ES8609475A1 - Procedimiento para preparar peptidos de interferon - Google Patents

Procedimiento para preparar peptidos de interferon

Info

Publication number
ES8609475A1
ES8609475A1 ES545725A ES545725A ES8609475A1 ES 8609475 A1 ES8609475 A1 ES 8609475A1 ES 545725 A ES545725 A ES 545725A ES 545725 A ES545725 A ES 545725A ES 8609475 A1 ES8609475 A1 ES 8609475A1
Authority
ES
Spain
Prior art keywords
type
same
genetic sequences
organisms producing
peptide coded
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES545725A
Other languages
English (en)
Other versions
ES545725A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Original Assignee
Boehringer Ingelheim International GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE3428370A external-priority patent/DE3428370A1/de
Priority claimed from DE19853505060 external-priority patent/DE3505060A1/de
Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Publication of ES8609475A1 publication Critical patent/ES8609475A1/es
Publication of ES545725A0 publication Critical patent/ES545725A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Plant Pathology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Electrotherapy Devices (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR NUEVOS PEPTIDOS DE INTERFERON DE HUMANO DE TIPO I. CONSISTE EN TRANSFORMAR UN ORGANISMO HOSPEDANTE APROPIADO, QUE CONTIENE UNA SECUENCIA CODIFICADORA PARA LOS NUEVOS PEPTIDOS DE INTERFERON, QUE ES HIBRIDIZADA EN CONDICIONES ESTRICTAS, TALES QUE PERMITEN RECONOCER UNA HOMOLOGIA QUE ES MAYOR QUE 85% CON LOS INSERTOS EN EL LUGAR DE CORTE CON PST-1 A) DEL PLASMIDO ES E76E9 (DEPOSITADO EN E. COLI HB 101 EN LA COLECCION DSM BAJO EL NUMERO DSM 3004), O CON VARIACIONES DEGENERADAS DE ESTOS INSERTOS, SIENDO ESTA INFORMACION EXPRESADA, A FIN DE PRODUCIR EL CORRESPONDIENTE INTERFERON EN EL ORGANISMO HOSPEDANTE; Y AISLAR EL PEPTIDO DE INTERFERON ASI OBTENIDO A PARTIR DE ESTE ORGANISMO HOSPEDANTE.
ES545725A 1984-08-01 1985-07-30 Procedimiento para preparar peptidos de interferon Expired ES8609475A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3428370A DE3428370A1 (de) 1984-08-01 1984-08-01 Interferon, genetische sequenzen, die hierfuer codieren, und diese produzierende organismen
DE19853505060 DE3505060A1 (de) 1985-02-14 1985-02-14 Neue interferone vom typ i, genetische sequenzen, die hierfuer codieren, und diese produzierende organismen

Publications (2)

Publication Number Publication Date
ES8609475A1 true ES8609475A1 (es) 1986-08-01
ES545725A0 ES545725A0 (es) 1986-08-01

Family

ID=25823496

Family Applications (2)

Application Number Title Priority Date Filing Date
ES545725A Expired ES8609475A1 (es) 1984-08-01 1985-07-30 Procedimiento para preparar peptidos de interferon
ES552431A Expired ES8708013A1 (es) 1984-08-01 1986-02-26 Procedimiento para preparar plasmidos de expresion prhw11 y prhw12

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES552431A Expired ES8708013A1 (es) 1984-08-01 1986-02-26 Procedimiento para preparar plasmidos de expresion prhw11 y prhw12

Country Status (21)

Country Link
EP (1) EP0170204B1 (es)
JP (2) JP2566909B2 (es)
KR (1) KR0136799B1 (es)
AT (1) ATE67786T1 (es)
AU (1) AU600653B2 (es)
BG (1) BG60445B2 (es)
CA (1) CA1340184C (es)
DD (1) DD246318A5 (es)
DE (1) DE3584198D1 (es)
DK (1) DK175194B1 (es)
ES (2) ES8609475A1 (es)
FI (1) FI90667C (es)
GR (1) GR851866B (es)
HK (1) HK187896A (es)
HU (1) HU205779B (es)
IE (1) IE58942B1 (es)
IL (1) IL75963A (es)
MX (1) MX9203645A (es)
NO (1) NO177863C (es)
NZ (1) NZ212937A (es)
PT (1) PT80901B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5231176A (en) * 1984-08-27 1993-07-27 Genentech, Inc. Distinct family DNA encoding of human leukocyte interferons
EP0490233A1 (de) * 1986-03-10 1992-06-17 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Monoclonale Antikörper gegen BgIII-Hybridinterferone, deren Verwendung und Verfahren zu ihrer Herstellung
DE3607835A1 (de) * 1986-03-10 1987-09-24 Boehringer Ingelheim Int Hybridinterferone, deren verwendung als arzneimittel und als zwischenprodukte zur herstellung von antikoerpern und deren verwendung sowie verfahren zu ihrer herstellung
US4863727A (en) * 1986-04-09 1989-09-05 Cetus Corporation Combination therapy using interleukin-2 and tumor necrosis factor
DE3633323A1 (de) * 1986-10-01 1988-04-07 Boehringer Ingelheim Int Neue monoklonale antikoerper gegen ifn-omega, verfahren zu ihrer herstellung und deren verwendung zur reinigung sowie zum nachweis von ifn-omega
DE3635867A1 (de) * 1986-10-22 1988-05-11 Boehringer Ingelheim Int Neue hefeexpressionsvektoren fuer ifn-omega, verfahren zu ihrer herstellung und deren verwendung
CA2309766C (en) 1997-11-20 2008-09-30 Vical Incorporated Treatment of cancer using cytokine-expressing polynucleotides and compositions therefor
WO2000040273A2 (en) * 1999-01-08 2000-07-13 Vical Incorporated Treatment of viral diseases using an interferon omega expressing polynucleotide
PT1481057E (pt) 2002-03-07 2006-05-31 Eidgenoess Tech Hochschule Sistema e metodo para a producao de proteinas glicosiladas recombinantes num hospedeiro procariota
KR20130101592A (ko) * 2002-03-07 2013-09-13 아이드게노쉬쉐 테흐니쉐 호흐슐레 쥬리히 원핵 숙주에서의 재조합 글리코실화 단백질 생산 방법 및 생산계
NZ542586A (en) 2003-04-09 2009-11-27 Biogenerix Ag Method of forming a covalent conjugate between a G-CSF peptide and PEG
WO2004096852A1 (fr) * 2003-04-25 2004-11-11 The Institute Of Microbiology And Epidemiology, Academy Of Military Medical Sciemces, Pla Interferon$g(v) humain recombinant, son procede d'expression et ses utilisations
DE602006017207D1 (de) 2005-05-11 2010-11-11 Eth Zuerich Rekombinante n-glykosylierte proteine aus prokaryontischen zellen
AU2009215341B2 (en) 2008-02-20 2015-03-26 Glaxosmithkline Biologicals S.A. Bioconjugates made from recombinant N-glycosylated proteins from procaryotic cells
TR201803015T4 (tr) 2009-11-19 2018-03-21 Glaxosmithkline Biologicals Sa Prokaryotik hücrelerde immünojenik polisakaridler üreten biyosentetik sistem.
HRP20180064T1 (hr) 2010-05-06 2018-02-23 Glaxosmithkline Biologicals Sa Cjepiva s kapsularnim biokonjugatima iz gram-pozitivnih bakterija
WO2013024156A2 (en) 2011-08-17 2013-02-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Combinations of anti-hcv-entry factor antibodies and interferons for the treatment and the prevention of hcv infection
WO2013024158A1 (en) 2011-08-17 2013-02-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Combinations of protein kinase inhibitors and interferons or of protein kinase inhibitors and direct acting antivirals for the treatment and the prevention of hcv infection
WO2014033266A1 (en) 2012-08-31 2014-03-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Anti-sr-bi antibodies for the inhibition of hepatitis c virus infection

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1217440A (en) * 1982-08-18 1987-02-03 Michael A. Innis INTERFERON .alpha. 6L
AU1946283A (en) * 1982-08-18 1984-03-07 Cetus Corporation Interferon-alpha 6l
DE3247922A1 (de) * 1982-12-24 1984-06-28 Boehringer Ingelheim International GmbH, 6507 Ingelheim Dna-sequenzen, deren herstellung, diese sequenzen enthaltende plasmide und deren verwendung zur synthese eukaryotischer genprodukte in prokaryoten
EP0174143B1 (en) * 1984-08-27 1989-11-08 Genentech, Inc. Novel, distinct family of human leukocyte interferons, compositions containing them, methods for their production, and dna and transfected hosts therefor

Also Published As

Publication number Publication date
ATE67786T1 (de) 1991-10-15
KR0136799B1 (ko) 1998-04-25
FI852956L (fi) 1986-02-02
DK346385D0 (da) 1985-07-30
IE58942B1 (en) 1993-12-01
NO177863B (no) 1995-08-28
FI90667C (fi) 1994-03-10
HUT39477A (en) 1986-09-29
FI90667B (fi) 1993-11-30
JP2566909B2 (ja) 1996-12-25
DK346385A (da) 1986-02-02
NO177863C (no) 1995-12-06
KR870001310A (ko) 1987-03-13
PT80901B (pt) 1989-01-17
HU205779B (en) 1992-06-29
NZ212937A (en) 1991-08-27
AU600653B2 (en) 1990-08-23
CA1340184C (en) 1998-12-15
ES545725A0 (es) 1986-08-01
FI852956A0 (fi) 1985-07-31
EP0170204B1 (de) 1991-09-25
GR851866B (es) 1985-12-02
HK187896A (en) 1996-10-18
JPH06181771A (ja) 1994-07-05
IL75963A (en) 1992-05-25
DK175194B1 (da) 2004-07-05
JP2567195B2 (ja) 1996-12-25
PT80901A (de) 1985-09-01
AU4554985A (en) 1986-02-06
IL75963A0 (en) 1985-12-31
ES552431A0 (es) 1987-09-01
DE3584198D1 (de) 1991-10-31
DD246318A5 (de) 1987-06-03
NO853012L (no) 1986-02-03
MX9203645A (es) 1992-09-01
BG60445B2 (bg) 1995-03-31
JPS61181381A (ja) 1986-08-14
EP0170204A3 (en) 1988-02-17
ES8708013A1 (es) 1987-09-01
EP0170204A2 (de) 1986-02-05
IE851906L (en) 1986-02-01

Similar Documents

Publication Publication Date Title
ES8708013A1 (es) Procedimiento para preparar plasmidos de expresion prhw11 y prhw12
EP0723555A4 (en) CHEMICAL PROTEINS WITH BLOCK SUPPLEMENT ACTIVATION
CA2085134A1 (en) Gdf-1
ZA91134B (en) New proteins produced by human lymphocytes,dna sequence encoding these proteins and their pharmaceutical and biological uses
IE812224L (en) Interferon
AU2964489A (en) Dna sequences, recombinant dna molecules and processes for producing human immune interferon-like polypeptides
HUT46061A (en) Dna sequences encoding hirudin-like protein and process for producing such proteins
EP0182372A3 (en) New factor viii coagulant polypeptides
IL70414A (en) Polypeptide having human h2-relaxin activity,double-stranded dna fragments coding therefor,vectors containing the dna fragments and methods for preparing the polypeptide,dna fragments and vectors
CA2115049A1 (en) Dna sequences encoding gelonin polypeptide
AU3802595A (en) Tripeptidyl aminopeptidase
MX9602977A (es) Proteinas que reparan la mala union de adn humano.
JPS615392B2 (es)
GR3033769T3 (en) Human interferon beta2A, vectors containing genes coding for said interferon, cell lines producing same.
EP0146903A3 (en) Production of a vector encoding a novel hybrid interferon species
CA2187386A1 (en) Gene encoding endo-.beta.-n-acetylglucosaminidase a
TW342413B (en) Novel toxins isolated from Bracon Hebetor
ATE386114T1 (de) Gene, die für lymphocyte spezifischen interferon- regulationsfaktor (lsirf) polypeptide kodiert
SG134394G (en) Genetic sequences, type I interferon peptide coded by them, and these organisms producing the same
WO1996038556A3 (fr) Deltap62, ses variants, sequences d'acides nucleiques les codant, et leurs utilisations en therapie genique anti-cancereuse
IL104985A0 (en) Protein compound,coding nucleotide sequences,producing cell line and uses thereof
EP0636694A3 (en) Human thymopoietin and related compound, process for production and recombinant DNA sequences.

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20060410