FI65256C - Foerfarande foer framstaellning av fast natriumamoxicillin - Google Patents

Foerfarande foer framstaellning av fast natriumamoxicillin Download PDF

Info

Publication number: FI65256C
Authority: FI; Finland
Prior art keywords: solution; spray; sodium; process according; dried
Prior art date: 1976-08-10

Application number

FI772388A

Other languages

English (en)

Finnish (fi)

Swedish (sv)

Other versions

FI65256B (fi

FI772388A7 (da

Inventor

David Horace Sutton Shean

John Robert Steel

Original Assignee

Beecham Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-08-10

Filing date

1977-08-08

Publication date

1984-04-10

1976-08-10 Priority claimed from GB33176/76A external-priority patent/GB1576731A/en

1977-08-08 Application filed by Beecham Group Ltd filed Critical Beecham Group Ltd

1978-02-11 Publication of FI772388A7 publication Critical patent/FI772388A7/fi

1983-12-30 Publication of FI65256B publication Critical patent/FI65256B/fi

1984-04-10 Application granted granted Critical

1984-04-10 Publication of FI65256C publication Critical patent/FI65256C/fi

Links

BYHDFCISJXIVBV-YWUHCJSESA-M amoxicillin sodium Chemical compound [Na+].C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C([O-])=O)(C)C)=CC=C(O)C=C1 BYHDFCISJXIVBV-YWUHCJSESA-M 0.000 title 1
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 44
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 36
238000000034 method Methods 0.000 claims description 36
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 30
229910052708 sodium Inorganic materials 0.000 claims description 30
239000011734 sodium Substances 0.000 claims description 30
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 claims description 12
239000007921 spray Substances 0.000 claims description 10
238000002360 preparation method Methods 0.000 claims description 8
229960003022 amoxicillin Drugs 0.000 claims description 7
LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 claims description 7
239000007787 solid Substances 0.000 claims description 7
238000001694 spray drying Methods 0.000 claims description 7
229960004920 amoxicillin trihydrate Drugs 0.000 claims description 5
239000000203 mixture Substances 0.000 claims description 5
238000004090 dissolution Methods 0.000 claims description 3
238000001816 cooling Methods 0.000 claims 1
239000000243 solution Substances 0.000 description 24
239000000047 product Substances 0.000 description 9
239000000126 substance Substances 0.000 description 5
239000000539 dimer Substances 0.000 description 4
239000012535 impurity Substances 0.000 description 4
HCYWNSXLUZRKJX-UHFFFAOYSA-N penicilloic acid Chemical compound N1C(C(O)=O)C(C)(C)SC1C(C(O)=O)NC(=O)CC1=CC=CC=C1 HCYWNSXLUZRKJX-UHFFFAOYSA-N 0.000 description 4
239000002904 solvent Substances 0.000 description 4
238000001035 drying Methods 0.000 description 3
239000000843 powder Substances 0.000 description 3
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
206010037660 Pyrexia Diseases 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
229960002793 amoxicillin sodium Drugs 0.000 description 2
230000015572 biosynthetic process Effects 0.000 description 2
239000000706 filtrate Substances 0.000 description 2
ILVPFTMKCHREDJ-UHFFFAOYSA-N methyl 5-amino-2-fluorobenzoate Chemical compound COC(=O)C1=CC(N)=CC=C1F ILVPFTMKCHREDJ-UHFFFAOYSA-N 0.000 description 2
150000003839 salts Chemical class 0.000 description 2
238000003860 storage Methods 0.000 description 2
239000000725 suspension Substances 0.000 description 2
229930182555 Penicillin Natural products 0.000 description 1
JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
240000004808 Saccharomyces cerevisiae Species 0.000 description 1
230000000844 anti-bacterial effect Effects 0.000 description 1
239000008280 blood Substances 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
239000012267 brine Substances 0.000 description 1
239000007884 disintegrant Substances 0.000 description 1
239000003814 drug Substances 0.000 description 1
239000008240 homogeneous mixture Substances 0.000 description 1
239000012456 homogeneous solution Substances 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
230000001788 irregular Effects 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
239000000463 material Substances 0.000 description 1
238000002156 mixing Methods 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
238000007911 parenteral administration Methods 0.000 description 1
239000013618 particulate matter Substances 0.000 description 1
RBKMMJSQKNKNEV-RITPCOANSA-N penicillanic acid Chemical compound OC(=O)[C@H]1C(C)(C)S[C@@H]2CC(=O)N21 RBKMMJSQKNKNEV-RITPCOANSA-N 0.000 description 1
229940049954 penicillin Drugs 0.000 description 1
150000002960 penicillins Chemical class 0.000 description 1
LMHHRCOWPQNFTF-UHFFFAOYSA-N s-propan-2-yl azepane-1-carbothioate Chemical compound CC(C)SC(=O)N1CCCCCC1 LMHHRCOWPQNFTF-UHFFFAOYSA-N 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

FI772388A 1976-08-10 1977-08-08 Foerfarande foer framstaellning av fast natriumamoxicillin FI65256C (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB33176/76A GB1576731A (en)	1976-08-10	1976-08-10	Process for the preparation of sodium amoxycillin
GB3317676		1976-08-10

Publications (3)

Publication Number	Publication Date
FI772388A7 FI772388A7 (da)	1978-02-11
FI65256B FI65256B (fi)	1983-12-30
FI65256C true FI65256C (fi)	1984-04-10

Family

ID=10349549

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI772388A FI65256C (fi)	1976-08-10	1977-08-08	Foerfarande foer framstaellning av fast natriumamoxicillin

Country Status (20)

Country	Link
AR (1)	AR213123A1 (da)
DK (1)	DK144566C (da)
ES (1)	ES461487A1 (da)
FI (1)	FI65256C (da)
GR (1)	GR63367B (da)
HK (1)	HK70083A (da)
HU (1)	HU174892B (da)
IE (1)	IE45401B1 (da)
IL (2)	IL52630A (da)
KE (1)	KE3319A (da)
MX (1)	MX4264E (da)
MY (1)	MY8400324A (da)
NO (1)	NO151041C (da)
NZ (1)	NZ184787A (da)
PH (2)	PH13998A (da)
PT (1)	PT66881B (da)
SE (1)	SE433218B (da)
SG (1)	SG50183G (da)
YU (1)	YU41074B (da)
ZA (1)	ZA774665B (da)

1977
- 1977-08-01 NZ NZ184787A patent/NZ184787A/xx unknown
- 1977-08-01 IL IL7752630A patent/IL52630A/xx unknown
- 1977-08-02 PT PT66881A patent/PT66881B/pt unknown
- 1977-08-02 ZA ZA00774665A patent/ZA774665B/xx unknown
- 1977-08-08 AR AR268722A patent/AR213123A1/es active
- 1977-08-08 SE SE7708979A patent/SE433218B/xx not_active IP Right Cessation
- 1977-08-08 FI FI772388A patent/FI65256C/fi not_active IP Right Cessation
- 1977-08-09 PH PH20099A patent/PH13998A/en unknown
- 1977-08-09 MX MX775984U patent/MX4264E/es unknown
- 1977-08-09 IE IE1663/77A patent/IE45401B1/en not_active IP Right Cessation
- 1977-08-09 ES ES77461487A patent/ES461487A1/es not_active Expired
- 1977-08-09 NO NO77772786A patent/NO151041C/no unknown
- 1977-08-09 GR GR54120A patent/GR63367B/el unknown
- 1977-08-09 DK DK354577A patent/DK144566C/da not_active IP Right Cessation
- 1977-08-10 HU HU77BE1304A patent/HU174892B/hu unknown
- 1977-08-10 YU YU1955/77A patent/YU41074B/xx unknown
1979
- 1979-03-20 PH PH22293A patent/PH14834A/en unknown
1980
- 1980-03-20 IL IL8059674A patent/IL59674A0/xx unknown
1983
- 1983-08-08 KE KE3319A patent/KE3319A/xx unknown
- 1983-08-12 SG SG501/83A patent/SG50183G/en unknown
- 1983-12-15 HK HK700/83A patent/HK70083A/xx not_active IP Right Cessation
1984
- 1984-12-31 MY MY1984324A patent/MY8400324A/xx unknown

Also Published As

Publication number	Publication date
NO772786L (no)	1978-02-13
PH13998A (en)	1980-11-28
PH14834A (en)	1981-12-16
MX4264E (es)	1982-03-08
IL52630A0 (en)	1977-10-31
NZ184787A (en)	1980-05-08
YU195577A (en)	1983-04-30
IE45401B1 (en)	1982-08-11
NO151041C (no)	1985-01-30
HK70083A (en)	1983-12-23
ES461487A1 (es)	1978-12-01
AR213123A1 (es)	1978-12-15
SG50183G (en)	1984-07-20
NO151041B (no)	1984-10-22
PT66881A (en)	1977-09-01
PT66881B (en)	1979-01-24
IL59674A0 (en)	1980-06-30
YU41074B (en)	1986-12-31
HU174892B (hu)	1980-04-28
IE45401L (en)	1978-02-10
ZA774665B (en)	1978-06-28
SE7708979L (sv)	1978-02-11
MY8400324A (en)	1984-12-31
FI65256B (fi)	1983-12-30
DK144566C (da)	1982-09-20
SE433218B (sv)	1984-05-14
GR63367B (en)	1979-10-22
KE3319A (en)	1983-08-26
DK144566B (da)	1982-03-29
FI772388A7 (da)	1978-02-11
IL52630A (en)	1980-09-16
DK354577A (da)	1978-02-11

Legal Events

Date	Code	Title	Description
2004-08-31	MA	Patent expired	Owner name: BEECHAM GROUP LIMITED

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