ES8801580A1 - Un procedimiento para producir una solucion de glicosido de antraciclina exenta de pirogenos, esteril - Google Patents

Un procedimiento para producir una solucion de glicosido de antraciclina exenta de pirogenos, esteril

Info

Publication number
ES8801580A1
ES8801580A1 ES556291A ES556291A ES8801580A1 ES 8801580 A1 ES8801580 A1 ES 8801580A1 ES 556291 A ES556291 A ES 556291A ES 556291 A ES556291 A ES 556291A ES 8801580 A1 ES8801580 A1 ES 8801580A1
Authority
ES
Spain
Prior art keywords
polydioxyl
polyalcoholes
anthracicline
solution
alcohols
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES556291A
Other languages
English (en)
Other versions
ES556291A0 (es
Inventor
Gaetano Gatti
Diego Oldani
Giuseppe Bottoni
Carlo Confalonieri
Luciano Gambini
Ponti Roberto De
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10583216&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8801580(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Farmitalia Carlo Erba SRL filed Critical Farmitalia Carlo Erba SRL
Publication of ES8801580A1 publication Critical patent/ES8801580A1/es
Publication of ES556291A0 publication Critical patent/ES556291A0/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PRODUCIR UNA SOLUCION DE GLICOSIDO DE ANTRACICLINA EXENTA DE PIROGENOS. CONSISTE ESENCIALMENTE EN DISOLVER UNA SAL FISIOLOGICAMENTE ACEPTABLE DE UN GLICOSIDO DE ANTRACICLINA, CUYA SAL NO ESTA EN FORMA DE LIOFILIZADO, EN UN DISOLVENTE FISIOLOGICAMENTE ACEPTABLE. EL DISOLVENTE SE ELIGE ENTRE AGUA, SOLUCION SALINA FISIOLOGICA, AMIDAS ALIFATICAS, ALCOHOLES TALES COMO ETANOL O ALCOHOL BENCILICO, GLICOLES Y POLIALCOHOLES, ESTERES DE POLIALCOHOLES, ESTERES DE POLIALCOHOLES, DIOXOLANOS, DERIVADOS DE PIRROLIDONA, ALCOHOLES GRASOS POLIOXIETILENADOS, ESTERES DE ACIDOS GRASOS POLIOXIETILENADOS, POLISORBATOS Y DERIVADOS DE POLIOXIETILENO DE POLIPROPILENGLICOLES. ANTES DE PASAR LA SOLUCION A TRAVES DEL FILTRO, SE AGREGA A DICHA SOLUCION UN ACIDO O TAMPON FISIOLOGICAMENTE ACEPTABLE PARA AJUSTAR EL PH, DENTRO DEL INTERVALO DE 2,5 A 5,0 SEGUN SE DESEE.
ES556291A 1985-08-02 1986-06-19 Un procedimiento para producir una solucion de glicosido de antraciclina exenta de pirogenos, esteril Expired ES8801580A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858519452A GB8519452D0 (en) 1985-08-02 1985-08-02 Injectable solutions

Publications (2)

Publication Number Publication Date
ES8801580A1 true ES8801580A1 (es) 1988-02-16
ES556291A0 ES556291A0 (es) 1988-02-16

Family

ID=10583216

Family Applications (1)

Application Number Title Priority Date Filing Date
ES556291A Expired ES8801580A1 (es) 1985-08-02 1986-06-19 Un procedimiento para producir una solucion de glicosido de antraciclina exenta de pirogenos, esteril

Country Status (34)

Country Link
US (1) US4946831A (es)
JP (1) JPH0655667B2 (es)
KR (1) KR920001773B1 (es)
CN (1) CN1064531C (es)
AT (1) AT397463B (es)
BE (1) BE905202A (es)
BG (1) BG60425B2 (es)
CA (1) CA1291037C (es)
CH (2) CH668911C1 (es)
CS (1) CS277561B6 (es)
CY (1) CY1592A (es)
DE (1) DE3621844C2 (es)
DK (1) DK167557B1 (es)
ES (1) ES8801580A1 (es)
FI (1) FI86800C (es)
FR (1) FR2585569B1 (es)
GB (2) GB8519452D0 (es)
GR (1) GR861556B (es)
HK (1) HK93990A (es)
HU (1) HU196123B (es)
IE (1) IE59297B1 (es)
IL (1) IL79129A (es)
IT (1) IT1204906B (es)
NL (2) NL191507C (es)
NO (1) NO170913C (es)
NZ (1) NZ216604A (es)
PH (1) PH22332A (es)
PT (1) PT82865B (es)
RU (2) RU1837883C (es)
SE (1) SE466383C (es)
SG (1) SG80690G (es)
UA (1) UA29383C2 (es)
YU (1) YU44788B (es)
ZA (1) ZA864792B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5124317A (en) * 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.P.A. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US5124318A (en) * 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.R.L. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US5977082A (en) 1985-08-02 1999-11-02 Pharmacia & Upjohn Company Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
IT1226072B (it) * 1986-12-05 1990-12-10 Erba Farmitalia Soluzioni iniettabili pronte all'uso contenenti un glicoside antraciclinico antitumorale.
FI883337L (fi) * 1987-07-16 1989-01-17 Bristol Myers Co Icke-vattenloesningar av doxorubicinhydroklorin.
FI883338A7 (fi) * 1987-07-16 1989-01-17 Bristol Myers Squibb Co Doksorubisiinihydrokloridin vesiliuoksia
DE3801178A1 (de) * 1988-01-18 1989-07-27 Hoechst Ag Stabilisierte trockenzubereitung zytostatisch wirksamer anthracyclin-antibiotika und verfahren zu ihrer herstellung
EP0372889B1 (en) * 1988-12-05 1993-03-24 Bristol-Myers Squibb Company Doxorubicin solutions
FI895733A7 (fi) * 1988-12-05 1990-06-06 Bristol Myers Squibb Co Doksorubisiinin vesiliuoksia
GB9200247D0 (en) * 1992-01-07 1992-02-26 Erba Carlo Spa Pharmaceutical compositions containing polymer derivative-bound anthracycline glycosides and a method for their preparation
DE19544532C2 (de) * 1995-11-29 1997-12-11 Pharma Dynamics Gmbh Verfahren zum Herstellen eines Doxorubicin-Lyophilisats
EP0848009B1 (en) * 1996-12-16 2000-08-16 Pharmachemie B.V. A process for preparing epirubicin or acid addition salts thereof from daunorubicin
BR9713661A (pt) 1996-12-30 2000-10-24 Battelle Memorial Institute Formulação e método para o tratamento de neoplasmas por inalação
US20090253220A1 (en) * 2003-10-28 2009-10-08 Sukanta Banerjee Absorbing Biomolecules into Gel-Shell Beads
WO2006122309A2 (en) * 2005-05-11 2006-11-16 Sicor, Inc. Stable lyophilized anthracycline glycosides
EP2771034B1 (en) * 2011-10-25 2018-08-08 Nektar Therapeutics Topoisomerase-i and-ii inhibitors for use in the treatment of patients suffering from cancer
CN102614118B (zh) * 2012-03-15 2014-04-30 北京协和药厂 注射用盐酸表柔比星制剂的制备方法及制剂

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU33730B (en) * 1967-04-18 1978-02-28 Farmaceutici Italia Process for preparing a novel antibiotic substance and salts thereof
GB1457632A (en) * 1974-03-22 1976-12-08 Farmaceutici Italia Adriamycins
GB1500421A (en) * 1975-01-22 1978-02-08 Farmaceutici Italia Optically active anthracyclinones
US4039663A (en) * 1975-03-19 1977-08-02 Societa' Farmaceutici Italia S.P.A. Daunomycins, process for their uses and intermediates
FR2314726A1 (fr) * 1975-06-16 1977-01-14 Rhone Poulenc Ind Nouveaux derives du naphtagene, leur preparation et les compositions qui les contiennent
GB1511559A (en) * 1975-09-26 1978-05-24 Farmaceutici Italia Anthracycline glycosides
FR2397425A1 (fr) * 1977-07-11 1979-02-09 Rhone Poulenc Ind Nouveaux derives de la daunorubicine, leur preparation et les compositions qui les contiennent
DE2738656A1 (de) * 1977-08-26 1979-03-08 Microbial Chem Res Found Anthracyclinglycoside, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US4177264A (en) * 1977-10-17 1979-12-04 Sri International N-benzyl anthracyclines
GB2007645B (en) * 1977-10-17 1982-05-12 Stanford Res Inst Int Benzyl anthracyclines and pharmaceutical compositions containing them
FR2430425A1 (fr) * 1978-07-07 1980-02-01 Rhone Poulenc Ind Nouveaux derives de la daunorubicine, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2433027A1 (fr) * 1978-08-08 1980-03-07 Rhone Poulenc Ind Nouveau procede de preparation de derives de la doxorubicine
US4325947A (en) * 1981-05-12 1982-04-20 Farmitalia Carlo Erba S.P.A. 4-Demethoxy-4'-deoxydoxorubicin
US4438105A (en) * 1982-04-19 1984-03-20 Farmaitalia Carlo Erba S.P.A 4'-Iododerivatives of anthracycline glycosides
US4464529A (en) * 1982-07-20 1984-08-07 Sri International Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin
JPS6092212A (ja) * 1983-10-26 1985-05-23 Kyowa Hakko Kogyo Co Ltd ドキソルビシン塩の製剤
IT1226072B (it) * 1986-12-05 1990-12-10 Erba Farmitalia Soluzioni iniettabili pronte all'uso contenenti un glicoside antraciclinico antitumorale.

Also Published As

Publication number Publication date
HU196123B (en) 1988-10-28
NO862587D0 (no) 1986-06-26
IL79129A (en) 1992-03-29
NO170913C (no) 2003-10-10
JPH0655667B2 (ja) 1994-07-27
DK167557B1 (da) 1993-11-22
SE8602743L (sv) 1987-02-03
PT82865A (en) 1986-07-01
IT1204906B (it) 1989-03-10
DK306286A (da) 1987-02-03
US4946831A (en) 1990-08-07
PT82865B (pt) 1989-01-17
RU2110263C1 (ru) 1998-05-10
FI862629L (fi) 1987-02-03
ATA176886A (de) 1993-09-15
YU44788B (en) 1991-02-28
FI86800C (fi) 1999-10-28
RU1837883C (ru) 1993-08-30
CN86104283A (zh) 1987-01-28
AU5885886A (en) 1987-02-12
BG60425B2 (bg) 1995-03-31
CH690490C2 (de) 2000-09-29
GR861556B (en) 1986-10-17
KR920001773B1 (ko) 1992-03-02
NL191507C (nl) 2000-02-16
NL300011I1 (nl) 2000-10-02
NO170913B (no) 1992-09-21
DE3621844A1 (de) 1987-03-05
BE905202A (fr) 1987-02-02
CN1064531C (zh) 2001-04-18
NO862587L (no) 1987-02-03
NL8601698A (nl) 1987-03-02
FI862629A0 (fi) 1986-06-19
HK93990A (en) 1990-11-23
GB8519452D0 (en) 1985-09-11
IE861598L (en) 1987-02-02
SG80690G (en) 1990-11-23
PH22332A (en) 1988-07-29
IE59297B1 (en) 1994-02-09
NZ216604A (en) 1989-10-27
ES556291A0 (es) 1988-02-16
JPS6248629A (ja) 1987-03-03
GB2178311B (en) 1989-10-11
CH668911C1 (de) 2000-05-31
CH668911A5 (de) 1989-02-15
DK306286D0 (da) 1986-06-27
DE3621844C2 (de) 1994-02-17
HUT42326A (en) 1987-07-28
IT8620917A0 (it) 1986-06-26
FI86800B (fi) 1992-07-15
SE466383B (sv) 1992-02-10
NL191507B (nl) 1995-04-18
CA1291037C (en) 1991-10-22
SE8602743D0 (sv) 1986-06-19
CS277561B6 (en) 1993-03-17
ZA864792B (en) 1988-02-24
FR2585569B1 (fr) 1990-01-19
SE466383C (sv) 1996-02-19
CS470886A3 (en) 1992-11-18
AU598197B2 (en) 1990-06-21
GB8614800D0 (en) 1986-07-23
YU103586A (en) 1988-04-30
GB2178311A (en) 1987-02-11
CY1592A (en) 1992-04-03
IL79129A0 (en) 1986-09-30
FR2585569A1 (fr) 1987-02-06
KR870001828A (ko) 1987-03-28
AT397463B (de) 1994-04-25
UA29383C2 (uk) 2000-11-15

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