FI104255B - Menetelmä ihmisen seerumialbumiinin N-terminaalifragmentteja sisältävien fuusioproteiinien valmistamiseksi - Google Patents

Menetelmä ihmisen seerumialbumiinin N-terminaalifragmentteja sisältävien fuusioproteiinien valmistamiseksi Download PDF

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Publication number
FI104255B
FI104255B FI915073A FI915073A FI104255B FI 104255 B FI104255 B FI 104255B FI 915073 A FI915073 A FI 915073A FI 915073 A FI915073 A FI 915073A FI 104255 B FI104255 B FI 104255B
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Finland
Prior art keywords
hsa
variant
sequence
polypeptide
terminal
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FI915073A
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English (en)
Finnish (fi)
Swedish (sv)
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FI915073A0 (fi
FI104255B1 (fi
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David James Ballance
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Delta Biotechnology Ltd
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Application granted granted Critical
Publication of FI104255B1 publication Critical patent/FI104255B1/fi
Publication of FI104255B publication Critical patent/FI104255B/fi

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76Albumins
    • C07K14/765Serum albumin, e.g. HSA
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K19/00Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/31Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/50Fusion polypeptide containing protease site

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FI915073A 1989-04-29 1991-10-28 Menetelmä ihmisen seerumialbumiinin N-terminaalifragmentteja sisältävien fuusioproteiinien valmistamiseksi FI104255B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB898909916A GB8909916D0 (en) 1989-04-29 1989-04-29 Polypeptides
GB8909916 1989-04-29
PCT/GB1990/000650 WO1990013653A1 (fr) 1989-04-29 1990-04-26 Proteines de fusion contenant des fragments n-terminaux de l'albumine serale humaine (hsa)
GB9000650 1990-04-26

Publications (3)

Publication Number Publication Date
FI915073A0 FI915073A0 (fi) 1991-10-28
FI104255B1 FI104255B1 (fi) 1999-12-15
FI104255B true FI104255B (fi) 1999-12-15

Family

ID=10656000

Family Applications (1)

Application Number Title Priority Date Filing Date
FI915073A FI104255B (fi) 1989-04-29 1991-10-28 Menetelmä ihmisen seerumialbumiinin N-terminaalifragmentteja sisältävien fuusioproteiinien valmistamiseksi

Country Status (12)

Country Link
EP (1) EP0470165A1 (fr)
JP (1) JP2781459B2 (fr)
KR (1) KR100227167B1 (fr)
AU (1) AU630450B2 (fr)
CA (1) CA2015687C (fr)
FI (1) FI104255B (fr)
GB (2) GB8909916D0 (fr)
HU (1) HUT61049A (fr)
IE (1) IE67651B1 (fr)
IL (1) IL94243A (fr)
WO (1) WO1990013653A1 (fr)
ZA (1) ZA903237B (fr)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5610148A (en) * 1991-01-18 1997-03-11 University College London Macroscopically oriented cell adhesion protein for wound treatment
US5629287A (en) * 1991-01-18 1997-05-13 University College London Depot formulations
FR2686899B1 (fr) * 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
FR2686900B1 (fr) * 1992-01-31 1995-07-21 Rhone Poulenc Rorer Sa Nouveaux polypeptides ayant une activite de stimulation des colonies de granulocytes, leur preparation et compositions pharmaceutiques les contenant.
WO1994016085A2 (fr) * 1992-12-30 1994-07-21 Zymogenetics, Inc. Proteines hybrides presentant des activites de reticulation et de liaison tissulaire
GB9408466D0 (en) * 1994-04-27 1994-06-22 Univ Nottingham Cloning and functional expression of neurotoxins
US5543308A (en) * 1994-10-18 1996-08-06 New England Biolabs, Inc. Isolated DNA encoding the FSEI restriction endonuclease and related methods for producing the same
US7112320B1 (en) 1995-06-07 2006-09-26 Andre Beaulieu Solid wound healing formulations containing fibronectin
US5877149A (en) 1995-06-07 1999-03-02 Beaulieu; Andre Deepithelialized skin diffusion cell system
US5641483A (en) * 1995-06-07 1997-06-24 Beaulieu; Andre Wound healing formulations containing human plasma fibronectin
GB9526733D0 (en) 1995-12-30 1996-02-28 Delta Biotechnology Ltd Fusion proteins
US6423512B1 (en) 1996-07-26 2002-07-23 Novartis Ag Fusion polypeptides
AR008077A1 (es) * 1996-07-26 1999-12-09 Talarico Salinas Laura Beatriz Un polipeptido de fusion o una sal del mismo, su uso, un proceso para prepararlos, una composicion farmaceutica que los comprende, y un vector.
US5932693A (en) * 1996-12-10 1999-08-03 Washington University Antithrombotic peptides
AU2149899A (en) 1998-01-23 1999-08-09 Novo Nordisk A/S Process for making desired polypeptides in yeast
DE69933216T2 (de) 1998-06-15 2007-09-20 GTC Biotherapeutics, Inc., Framingham Erythropoietin-analog-menschliches serum-albumin fusionsprotein
EP2213743A1 (fr) * 2000-04-12 2010-08-04 Human Genome Sciences, Inc. Protéines de fusion d'albumine
US6946134B1 (en) 2000-04-12 2005-09-20 Human Genome Sciences, Inc. Albumin fusion proteins
US7507413B2 (en) 2001-04-12 2009-03-24 Human Genome Sciences, Inc. Albumin fusion proteins
KR100888915B1 (ko) 2001-08-15 2009-03-16 다카라 바이오 가부시키가이샤 항원특이적 세포상해성 t 세포 확대배양방법
WO2005003296A2 (fr) 2003-01-22 2005-01-13 Human Genome Sciences, Inc. Proteines hybrides d'albumine
AU2002364586A1 (en) 2001-12-21 2003-07-30 Delta Biotechnology Limited Albumin fusion proteins
JP4406566B2 (ja) 2002-03-25 2010-01-27 タカラバイオ株式会社 細胞傷害性リンパ球の製造方法
KR101331746B1 (ko) * 2003-08-22 2013-11-20 다카라 바이오 가부시키가이샤 세포 상해성 림프구의 제조 방법
US7850970B2 (en) 2003-08-26 2010-12-14 The Regents Of The University Of Colorado Inhibitors of serine protease activity and their use in methods and compositions for treatment of bacterial infections
GB0329681D0 (en) 2003-12-23 2004-01-28 Delta Biotechnology Ltd Gene expression technique
US9057061B2 (en) 2003-12-23 2015-06-16 Novozymes Biopharma Dk A/S Gene expression technique
WO2006067511A1 (fr) 2004-12-23 2006-06-29 Novozymes Delta Limited Technique d'expression genetique
GB0329722D0 (en) 2003-12-23 2004-01-28 Delta Biotechnology Ltd Modified plasmid and use thereof
EP1816201A1 (fr) 2006-02-06 2007-08-08 CSL Behring GmbH Facteur de coagulation VIIa modifié ayant une stabilité 'half-life' améliorée
WO2007146038A2 (fr) 2006-06-07 2007-12-21 Human Genome Sciences, Inc. Protéines de fusion d'albumine
EP2049560B1 (fr) 2006-07-13 2013-05-15 Novozymes Biopharma DK A/S Procédé de fabrication de particules d'un matériau protéique
KR101722961B1 (ko) 2009-02-11 2017-04-04 알부메딕스 에이/에스 알부민 변이체 및 접합체
EP2493921B1 (fr) 2009-10-30 2018-09-26 Albumedix Ltd Variants d'albumine
EP2556087A1 (fr) 2010-04-09 2013-02-13 Novozymes Biopharma DK A/S Dérivés et variants d'albumine
WO2012178102A2 (fr) * 2011-06-24 2012-12-27 The Regents Of The Unversity Of Colorado, A Body Corporate Compositions, procédés et utilisations de molécules de fusion de l'alpha-1 antitrypsine
EP2780364A2 (fr) 2011-11-18 2014-09-24 Eleven Biotherapeutics, Inc. Protéines ayant une demi-vie et d'autres propriétés améliorées
DK2825556T3 (en) 2012-03-16 2018-04-16 Albumedix As albumin Variants
MX2015005363A (es) 2012-11-08 2015-11-06 Novozymes Biopharma Dk As Variantes de albumina.
EP2968587A2 (fr) 2013-03-13 2016-01-20 Bristol-Myers Squibb Company Domaines d'échafaudage à base de fibronectine liés à une sérum albumine ou fragment se liant à celle-ci
JP7007261B2 (ja) 2015-08-20 2022-01-24 アルブミディクス リミティド アルブミン変異体及びコンジュゲート
WO2018089702A1 (fr) * 2016-11-10 2018-05-17 Keros Therapeutics, Inc. Polypeptides de fusion gdnf et leurs procédés d'utilisation
CA3117961A1 (fr) * 2018-10-29 2020-05-07 Spin Therapeutics, Llc Compositions et methodes pour les dereglements de l'alpha-1 antitrypsine
EP3711772A1 (fr) 2019-03-20 2020-09-23 Oslo Universitetssykehus HF Protéines recombinantes et protéines de fusion

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE459586B (sv) * 1987-09-14 1989-07-17 Mta Szegedi Biolog Koezponti Strukturgen som kodar foer autentiskt humant serum albumin och foerfarande foer dess framstaellning
GB8725529D0 (en) * 1987-10-30 1987-12-02 Delta Biotechnology Ltd Polypeptides

Also Published As

Publication number Publication date
GB8909916D0 (en) 1989-06-14
HU904413D0 (en) 1992-01-28
FI915073A0 (fi) 1991-10-28
HUT61049A (en) 1992-11-30
WO1990013653A1 (fr) 1990-11-15
IL94243A (en) 1995-10-31
KR920701451A (ko) 1992-08-11
EP0470165A1 (fr) 1992-02-12
GB2246783B (en) 1992-10-14
IE901554L (en) 1990-10-29
AU5564690A (en) 1990-11-29
IL94243A0 (en) 1991-01-31
FI104255B1 (fi) 1999-12-15
GB2246783A (en) 1992-02-12
JPH04506598A (ja) 1992-11-19
JP2781459B2 (ja) 1998-07-30
ZA903237B (en) 1991-03-27
AU630450B2 (en) 1992-10-29
CA2015687C (fr) 2000-08-29
KR100227167B1 (ko) 1999-10-15
GB9119043D0 (en) 1991-12-04
IE67651B1 (en) 1996-04-17
CA2015687A1 (fr) 1990-10-29

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