FI104363B - Förbättrande med additiv av inbördes farmakologiska verkningar av immunosuppressanter och interferon - Google Patents
Förbättrande med additiv av inbördes farmakologiska verkningar av immunosuppressanter och interferon Download PDFInfo
- Publication number
- FI104363B FI104363B FI972121A FI972121A FI104363B FI 104363 B FI104363 B FI 104363B FI 972121 A FI972121 A FI 972121A FI 972121 A FI972121 A FI 972121A FI 104363 B FI104363 B FI 104363B
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- cyclosporins
- interferons
- rapamycin
- peptides
- amino acid
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Zoology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Claims (5)
1. Vilken som heist blandning som innehäller immunsuppressorer cyklosporinema, FK506 eller rapamycin, och naturliga eller rekombinanta interferoner av typen I, in-terferonerna α, β,ω,τ,eller bioaktiva peptider motsvarande deras struktur, eller re- kombinantproteiner innehällande en eller flera sagda peptiders struktur, vilken blandning är avsedd att ömsesidigt oka sagda immunsuppressorernas och interfero-nernas aktivitet och/eller minska den terapeutiska dosen av dessa, varvid läkemed-lens icke-önskade biverkningar undviks vid transplantation av organ eller vävnader eller behandling av cancer, säsom lymfom,, leukemier, myelom, adenokarcinom; au-toimmuna och kroniska inflammationssjukdomar säsom reumatoid artrit, myasthenia gravis, lupus erythematosus, uveit, hyperproliferativa sjukdomar säsom psoriasis vulgaris. vid vilka FK506 eller rapamycin och interferoner används.
2. Blandningar enligt patentkrav 1 innehällande immunsuppressorer cyklosporinema, FK506 eller rapamycin tillsammans med en eller flera peptider innehällande ätminsto-ne 5 identiska aminosyrarester ur följande tabell. L TEKKY S P RRRRHRR QDND DD MLMN NL I S S S K K G H E A E A G I där varje aminosyra i den översta sekvensen kan ersättas med vilken som heist ne-danför den belägen aminosyrarest.
3. Läkemedelsblandningar enligt krav 1 innehällande immunsuppressorer cyklospo-rinerna..FK506 eller rapamycin och rekombinanta polypeptider innehällande en eller flera polypeptidsekvenser enligt krav 2.
4. Blandningar enligt kraven 1 och 2 innehällande immunsuppressorer syklospori-nerna, FK506 eller rapamycin och bioaktiva peptider eller interferoner, i vilka sagda aktiva peptider eller interferoner är genetiskt eller kemiskt modifierade, eller genetiskt, 17 104363 kemiskt eller fysikaliskt bundna till lägmolekulära eller högmolekulära ämnen med avsikt att röka peptidernas eller interferonernas stabilitet under fysiologiska förhäl-landen och/eller med avsikt att reglera peptidernas biotillgänlighet.
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI972121A FI104363B (sv) | 1997-05-19 | 1997-05-19 | Förbättrande med additiv av inbördes farmakologiska verkningar av immunosuppressanter och interferon |
| PCT/FI1998/000418 WO1998052594A1 (en) | 1997-05-19 | 1998-05-18 | Compositions for enhancing immunosuppressants' pharmaceutical activities |
| AU74352/98A AU7435298A (en) | 1997-05-19 | 1998-05-18 | Compositions for enhancing immunosuppressants' pharmaceutical acti vities |
| AT98921528T ATE234624T1 (de) | 1997-05-19 | 1998-05-18 | Zusammensetzungen zur verstärkung der pharmakologischen aktivität von immunosuppressiva |
| JP55000998A JP2001526675A (ja) | 1997-05-19 | 1998-05-18 | 免疫抑制剤の薬剤活性を向上させる組成物 |
| EP98921528A EP0981359B1 (en) | 1997-05-19 | 1998-05-18 | Compositions for enhancing immunosuppressants' pharmacological activities |
| DE69812347T DE69812347T9 (de) | 1997-05-19 | 1998-05-18 | Zusammensetzungen zur verstärkung der pharmakologischen aktivität von immunosuppressiva |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI972121A FI104363B (sv) | 1997-05-19 | 1997-05-19 | Förbättrande med additiv av inbördes farmakologiska verkningar av immunosuppressanter och interferon |
| FI972121 | 1997-05-19 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI972121A0 FI972121A0 (fi) | 1997-05-19 |
| FI972121L FI972121L (sv) | 1998-11-20 |
| FI104363B true FI104363B (sv) | 2000-01-14 |
Family
ID=8548873
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI972121A FI104363B (sv) | 1997-05-19 | 1997-05-19 | Förbättrande med additiv av inbördes farmakologiska verkningar av immunosuppressanter och interferon |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0981359B1 (sv) |
| JP (1) | JP2001526675A (sv) |
| AT (1) | ATE234624T1 (sv) |
| AU (1) | AU7435298A (sv) |
| DE (1) | DE69812347T9 (sv) |
| FI (1) | FI104363B (sv) |
| WO (1) | WO1998052594A1 (sv) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI20021774A7 (sv) * | 2002-10-07 | 2004-04-08 | Dmitry Aleksandrovich Dolgikh | Peptider och rekombinanta proteiner som imiterar antivirala och antiproliferativa aktiviteter av interferoner |
| TW200902047A (en) * | 2003-02-14 | 2009-01-16 | Combinatorx Inc | Methods and reagents for the treatment of diseases and disorders associated with increased levels of proinflammatory cytokines |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990009806A2 (en) * | 1989-03-02 | 1990-09-07 | University Of Florida | Composition for the inhibition of tumors and for the non-cytotoxic inhibition of replication of viruses |
| TW585911B (en) * | 1992-10-30 | 2004-05-01 | Univ Florida | Ovine and bovine interferon TAU, compositions thereof and pharmaceutical uses thereof |
| FR2706772A1 (en) * | 1993-06-22 | 1994-12-30 | Vacsyn Sa | Prevention and treatment of septic syndrome with an immunosuppressant, in particular cyclosporin. |
-
1997
- 1997-05-19 FI FI972121A patent/FI104363B/sv not_active IP Right Cessation
-
1998
- 1998-05-18 DE DE69812347T patent/DE69812347T9/de not_active Expired - Fee Related
- 1998-05-18 EP EP98921528A patent/EP0981359B1/en not_active Expired - Lifetime
- 1998-05-18 WO PCT/FI1998/000418 patent/WO1998052594A1/en not_active Ceased
- 1998-05-18 AT AT98921528T patent/ATE234624T1/de not_active IP Right Cessation
- 1998-05-18 JP JP55000998A patent/JP2001526675A/ja not_active Ceased
- 1998-05-18 AU AU74352/98A patent/AU7435298A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE69812347T9 (de) | 2004-09-23 |
| FI972121A0 (fi) | 1997-05-19 |
| FI972121L (sv) | 1998-11-20 |
| EP0981359B1 (en) | 2003-03-19 |
| WO1998052594A1 (en) | 1998-11-26 |
| JP2001526675A (ja) | 2001-12-18 |
| EP0981359A1 (en) | 2000-03-01 |
| DE69812347D1 (de) | 2003-04-24 |
| AU7435298A (en) | 1998-12-11 |
| DE69812347T2 (de) | 2004-02-19 |
| ATE234624T1 (de) | 2003-04-15 |
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| Date | Code | Title | Description |
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| MA | Patent expired |