FI944187L - Isosteeriset antiherpespeptidijohdannaiset - Google Patents

Isosteeriset antiherpespeptidijohdannaiset Download PDF

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Publication number
FI944187L
FI944187L FI944187A FI944187A FI944187L FI 944187 L FI944187 L FI 944187L FI 944187 A FI944187 A FI 944187A FI 944187 A FI944187 A FI 944187A FI 944187 L FI944187 L FI 944187L
Authority
FI
Finland
Prior art keywords
isosteric
peptide derivatives
antiherpes
antiherpes peptide
derivatives
Prior art date
Application number
FI944187A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI944187A7 (fi
FI944187A0 (fi
Inventor
Pierre-Louis Bealieu
Robert Deziel
Neil Moss
Raymond Plante
Original Assignee
Bio Mega Boehringer Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bio Mega Boehringer Ingelheim filed Critical Bio Mega Boehringer Ingelheim
Publication of FI944187A7 publication Critical patent/FI944187A7/fi
Publication of FI944187A0 publication Critical patent/FI944187A0/fi
Publication of FI944187L publication Critical patent/FI944187L/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI944187A 1992-03-12 1993-03-12 Isosteeriset antiherpespeptidijohdannaiset FI944187L (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84991892A 1992-03-12 1992-03-12
PCT/CA1993/000095 WO1993018056A1 (en) 1992-03-12 1993-03-12 Isosteric antiherpes peptide derivatives

Publications (3)

Publication Number Publication Date
FI944187A7 FI944187A7 (fi) 1994-09-12
FI944187A0 FI944187A0 (fi) 1994-09-12
FI944187L true FI944187L (fi) 1994-09-12

Family

ID=25306833

Family Applications (1)

Application Number Title Priority Date Filing Date
FI944187A FI944187L (fi) 1992-03-12 1993-03-12 Isosteeriset antiherpespeptidijohdannaiset

Country Status (24)

Country Link
EP (1) EP0560267B1 (lt)
JP (1) JPH0625131A (lt)
KR (1) KR950700322A (lt)
AT (1) ATE169931T1 (lt)
BR (1) BR9306074A (lt)
CA (1) CA2131186C (lt)
CZ (1) CZ220994A3 (lt)
DE (1) DE69320390T2 (lt)
EE (1) EE9400312A (lt)
FI (1) FI944187L (lt)
HU (2) HUT68675A (lt)
IL (1) IL105001A0 (lt)
LT (1) LT3270B (lt)
LV (1) LV10461B (lt)
MX (1) MX9301343A (lt)
NO (1) NO943345L (lt)
NZ (1) NZ251266A (lt)
PH (1) PH30453A (lt)
RU (1) RU94040865A (lt)
SG (1) SG42995A1 (lt)
SK (1) SK107794A3 (lt)
TW (1) TW278080B (lt)
WO (1) WO1993018056A1 (lt)
ZA (1) ZA931745B (lt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2139169C (en) * 1994-12-28 2001-05-01 Boehringer Ingelheim (Canada) Ltd./ Boehringer Ingelheim (Canada) Ltee Antiherpes peptidomimetic compounds
US5846941A (en) * 1992-03-12 1998-12-08 Boehringer Ingelheim (Canada) Ltd. Isosteric antiherpes peptide derivatives II
CA2095408A1 (en) * 1993-05-03 1994-11-04 James Gus Chafouleas Method of combating acyclovir-resistant herpes simplex viral infections
CA2152541C (en) * 1995-06-23 1998-12-15 Boehringer Ingelheim (Canada) Ltd./ Boehringer Ingelheim (Canada) Ltee Herpes ribonucleotide reductase inhibitors
US5948935A (en) * 1997-01-23 1999-09-07 Boehringer Ingelheim (Canada) Ltd. Process and intermediates for (s)-α-amino-1-carboxycyclopentaneacetic acid
CA2320117A1 (en) * 1998-02-12 1999-08-19 Emory University Sphingolipid derivatives and their methods of use
AU2019339777B2 (en) 2018-09-12 2022-09-01 Novartis Ag Antiviral pyridopyrazinedione compounds
US11667613B2 (en) 2019-09-26 2023-06-06 Novartis Ag Antiviral pyrazolopyridinone compounds

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US481432A (en) 1892-08-23 soler
US4795740A (en) 1986-05-20 1989-01-03 Cohen Eric A Antiviral peptides and means for treating herpes infections
US4837304A (en) 1987-05-22 1989-06-06 Merck & Co., Inc. Inhibitor of ribonucleotide reductase
US4845195A (en) 1987-05-22 1989-07-04 Merck & Co., Inc. Inhibitor of ribonucleotide reductase
EP0411333B1 (en) * 1989-07-07 1995-05-31 Bio-Mega/Boehringer Ingelheim Research Inc. Antiherpes tetrapeptide derivatives having a substituted aspartic acid side chain
CA1340682C (en) * 1989-07-07 1999-07-27 Pierre Lavallee Antiviral peptides having a 2-oxoalkyl amino acid side chain
EP0411334B1 (en) 1989-07-07 1995-02-22 Bio-Mega/Boehringer Ingelheim Research Inc. Antiherpes pentapeptide derivatives having a substituted aspartic acid side chain
CA1340684C (en) 1989-07-07 1999-07-27 Pierre Louis Beaulieu Antiherpes pentapeptides
US5110799A (en) 1989-07-28 1992-05-05 Merck & Co., Inc. Antiherpetic agents
CA2018801C (en) 1990-06-12 2000-08-22 Pierre Louis Beaulieu Antiherpes peptide derivatives having a 1,4-dioxo c n-terminus
CA2033447C (en) * 1990-12-31 1999-08-31 Robert Deziel Synergistic combination for treating herpes infections

Also Published As

Publication number Publication date
MX9301343A (es) 1994-01-31
TW278080B (lt) 1996-06-11
AU671825B2 (en) 1996-09-12
LT3270B (en) 1995-05-25
ATE169931T1 (de) 1998-09-15
HU9402593D0 (en) 1994-11-28
RU94040865A (ru) 1996-08-10
FI944187A7 (fi) 1994-09-12
DE69320390D1 (de) 1998-09-24
PH30453A (en) 1997-05-28
DE69320390T2 (de) 1999-02-11
AU3880793A (en) 1993-10-05
FI944187A0 (fi) 1994-09-12
IL105001A0 (en) 1993-07-08
HU211926A9 (en) 1996-01-29
WO1993018056A1 (en) 1993-09-16
CA2131186A1 (en) 1993-09-16
SK107794A3 (en) 1995-03-08
NO943345D0 (no) 1994-09-09
ZA931745B (en) 1993-09-24
NO943345L (no) 1994-09-09
BR9306074A (pt) 1997-11-18
EE9400312A (et) 1996-04-15
JPH0625131A (ja) 1994-02-01
KR950700322A (ko) 1995-01-16
CZ220994A3 (en) 1995-09-13
NZ251266A (en) 1996-08-27
LV10461A (lv) 1995-02-20
EP0560267A1 (en) 1993-09-15
CA2131186C (en) 2000-12-12
EP0560267B1 (en) 1998-08-19
SG42995A1 (en) 1997-10-17
LV10461B (en) 1996-02-20
HUT68675A (en) 1995-07-28
LTIP408A (en) 1994-09-25

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Legal Events

Date Code Title Description
GB Transfer or assigment of application

Owner name: BOEHRINGER INGELHEIM (CANADA) LTD.

FD Application lapsed