FI943473A7 - Bentsopyraani ja senkaltaiset LTB4-antagonistit - Google Patents

Bentsopyraani ja senkaltaiset LTB4-antagonistit Download PDF

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Publication number
FI943473A7
FI943473A7 FI943473A FI943473A FI943473A7 FI 943473 A7 FI943473 A7 FI 943473A7 FI 943473 A FI943473 A FI 943473A FI 943473 A FI943473 A FI 943473A FI 943473 A7 FI943473 A7 FI 943473A7
Authority
FI
Finland
Prior art keywords
benzopyran
similar
ltb4 antagonists
ltb4
antagonists
Prior art date
Application number
FI943473A
Other languages
English (en)
Swedish (sv)
Other versions
FI943473A0 (fi
FI943473L (fi
Inventor
Jr Lawrence Sherman Melvin
Lawrence Alan Reiter
Sally G Ruggeri
Kevin Koch
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of FI943473A0 publication Critical patent/FI943473A0/fi
Publication of FI943473L publication Critical patent/FI943473L/fi
Publication of FI943473A7 publication Critical patent/FI943473A7/fi

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/08Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing alicyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • C07C255/01Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/11Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton
    • C07C255/13Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46Friedel-Crafts reactions
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/58Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Quinoline Compounds (AREA)
FI943473A 1992-01-23 1992-10-13 Bentsopyraani ja senkaltaiset LTB4-antagonistit FI943473A7 (fi)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US82467892A 1992-01-23 1992-01-23
US89005592A 1992-05-28 1992-05-28
PCT/US1992/008555 WO1993015066A1 (en) 1992-01-23 1992-10-13 Benzopyran and related ltb4 antagonists

Publications (3)

Publication Number Publication Date
FI943473A0 FI943473A0 (fi) 1994-07-22
FI943473L FI943473L (fi) 1994-07-22
FI943473A7 true FI943473A7 (fi) 1994-07-22

Family

ID=27124835

Family Applications (1)

Application Number Title Priority Date Filing Date
FI943473A FI943473A7 (fi) 1992-01-23 1992-10-13 Bentsopyraani ja senkaltaiset LTB4-antagonistit

Country Status (27)

Country Link
US (1) US5550152A (fi)
EP (1) EP0623122B1 (fi)
JP (1) JP2813464B2 (fi)
KR (1) KR950700274A (fi)
CN (1) CN1074681A (fi)
AP (1) AP385A (fi)
AT (1) ATE149493T1 (fi)
AU (1) AU2773392A (fi)
BG (1) BG98873A (fi)
BR (1) BR9207064A (fi)
CA (1) CA2117349C (fi)
CZ (1) CZ395492A3 (fi)
DE (1) DE69217998T2 (fi)
DK (1) DK0623122T3 (fi)
ES (1) ES2098547T3 (fi)
FI (1) FI943473A7 (fi)
GR (1) GR3022999T3 (fi)
HU (1) HUT67929A (fi)
IL (1) IL104421A0 (fi)
IS (1) IS3968A (fi)
MX (1) MX9300313A (fi)
NO (1) NO942758L (fi)
OA (1) OA10713A (fi)
PT (1) PT101182A (fi)
TW (1) TW213456B (fi)
UY (1) UY23537A1 (fi)
WO (1) WO1993015066A1 (fi)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9300312A (es) * 1992-01-23 1993-07-31 Pfizer Antagonistas benzopiranicos y relacionado de ltb.
NZ285154A (en) * 1994-10-13 1998-11-25 Pfizer Optionally heterocyclically substituted benzopyran and benzo-fused derivatives, preparation and use as leukotriene antagonists
RU2128655C1 (ru) 1994-10-13 1999-04-10 Пфайзер Инк. Бензопирановые и бензоконденсированные соединения, промежуточные соединения, фармацевтическая композиция и способ ингибирования
DK0925292T3 (da) * 1996-09-16 2004-01-12 Pfizer Fremgangsmåder og mellemprodukter til fremstilling af substituerede chromanolderivater
US6416733B1 (en) 1996-10-07 2002-07-09 Bristol-Myers Squibb Pharma Company Radiopharmaceuticals for imaging infection and inflammation
IL121931A (en) * 1996-10-17 2000-02-17 Pfizer Pharmaceutical compositions for preventing allograft rejection
EP0963755A3 (en) * 1998-04-16 2001-03-14 Pfizer Products Inc. Use of benzopyranes for preventing allograft rejection
CA2427911A1 (en) 2000-11-03 2002-05-10 Bristol Myers Squibb Company Simultaneous dual isotope imaging of cardiac perfusion and cardiac inflammation
US6541613B2 (en) * 2000-12-15 2003-04-01 Uyrex Corporation Isoflavone derivatives
US6958156B2 (en) * 2000-12-15 2005-10-25 Vyrex Corporation Isoflavone derivatives
MXPA03006876A (es) * 2001-01-30 2003-11-13 Pfizer Prod Inc Intermedios y procedimientos para preparar derivados de cromanol sustituido.
JP2008506768A (ja) * 2004-07-22 2008-03-06 ファルマシア コーポレーション Cox−2選択的阻害剤とltb4受容体アンタゴニストを組み合わせて用いる炎症および疼痛を治療するための組成物
KR101107800B1 (ko) * 2006-10-31 2012-01-25 화이자 프로덕츠 인코포레이티드 무기질코르티코이드 수용체 길항제로서의 피라졸린 화합물
CN104710438B (zh) * 2013-12-11 2019-11-29 中国科学院上海药物研究所 促进iPS细胞产生的螺环类化合物及其制备方法和用途
US10849954B2 (en) * 2014-11-11 2020-12-01 Juntendo Educational Foundation Preventive or therapeutic agent for age-related macular degeneration
US10029995B2 (en) 2015-09-03 2018-07-24 Forma Therapeutics, Inc. [6,6] fused bicyclic HDAC8 inhibitors
WO2017095722A1 (en) 2015-11-30 2017-06-08 Merck Sharp & Dohme Corp. Aryl acylsulfonamides as blt1 antagonists
EP3383868B1 (en) 2015-11-30 2022-10-05 Merck Sharp & Dohme LLC Aryl sulfonamides as blt1 antagonists
WO2017095725A1 (en) 2015-11-30 2017-06-08 Merck Sharp & Dohme Corp. Aryl sulfonamides as blt1 antagonists
EP3383389B1 (en) 2015-11-30 2021-04-28 Merck Sharp & Dohme Corp. Aryl acylsulfonamides as blt1 antagonists
CN109289091B (zh) * 2018-10-09 2021-04-13 温州医科大学附属第一医院 一种用于装载骨髓间充质干细胞的复合支架及其制备方法
CN111647003B (zh) * 2020-06-08 2022-06-21 中国科学院昆明植物研究所 三环氧六氢色酮a及其药物组合物和其应用
CN111671745A (zh) * 2020-07-29 2020-09-18 北京大学 化合物在治疗溃疡性结肠炎药物制备中的应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4565882A (en) * 1984-01-06 1986-01-21 G. D. Searle & Co. Substituted dihydrobenzopyran-2-carboxylates
CA1320490C (en) * 1987-01-12 1993-07-20 Darrel M. Gapinski Anti-inflammatory agents
US4889871A (en) * 1987-05-29 1989-12-26 G. D. Searle & Co. Alkoxy-substituted dihydrobenzopyran-2-carboxylate derivatives
US5059609A (en) * 1987-10-19 1991-10-22 Pfizer Inc. Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases
WO1990015801A1 (en) * 1989-06-22 1990-12-27 Pfizer Inc. Substituted sulfonamides and related compounds in the treatment of asthma, arthritis and related diseases

Also Published As

Publication number Publication date
CA2117349C (en) 2000-02-29
FI943473A0 (fi) 1994-07-22
DK0623122T3 (da) 1997-04-21
AP385A (en) 1995-05-15
TW213456B (fi) 1993-09-21
JP2813464B2 (ja) 1998-10-22
NO942758D0 (no) 1994-07-22
ATE149493T1 (de) 1997-03-15
CN1074681A (zh) 1993-07-28
EP0623122A1 (en) 1994-11-09
AP9200441A0 (en) 1993-01-31
UY23537A1 (es) 1993-06-28
NO942758L (no) 1994-07-22
MX9300313A (es) 1994-06-30
DE69217998D1 (de) 1997-04-10
PT101182A (pt) 1994-03-31
US5550152A (en) 1996-08-27
FI943473L (fi) 1994-07-22
ES2098547T3 (es) 1997-05-01
AU2773392A (en) 1993-09-01
JPH07503464A (ja) 1995-04-13
KR950700274A (ko) 1995-01-16
GR3022999T3 (en) 1997-07-30
IL104421A0 (en) 1993-05-13
OA10713A (en) 2002-12-04
IS3968A (is) 1993-07-24
WO1993015066A1 (en) 1993-08-05
HUT67929A (en) 1995-05-29
CA2117349A1 (en) 1993-08-05
DE69217998T2 (de) 1997-06-12
BR9207064A (pt) 1995-12-19
HU9402163D0 (en) 1994-09-28
BG98873A (bg) 1995-03-31
CZ395492A3 (en) 1994-03-16
EP0623122B1 (en) 1997-03-05

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