FI120671B - Hiukkasten siirrossa yliäänikaasuvirtausta käyttävä neulaton injektioruisku - Google Patents

Hiukkasten siirrossa yliäänikaasuvirtausta käyttävä neulaton injektioruisku Download PDF

Info

Publication number: FI120671B
Authority: FI; Finland
Prior art keywords: syringe according; injection syringe; nozzle; gas; particles
Prior art date: 1993-04-08

Application number

FI954788A

Other languages

English (en)

Finnish (fi)

Swedish (sv)

Other versions

FI954788L (fi

FI954788A0 (fi

Inventor

Brian John Bellhouse

David Francis Sarphie

John Christopher Greenford

Original Assignee

Powderject Res Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-04-08

Filing date

1995-10-06

Publication date

2010-01-29

1993-04-08 Priority claimed from GB939307459A external-priority patent/GB9307459D0/en

1993-09-06 Priority claimed from GB939318407A external-priority patent/GB9318407D0/en

1993-10-15 Priority claimed from GB939321356A external-priority patent/GB9321356D0/en

1993-12-21 Priority claimed from GB939326069A external-priority patent/GB9326069D0/en

1995-10-06 Application filed by Powderject Res Ltd filed Critical Powderject Res Ltd

1995-10-06 Publication of FI954788L publication Critical patent/FI954788L/fi

1995-10-06 Publication of FI954788A0 publication Critical patent/FI954788A0/fi

2010-01-29 Application granted granted Critical

2010-01-29 Publication of FI120671B publication Critical patent/FI120671B/fi

Links

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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
- A61M5/3015—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules for injecting a dose of particles in form of powdered drug, e.g. mounted on a rupturable membrane and accelerated by a gaseous shock wave or supersonic gas flow
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
- C12M35/04—Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/89—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microinjection
- C12N15/895—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microinjection using biolistic methods
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/42—Reducing noise
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M5/2053—Media being expelled from injector by pressurised fluid or vacuum

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Wood Science & Technology (AREA)
Biotechnology (AREA)
Zoology (AREA)
Biomedical Technology (AREA)
General Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Biochemistry (AREA)
Sustainable Development (AREA)
Cell Biology (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Hematology (AREA)
Mechanical Engineering (AREA)
Heart & Thoracic Surgery (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Anesthesiology (AREA)
Vascular Medicine (AREA)
Molecular Biology (AREA)
Plant Pathology (AREA)
Medicinal Chemistry (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Obesity (AREA)
Infusion, Injection, And Reservoir Apparatuses (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

FI954788A 1993-04-08 1995-10-06 Hiukkasten siirrossa yliäänikaasuvirtausta käyttävä neulaton injektioruisku FI120671B (fi)

Applications Claiming Priority (10)

Application Number	Priority Date	Filing Date	Title
GB9307459		1993-04-08
GB939307459A GB9307459D0 (en)	1993-04-08	1993-04-08	Particle delivery apparatus
GB9318407		1993-09-06
GB939318407A GB9318407D0 (en)	1993-09-06	1993-09-06	Particle delivery apparatus
GB939321356A GB9321356D0 (en)	1993-10-15	1993-10-15	Particle delivery apparatus
GB9321356		1993-10-15
GB9326069		1993-12-21
GB939326069A GB9326069D0 (en)	1993-12-21	1993-12-21	Particle delivery apparatus
GB9400753		1994-04-08
PCT/GB1994/000753 WO1994024263A1 (fr)	1993-04-08	1994-04-08	Seringue sans aiguille permettant d'administrer des particules a l'aide d'un jet de gaz supersonique

Publications (3)

Publication Number	Publication Date
FI954788L FI954788L (fi)	1995-10-06
FI954788A0 FI954788A0 (fi)	1995-10-06
FI120671B true FI120671B (fi)	2010-01-29

Family

ID=27451010

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI954788A FI120671B (fi)	1993-04-08	1995-10-06	Hiukkasten siirrossa yliäänikaasuvirtausta käyttävä neulaton injektioruisku

Country Status (31)

Country	Link
US (5)	US5630796A (fr)
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Families Citing this family (336)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0679088B1 (fr)	1992-09-29	2002-07-10	Inhale Therapeutic Systems	Liberation dans les poumons de fragments actifs d'hormone parathyroidienne
TW360548B (en)	1993-04-08	1999-06-11	Powderject Res Ltd	Products for therapeutic use
DK0690732T3 (da) *	1994-01-21	2003-05-19	Powderject Vaccines Inc	Gasdrevet genindførselsinstrument
ATE416755T1 (de)	1994-03-07	2008-12-15	Nektar Therapeutics	Verfahren und zusammensetzung für die pulmonale darreichung von insulin
US5899880A (en) *	1994-04-08	1999-05-04	Powderject Research Limited	Needleless syringe using supersonic gas flow for particle delivery
US6290991B1 (en)	1994-12-02	2001-09-18	Quandrant Holdings Cambridge Limited	Solid dose delivery vehicle and methods of making same
ATE252373T1 (de) *	1994-08-04	2003-11-15	Elan Drug Delivery Ltd	Feste verabreichungssysteme zur gesteuerten freisetzung von darin eingebauten molekülen sowie verfahren zu deren herstellung
US6586006B2 (en)	1994-08-04	2003-07-01	Elan Drug Delivery Limited	Solid delivery systems for controlled release of molecules incorporated therein and methods of making same
GB9416663D0 (en) *	1994-08-17	1994-10-12	Oxford Bioscience Limited	Particle delivery
GB9426379D0 (en) *	1994-12-23	1995-03-01	Oxford Biosciences Ltd	Particle delivery
GB9502879D0 (en) *	1995-02-14	1995-04-05	Oxford Biosciences Ltd	Particle delivery
US5766901A (en) *	1995-05-04	1998-06-16	The Board Of Trustees Of The Leland Stanford Junior University	Apparatus and method for delivering a nucleotide into cell nuclei
US6474369B2 (en)	1995-05-26	2002-11-05	Penjet Corporation	Apparatus and method for delivering a lyophilized active with a needle-less injector
US7223739B1 (en)	1995-06-07	2007-05-29	Powderject Vaccines, Inc.	Adjuvanted genetic vaccines
DE69628095T2 (de) *	1995-08-02	2004-02-19	The Boc Group Plc, Windlesham	Gaszuführvorrichtung
GB9515846D0 (en) *	1995-08-02	1995-10-04	Boc Group Plc	Gas capsule
US6080130A (en) *	1998-11-14	2000-06-27	Castellano; Thomas P.	Gas power source for a needle-less injector
US6013050A (en) *	1995-10-20	2000-01-11	Powderject Research Limited	Particle delivery
GB9605690D0 (en) *	1996-03-19	1996-05-22	Oxford Biosciences Ltd	Particle delivery
CA2257141C (fr) *	1996-06-14	2006-11-28	Powderject Vaccines, Inc.	Module de conduite d'echantillons pour un appareil d'acceleration de particules
US6893664B1 (en)	1996-06-17	2005-05-17	Powderject Research Limited	Particle delivery techniques
KR100376646B1 (ko)	1996-07-01	2003-03-15	파마시아 에이비	전달 장치 및 이것의 작동 방법
CA2209406C (fr)	1996-07-24	2007-05-15	David W. Birch	Capsule de gaz et systdme de distribution de gaz
US6468782B1 (en)	1996-12-05	2002-10-22	Quadrant Healthcare (Uk) Limited	Methods of preserving prokaryotic cells and compositions obtained thereby
DE19701494A1 (de)	1997-01-17	1998-07-23	Boehringer Mannheim Gmbh	Transdermales Injektionssystem
US5947928A (en) *	1997-06-19	1999-09-07	Mile Creek Capital, Llc	Drug delivery system
EP0888791A1 (fr) *	1997-07-04	1999-01-07	PowderJect Research Limited	Seringue et capsule de medicament correspondante
EP0888790A1 (fr) *	1997-07-04	1999-01-07	PowderJect Research Limited	Appareil d'apport de particules medicamenteuses
US6074360A (en)	1997-07-21	2000-06-13	Boehringer Mannheim Gmbh	Electromagnetic transdermal injection device and methods related thereto
US6171276B1 (en)	1997-08-06	2001-01-09	Pharmacia & Upjohn Ab	Automated delivery device and method for its operation
US6309623B1 (en)	1997-09-29	2001-10-30	Inhale Therapeutic Systems, Inc.	Stabilized preparations for use in metered dose inhalers
US20060165606A1 (en)	1997-09-29	2006-07-27	Nektar Therapeutics	Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6565885B1 (en)	1997-09-29	2003-05-20	Inhale Therapeutic Systems, Inc.	Methods of spray drying pharmaceutical compositions
DE19820172A1 (de) *	1997-09-30	2005-01-27	Wolfgang Wagner	Einrichtung und einrichtungsbezogenes Verfahren zur Einbringung eines Diagnostikträgers oder einer Arznei unter die Haut eines Lebewesens
DK1032429T3 (da) *	1997-11-20	2003-09-22	Aventis Pasteur	Fremgangsmåde til DNA-afgivelse in vivo ved anvendelse af et nålefrit apparatur
CA2312900A1 (fr) *	1997-12-02	1999-06-10	Powderject Vaccines, Inc.	Administration transdermique de compositions particulaires de vaccins
CA2315256A1 (fr) *	1997-12-16	1999-06-24	Valentis, Inc.	Injection sans aiguille de molecules d'acide nucleique formules
GB9802506D0 (en)	1998-02-05	1998-04-01	Boc Group Plc	Needleless medical device
GB9802508D0 (en) *	1998-02-05	1998-04-01	Boc Group Plc	Needleless medical device
US6686339B1 (en)	1998-08-20	2004-02-03	Aventis Pasteur Limited	Nucleic acid molecules encoding inclusion membrane protein C of Chlamydia
US6693087B1 (en)	1998-08-20	2004-02-17	Aventis Pasteur Limited	Nucleic acid molecules encoding POMP91A protein of Chlamydia
WO2000011181A1 (fr)	1998-08-20	2000-03-02	Connaught Laboratories Limited	MOLECULES D'ACIDE NUCLEIQUE CODANT LA PROTEINE MEMBRANE D'INCLUSION C DE $i(CHLAMYDIA)
GB9818627D0 (en) *	1998-08-26	1998-10-21	Glaxo Group Ltd	Improvements in dva vaccination
GB9819272D0 (en) *	1998-09-03	1998-10-28	Andaris Ltd	Microparticles
WO2000014547A1 (fr) *	1998-09-04	2000-03-16	Powderject Research Limited	Immunodiagnostics au moyen de procedes d'administration de particules
JP2002524120A (ja) *	1998-09-04	2002-08-06	パウダージェクトリサーチリミテッド	粒子送達法を使用するモニタリング方法
US6602678B2 (en)	1998-09-04	2003-08-05	Powderject Research Limited	Non- or minimally invasive monitoring methods
USD434848S (en) *	1998-09-08	2000-12-05	Powderject Research Limited	Disposable injector
IL142276A0 (en) *	1998-10-01	2002-03-10	Powderject Res Ltd	Spray coated microparticles for use in needleless syringes
NZ511798A (en) *	1998-10-19	2004-01-30	Powderject Vaccines Inc	Minimal promoters comprising a promoter not linked to its native enhancer and such minimal promoters linked to an antigen
FR2785293B1 (fr)	1998-10-30	2002-07-05	Pasteur Merieux Serums Vacc	Acides nucleiques et polypeptides specifiques des souches pathogenes du genre neisseria
US6881723B1 (en)	1998-11-05	2005-04-19	Powderject Vaccines, Inc.	Nucleic acid constructs
US6264629B1 (en)	1998-11-18	2001-07-24	Bioject, Inc.	Single-use needle-less hypodermic jet injection apparatus and method
GB9825763D0 (en) *	1998-11-25	1999-01-20	Boc Group Plc	Filling containers with gas
EP1148902A1 (fr) *	1999-01-22	2001-10-31	PowderJect Research Limited	Methode favorisant l'administration transdermique sans aiguille de medicaments en poudre
US20070196490A1 (en) *	1999-01-22	2007-08-23	Powderject Research Limited	Method of enhancing needleless transdermal powered drug delivery
US6849060B1 (en) *	1999-01-29	2005-02-01	Powderject Research Limited	Particle delivery device
US6328714B1 (en)	1999-01-29	2001-12-11	Powderject Research Limited	Particle delivery device
KR100845769B1 (ko)	1999-02-03	2008-07-11	파우더젝트 리서치 리미티드	하이드로겔 입자 제제
AU3593200A (en)	1999-02-09	2000-08-29	Powderject Vaccines, Inc.	(mycobacterium tuberculosis), immunization
EP1158961A1 (fr) *	1999-03-08	2001-12-05	PowderJect Research Limited	Administration de formulations microparticulaires a l'aide d'une seringue sans aiguille pour la liberation lente de composes bioactifs
US20050214227A1 (en) *	1999-03-08	2005-09-29	Powderject Research Limited	Microparticle formulations for sustained-release of bioactive compounds
GB9905933D0 (en) *	1999-03-15	1999-05-05	Powderject Res Ltd	Neeedleless syringe
US7013617B2 (en)	1999-04-01	2006-03-21	The Boc Group, Plc	Method of filling and sealing
US7060048B1 (en) *	1999-04-16	2006-06-13	Powerject Research Limited	Needleless syringe
ATE251922T1 (de) *	1999-04-16	2003-11-15	Powderject Res Ltd	Nadellose spritze
JP2002542183A (ja)	1999-04-16	2002-12-10	ノボノルディスクアクティーゼルスカブ	成形可能な乾燥した医薬製剤
WO2000067825A1 (fr)	1999-05-07	2000-11-16	Microheart, Inc.	Appareil et procede d"administration d"agents therapeutiques et diagnostiques
US7147633B2 (en)	1999-06-02	2006-12-12	Boston Scientific Scimed, Inc.	Method and apparatus for treatment of atrial fibrillation
FR2796290B1 (fr) *	1999-07-16	2001-09-14	Cross Site Technologies	Seringue sans aiguille fonctionnant avec un generateur d'onde de choc a travers une paroi
FR2796288B1 (fr) *	1999-07-16	2001-08-10	Cross Site Technologies	Seringue sans aiguille avec injecteur a elements emboites
GB9916800D0 (en) *	1999-07-16	1999-09-22	Powderject Res Ltd	Needleless syringe
US20050027239A1 (en) *	1999-08-20	2005-02-03	Stout Richard R.	Intradermal injection system for injecting DNA-based injectables into humans
US6319224B1 (en) *	1999-08-20	2001-11-20	Bioject Medical Technologies Inc.	Intradermal injection system for injecting DNA-based injectables into humans
US6811783B1 (en)	1999-09-07	2004-11-02	Aventis Pasteur Limited	Immunogenic compositions for protection against chlamydial infection
DE19946059A1 (de) *	1999-09-25	2001-03-29	Roche Diagnostics Gmbh	System zur transdermalen Gewinnung von Körperflüssigkeit
GB9923306D0 (en)	1999-10-01	1999-12-08	Isis Innovation	Diagnostic and therapeutic epitope, and transgenic plant
ATE285806T1 (de)	1999-10-11	2005-01-15	Felton International Inc	Universelle antiinfektionsschutzvorrichtung für nadellose injektoren
CA2388337C (fr)	1999-10-22	2013-01-08	Aventis Pasteur Limited	Procede visant a provoquer et/ou stimuler une reponse immunitaire aux antigenes tumoraux
CN1182874C (zh) *	1999-10-29	2005-01-05	安增子摩祺株式会社	糖尿病性局部缺血疾病的基因治疗制剂
US20040234539A1 (en) *	1999-11-03	2004-11-25	Powderject Research Limited	Nucleic acid vaccine compositions having a mammalian cd80/cd86 gene promoter driving antigen expression
US7196066B1 (en)	1999-11-03	2007-03-27	Powderject Vaccines, Inc.	DNA-vaccines based on constructs derived from the genomes of human and animal pathogens
FR2800619B1 (fr) *	1999-11-05	2002-02-08	Cross Site Technologies	Seringue sans aiguille avec un moyen de poussee temporairement retenu
US20040109874A1 (en) *	1999-11-10	2004-06-10	Powderject Vaccines, Inc.	Induction of mucosal immunity by vaccination via the skin route
US6770054B1 (en)	1999-11-23	2004-08-03	Felton International, Inc.	Injector assembly with driving means and locking means
US7887506B1 (en)	1999-11-23	2011-02-15	Pulse Needlefree Systems, Inc.	Safety mechanism to prevent accidental patient injection and methods of same
US7029457B2 (en)	1999-11-23	2006-04-18	Felton International, Inc.	Jet injector with hand piece
FR2802103B1 (fr)	1999-12-08	2003-10-03	Poudres & Explosifs Ste Nale	Seringue sans aiguille fonctionnant avec entrainement du principe actif par effet tube a choc
FR2802102B1 (fr) *	1999-12-08	2002-07-12	Poudres & Explosifs Ste Nale	Seringue sans aiguille munie d'un tube d'ejection a section constante
FR2802820B1 (fr)	1999-12-27	2002-10-18	Poudres & Explosifs Ste Nale	Seringue sans aiguille fonctionnant par effet tube a choc, avec maintien prealable du principe actif sur le cote
FR2804329B1 (fr)	2000-02-02	2002-12-13	Poudres & Explosifs Ste Nale	Seringue sans aiguille munie d'un opercule contenant le principe actif
US6689092B2 (en)	2000-03-03	2004-02-10	Boehringer International Gmbh	Needle-less injector of miniature type
GB0006263D0 (en) *	2000-03-15	2000-05-03	Powderject Res Ltd	Apparatus and method for adjusting the characteristics of a needleless syringe
US6716190B1 (en) *	2000-04-19	2004-04-06	Scimed Life Systems, Inc.	Device and methods for the delivery and injection of therapeutic and diagnostic agents to a target site within a body
EP1792995A3 (fr)	2000-05-08	2007-06-13	Sanofi Pasteur Limited	Antigènes de chlamydia et fragments d'adn correspondants, et utilisations de ceux-ci
DK1282702T3 (da)	2000-05-10	2007-04-02	Sanofi Pasteur Ltd	Immunogene polypeptider, som er kodet af KAGE-minigener, og anvendelser deraf
US7871598B1 (en)	2000-05-10	2011-01-18	Novartis Ag	Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
AU2001268762A1 (en) *	2000-05-26	2001-12-03	George Vizirgianakis	Treatment and therapy apparatus
US6706032B2 (en) *	2000-06-08	2004-03-16	Massachusetts Institute Of Technology	Localized molecular and ionic transport to and from tissues
US20040213798A1 (en) *	2000-06-08	2004-10-28	Powderject Vaccines, Inc.	Spray-dried alum compositions
US7597692B2 (en) *	2000-06-08	2009-10-06	Massachusetts Institute Of Technology	Microscission processes and procedures
US20020120228A1 (en) *	2000-06-08	2002-08-29	Yuh-Fun Maa	Powder compositions
JP2003535119A (ja) *	2000-06-08	2003-11-25	パウダージェクトワクチンズ，インコーポレーテッド	粉末組成物
GB0018035D0 (en)	2000-07-21	2000-09-13	Powderject Res Ltd	Needleless syringe
WO2002019989A2 (fr) *	2000-09-08	2002-03-14	Powderject Research Limited	Formulation de particules d'alginate
US6824822B2 (en) *	2001-08-31	2004-11-30	Alkermes Controlled Therapeutics Inc. Ii	Residual solvent extraction method and microparticles produced thereby
US6981660B2 (en) *	2000-09-25	2006-01-03	Evit Labs	Shock wave aerosolization apparatus and method
US6742721B2 (en) *	2000-09-25	2004-06-01	Evit Laboratories	Shock wave aerosolization method and apparatus
GB0025147D0 (en)	2000-10-13	2000-11-29	Torsana Diabetes Diagnostics A	Optical sensor for in situ measurement of analytes
DK1379273T3 (da)	2000-11-27	2009-11-09	Powderject Vaccines Inc	Nukleinsyreadjuvanser
US7931614B2 (en) *	2000-11-30	2011-04-26	Valeritas, Inc.	Injection systems
GB0100756D0 (en) *	2001-01-11	2001-02-21	Powderject Res Ltd	Needleless syringe
US6644309B2 (en)	2001-01-12	2003-11-11	Becton, Dickinson And Company	Medicament respiratory delivery device and method
US6443152B1 (en)	2001-01-12	2002-09-03	Becton Dickinson And Company	Medicament respiratory delivery device
US6722364B2 (en) *	2001-01-12	2004-04-20	Becton, Dickinson And Company	Medicament inhalation delivery devices and methods for using the same
ES2191528B1 (es) *	2001-02-05	2004-06-16	Danone, S.A.	Dispositivo para la dosificacion de substancias liquidas.
GB0103348D0 (en) *	2001-02-10	2001-03-28	Medical Res Council	Delivery of biologically active agents
CA2440983A1 (fr)	2001-03-14	2002-09-26	Penjet Corporation	Systemes et procedes d'extraction de gaz dissous dans des liquides
JP2004529906A (ja)	2001-03-19	2004-09-30	イオマイコーポレイシヨン	経皮的免疫賦活
US20050192530A1 (en) *	2001-04-13	2005-09-01	Penjet Corporation	Method and apparatus for needle-less injection with a degassed fluid
US6613010B2 (en)	2001-04-13	2003-09-02	Penjet Corporation	Modular gas-pressured needle-less injector
US6755220B2 (en)	2001-04-27	2004-06-29	Penjet Corporation	Method and apparatus for filling or refilling a needle-less injector
DE10121255A1 (de) *	2001-04-30	2002-11-07	Switch Biotech Ag	Verwendung von alpha 1-Antichymotrypsin Polypeptiden oder diese kodierende Nukleinsäuren, oder einer ein ACT Polypeptid oder diese kodierende Nukleinsäure exprimierende Zelle, zur Behandlung und/oder Prävention von diabetes-assoziierten und/oder arteriellen schlecht heilenden Wunden und zur Identifizierung von pharmakologisch aktiven Substanzen
US6648850B2 (en) *	2001-06-08	2003-11-18	Bioject, Inc.	Durable needle-less jet injector apparatus and method
WO2002101412A2 (fr) *	2001-06-08	2002-12-19	Powderject Vaccines, Inc.	Compositions lyophilisees de pulverisation
CA2454412C (fr) *	2001-07-26	2010-03-30	Powderject Research Limited	Cassette de particules, procede et dispositif correspondant
GB0118266D0 (en) *	2001-07-26	2001-09-19	Powderject Res Ltd	Silencing device and method for needleless syringe
US8061006B2 (en)	2001-07-26	2011-11-22	Powderject Research Limited	Particle cassette, method and kit therefor
US20030019558A1 (en) *	2001-07-26	2003-01-30	Smith Edward R.	Particle cassette, method and kit therefor
DE10163325B4 (de) *	2001-07-30	2005-07-28	Tecpharma Licensing Ag	Verriegelungssperre für eine Verbindung von Gehäuseabschnitten eines Verabreichungsgeräts
DE10163326A1 (de) *	2001-07-30	2003-02-27	Disetronic Licensing Ag	Verabreichungsgerät mit Dosiervorrichtung
DE10163328B4 (de) *	2001-07-30	2005-08-11	Tecpharma Licensing Ag	Verabreichungsgerät mit Verdrehsicherung
DE10163327A1 (de) *	2001-07-30	2003-02-27	Disetronic Licensing Ag	Reservoirmodul mit Kolbenstange
DE20112501U1 (de) *	2001-07-30	2002-12-19	Disetronic Licensing Ag, Burgdorf	Verriegelungssperre für eine Verbindung von Gehäuseteilen eines Injektions- oder Infusionsgeräts
US20050191361A1 (en) *	2001-08-03	2005-09-01	Powederject Research Ltd.	Hydrogel particle formation
US6824526B2 (en)	2001-10-22	2004-11-30	Penjet Corporation	Engine and diffuser for use with a needle-less injector
AU2002346424A1 (en) *	2001-11-19	2003-06-10	Becton, Dickinson And Company	Pharmaceutical compositions in particulate form
US20050176084A1 (en)	2001-12-17	2005-08-11	Burkoth Terry L.	Non-or minimally invasive monitoring methods
US8454997B2 (en)	2001-12-18	2013-06-04	Novo Nordisk A/S	Solid dose micro implant
PT1458360E (pt)	2001-12-19	2011-07-13	Novartis Ag	Derivados de indole como agonistas do recetor s1p1
DE20209051U1 (de)	2001-12-21	2003-04-24	Disetronic Licensing Ag, Burgdorf	Injektionsgerät mit endpositionsblockiertem Dosiseinstellglied
US20030130614A1 (en) *	2002-01-09	2003-07-10	Johnson Lanny L.	Device for delivering liquid medications or nutrients and gases to local tissue
AU2003208305A1 (en)	2002-02-18	2003-09-04	Danfoss A/S	Device for administering of medication in fluid form
US20030163111A1 (en) *	2002-02-26	2003-08-28	Daellenbach Keith K.	End effector for needle-free injection system
CA2380671A1 (fr) *	2002-04-05	2003-10-05	Stephane Dufresne	Seringue sans aiguille pour l'injection sous-cutanee de gouttelettes medicamenteuses
EP1356820A1 (fr)	2002-04-26	2003-10-29	Institut National De La Sante Et De La Recherche Medicale (Inserm)	Vaccin ADN combiné avec un inducteur de l'apoptose de cellules tumorales
US7607436B2 (en) *	2002-05-06	2009-10-27	The Research Foundation Of State University Of New York	Methods, devices and formulations for targeted endobronchial therapy
US8245708B2 (en) *	2002-05-07	2012-08-21	The Research Foundation Of State University Of New York	Methods, devices and formulations for targeted endobronchial therapy
US7156823B2 (en) *	2002-06-04	2007-01-02	Bioject Inc.	High workload needle-free injection system
GB0212885D0 (en)	2002-06-05	2002-07-17	Isis Innovation	Therapeutic epitopes and uses thereof
JP4791730B2 (ja) *	2002-09-27	2011-10-12	パウダージェクトリサーチリミテッド	核酸コーティング粒子
US7458982B2 (en) *	2002-10-04	2008-12-02	Photokinetix, Inc.	Photokinetic delivery of biologically active substances using pulsed incoherent light
US7018356B2 (en)	2002-10-31	2006-03-28	Wise Roger R	Method and apparatus for adjusting the contents of a needle-less injector
DE60333435D1 (de) *	2003-02-03	2010-09-02	Bioware Technology Co Ltd	Genpistole mit Niederdruckgasbeschleunigung
DE10306716A1 (de) *	2003-02-17	2004-09-02	Lell, Peter, Dr.-Ing.	Vorrichtung zum Injizieren eines staub-oder pulverförmigen Stoffs in ein Gewebe eines Körpers
WO2004086938A2 (fr)	2003-03-25	2004-10-14	Herndon Terry O	Dispositif de perforation et procede servant a creer des conduits microscopiques
DE10316237A1 (de) *	2003-04-09	2004-11-04	Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.	Kanüle und Verfahren zur Einführung einer Kanüle in biologisches Material
FR2853836B1 (fr) *	2003-04-16	2006-01-06	Crossject	Seringue sans aiguille avec un injecteur-receptacle optimise
EP1620147A4 (fr) *	2003-04-21	2008-06-11	Corium Internat Inc	Appareil et methodes pour une distribution repetitive de medicaments par microjet
US20060184101A1 (en) *	2003-04-21	2006-08-17	Ravi Srinivasan	Microjet devices and methods for drug delivery
WO2004110533A1 (fr) *	2003-05-09	2004-12-23	Anges Mg, Inc.	Seringue sans aiguille contenant un agent therapeutique
CA2528545C (fr)	2003-06-13	2014-08-12	John Claude Savoir	Formulation pharmaceutique pour la contraception et le traitement hormonal substitutif
HU225252B1 (hu) *	2003-08-21	2006-08-28	S Istvan Lindmayer	Tû nélküli injekciós berendezés
US7131961B2 (en) *	2003-10-01	2006-11-07	Bioject, Inc.	Needle-free injection system
PT1685251E (pt) *	2003-10-10	2014-04-15	Powderject Vaccines Inc	Construções de ácido nucleico
US7442182B2 (en) *	2003-10-24	2008-10-28	Bioject, Inc.	Spring powered needle-free injection system
US8147426B2 (en) *	2003-12-31	2012-04-03	Nipro Diagnostics, Inc.	Integrated diagnostic test system
US20050209554A1 (en) *	2004-03-19	2005-09-22	Sergio Landau	Needle-free single-use cartridge and injection system
US20050209553A1 (en) *	2004-03-19	2005-09-22	Sergio Landau	Needle-free single-use cartridge and injection system
JP4210231B2 (ja) *	2004-03-25	2009-01-14	株式会社資生堂	皮膚のシワを改善する美容方法及びシワ改善具
US20060110423A1 (en) *	2004-04-15	2006-05-25	Wright Steven G	Polymer-based sustained release device
US7456254B2 (en)	2004-04-15	2008-11-25	Alkermes, Inc.	Polymer-based sustained release device
US8617613B2 (en)	2004-04-15	2013-12-31	Alkermes Pharma Ireland Limited	Polymer-based sustained release device
AU2005237287B2 (en)	2004-04-28	2011-08-11	Btg International Limited	Epitopes related to coeliac disease
US10105437B2 (en)	2004-04-28	2018-10-23	Btg International Limited	Epitopes related to coeliac disease
CA2566199C (fr)	2004-05-12	2013-10-22	Baxter International Inc.	Administration de microspheres d'oligonucleotides antisens pour induire une tolerance de cellules dendritiques pour le traitement du diabete de type 1 insulino-dependant
EP1765294B1 (fr)	2004-05-12	2008-09-24	Baxter International Inc.	Production et administration de microsphères d'acide nucléique
US7717874B2 (en) *	2004-05-28	2010-05-18	Bioject, Inc.	Needle-free injection system
US20060038044A1 (en) *	2004-08-23	2006-02-23	Van Steenkiste Thomas H	Replaceable throat insert for a kinetic spray nozzle
US20060089593A1 (en) *	2004-10-26	2006-04-27	Sergio Landau	Needle-free injection device for individual users
US20060089594A1 (en) *	2004-10-26	2006-04-27	Sergio Landau	Needle-free injection device
BRPI0515759B8 (pt)	2004-12-01	2021-06-22	Acushot Inc	dispositivo de injeção sem agulha e kit para utilização do mesmo
US20090023671A1 (en) *	2005-01-06	2009-01-22	Brashears Sarah J	Rnai Agents for Maintenance of Stem Cells
GB0507997D0 (en) *	2005-02-01	2005-05-25	Powderject Vaccines Inc	Nucleic acid constructs
US11246913B2 (en)	2005-02-03	2022-02-15	Intarcia Therapeutics, Inc.	Suspension formulation comprising an insulinotropic peptide
EP1858542A4 (fr) *	2005-02-24	2009-08-19	Joslin Diabetes Center Inc	Compositions et methodes permettant de traiter la permeabilite vasculaire
DE102005015801A1 (de)	2005-04-06	2006-10-19	Schreiner Group Gmbh & Co. Kg	Folienbasierter Schutzmechanismus
US20070118093A1 (en) *	2005-06-20	2007-05-24	Von Muhlen Marcio G	High-speed jet devices for drug delivery
US8591457B2 (en) *	2005-08-10	2013-11-26	Alza Corporation	Method for making a needle-free jet injection drug delivery device
EP2258441A3 (fr)	2005-09-02	2011-09-21	Intercell USA, Inc.	Dispositifs d administration transcutanée de vaccins et d'administration transdermique de médicaments
EP1954336A4 (fr) *	2005-11-29	2012-05-09	Biodesign Res & Dev	Pulverisation electrostatique percutanee hypodermique (hypopulverisation electrostatique)
JP4402648B2 (ja)	2005-12-16	2010-01-20	オリンパス株式会社	被検体内導入装置
US20080161755A1 (en) *	2006-01-27	2008-07-03	Bioject Inc.	Needle-free injection device and priming system
RU2008129182A (ru)	2006-01-31	2010-03-10	Ново Нордиск А/С (DK)	Изолирующий компонент для предварительно заполненного медицинского струйного инъектора
GB0611443D0 (en)	2006-06-09	2006-07-19	Powderject Res Ltd	Improvements in, or relating to, particle cassettes
EP2359808B1 (fr)	2006-08-09	2013-05-22	Intarcia Therapeutics, Inc	Système de libération osmotique avec ensemble de piston
CN100446823C (zh) *	2006-09-19	2008-12-31	宁波新芝生物科技股份有限公司	一种无创介入治疗系统
US7547293B2 (en) *	2006-10-06	2009-06-16	Bioject, Inc.	Triggering mechanism for needle-free injector
AU2007306936B2 (en)	2006-10-12	2014-02-06	The University Of Queensland	Compositions and methods for modulating immune responses
FR2908753B1 (fr) *	2006-11-16	2011-11-11	Becton Dickinson France	Dispositif pour delivrer automatiquement des doses successives de produit
DE102007004855B4 (de)	2007-01-31	2014-03-27	Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.	Vorrichtung und Verfahren zur Deposition von biologischem Material in einem Zielsubstrat
JP2008199905A (ja) *	2007-02-16	2008-09-04	Snow Brand Milk Prod Co Ltd	乳酸菌生残性向上剤
US7744563B2 (en) *	2007-02-23	2010-06-29	Bioject, Inc.	Needle-free injection devices and drug delivery systems therefor
WO2008133908A2 (fr)	2007-04-23	2008-11-06	Intarcia Therapeutics, Inc.	Formulations en suspension de peptides insulinotropes et leurs utilisations
GB0708758D0 (en)	2007-05-04	2007-06-13	Powderject Res Ltd	Particle cassettes and process thereof
EP2154969B1 (fr)	2007-05-16	2015-11-18	The Brigham and Women's Hospital, Inc.	Traitement des synucléinopathies
GB2449312B (en)	2007-05-18	2012-03-14	Malvern Instr Ltd	Method and apparatus for dispersing a sample of particulate material
JP4780034B2 (ja) *	2007-05-18	2011-09-28	株式会社島津製作所	針無注射器
EP2612867A1 (fr)	2007-11-01	2013-07-10	Perseid Therapeutics LLC	Acides nucléiques et polypeptides immunosuppresseurs
CA2726861C (fr)	2008-02-13	2014-05-27	Intarcia Therapeutics, Inc.	Dispositifs, formulations et methodes d'administration de plusieurs agents benefiques
US20110117673A1 (en) *	2008-07-16	2011-05-19	Johnson Brandon T	Methods and systems to collect and prepare samples, to implement, initiate and perform assays, and to control and manage fluid flow
US8021873B2 (en)	2008-07-16	2011-09-20	Boston Microfluidics	Portable, point-of-care, user-initiated fluidic assay methods and systems
JP2012503206A (ja)	2008-09-22	2012-02-02	オレゴンヘルスアンドサイエンスユニバーシティ	Ｍｙｃｏｂａｃｔｅｒｉｕｍｔｕｂｅｒｃｕｌｏｓｉｓ感染を検出するための方法
DE102008048981A1 (de) *	2008-09-25	2010-04-15	Lts Lohmann Therapie-Systeme Ag	Injektor und Zwei-Kammer-System mit sterilen Komponenten
US9207242B2 (en)	2008-10-09	2015-12-08	The University Of Hong Kong	Cadherin-17 as diagnostic marker and therapeutic target for liver cancer
US9072688B2 (en) *	2008-10-31	2015-07-07	The Invention Science Fund I, Llc	Compositions and methods for therapeutic delivery with frozen particles
US9060934B2 (en)	2008-10-31	2015-06-23	The Invention Science Fund I, Llc	Compositions and methods for surface abrasion with frozen particles
US8788211B2 (en) *	2008-10-31	2014-07-22	The Invention Science Fund I, Llc	Method and system for comparing tissue ablation or abrasion data to data related to administration of a frozen particle composition
US20100111857A1 (en)	2008-10-31	2010-05-06	Boyden Edward S	Compositions and methods for surface abrasion with frozen particles
US8725420B2 (en)	2008-10-31	2014-05-13	The Invention Science Fund I, Llc	Compositions and methods for surface abrasion with frozen particles
US9050070B2 (en)	2008-10-31	2015-06-09	The Invention Science Fund I, Llc	Compositions and methods for surface abrasion with frozen particles
US9060926B2 (en) *	2008-10-31	2015-06-23	The Invention Science Fund I, Llc	Compositions and methods for therapeutic delivery with frozen particles
US8721583B2 (en)	2008-10-31	2014-05-13	The Invention Science Fund I, Llc	Compositions and methods for surface abrasion with frozen particles
US9072799B2 (en)	2008-10-31	2015-07-07	The Invention Science Fund I, Llc	Compositions and methods for surface abrasion with frozen particles
US8762067B2 (en) *	2008-10-31	2014-06-24	The Invention Science Fund I, Llc	Methods and systems for ablation or abrasion with frozen particles and comparing tissue surface ablation or abrasion data to clinical outcome data
US20100111834A1 (en) *	2008-10-31	2010-05-06	Searete Llc, A Limited Liability Corporation Of The State Of Delaware	Compositions and methods for therapeutic delivery with frozen particles
US8793075B2 (en)	2008-10-31	2014-07-29	The Invention Science Fund I, Llc	Compositions and methods for therapeutic delivery with frozen particles
US8409376B2 (en)	2008-10-31	2013-04-02	The Invention Science Fund I, Llc	Compositions and methods for surface abrasion with frozen particles
US8545855B2 (en) *	2008-10-31	2013-10-01	The Invention Science Fund I, Llc	Compositions and methods for surface abrasion with frozen particles
US9050317B2 (en)	2008-10-31	2015-06-09	The Invention Science Fund I, Llc	Compositions and methods for therapeutic delivery with frozen particles
US8551505B2 (en) *	2008-10-31	2013-10-08	The Invention Science Fund I, Llc	Compositions and methods for therapeutic delivery with frozen particles
US8731841B2 (en) *	2008-10-31	2014-05-20	The Invention Science Fund I, Llc	Compositions and methods for therapeutic delivery with frozen particles
US8731840B2 (en)	2008-10-31	2014-05-20	The Invention Science Fund I, Llc	Compositions and methods for therapeutic delivery with frozen particles
US8232093B2 (en)	2009-02-05	2012-07-31	Indian Institute Of Science	Apparatus and method for genetically transforming cells
JP2012519575A (ja) *	2009-03-09	2012-08-30	パーデュー・リサーチ・ファウンデーション	物質を迅速に混合し患者に送達するための小型装置
WO2010105096A2 (fr)	2009-03-11	2010-09-16	University Of Massachusetts	Modulation de la réplication du cytomégalovirus humain par micro-arn 132 (mir132), micro-arn 145 (mir145) et micro-arn 212 (mir212)
CA2756070C (fr)	2009-03-27	2019-08-20	Institut National De La Sante Et De La Recherche Medicale (Inserm)	Acide nucleique antisens de resistance a la kanamycine pour le traitement d'un cancer
EP2756845B1 (fr)	2009-04-03	2017-03-15	Dicerna Pharmaceuticals, Inc.	Procédés et compositions pour l'inhibition spécifique de KRAS par de l'ARN double brin asymétrique
GB0906215D0 (en)	2009-04-09	2009-05-20	Lalvani Ajit	Diagnostic test
TWI439302B (zh)	2009-07-14	2014-06-01	Chien Lung Chen	傳輸裝置
CN101987218B (zh) *	2009-07-30	2013-07-10	陈建龙	传输装置
RU2547990C2 (ru)	2009-09-28	2015-04-10	Интарсия Терапьютикс, Инк.	Быстрое достижение и/или прекращение существенной стабильной доставки лекарственного средства
EP2482837A4 (fr)	2009-09-29	2013-05-22	Joslin Diabetes Center Inc	Utilisation d'inhibiteurs de la protéine kinase c delta (pkcd) pour traiter le diabète, l'obésité et la stéatose hépatique
CN102713629B (zh)	2009-11-20	2016-02-24	俄勒冈健康科学大学	用于检测结核分枝杆菌感染的方法
WO2011063349A1 (fr) *	2009-11-20	2011-05-26	Talima Therapeutics, Inc.	Dispositifs d'implantation de compositions et procédés et nécessaires à cet effet
CN102178990B (zh) *	2010-01-08	2013-10-09	江苏丞宇米特医疗科技有限公司	无针注射器
EP2533814A2 (fr)	2010-02-11	2012-12-19	Ablynx N.V.	Administration de domaines variables d'immunoglobuline et de produits de construction de ceux-ci
CN101797411B (zh) *	2010-03-18	2011-12-07	傅雅芬	一种气压式无针注射器动力头
WO2011123762A1 (fr) *	2010-04-01	2011-10-06	Glucago Llc	Procédé et dispositif pour mélanger des substances
US8895017B2 (en)	2010-06-07	2014-11-25	Pfizer Inc.	HER-2 peptides and vaccines
JP5934710B2 (ja) *	2010-10-07	2016-06-15	マサチューセッツインスティテュートオブテクノロジー	ローレンツ力直動型の無針式ジェット注射システムを用いた固形物および／または流体の供給
US9211378B2 (en)	2010-10-22	2015-12-15	Cequr Sa	Methods and systems for dosing a medicament
US11311610B2 (en)	2010-11-01	2022-04-26	University Of Technology Sydney	Immune-modulating agents and uses therefor
GB201021881D0 (en) *	2010-12-23	2011-02-02	Profibrix Bv	Powder delivery device
US20120208755A1 (en)	2011-02-16	2012-08-16	Intarcia Therapeutics, Inc.	Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
US8388569B2 (en)	2011-04-19	2013-03-05	Xerox Corporation	Delivery devices and methods with collimated gas stream and particle source
US8486002B2 (en)	2011-04-19	2013-07-16	Palo Alto Research Center Incorporated	Drug delivery devices and methods with collimated gas stream and release-activatable tape
US8430839B2 (en)	2011-04-19	2013-04-30	Palo Alto Research Center Incorporated	Drug delivery devices and methods with collimated gas stream and drug reservoir
ES2490915B1 (es)	2011-09-12	2015-09-17	Laboratorios Del Dr. Esteve, S.A.	Método para monitorizar las respuestas de linfocitos T citotóxicos (LTC) mediante una reacción de hipersensibilidad de tipo retardado usando epítopos de LTC definidos
AU2012340086A1 (en)	2011-11-17	2014-05-29	The Regents Of The University Of California	Therapeutic RNA switches compositions and methods of use
US20140058319A1 (en) *	2012-03-20	2014-02-27	Glucago Llc	Compact Device For Rapidly Mixing and Delivering Substances To a Patient
US8992469B2 (en)	2012-06-26	2015-03-31	Glucago Llc	Reconstitution device
USD728161S1 (en)	2012-08-08	2015-04-28	Young Nails Inc.	Nail care device
US9125995B2 (en)	2012-12-05	2015-09-08	Glucago Llc	Reconstitution devices
US9345487B2 (en)	2013-02-05	2016-05-24	Path Scientific, Llc	Precision bone drill and method of use
EP2851086A1 (fr)	2013-09-20	2015-03-25	Sanofi	Serpines Procédés de régénération thérapeutique et de fonction des cellules beta
EP2769732A1 (fr)	2013-02-22	2014-08-27	Sanofi	Serpines Procédés de régénération thérapeutique et de fonction des cellules beta
WO2014128257A1 (fr)	2013-02-22	2014-08-28	Sanofi	Serpines : procédés de régénération de cellules bêta thérapeutique et fonction
CN105377355A (zh)	2013-03-14	2016-03-02	拇趾公司	治疗甲单元的感染、疾病或病症的方法
US9808579B2 (en) *	2013-05-08	2017-11-07	Elwha Llc	Needleless injector systems, and related methods and components
WO2014183216A1 (fr) *	2013-05-17	2014-11-20	Socpra Sciences Et Génie S.E.C.	Seringue sans aiguille et procédé d'administration de particules thérapeutiques
TWI689323B (zh) *	2014-02-26	2020-04-01	普樂藥業有限公司	顆粒輸送裝置及方法
WO2015171964A1 (fr) *	2014-05-07	2015-11-12	Sri International	Dispositif d'injection sans aiguille
US9737251B2 (en)	2014-05-28	2017-08-22	Verily Life Sciences Llc	Needle-free blood draw
EP2959931A1 (fr) *	2014-06-24	2015-12-30	LTS LOHMANN Therapie-Systeme AG	Dispositif d'injection sans aiguille
US9889085B1 (en)	2014-09-30	2018-02-13	Intarcia Therapeutics, Inc.	Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
EP3011988A1 (fr) *	2014-10-22	2016-04-27	LTS LOHMANN Therapie-Systeme AG	Dispositif d'injection sans aiguille doté d'un gel et d'une membrane
WO2016077382A2 (fr)	2014-11-11	2016-05-19	Massachusetts Eye & Ear Infirmary	Vaccins contre la conjonctivite
DK3569711T3 (da)	2014-12-15	2021-02-22	Dicerna Pharmaceuticals Inc	Ligandmodificerede dobbeltstrengede nukleinsyrer
US10078207B2 (en)	2015-03-18	2018-09-18	Endochoice, Inc.	Systems and methods for image magnification using relative movement between an image sensor and a lens assembly
PL3277814T3 (pl)	2015-04-03	2020-11-30	University Of Massachusetts	Związki oligonukleotydowe ukierunkowane na mrna huntingtyny
RS62672B1 (sr)	2015-04-03	2021-12-31	Univ Massachusetts	Oligonukleotidna jedinjenja za tretman preeklampsije i drugih angiogenskih poremećaja
US20160319278A1 (en)	2015-04-03	2016-11-03	University Of Massachusetts	Fully stabilized asymmetric sirna
CA2985235A1 (fr)	2015-05-07	2016-11-10	Shire Human Genetic Therapies, Inc.	Therapie genique par glucocerebrosidase pour la maladie de parkinson
RU2730996C2 (ru)	2015-06-03	2020-08-26	Интарсия Терапьютикс, Инк.	Системы установки и извлечения имплантата
US20160361240A1 (en)	2015-06-11	2016-12-15	The Procter & Gamble Company	Apparatus and methods for modifying keratinous surfaces
EP4512819A3 (fr)	2015-08-12	2025-08-06	The General Hospital Corporation	Compositions et procédés qui favorisent la réponse à l'hypoxie ou à l'hypoxie pour le traitement et la prévention d'un dysfonctionnement mitochondrial et de troubles du stress oxydatif
WO2017030973A1 (fr)	2015-08-14	2017-02-23	University Of Massachusetts	Conjugués bioactifs pour l'administration d'oligonucléotides
EP3356415B1 (fr)	2015-09-29	2024-05-01	Amgen Inc.	Inhibiteurs de l'asgr pour réduire les taux de cholestérol
AU2016355178B9 (en)	2015-11-19	2019-05-30	Massachusetts Institute Of Technology	Lymphocyte antigen CD5-like (CD5L)-interleukin 12B (p40) heterodimers in immunity
JP7088843B2 (ja) *	2015-12-28	2022-06-21	イノビオファーマシューティカルズ，インコーポレイティド	皮内ジェット注射式電気穿孔装置
US10478503B2 (en)	2016-01-31	2019-11-19	University Of Massachusetts	Branched oligonucleotides
KR102574993B1 (ko)	2016-05-16	2023-09-06	인타르시아 세라퓨틱스 인코포레이티드	글루카곤-수용체 선택적 폴리펩티드 및 이들의 이용 방법
USD840030S1 (en)	2016-06-02	2019-02-05	Intarcia Therapeutics, Inc.	Implant placement guide
USD860451S1 (en)	2016-06-02	2019-09-17	Intarcia Therapeutics, Inc.	Implant removal tool
CA3033368A1 (fr)	2016-08-12	2018-02-15	University Of Massachusetts	Oligonucleotides conjugues
US10443055B2 (en)	2016-12-22	2019-10-15	Beth Israel Deaconess Medical Center	Compounds that target MYC microRNA responsive elements for the treatment of MYC-associated cancer
JP7286542B2 (ja)	2017-01-03	2023-06-05	インターシアセラピューティクス，インコーポレイティド	Ｇｌｐ－１受容体アゴニストの持続的投与及び薬物の同時投与を含む方法
JP7406793B2 (ja)	2017-06-23	2023-12-28	ユニバーシティーオブマサチューセッツ	２テイル自己デリバリー型ｓｉＲＮＡおよび関連方法
EP3664834A1 (fr)	2017-08-11	2020-06-17	Dana Farber Cancer Institute, Inc.	Utilisation d'un agent de toxine botulique pour le traitement de troubles à plasmocytes
US11821003B2 (en)	2017-08-14	2023-11-21	Sanford Burnham Prebys Medical Discovery Institute	Cardiogenic mesoderm formation regulators
US11413288B2 (en)	2017-11-01	2022-08-16	Dana-Farber Cancer Institute, Inc.	Methods of treating cancers
CN108553748A (zh) *	2018-05-11	2018-09-21	江秀秀	B超监视下体内多种细胞植入仪
JP7665509B2 (ja)	2018-05-11	2025-04-21	アルファアノマリックエスアエス	７’－５’－アルファ－アノマー二環式糖ヌクレオシドを含むオリゴヌクレオチドコンジュゲート
USD933219S1 (en)	2018-07-13	2021-10-12	Intarcia Therapeutics, Inc.	Implant removal tool and assembly
WO2020033899A1 (fr)	2018-08-10	2020-02-13	University Of Massachusetts	Oligonucléotides modifiés ciblant des snp
US11279930B2 (en)	2018-08-23	2022-03-22	University Of Massachusetts	O-methyl rich fully stabilized oligonucleotides
CA3110661A1 (fr)	2018-08-29	2020-03-05	University Of Massachusetts	Inhibition de proteines kinases pour traiter la maladie de friedreich
KR102199724B1 (ko) *	2018-10-05	2021-01-07	주식회사 피테크	무바늘 무통 주사 장치
AU2019397033B2 (en)	2018-12-12	2023-06-29	Kite Pharma, Inc.	Chimeric antigen receptors and CAR-T cells and methods of use
US12544403B2 (en)	2019-01-10	2026-02-10	The General Hospital Corporation	Methods to treat mitochondrial-associated dysfunctions or diseases
CN113614232A (zh)	2019-01-18	2021-11-05	马萨诸塞大学	动态药代动力学修饰锚
US12377046B1 (en)	2019-04-24	2025-08-05	Wellomics LLC	Delivery system matrices
US11629347B2 (en)	2019-05-06	2023-04-18	University Of Massachusetts	Anti-C9ORF72 oligonucleotides and related methods
IT201900007060A1 (it)	2019-05-21	2020-11-21	St Superiore Di Sanita	Cellule tumorali ingegnerizzate e loro usi
CN110038212A (zh) *	2019-05-29	2019-07-23	徐小棠	一种呼吸内科护理给药多用装置
EP3976764B1 (fr)	2019-05-30	2025-07-23	Viti, Inc.	Méthodes de détection d'une infection par mycobacterium tuberculosis
CN110180051B (zh) *	2019-07-13	2021-04-02	河南省中医院（河南中医药大学第二附属医院）	产科护理用清洗装置
IT201900012540A1 (it)	2019-07-22	2021-01-22	Humanitas Mirasole Spa	Inibitori di CHI3L1 e loro usi
KR20220047989A (ko)	2019-08-09	2022-04-19	유니버시티 오브 매사추세츠	Snp를 표적화하는 화학적으로 변형된 올리고뉴클레오타이드
US12365894B2 (en)	2019-09-16	2025-07-22	University Of Massachusetts	Branched lipid conjugates of siRNA for specific tissue delivery
EP4081302A4 (fr)	2019-12-23	2025-01-29	University Of Massachusetts	Oligonucléotides servant à la modulation d'expression de gène propre à un tissu
EP4103715A4 (fr)	2020-02-14	2024-03-06	University Of Massachusetts	Oligonucléotides ciblant la frataxine et procédés associés
EP4110913A4 (fr)	2020-02-28	2024-07-24	University of Massachusetts	Oligonucléotides pour la modulation de prnp
US20230220085A1 (en)	2020-02-28	2023-07-13	The Brigham And Women’S Hospital, Inc.	Selective modulation of transforming growth factor beta superfamily signaling via multi-specific antibodies
JP7837560B2 (ja)	2020-03-26	2026-03-31	ユニバーシティーオブマサチューセッツ	安定性の向上を有する修飾オリゴヌクレオチドの合成
WO2021195510A1 (fr)	2020-03-27	2021-09-30	University Of Massachusetts	Modulation de c9orf72 à partir d'arnsi à double action
CN115916218A (zh)	2020-04-23	2023-04-04	斯格本斯眼科研究所有限公司	用于治疗纤维化的方法和材料
CN111569194A (zh) *	2020-05-06	2020-08-25	许昌学院	一种糖尿病用胰岛素注射器
WO2021242883A1 (fr)	2020-05-26	2021-12-02	University Of Massachusetts	Oligonucléotides synthétiques ayant des régions de séquences et de modifications de groupe
GB202105455D0 (en)	2021-04-16	2021-06-02	Ucl Business Ltd	Composition
CN117677699A (zh)	2021-06-23	2024-03-08	马萨诸塞大学	用于治疗先兆子痫和其他血管生成病症的优化抗flt1寡核苷酸化合物
CN118139663A (zh) *	2021-06-24	2024-06-04	阿维塔斯有限公司	喷雾喷嘴
GB202112471D0 (en)	2021-09-01	2021-10-13	King S College London	Microna systems
WO2024052732A1 (fr) *	2022-09-07	2024-03-14	Particle Vaccine Canada Ltd.	Procédé et appareil d'administration épidermique de médicaments en poudre
WO2024200831A1 (fr)	2023-03-30	2024-10-03	Vivadju	Acide nucléique pvax14 en combinaison avec l'acide all-trans rétinoïque (atra) et un inhibiteur de point de contrôle pour le traitement du cancer

Family Cites Families (77)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE170094C (fr)
US1300654A (en)	1919-01-30	1919-04-15	William H Rose	Dry-spraying machine.
US2151418A (en)	1937-05-12	1939-03-21	Scott & Bowne	Powder applicator
US2147158A (en)	1937-09-28	1939-02-14	Goldenthal Philip	Powder insufflator
US2307986A (en)	1940-02-15	1943-01-12	Bolte	Insufflator
US2605763A (en) *	1948-01-31	1952-08-05	Becton Dickinson Co	Injection device
GB677523A (en) *	1948-04-13	1952-08-20	Becton Dickinson Co	Discharge structure for hypodermic injection device
US2478715A (en)	1948-07-14	1949-08-09	Vilbiss Co	Powder blower
US2594093A (en)	1949-02-05	1952-04-22	Armour & Co	Powder container
US2470298A (en)	1949-02-07	1949-05-17	Abbott Lab	Powdered medicine dispenser
DE1047385B (de) *	1952-03-08	1958-12-24	Armour & Co	Puderzerstaeuber mit einem auswechselbaren Puderbehaelter
US3216562A (en)	1963-06-13	1965-11-09	Driaire Inc	Easy-open capsule
IL28680A (en)	1966-12-16	1971-12-29	American Home Prod	Stabilized aqueous suspensions of benzathine penicillin
US3674028A (en) *	1969-06-04	1972-07-04	Ims Ltd	Multi-mix
US3736933A (en) *	1970-12-02	1973-06-05	B Szabo	Burstable seamed hypodermic applicators
US3788315A (en) *	1971-04-20	1974-01-29	S Laurens	Disposable cutaneous transjector
US3914573A (en) *	1971-05-17	1975-10-21	Geotel Inc	Coating heat softened particles by projection in a plasma stream of Mach 1 to Mach 3 velocity
US3853125A (en) *	1971-10-05	1974-12-10	W Clark	Disposable needleless injector
US3782380A (en) *	1973-01-04	1974-01-01	Gaast H V D	Medicament injecting device
US4069819A (en) *	1973-04-13	1978-01-24	Societa Farmaceutici S.P.A.	Inhalation device
US3946732A (en) *	1973-08-08	1976-03-30	Ampoules, Inc.	Two-chamber mixing syringe
US3967761A (en)	1974-04-08	1976-07-06	Southwest Research Institute	System for injecting particulate material into the combustion chamber of a repetitive combustion coating apparatus
US3952741A (en) *	1975-01-09	1976-04-27	Bend Research Inc.	Controlled release delivery system by an osmotic bursting mechanism
US3982605A (en) *	1975-05-05	1976-09-28	The Carborundum Company	Nozzle noise silencer
FR2360031A1 (fr) *	1976-07-27	1978-02-24	Klein Max	Dispositif distributeur silencieux d'un jet de gaz et application au diagnostic medical
JPS602489B2 (ja) *	1977-05-02	1985-01-22	株式会社豊田中央研究所	低騒音用圧力流体放出装置
EP0006724B1 (fr) *	1978-06-16	1982-12-01	Phares Pharmaceutical Research N.V.	Compositions pharmaceutiques contenant de l'urée
US4226236A (en) *	1979-05-07	1980-10-07	Abbott Laboratories	Prefilled, vented two-compartment syringe
US4778054A (en)	1982-10-08	1988-10-18	Glaxo Group Limited	Pack for administering medicaments to patients
GB2129691B (en)	1982-10-08	1987-08-05	Glaxo Group Ltd	Devices for administering medicaments to patients
US4515586A (en)	1982-11-30	1985-05-07	Abbott Laboratories	Powder syringe mixing system
US4652261A (en) *	1984-06-22	1987-03-24	Regents Of The University Of Minnesota	Drug-injection animal capture collar
US4945050A (en) *	1984-11-13	1990-07-31	Cornell Research Foundation, Inc.	Method for transporting substances into living cells and tissues and apparatus therefor
US5100792A (en) *	1984-11-13	1992-03-31	Cornell Research Foundation, Inc.	Method for transporting substances into living cells and tissues
US5036006A (en) *	1984-11-13	1991-07-30	Cornell Research Foundation, Inc.	Method for transporting substances into living cells and tissues and apparatus therefor
US4596556A (en) *	1985-03-25	1986-06-24	Bioject, Inc.	Hypodermic injection apparatus
AU591152B2 (en)	1985-07-30	1989-11-30	Glaxo Group Limited	Devices for administering medicaments to patients
DK179286D0 (da)	1986-04-18	1986-04-18	Nordisk Gentofte	Insulinpraeparat
USRE33801E (en)	1986-05-09	1992-01-21	Dentsply Research & Development Corp.	Mixing and discharge capsule
US5120657A (en)	1986-12-05	1992-06-09	Agracetus, Inc.	Apparatus for genetic transformation
IN170021B (fr) *	1987-05-26	1992-01-25	Deita Freyberg Gmbh
GB2206794A (en) *	1987-07-14	1989-01-18	Richard Kiteley Power	Syringe
US4853229A (en) *	1987-10-26	1989-08-01	Alza Corporation	Method for adminstering tiny pills
US5179022A (en) *	1988-02-29	1993-01-12	E. I. Du Pont De Nemours & Co.	Biolistic apparatus for delivering substances into cells and tissues in a non-lethal manner
BR8801952A (pt) *	1988-04-22	1989-11-14	Sergio Landau	Capsula descartavel,nao re-utilizavel,contendo dose individual de vacina a ser injetada hipodermicamente,sem agulha,com aparelho injetor a pressao
FR2638359A1 (fr) *	1988-11-03	1990-05-04	Tino Dalto	Guide de seringue avec reglage de la profondeur de penetration de l'aiguille dans la peau
HU210142B (en) *	1989-04-20	1995-02-28	Sinai School Medicine	Process for producing hepatospecific insulin-analogues and pharmaceutical compositions containing them
US5239991A (en)	1989-06-21	1993-08-31	Fisons Plc	Disposable powder medicament inhalation device with peel-off cover
HU200699B (en) *	1989-07-05	1990-08-28	Gyula Erdelyi	Neddleless hypodermic syringe particularly for blinds and poor-sighted persons
GB8918879D0 (en) *	1989-08-18	1989-09-27	Danbiosyst Uk	Pharmaceutical compositions
US5064413A (en) *	1989-11-09	1991-11-12	Bioject, Inc.	Needleless hypodermic injection device
WO1991013595A1 (fr) *	1990-03-15	1991-09-19	The United States Of America, As Represented By The Secretary Of The Army	Traitement chimiotherapeutique d'infections bacteriennes a l'aide d'un antibiotique encapsule dans une matrice polymere biodegradable
US5062830A (en) *	1990-04-04	1991-11-05	Derata Corporation	Dry disposable nozzle assembly for medical jet injector
GB9011588D0 (en) *	1990-05-24	1990-07-11	Wellcome Found	Prostaglandin analogues for use in medicine
US5204253A (en) *	1990-05-29	1993-04-20	E. I. Du Pont De Nemours And Company	Method and apparatus for introducing biological substances into living cells
US5149655A (en) *	1990-06-21	1992-09-22	Agracetus, Inc.	Apparatus for genetic transformation
IT1243344B (it)	1990-07-16	1994-06-10	Promo Pack Sa	Inalatore plurimonodose per medicamenti in polvere
GB9016789D0 (en) *	1990-07-31	1990-09-12	Lilly Industries Ltd	Medicament administering devices
WO1992004439A1 (fr) *	1990-08-30	1992-03-19	Brian John Bellhouse	Appareil balistique
US5042472A (en)	1990-10-15	1991-08-27	Merck & Co., Inc.	Powder inhaler device
US5046618A (en)	1990-11-19	1991-09-10	R. P. Scherer Corporation	Child-resistant blister pack
US5188615A (en)	1990-11-19	1993-02-23	Habley Medical Technology Corp.	Mixing vial
DK288590D0 (da) *	1990-12-04	1990-12-04	Michael Morris	Blandings/oploesnings-sproejte til cytostatika for medicinsk behandling af cancer patienter
GB9027422D0 (en) *	1990-12-18	1991-02-06	Scras	Osmotically driven infusion device
GB9100950D0 (en) *	1991-01-16	1991-02-27	Dunne Miller Weston Ltd	Metered dose atomising and delivery device
US5360410A (en)	1991-01-16	1994-11-01	Senetek Plc	Safety syringe for mixing two-component medicaments
US5492112A (en)	1991-05-20	1996-02-20	Dura Pharmaceuticals, Inc.	Dry powder inhaler
US5102388A (en)	1991-07-15	1992-04-07	Richmond John E	Sequential delivery syringe
GB9118204D0 (en) *	1991-08-23	1991-10-09	Weston Terence E	Needle-less injector
EP0558879B1 (fr)	1992-03-04	1997-05-14	Astra Aktiebolag	Inhalateur jetable
JP3166123B2 (ja)	1992-09-09	2001-05-14	フアイソンズ・ピーエルシー	薬剤パッケージング
TW360548B (en) *	1993-04-08	1999-06-11	Powderject Res Ltd	Products for therapeutic use
US5349947A (en) *	1993-07-15	1994-09-27	Newhouse Michael T	Dry powder inhaler and process that explosively discharges a dose of powder and gas from a soft plastic pillow
US5415162A (en)	1994-01-18	1995-05-16	Glaxo Inc.	Multi-dose dry powder inhalation device
DK0690732T3 (da)	1994-01-21	2003-05-19	Powderject Vaccines Inc	Gasdrevet genindførselsinstrument
US5483954A (en)	1994-06-10	1996-01-16	Mecikalski; Mark B.	Inhaler and medicated package
JP3320261B2 (ja) *	1995-06-01	2002-09-03	株式会社ユニシアジェックス	吸入式投薬器

1994
- 1994-04-07 TW TW086113385A patent/TW360548B/zh not_active IP Right Cessation
- 1994-04-07 TW TW083103025A patent/TW404844B/zh not_active IP Right Cessation
- 1994-04-08 SK SK1248-95A patent/SK283855B6/sk not_active IP Right Cessation
- 1994-04-08 EP EP96109925A patent/EP0734737B1/fr not_active Expired - Lifetime
- 1994-04-08 NZ NZ263606A patent/NZ263606A/xx not_active IP Right Cessation
- 1994-04-08 ES ES94912038T patent/ES2098131T3/es not_active Expired - Lifetime
- 1994-04-08 UA UA95094347A patent/UA41360C2/uk unknown
- 1994-04-08 CZ CZ19952608A patent/CZ290476B6/cs not_active IP Right Cessation
- 1994-04-08 DE DE69434760T patent/DE69434760T2/de not_active Expired - Lifetime
- 1994-04-08 WO PCT/GB1994/000753 patent/WO1994024263A1/fr not_active Ceased
- 1994-04-08 ES ES96109925T patent/ES2267106T3/es not_active Expired - Lifetime
- 1994-04-08 HU HU9802714A patent/HU228144B1/hu unknown
- 1994-04-08 AT AT96109925T patent/ATE329006T1/de active
- 1994-04-08 DK DK96109925T patent/DK0734737T3/da active
- 1994-04-08 PT PT96109925T patent/PT734737E/pt unknown
- 1994-04-08 AU AU64351/94A patent/AU674742B2/en not_active Expired
- 1994-04-08 TJ TJ95000044A patent/TJ248B/xx unknown
- 1994-04-08 JP JP52287794A patent/JP3260375B2/ja not_active Expired - Lifetime
- 1994-04-08 KR KR1019950704408A patent/KR100332147B1/ko not_active Expired - Lifetime
- 1994-04-08 SI SI9430481T patent/SI0734737T1/sl unknown
- 1994-04-08 RU RU95119388A patent/RU2129021C1/ru active
- 1994-04-08 DE DE69401651T patent/DE69401651T2/de not_active Expired - Lifetime
- 1994-04-08 DK DK94912038.0T patent/DK0693119T3/da active
- 1994-04-08 CN CN94191721A patent/CN1109102C/zh not_active Expired - Lifetime
- 1994-04-08 BR BR9406455A patent/BR9406455A/pt not_active Application Discontinuation
- 1994-04-08 RO RO95-01747A patent/RO118569B1/ro unknown
- 1994-04-08 EP EP99113305A patent/EP0951917A3/fr not_active Withdrawn
- 1994-04-08 SI SI9430045T patent/SI0693119T1/xx unknown
- 1994-04-08 CA CA002159452A patent/CA2159452C/fr not_active Expired - Lifetime
- 1994-04-08 HU HU9502911A patent/HU216308B/hu unknown
- 1994-04-08 EP EP05028150.0A patent/EP1637173B1/fr not_active Expired - Lifetime
- 1994-04-08 EP EP94912038A patent/EP0693119B1/fr not_active Expired - Lifetime
- 1994-04-08 PL PL94311005A patent/PL174974B1/pl unknown
- 1994-04-08 AT AT94912038T patent/ATE148497T1/de active
1995
- 1995-06-07 US US08/474,367 patent/US5630796A/en not_active Expired - Lifetime
- 1995-10-04 BG BG100047A patent/BG61993B1/bg unknown
- 1995-10-06 OA OA60719A patent/OA10234A/en unknown
- 1995-10-06 NO NO19953994A patent/NO314570B1/no not_active IP Right Cessation
- 1995-10-06 FI FI954788A patent/FI120671B/fi not_active IP Right Cessation
1997
- 1997-03-17 LV LVP-97-41A patent/LV11833B/en unknown
- 1997-03-26 GR GR970400626T patent/GR3022939T3/el unknown
- 1997-12-05 US US08/986,124 patent/US6168587B1/en not_active Expired - Lifetime
1999
- 1999-02-10 US US09/248,743 patent/US6881200B2/en not_active Expired - Lifetime
2001
- 2001-09-27 JP JP2001298589A patent/JP2002179557A/ja active Pending
2002
- 2002-12-09 US US10/314,336 patent/US7618394B2/en not_active Expired - Fee Related
2006
- 2006-07-12 JP JP2006192130A patent/JP4430636B2/ja not_active Expired - Lifetime
- 2006-11-06 JP JP2006301005A patent/JP2007051160A/ja active Pending
2007
- 2007-08-31 US US11/848,432 patent/US7942846B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
LV11833A (lv)	1997-08-20
US7618394B2 (en)	2009-11-17
AU6435194A (en)	1994-11-08
NZ263606A (en)	1997-08-22
KR100332147B1 (ko)	2002-08-14
PL311005A1 (en)	1996-01-22
HU228144B1 (en)	2012-12-28
US6168587B1 (en)	2001-01-02
DE69401651D1 (de)	1997-03-13
DE69434760D1 (de)	2006-07-20
DK0734737T3 (da)	2006-10-09
AU674742B2 (en)	1997-01-09
ES2098131T3 (es)	1997-04-16
NO314570B1 (no)	2003-04-14
SI0693119T1 (en)	1997-10-31
CA2159452C (fr)	2000-11-21
CA2159452A1 (fr)	1994-10-27
EP1637173B1 (fr)	2014-05-21
JPH08509604A (ja)	1996-10-15
US20050165348A1 (en)	2005-07-28
DE69434760T2 (de)	2007-05-16
EP0734737A3 (fr)	1997-03-12
DE69401651T2 (de)	1997-05-15
DK0693119T3 (da)	1997-07-28
SI0734737T1 (sl)	2006-10-31
HUT73516A (en)	1996-08-28
ES2267106T3 (es)	2007-03-01
HU9802714D0 (en)	1999-01-28
EP1637173A2 (fr)	2006-03-22
EP0693119B1 (fr)	1997-01-29
JP3260375B2 (ja)	2002-02-25
WO1994024263A1 (fr)	1994-10-27
EP1637173A3 (fr)	2007-09-05
EP0734737B1 (fr)	2006-06-07
SK283855B6 (sk)	2004-03-02
HK1000351A1 (en)	1998-03-06
TW404844B (en)	2000-09-11
BG61993B1 (bg)	1998-12-30
BR9406455A (pt)	1996-01-02
BG100047A (bg)	1996-04-30
SK124895A3 (en)	1997-01-08
US6881200B2 (en)	2005-04-19
UA41360C2 (uk)	2001-09-17
NO953994D0 (no)	1995-10-06
JP2002179557A (ja)	2002-06-26
CN1109102C (zh)	2003-05-21
US5630796A (en)	1997-05-20
US20020188248A1 (en)	2002-12-12
JP4430636B2 (ja)	2010-03-10
HU216308B (hu)	1999-06-28
JP2006320737A (ja)	2006-11-30
EP0951917A3 (fr)	2000-01-05
LV11833B (en)	1997-12-20
EP0951917A2 (fr)	1999-10-27
US20070299390A1 (en)	2007-12-27
OA10234A (en)	1997-10-07
EP0734737A2 (fr)	1996-10-02
PT734737E (pt)	2006-09-29
TJ248B (en)	1999-12-23
RO118569B1 (ro)	2003-07-30
GR3022939T3 (en)	1997-06-30
EP0693119A1 (fr)	1996-01-24
JP2007051160A (ja)	2007-03-01
HU9502911D0 (en)	1995-12-28
TW360548B (en)	1999-06-11
PL174974B1 (pl)	1998-10-30
ATE329006T1 (de)	2006-06-15
FI954788L (fi)	1995-10-06
ATE148497T1 (de)	1997-02-15
FI954788A0 (fi)	1995-10-06
RU2129021C1 (ru)	1999-04-20
US7942846B2 (en)	2011-05-17
CZ260895A3 (en)	1996-05-15
NO953994L (no)	1995-10-06
CN1120852A (zh)	1996-04-17
CZ290476B6 (cs)	2002-07-17

Legal Events

Date

Code

Title

Description

1997-08-25

HC

Name/ company changed in application

Owner name: POWDERJECT RESEARCH LIMITED