ES8801189A1 - Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos. - Google Patents

Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.

Info

Publication number
ES8801189A1
ES8801189A1 ES556753A ES556753A ES8801189A1 ES 8801189 A1 ES8801189 A1 ES 8801189A1 ES 556753 A ES556753 A ES 556753A ES 556753 A ES556753 A ES 556753A ES 8801189 A1 ES8801189 A1 ES 8801189A1
Authority
ES
Spain
Prior art keywords
formula
procedure
hydroxyphenoxialchyleneheterociclyl
preparation
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES556753A
Other languages
English (en)
Other versions
ES556753A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Inc
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Publication of ES8801189A1 publication Critical patent/ES8801189A1/es
Publication of ES556753A0 publication Critical patent/ES556753A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/58—Two sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/16—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/70—Sulfur atoms
    • C07D277/74—Sulfur atoms substituted by carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C07D285/135—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C07D309/40—Oxygen atoms attached in positions 3 and 4, e.g. maltol

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE COMPUESTOS DE FORMULA (I) Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES. COMPRENDE LA REACCION DE UNA AMINA DE FORMULA (II) CON UN ACIDO CARBOXILICO DE FORMULA (III) O UNO DE SUS DERIVADOS, PARA OBTENER UN COMPUESTO DE FORMULA (I), EN LA QUE R1 REPRESENTA ACILO, R2 ES ALQUILO INFERIOR, A ES ALQUILENO INFERIOR OPCIONALMENTE SUSTITUIDO CON UN HIDROXI, HET ES ANILLO HETEROCICLICO Y R3, R4 Y R5 PUEDEN SER VARIOS TIPOS DE RADICALES. LA REACCION SE EFECTUA EN UN DISOLVENTE INERTE, EN PRESENCIA DE UN AGENTE DE CONDENSACION. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA LA PROFILAXIS Y EL TRATAMIENTO DE VARIAS ENFERMEDADES ALERGICAS Y TRASTORNOS ISQUEMICOS DEL CORAZ''ON Y DEL CEREBRO.
ES556753A 1984-11-12 1986-06-25 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos. Expired ES8801189A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP23899184 1984-11-12
JP21932785 1985-10-01

Publications (2)

Publication Number Publication Date
ES8801189A1 true ES8801189A1 (es) 1987-12-16
ES556753A0 ES556753A0 (es) 1987-12-16

Family

ID=26523058

Family Applications (9)

Application Number Title Priority Date Filing Date
ES548772A Expired ES8707947A1 (es) 1984-11-12 1985-11-11 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.
ES556746A Expired ES8801231A1 (es) 1984-11-12 1986-06-25 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.
ES556751A Expired ES8801235A1 (es) 1984-11-12 1986-06-25 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.
ES556747A Expired ES8801187A1 (es) 1984-11-12 1986-06-25 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.
ES556750A Expired ES8801234A1 (es) 1984-11-12 1986-06-25 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.
ES556753A Expired ES8801189A1 (es) 1984-11-12 1986-06-25 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.
ES556752A Expired ES8801188A1 (es) 1984-11-12 1986-06-25 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.
ES556749A Expired ES8801233A1 (es) 1984-11-12 1986-06-25 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.
ES556748A Expired ES8801232A1 (es) 1984-11-12 1986-06-25 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxolicas.

Family Applications Before (5)

Application Number Title Priority Date Filing Date
ES548772A Expired ES8707947A1 (es) 1984-11-12 1985-11-11 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.
ES556746A Expired ES8801231A1 (es) 1984-11-12 1986-06-25 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.
ES556751A Expired ES8801235A1 (es) 1984-11-12 1986-06-25 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.
ES556747A Expired ES8801187A1 (es) 1984-11-12 1986-06-25 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.
ES556750A Expired ES8801234A1 (es) 1984-11-12 1986-06-25 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES556752A Expired ES8801188A1 (es) 1984-11-12 1986-06-25 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.
ES556749A Expired ES8801233A1 (es) 1984-11-12 1986-06-25 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.
ES556748A Expired ES8801232A1 (es) 1984-11-12 1986-06-25 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxolicas.

Country Status (8)

Country Link
US (2) US4855310A (es)
EP (1) EP0181779B1 (es)
KR (1) KR900004804B1 (es)
AT (1) ATE102930T1 (es)
CA (1) CA1269982A (es)
DE (1) DE3587777T2 (es)
ES (9) ES8707947A1 (es)
PH (1) PH22520A (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
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JPS61186368A (ja) * 1985-02-14 1986-08-20 Kyorin Pharmaceut Co Ltd 新規な抗アレルギ−薬およびその製造方法
US5180730A (en) * 1985-07-22 1993-01-19 Yamanouchi Pharmaceutical Co., Ltd. Heterocyclic compounds
US4803211A (en) * 1985-07-22 1989-02-07 Yamanouchi Pharmaceutical Co., Ltd. Thiadizazole compounds as antagonists of SRS-A
US4942245A (en) * 1987-04-20 1990-07-17 Kyorin Pharmaceutical Co., Ltd. Benzimidazole Derivatives
JPH0667836B2 (ja) * 1989-03-01 1994-08-31 東洋紡績株式会社 アミド系化合物からなる抗アレルギー剤
US5102897A (en) * 1990-03-27 1992-04-07 Warner-Lambert Company 3,5-ditertiarybutyl-4-hydroxyphenyl, 1,3,4-thiadiazoles and oxadiazoles linked by carbon, oxygen, and sulfur residues
DE4035599A1 (de) * 1990-11-06 1992-05-07 Dresden Arzneimittel Neue 5-(phenoxyalkanoylamino)-uracile, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
EP0973936A1 (en) * 1997-04-11 2000-01-26 Eli Lilly And Company Combinatorial libraries of peptidomimetic aminothioether acids
HK1045157A1 (zh) * 1999-01-22 2002-11-15 依兰制药公司 抑制vla-4介导的白细胞粘着的化合物
AR035838A1 (es) 1999-01-22 2004-07-21 Elan Pharm Inc Compuestos multiciclicos que inhiben la adhesion de leucocitos mediada por vla-4 y el uso de los mismos para la preparacion de un medicamento
TW593284B (en) * 1999-01-22 2004-06-21 Elan Pharm Inc Fused ring heteroaryl and heterocyclic compounds which inhibit leukocyte adhesion mediated by VLA-4
US6436904B1 (en) * 1999-01-25 2002-08-20 Elan Pharmaceuticals, Inc. Compounds which inhibit leukocyte adhesion mediated by VLA-4
AU3246600A (en) 1999-03-01 2000-09-21 Elan Pharmaceuticals, Inc. Alpha-aminoacetic acid derivatives useful as alpha 4 beta 7 receptor antagonists
US6552073B1 (en) * 2002-03-01 2003-04-22 Exonhit Therapeutics Sa Compounds and methods of treating cell proliferative diseases
TWI281470B (en) * 2002-05-24 2007-05-21 Elan Pharm Inc Heterocyclic compounds which inhibit leukocyte adhesion mediated by alpha4 integrins
TW200307671A (en) * 2002-05-24 2003-12-16 Elan Pharm Inc Heteroaryl compounds which inhibit leukocyte adhesion mediated by α 4 integrins
EP1521577A1 (en) * 2002-06-13 2005-04-13 QLT, Inc. Methods of using isothiazole derivatives to treat cancer or inflammation
ATE493405T1 (de) * 2005-09-29 2011-01-15 Elan Pharm Inc Pyrimidinylamidverbindungen, die die durch vla-4 vermittelte leukozytenadhäsion inhibieren
ZA200803016B (en) 2005-09-29 2009-10-28 Elan Pharmaceuticals Inc Wyeth Carbamate compounds which inhibit leukocyte adhesion mediated by VLA-4
EA017110B1 (ru) * 2006-02-27 2012-09-28 Элан Фамэсьютикэлс, Инк. ПИРИМИДИНИЛСУЛЬФОНАМИДНЫЕ СОЕДИНЕНИЯ (ВАРИАНТЫ), СПОСОБ ПОЛУЧЕНИЯ ПИРИМИДИНИЛСУЛЬФОНАМИДНЫХ СОЕДИНЕНИЙ (ВАРИАНТЫ), ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СПОСОБ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЯ, ОПОСРЕДОВАННОГО ИНТЕГРИНОМ α4, СПОСОБ СНИЖЕНИЯ И/ИЛИ ПРЕДУПРЕЖДЕНИЯ ВОСПАЛИТЕЛЬНОГО КОМПОНЕНТА ЗАБОЛЕВАНИЯ ИЛИ АУТОИММУННОГО ОТВЕТА
SG10201401836RA (en) * 2009-04-27 2014-10-30 Elan Pharm Inc Pyridinone antagonists of alpha-4 integrins
CN103772312B (zh) 2009-10-02 2016-08-17 埃维克辛公司 抗炎症的2-羰基噻唑和2-羰基恶唑
US20150376161A1 (en) 2013-01-29 2015-12-31 Avexxin As Antiiflammatory and antitumor 2-oxothiazoles abd 2-oxothiophenes compounds
GB201413695D0 (en) 2014-08-01 2014-09-17 Avexxin As Compound
GB201604318D0 (en) 2016-03-14 2016-04-27 Avexxin As Combination therapy
EP4031537A1 (en) * 2019-09-17 2022-07-27 The Lubrizol Corporation 2,5-dimercapto-1,3,4-thiadiazole ("dmtd") derivatives

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JPS591268B2 (ja) * 1978-10-18 1984-01-11 興和株式会社 チアジアゾ−ル誘導体
US4411905A (en) * 1979-09-04 1983-10-25 Richardson-Merrell Inc. Antisecretory 1,2,4-triazole-3-thiols
AU554388B2 (en) * 1981-06-15 1986-08-21 American Home Products Corporation Alpha-phenyl-2-(aza)benzothiazolylthioglycolic acid derivatives
DE3270324D1 (en) * 1982-01-22 1986-05-07 Basf Ag Aminothiadiazoles, process for their preparation and their use in combating unwanted plant growth
US4517188A (en) * 1983-05-09 1985-05-14 Mead Johnson & Company 1-Pyrimidinyloxy-3-hetaryl-alkylamino-2-propanols
US4672066A (en) * 1985-04-22 1987-06-09 Hoffmann-La Roche Inc. Derivatives of 4-acetyl-3-hydroxy-2-alkyl-phenoxycarboxylic acids
US4803211A (en) * 1985-07-22 1989-02-07 Yamanouchi Pharmaceutical Co., Ltd. Thiadizazole compounds as antagonists of SRS-A

Also Published As

Publication number Publication date
ES8801235A1 (es) 1987-12-16
ES8801188A1 (es) 1987-12-16
ES556751A0 (es) 1987-12-16
US4908368A (en) 1990-03-13
KR900004804B1 (ko) 1990-07-06
ES556748A0 (es) 1987-12-16
EP0181779B1 (en) 1994-03-16
ES8801234A1 (es) 1987-12-16
ES556750A0 (es) 1987-12-16
PH22520A (en) 1988-10-17
ES556746A0 (es) 1987-12-16
ES556749A0 (es) 1987-12-16
CA1269982A (en) 1990-06-05
ES8801231A1 (es) 1987-12-16
US4855310A (en) 1989-08-08
ES8801233A1 (es) 1987-12-16
DE3587777D1 (de) 1994-04-21
KR860004041A (ko) 1986-06-16
ES556747A0 (es) 1987-12-16
ES8801187A1 (es) 1987-12-16
DE3587777T2 (de) 1994-06-23
ES8707947A1 (es) 1987-09-01
ES556753A0 (es) 1987-12-16
ES548772A0 (es) 1987-09-01
ATE102930T1 (de) 1994-04-15
EP0181779A1 (en) 1986-05-21
ES8801232A1 (es) 1987-12-16
ES556752A0 (es) 1987-12-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19971001