ES8801247A1 - Un procedimiento para la preparacion de nuevos derivados de carbazolona - Google Patents

Un procedimiento para la preparacion de nuevos derivados de carbazolona

Info

Publication number
ES8801247A1
ES8801247A1 ES556101A ES556101A ES8801247A1 ES 8801247 A1 ES8801247 A1 ES 8801247A1 ES 556101 A ES556101 A ES 556101A ES 556101 A ES556101 A ES 556101A ES 8801247 A1 ES8801247 A1 ES 8801247A1
Authority
ES
Spain
Prior art keywords
phenyl
hydrogen
imidazolylmethyl
carbazol
tetrahydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES556101A
Other languages
English (en)
Other versions
ES556101A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848401888A external-priority patent/GB8401888D0/en
Priority claimed from GB848425959A external-priority patent/GB8425959D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ES556101A0 publication Critical patent/ES556101A0/es
Publication of ES8801247A1 publication Critical patent/ES8801247A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

METODO DE PREPARAR NUEVOS DERIVADOS DE CARBAZOLONA. CONSISTE EN OXIDAR UN COMPUESTO DE FORMULA (II), O UNA SAL O DERIVADO PROTEGIDO DEL MISMO, MEDIANTE UN AGENTE OXIDANTE ADECUADO PARA LA CONVERSION DEL GRUPO C-OH O CH2 EN UN GRUPO CFO, EN PRESENCIA DE UN DISOLVENTE ADECUADO, PARA OBTENER NUEVOS DERIVADOS DE CARBAZOLONA DE FORMULA (I), DONDE R1 ES H, UN GRUPO ALQUILO DE C 1 A 10, CICLOALQUILO DE C 3 A 7, ALQUENILO DE C 3 A 6, FENILO O FENIL-ALQUILO DE C 1 A 3 Y UNO DE LOS GRUPOS REPRESENTADOS POR R2, R3 Y R4 ES H O UN GRUPO ALQUILO DE C 1 A 6, CICLOALQUILO C 3 A 7 Y OTROS. TIENEN UTILIDAD EN EL TRATAMIENTO DE LA JAQUECA Y LOS TRASTORNOS PSICOTICOS.
ES556101A 1984-01-25 1986-06-16 Un procedimiento para la preparacion de nuevos derivados de carbazolona Expired ES8801247A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848401888A GB8401888D0 (en) 1984-01-25 1984-01-25 Heterocyclic compounds
GB848425959A GB8425959D0 (en) 1984-10-15 1984-10-15 Heterocyclic compounds

Publications (2)

Publication Number Publication Date
ES556101A0 ES556101A0 (es) 1987-12-16
ES8801247A1 true ES8801247A1 (es) 1987-12-16

Family

ID=26287221

Family Applications (3)

Application Number Title Priority Date Filing Date
ES539852A Expired ES8609309A1 (es) 1984-01-25 1985-01-25 Un nuevo procedimiento para la preparacion de nuevos derivados. de carbazolona.
ES548430A Expired ES8708224A1 (es) 1984-01-25 1985-10-31 Un procedimiento para la preparacion de nuevos derivados de carbazolona
ES556101A Expired ES8801247A1 (es) 1984-01-25 1986-06-16 Un procedimiento para la preparacion de nuevos derivados de carbazolona

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES539852A Expired ES8609309A1 (es) 1984-01-25 1985-01-25 Un nuevo procedimiento para la preparacion de nuevos derivados. de carbazolona.
ES548430A Expired ES8708224A1 (es) 1984-01-25 1985-10-31 Un procedimiento para la preparacion de nuevos derivados de carbazolona

Country Status (29)

Country Link
KR (1) KR920003064B1 (es)
AT (1) AT392276B (es)
AU (1) AU579132B2 (es)
BE (1) BE901576A (es)
CA (1) CA1252793A (es)
CH (1) CH664152A5 (es)
CY (1) CY1479A (es)
CZ (1) CZ404391A3 (es)
DE (2) DE3502508A1 (es)
DK (1) DK169521B1 (es)
ES (3) ES8609309A1 (es)
FI (1) FI84349C (es)
FR (1) FR2561244B1 (es)
GB (1) GB2153821B (es)
GR (1) GR850219B (es)
HK (1) HK33189A (es)
HU (1) HU193592B (es)
IE (1) IE57809B1 (es)
IL (1) IL74165A (es)
IT (1) IT1182150B (es)
LU (2) LU85743A1 (es)
NL (2) NL190373C (es)
NO (2) NO164025C (es)
NZ (1) NZ210940A (es)
PH (1) PH22672A (es)
PT (1) PT79890B (es)
SE (1) SE460359B (es)
SG (1) SG7089G (es)
SK (1) SK404391A3 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2043535A1 (es) * 1992-03-13 1993-12-16 Vita Invest Sa Procedimiento para la obtencion de la 1,2,3,9-tetrahidro-9-metil-3-(2-metil-1h-imidazol-1-il)metil*-4h-carbazol-4-ona.

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4695578A (en) * 1984-01-25 1987-09-22 Glaxo Group Limited 1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances
DE3680123D1 (en) * 1985-01-23 1991-08-14 Glaxo Group Ltd Tetrahydrocarbazolonderivate.
EP0385517B1 (en) * 1985-03-14 1993-04-14 BEECHAM GROUP plc Medicaments for the treatment of emesis
US5578628A (en) * 1985-06-25 1996-11-26 Glaxo Group Limited Medicaments for the treatment of nausea and vomiting
GB8516083D0 (en) * 1985-06-25 1985-07-31 Glaxo Group Ltd Heterocyclic compounds
GB8518743D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Heterocyclic compounds
US5204356A (en) * 1985-07-24 1993-04-20 Glaxo Group Limited Treatment of anxiety
GB8518745D0 (en) 1985-07-24 1985-08-29 Glaxo Group Ltd Heterocyclic compounds
GB8518742D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Process
GB8518658D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Medicaments
GB8518741D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Process
GB8617994D0 (en) * 1986-07-23 1986-08-28 Glaxo Group Ltd Heterocyclic compounds
HU895334D0 (en) * 1986-07-30 1990-01-28 Sandoz Ag Process for the preparation of nasal pharmaceutical compositions
AT396870B (de) * 1986-08-07 1993-12-27 Sandoz Ag Verfahren zur herstellung einer galenischen formulierung zur nasalen verabreichung von serotoninantagonisten
GB8623819D0 (en) * 1986-10-03 1986-11-05 Glaxo Group Ltd Heterocyclic compounds
WO1988003801A1 (en) * 1986-11-21 1988-06-02 Glaxo Group Limited Medicaments for treatment or prevention of withdrawal syndrome
GB8627909D0 (en) * 1986-11-21 1986-12-31 Glaxo Group Ltd Medicaments
GR871809B (en) * 1986-11-28 1988-03-07 Glaxo Group Ltd Process for the preparation of tricyclic ketones
US5202343A (en) * 1986-11-28 1993-04-13 Glaxo Group Limited Tricyclic ketones useful as HT3 -receptor antagonists
GB8628475D0 (en) * 1986-11-28 1987-01-07 Glaxo Group Ltd Medicaments
GB8812002D0 (en) * 1988-05-20 1988-06-22 Glaxo Group Ltd Chemical compounds
GB8630071D0 (en) * 1986-12-17 1987-01-28 Glaxo Group Ltd Medicaments
DE3788057T2 (de) * 1986-12-17 1994-03-03 Glaxo Group Ltd Verwendung von heterocyclischen Verbindungen zur Behandlung von Depressionen.
JP2608078B2 (ja) * 1986-12-17 1997-05-07 グラクソ、グループ、リミテッド 医 薬
GB8630079D0 (en) * 1986-12-17 1987-01-28 Glaxo Group Ltd Medicaments
US5200414A (en) * 1986-12-17 1993-04-06 Glaxo Group Limited Methods for the treatment of cognitive disorders
US5190954A (en) * 1986-12-17 1993-03-02 Glaxo Group Limited Methods for the treatment of cognitive disorders
DE3876006T2 (de) * 1987-04-14 1993-03-25 Glaxo Group Ltd Keton-derivate.
DE3874229T2 (de) * 1987-06-16 1993-03-25 British Tech Group Verwendung von dioxopiperidin-derivaten zur herstellung eines topischen praeparates als analgetika.
DE3822792C2 (de) * 1987-07-11 1997-11-27 Sandoz Ag Neue Verwendung von 5HT¶3¶-Antagonisten
GB8723157D0 (en) * 1987-10-02 1987-11-04 Beecham Group Plc Compounds
CA1304082C (en) * 1987-10-22 1992-06-23 Tetsuya Tahara Benzoxazine compounds and pharmaceutical use thereof
JPH01258673A (ja) * 1987-10-22 1989-10-16 Glaxo Group Ltd ケトン誘導体
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
GB8805269D0 (en) * 1988-03-04 1988-04-07 Glaxo Group Ltd Medicaments
US5116984A (en) * 1988-04-07 1992-05-26 Glaxo Group Limited Imidazole derivatives
DK185489A (da) * 1988-04-22 1989-10-23 Duphar Int Res Imidazolylmethyl-cycloalkanoebaaindoloner, deres fremstilling og anvendelse
EP0339959A3 (en) * 1988-04-27 1991-03-20 Glaxo Group Limited Lactam derivatives
GB8812636D0 (en) * 1988-05-27 1988-06-29 Glaxo Group Ltd Chemical compounds
AU627221B2 (en) * 1988-09-27 1992-08-20 Fujisawa Pharmaceutical Co., Ltd. Pyridoindole derivatives and processes for preparation thereof
US5290785A (en) * 1988-09-27 1994-03-01 Fujisawa Pharmaceutical Co., Ltd. Therapeutic agent for ischemic diseases
US5173493A (en) * 1988-09-27 1992-12-22 Fujisawa Pharmaceutical Company, Ltd. Pyridoindole derivatives and processes for preparation thereof
FR2639944B1 (fr) * 1988-12-06 1991-01-18 Adir Nouveaux derives de l'indole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP0377238A1 (en) * 1988-12-22 1990-07-11 Duphar International Research B.V New annelated indolo (3,2-c)-lactams
US5223625A (en) * 1988-12-22 1993-06-29 Duphar International Research B.V. Annelated indolo [3,2,-C]lactams
CA2004911A1 (en) * 1988-12-22 1990-06-22 Mitsuaki Ohta 4,5,6,7-tetrahydrobenzimidazole derivatives
EP0392663A1 (en) * 1989-03-13 1990-10-17 Ono Pharmaceutical Co., Ltd. Carboline derivative as a 5-HT3 receptor antagonist
KR920700034A (ko) * 1989-04-21 1992-02-19 예안 크라메르·한스 루돌프 하우스 5-ht₃수용체 길항제의 치료용도
GB8914804D0 (en) * 1989-06-28 1989-08-16 Glaxo Group Ltd Process
GB8917557D0 (en) * 1989-08-01 1989-09-13 Glaxo Group Ltd Medicaments
US5276050A (en) * 1989-08-01 1994-01-04 Glaxo Group Limited Medicaments
US5126343A (en) * 1989-09-11 1992-06-30 G. D. Searle & Co. N-azabicyclo [3.3.0]octane amides of aromatic acids
GB2236751B (en) 1989-10-14 1993-04-28 Wyeth John & Brother Ltd Heterocyclic compounds
GB8928837D0 (en) * 1989-12-21 1990-02-28 Beecham Group Plc Pharmaceuticals
US5187166A (en) * 1990-07-31 1993-02-16 Nisshin Flour Milling Co., Ltd. Azabicyclo derivatives and their use as antiemetics
CA2112487C (en) 1991-06-26 2003-04-15 James W. Young Method and compositions for treating emesis, nausea and other disorders using optically pure r(+) ondansetron
JPH05310732A (ja) * 1992-03-12 1993-11-22 Mitsubishi Kasei Corp シンノリン−３−カルボン酸誘導体
CA2106642C (en) * 1992-10-14 2005-08-16 Peter Bod Carbazolone derivatives and process for preparing the same
HU212934B (en) 1992-10-14 1996-12-30 Richter Gedeon Vegyeszet Process for producing novel alkoxalylated carbazolone derivatives
JPH08507514A (ja) * 1993-03-08 1996-08-13 藤沢薬品工業株式会社 脳血管性疾患を治療または予防するための薬物
GB9310756D0 (en) * 1993-05-25 1993-07-14 Glaxo Lab Sa Compositions
GB2325408B (en) * 1994-06-28 1999-01-27 Kenneth Francis Prendergast Chewing gum formulation comprising ondansetron
GB9423588D0 (en) * 1994-11-22 1995-01-11 Glaxo Wellcome Inc Compositions
AU702594B2 (en) * 1995-10-13 1999-02-25 Duphar International Research B.V. Process for the preparation of enantiomerically pure imidazolyl compounds
US6365743B1 (en) 1995-10-13 2002-04-02 Duphar International Research B.V. Process for the preparation of enantiomerically pure imidazolyl compounds
US5969137A (en) * 1996-09-19 1999-10-19 Virginia Commonwealth University Benzylamidine derivatives with serotonin receptor binding activity
WO2000051582A2 (en) 1999-03-01 2000-09-08 Sepracor Inc. Methods for treating apnea and apnea disorders using optically pure r(+)ondansetron
EP1207160A1 (en) * 2000-11-20 2002-05-22 Hanmi Pharm. Co., Ltd. Process for the preparation of 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)-methyl)-4H-carbazol-4-one
RU2207340C2 (ru) * 2001-08-10 2003-06-27 Ципла Лтд. Способ получения 1,2,3,9-тетрагидро-9-метил-3-[(2-метил-1н-имидазол-1-ил)метил]-4н-карбазол -4-она или его фармацевтически приемлемых солей
MXPA04010846A (es) 2002-04-29 2005-01-25 Biogal Gyogyszergyar Proceso para preparar 1, 2, 3, 9-tetrahidro -9- metil-3 -[(2-metil -1h-imidazol -1-il) metil]- 4h- carbazol -4- ona.
FI6164U1 (fi) * 2003-01-09 2004-03-15 Synthon Bv Ondansetronmuotoja
GB2398071B (en) * 2003-01-24 2006-06-07 Synthon Bv Process for making ondansetron and intermediate thereof
ES2238001B1 (es) * 2004-01-21 2006-11-01 Vita Cientifica, S.L. Nuevas formas polimorficas de ondansetron, procedimientos para su preparacion, composiciones farmaceuticas que los contienen y su uso como aantiemeticos.
US7288660B2 (en) 2004-05-07 2007-10-30 Taro Pharmaceutical Industries Limited Process for preparing ondansetron hydrochloride dihydrate having a defined particle size
WO2007004041A2 (en) * 2005-07-05 2007-01-11 Orchid Research Laboratories Limited New compounds and their pharmaceutical use
ES2664599T3 (es) 2009-05-20 2018-04-20 INSERM (Institut National de la Santé et de la Recherche Médicale) Antagonistas del receptor 5-HT3 de serotonina para uso en el tratamiento de trastornos vestibulares lesionales
EP2253316B1 (en) 2009-05-20 2013-08-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Serotonin 5-HT3 receptor antagonists for use in the treatment or prevention of an inner ear pathology with vestibular deficits
CN115611864A (zh) * 2022-11-01 2023-01-17 常州兰陵制药有限公司 一种昂丹司琼类化合物及其制备方法与应用
GB202301322D0 (en) 2023-01-30 2023-03-15 Therakind Ltd Antiemetic pharmaceutical compositions for nasal delivery

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3740404A (en) * 1969-05-09 1973-06-19 American Cyanamid Co Piperidinomethylenedihydrocarbazolones
US3634420A (en) * 1969-05-09 1972-01-11 American Cyanamid Co 3(morpholinomethyl)-2 3-dihydro-carbazol-4(1h)-ones
DE3680123D1 (en) * 1985-01-23 1991-08-14 Glaxo Group Ltd Tetrahydrocarbazolonderivate.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2043535A1 (es) * 1992-03-13 1993-12-16 Vita Invest Sa Procedimiento para la obtencion de la 1,2,3,9-tetrahidro-9-metil-3-(2-metil-1h-imidazol-1-il)metil*-4h-carbazol-4-ona.

Also Published As

Publication number Publication date
SK277923B6 (en) 1995-08-09
ES556101A0 (es) 1987-12-16
FI84349C (fi) 1991-11-25
BE901576A (fr) 1985-07-25
DK35785D0 (da) 1985-01-25
ES548430A0 (es) 1987-10-01
NL190373C (nl) 1994-02-01
ES8708224A1 (es) 1987-10-01
DE3502508A1 (de) 1985-08-14
LU88268I2 (es) 1994-02-03
PH22672A (en) 1988-11-14
PT79890B (en) 1987-02-03
AU3809785A (en) 1985-08-01
SG7089G (en) 1989-06-09
IT8547600A0 (it) 1985-01-25
HUT37784A (en) 1986-02-28
KR850005439A (ko) 1985-08-26
IE850187L (en) 1985-07-25
GB2153821B (en) 1988-01-20
NL940009I1 (nl) 1994-07-18
CA1252793A (en) 1989-04-18
SK404391A3 (en) 1995-08-09
NO164025B (no) 1990-05-14
IL74165A (en) 1988-11-15
ATA20485A (de) 1990-08-15
SE8500368L (sv) 1985-07-26
NO164025C (no) 1990-08-22
KR920003064B1 (ko) 1992-04-13
NL190373B (nl) 1993-09-01
LU85743A1 (fr) 1986-08-04
ES8609309A1 (es) 1986-07-16
DE19375046I2 (de) 2002-10-10
FR2561244A1 (fr) 1985-09-20
HU193592B (en) 1987-11-30
SE460359B (sv) 1989-10-02
IT1182150B (it) 1987-09-30
CZ404391A3 (en) 1993-04-14
GR850219B (es) 1985-05-23
NO1994022I1 (no) 1994-11-09
CY1479A (en) 1989-07-21
DK169521B1 (da) 1994-11-21
DK35785A (da) 1985-07-26
GB8501889D0 (en) 1985-02-27
PT79890A (en) 1985-02-01
ES539852A0 (es) 1986-07-16
FI850323A0 (fi) 1985-01-25
IE57809B1 (en) 1993-04-21
AU579132B2 (en) 1988-11-17
GB2153821A (en) 1985-08-29
FR2561244B1 (fr) 1988-03-04
NZ210940A (en) 1989-08-29
NO850300L (no) 1985-07-26
FI84349B (fi) 1991-08-15
NL8500202A (nl) 1985-08-16
NL940009I2 (nl) 1999-05-03
SE8500368D0 (sv) 1985-01-25
FI850323L (fi) 1985-07-26
DE3502508C2 (es) 1990-05-03
CH664152A5 (fr) 1988-02-15
AT392276B (de) 1991-02-25
HK33189A (en) 1989-04-28

Similar Documents

Publication Publication Date Title
ES8609309A1 (es) Un nuevo procedimiento para la preparacion de nuevos derivados. de carbazolona.
DE3851597D1 (de) Lactamderivate.
NO931695L (no) Nye 4-arylpiperaciner og 4-arylpiperidiner
ATE219077T1 (de) Endothelin antagoniste
SE8704746L (sv) Tricykliska ketoner
SI0773943T1 (en) Compounds useful as antiproliferative agents and garft inhibitors
DK0409435T3 (da) Heteroarylpiperaziner som antipsykotiske midler
DK0437030T3 (da) Anvendelse af 4-substituerede imidazoler til nedsættelse af det intraoculære tryk
PL309874A1 (en) Novel derivatives of pyrrolocarbasol, method of obtaining them and pharmaceutical composition containing such derivatives
ES2000935A6 (es) Un procedimiento para la preparacion de 3-imidazolin-metiltetrahidrocarbazolonas.
ES2000936A6 (es) Un procedimiento para la preparacion de 3-imidazolin -metiltetrahidrocarbazolonas.
NO972887L (no) Piperidineddiksyrederivater anvendelige som fibrinogen-antagonistmiddel
NZ216750A (en) Morpholino derivatives and fungicides
EP0356098A3 (en) Lactam derivatives
GB8701494D0 (en) Chemical compounds
DE3674546D1 (de) Amidderivate.
NO893523L (no) Antihypertensive 3-piperidinyl-indazolderivater.
DE69806640D1 (de) 17beta-aryl(arylmethyl)oxy(thio)alkyl-androstanderivative
FI892415A0 (fi) Tricykliska ketoner.
MY103831A (en) Lactam derivatives.
FI884049A7 (fi) Laktamderivat.

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20071029