater
IT8423896A1 (it)	1986-06-05	Diacilderivati della glicerilfosforilcolina ad attività terapeutica, procedimento per la loro preparazione e relative composizioni farmaceutiche.
DE68903226D1 (de)	1992-11-26	Dideoxydidehydrocarbocyclische nukleoside.
ATE100459T1 (de)	1994-02-15	Antifungale antibiotika.
ES8707553A1 (es)	1987-08-01	Procedimiento para la obtencion de un peptido.
ATE69227T1 (de)	1991-11-15	Pharmakologisch wirksame pyrazolopyridine.
ES2035915T3 (es)	1993-05-01	Agentes antiarritmicos n-fenetil-aminoalquil-benzamida.
DK412985D0 (da)	1985-09-11	Prolinforbindelse og farmaceutisk praeparat indeholdende forbindelsen
NO862390D0 (no)	1986-06-16	Fremgangsmaate for fremstilling av terapeutisk aktive 1,4-dihydropyridinderivater.
FI893121L (fi)	1989-06-27	Menetelmä farmakologisesti aktiivisten 6,21-dimetyyli-19-norprogesteronijohdannaisten valmistamiseksi
NO169171C (no)	1992-05-20	Analogifremgangsmaate for fremstilling av terapeutisk aktive glycero-3(2)-fosfo-l-serinderivater
NO882256L (no)	1988-11-28	Fremgangsmaate for fremstilling av farmakologisk aktive kinolinforbindelser.
ATE118007T1 (de)	1995-02-15	Penemderivate.
ES2061667T3 (es)	1994-12-16	Agente hipotensivo para el tratamiento o prevencion de la hipertension.
NO166529C (no)	1991-08-07	Analogifremgangsmaate for fremstilling av terapeutisk aktive 2,5-pyrolidindion derivater.
ES2033859T3 (es)	1993-04-01	Acidos y esteres 2-amino-3-aroil-gamma-oxobencenbutanoicos.
IT8920756A0 (it)	1989-06-02	Derivato liposolubile dell'alfa tocoferolo.
IT8820662A0 (it)	1988-05-20	Derivato liposolubile dell'alfa tocoferolo.
SU1455633A1 (ru)	1999-05-27	О,о-диизопропил-о-[1, 1-диметил-2-пропилтио-2-(о-о-диизопропилфосфорил)- имино]-этилфосфат, обладающий бактерицидной активностью