AP385A - Benzopyrans and related LTB4 antagonists. - Google Patents

Benzopyrans and related LTB4 antagonists. Download PDF

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Publication number
AP385A
AP385A APAP/P/1992/000441A AP9200441A AP385A AP 385 A AP385 A AP 385A AP 9200441 A AP9200441 A AP 9200441A AP 385 A AP385 A AP 385A
Authority
AP
ARIPO
Prior art keywords
alkyl
phenyl
compound
hydrogen
formula
Prior art date
Application number
APAP/P/1992/000441A
Other languages
English (en)
Other versions
AP9200441A0 (en
Inventor
Kevin Koch
Jr Lawrence Sherman Melvin
Lawrence Alan Reiter
Sally G Ruggeri
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of AP9200441A0 publication Critical patent/AP9200441A0/xx
Application granted granted Critical
Publication of AP385A publication Critical patent/AP385A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/08—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing alicyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/11—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton
    • C07C255/13—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Quinoline Compounds (AREA)
APAP/P/1992/000441A 1992-01-23 1992-11-10 Benzopyrans and related LTB4 antagonists. AP385A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82467892A 1992-01-23 1992-01-23
US89005592A 1992-05-28 1992-05-28

Publications (2)

Publication Number Publication Date
AP9200441A0 AP9200441A0 (en) 1993-01-31
AP385A true AP385A (en) 1995-05-15

Family

ID=27124835

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1992/000441A AP385A (en) 1992-01-23 1992-11-10 Benzopyrans and related LTB4 antagonists.

Country Status (27)

Country Link
US (1) US5550152A (fi)
EP (1) EP0623122B1 (fi)
JP (1) JP2813464B2 (fi)
KR (1) KR950700274A (fi)
CN (1) CN1074681A (fi)
AP (1) AP385A (fi)
AT (1) ATE149493T1 (fi)
AU (1) AU2773392A (fi)
BG (1) BG98873A (fi)
BR (1) BR9207064A (fi)
CA (1) CA2117349C (fi)
CZ (1) CZ395492A3 (fi)
DE (1) DE69217998T2 (fi)
DK (1) DK0623122T3 (fi)
ES (1) ES2098547T3 (fi)
FI (1) FI943473L (fi)
GR (1) GR3022999T3 (fi)
HU (1) HUT67929A (fi)
IL (1) IL104421A0 (fi)
IS (1) IS3968A (fi)
MX (1) MX9300313A (fi)
NO (1) NO942758D0 (fi)
OA (1) OA10713A (fi)
PT (1) PT101182A (fi)
TW (1) TW213456B (fi)
UY (1) UY23537A1 (fi)
WO (1) WO1993015066A1 (fi)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9300312A (es) * 1992-01-23 1993-07-31 Pfizer Antagonistas benzopiranicos y relacionado de ltb.
MX9702734A (es) * 1994-10-13 1997-06-28 Pfizer Benzopirano y compuestos benzocondensados, su preparacion y su uso como antagonistas de leucotrieno b4 (ltb4).
CN1160399A (zh) * 1994-10-13 1997-09-24 美国辉瑞有限公司 苯并吡喃和苯并稠合化合物、其制备方法和它们作为白三烯b4(ltb4)拮抗剂的用途
SK31399A3 (en) * 1996-09-16 2000-05-16 Pfizer Processes and intermediates for preparing substituted chromanol derivatives
US6416733B1 (en) 1996-10-07 2002-07-09 Bristol-Myers Squibb Pharma Company Radiopharmaceuticals for imaging infection and inflammation
IL121931A (en) * 1996-10-17 2000-02-17 Pfizer Pharmaceutical compositions for preventing allograft rejection
EP0963755A3 (en) * 1998-04-16 2001-03-14 Pfizer Products Inc. Use of benzopyranes for preventing allograft rejection
CA2427911A1 (en) 2000-11-03 2002-05-10 Bristol Myers Squibb Company Simultaneous dual isotope imaging of cardiac perfusion and cardiac inflammation
US6958156B2 (en) * 2000-12-15 2005-10-25 Vyrex Corporation Isoflavone derivatives
US6541613B2 (en) * 2000-12-15 2003-04-01 Uyrex Corporation Isoflavone derivatives
MXPA03006876A (es) * 2001-01-30 2003-11-13 Pfizer Prod Inc Intermedios y procedimientos para preparar derivados de cromanol sustituido.
EP1773396A1 (en) * 2004-07-22 2007-04-18 Pharmacia Corporation Compositions for treatment of inflammation and pain using a combination of a cox-2 selective inhibitor and a ltb4 receptor antagonist
ES2375877T3 (es) * 2006-10-31 2012-03-07 Pfizer Products Inc. Compuestos de pirazolina como antagonistas de receptores de mineralocorticoides.
CN104710438B (zh) * 2013-12-11 2019-11-29 中国科学院上海药物研究所 促进iPS细胞产生的螺环类化合物及其制备方法和用途
WO2016076006A1 (ja) * 2014-11-11 2016-05-19 学校法人順天堂 加齢黄斑変性症予防又は治療剤
AR105911A1 (es) 2015-09-03 2017-11-22 Forma Therapeutics Inc Inhibidores de hdac8 bicíclicos fusionados [6,6]
US10336733B2 (en) 2015-11-30 2019-07-02 Merk Sharp & Dohme Corp. Aryl acylsulfonamides as BLT1 antagonists
WO2017095725A1 (en) 2015-11-30 2017-06-08 Merck Sharp & Dohme Corp. Aryl sulfonamides as blt1 antagonists
WO2017095724A1 (en) 2015-11-30 2017-06-08 Merck Sharp & Dohme Corp. Aryl sulfonamides as blt1 antagonists
US10370368B2 (en) 2015-11-30 2019-08-06 Merck Sharp & Dohme Corp. Aryl acylsulfonamides as BLT1 antagonists
CN109289091B (zh) * 2018-10-09 2021-04-13 温州医科大学附属第一医院 一种用于装载骨髓间充质干细胞的复合支架及其制备方法
CN111647003B (zh) * 2020-06-08 2022-06-21 中国科学院昆明植物研究所 三环氧六氢色酮a及其药物组合物和其应用
CN111671745A (zh) * 2020-07-29 2020-09-18 北京大学 化合物在治疗溃疡性结肠炎药物制备中的应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0276064A1 (en) * 1987-01-12 1988-07-27 Eli Lilly And Company Anti-inflammatory agents
EP0404440A2 (en) * 1989-06-22 1990-12-27 Pfizer Inc. Substituted sulfonamides and related compounds in the treatment of asthma, arthritis, and related diseases
US5059609A (en) * 1987-10-19 1991-10-22 Pfizer Inc. Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4565882A (en) * 1984-01-06 1986-01-21 G. D. Searle & Co. Substituted dihydrobenzopyran-2-carboxylates
US4889871A (en) * 1987-05-29 1989-12-26 G. D. Searle & Co. Alkoxy-substituted dihydrobenzopyran-2-carboxylate derivatives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0276064A1 (en) * 1987-01-12 1988-07-27 Eli Lilly And Company Anti-inflammatory agents
US5059609A (en) * 1987-10-19 1991-10-22 Pfizer Inc. Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases
EP0404440A2 (en) * 1989-06-22 1990-12-27 Pfizer Inc. Substituted sulfonamides and related compounds in the treatment of asthma, arthritis, and related diseases

Also Published As

Publication number Publication date
ATE149493T1 (de) 1997-03-15
HUT67929A (en) 1995-05-29
CN1074681A (zh) 1993-07-28
BR9207064A (pt) 1995-12-19
ES2098547T3 (es) 1997-05-01
AP9200441A0 (en) 1993-01-31
GR3022999T3 (en) 1997-07-30
OA10713A (en) 2002-12-04
BG98873A (bg) 1995-03-31
UY23537A1 (es) 1993-06-28
IS3968A (is) 1993-07-24
JPH07503464A (ja) 1995-04-13
DE69217998D1 (de) 1997-04-10
IL104421A0 (en) 1993-05-13
CZ395492A3 (en) 1994-03-16
EP0623122B1 (en) 1997-03-05
WO1993015066A1 (en) 1993-08-05
JP2813464B2 (ja) 1998-10-22
FI943473A0 (fi) 1994-07-22
NO942758L (no) 1994-07-22
CA2117349C (en) 2000-02-29
MX9300313A (es) 1994-06-30
DK0623122T3 (da) 1997-04-21
CA2117349A1 (en) 1993-08-05
FI943473A7 (fi) 1994-07-22
TW213456B (fi) 1993-09-21
US5550152A (en) 1996-08-27
FI943473L (fi) 1994-07-22
DE69217998T2 (de) 1997-06-12
PT101182A (pt) 1994-03-31
AU2773392A (en) 1993-09-01
EP0623122A1 (en) 1994-11-09
NO942758D0 (no) 1994-07-22
HU9402163D0 (en) 1994-09-28
KR950700274A (ko) 1995-01-16

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