NO943345L - Isostere anti-herpes peptid-derivater - Google Patents

Isostere anti-herpes peptid-derivater

Info

Publication number
NO943345L
NO943345L NO943345A NO943345A NO943345L NO 943345 L NO943345 L NO 943345L NO 943345 A NO943345 A NO 943345A NO 943345 A NO943345 A NO 943345A NO 943345 L NO943345 L NO 943345L
Authority
NO
Norway
Prior art keywords
alkyl
acid residue
peptide derivatives
isostere
nhch
Prior art date
Application number
NO943345A
Other languages
English (en)
Other versions
NO943345D0 (no
Inventor
Pierre Louis Beaulieu
Robert Deziel
Neil Moss
Raymond Plante
Original Assignee
Bio Mega Boehringer Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bio Mega Boehringer Ingelheim filed Critical Bio Mega Boehringer Ingelheim
Publication of NO943345D0 publication Critical patent/NO943345D0/no
Publication of NO943345L publication Critical patent/NO943345L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Peptid-derivater med formelen A-B-D-CH2CH {CH2C (O) R1} C (O) -NHCH {CR2 (R3) COOH} C (O) -E hvor A er en terminal gruppe, f.eks. eventuelt substituert fenylalkanoyl, og B er en N-metylaminosyre-rest; eller A og B sammen danner mettet eller umettet alkylaminokarbonyl; D er en aminosyre-rest; R1 er alkyl, cykloalkyl, monosubstituert eller di-substituert amino; R2 er hydrogen eller alkyl og R3 er alkyl, eller R2 er hydrogen og R3 er fenylalkyl, eller R2 og R3 sammen danner¿cykloalkyl; og E er en terminal enhet, f.eks. alkylamino eller en monovalent aminosyre-rest, så som NHCH- (alkyl)C(0)OH, er beskrevet. Derivatene er nyttige for be- handling av herpes-infeksjoner.
NO943345A 1992-03-12 1994-09-09 Isostere anti-herpes peptid-derivater NO943345L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84991892A 1992-03-12 1992-03-12
PCT/CA1993/000095 WO1993018056A1 (en) 1992-03-12 1993-03-12 Isosteric antiherpes peptide derivatives

Publications (2)

Publication Number Publication Date
NO943345D0 NO943345D0 (no) 1994-09-09
NO943345L true NO943345L (no) 1994-09-09

Family

ID=25306833

Family Applications (1)

Application Number Title Priority Date Filing Date
NO943345A NO943345L (no) 1992-03-12 1994-09-09 Isostere anti-herpes peptid-derivater

Country Status (24)

Country Link
EP (1) EP0560267B1 (no)
JP (1) JPH0625131A (no)
KR (1) KR950700322A (no)
AT (1) ATE169931T1 (no)
BR (1) BR9306074A (no)
CA (1) CA2131186C (no)
CZ (1) CZ220994A3 (no)
DE (1) DE69320390T2 (no)
EE (1) EE9400312A (no)
FI (1) FI944187A0 (no)
HU (2) HUT68675A (no)
IL (1) IL105001A0 (no)
LT (1) LT3270B (no)
LV (1) LV10461B (no)
MX (1) MX9301343A (no)
NO (1) NO943345L (no)
NZ (1) NZ251266A (no)
PH (1) PH30453A (no)
RU (1) RU94040865A (no)
SG (1) SG42995A1 (no)
SK (1) SK107794A3 (no)
TW (1) TW278080B (no)
WO (1) WO1993018056A1 (no)
ZA (1) ZA931745B (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5846941A (en) * 1992-03-12 1998-12-08 Boehringer Ingelheim (Canada) Ltd. Isosteric antiherpes peptide derivatives II
CA2095408A1 (en) * 1993-05-03 1994-11-04 James Gus Chafouleas Method of combating acyclovir-resistant herpes simplex viral infections
CA2230750C (en) * 1994-12-28 2002-05-21 Boehringer Ingelheim (Canada) Ltd./ Boehringer Ingelheim (Canada) Ltee Antiherpes peptidomimetic compounds
CA2152541C (en) * 1995-06-23 1998-12-15 Boehringer Ingelheim (Canada) Ltd./ Boehringer Ingelheim (Canada) Ltee Herpes ribonucleotide reductase inhibitors
US5948935A (en) * 1997-01-23 1999-09-07 Boehringer Ingelheim (Canada) Ltd. Process and intermediates for (s)-α-amino-1-carboxycyclopentaneacetic acid
EP1053243B1 (en) * 1998-02-12 2011-03-30 Emory University Sphingolipid derivatives and their methods of use
US11072610B2 (en) 2018-09-12 2021-07-27 Novartis Ag Antiviral pyridopyrazinedione compounds
CN114667285B (zh) 2019-09-26 2025-08-08 诺华股份有限公司 抗病毒吡唑并吡啶酮化合物

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US481432A (en) 1892-08-23 soler
US4795740A (en) 1986-05-20 1989-01-03 Cohen Eric A Antiviral peptides and means for treating herpes infections
US4845195A (en) 1987-05-22 1989-07-04 Merck & Co., Inc. Inhibitor of ribonucleotide reductase
US4837304A (en) 1987-05-22 1989-06-06 Merck & Co., Inc. Inhibitor of ribonucleotide reductase
CA1340684C (en) 1989-07-07 1999-07-27 Pierre Louis Beaulieu Antiherpes pentapeptides
EP0411333B1 (en) * 1989-07-07 1995-05-31 Bio-Mega/Boehringer Ingelheim Research Inc. Antiherpes tetrapeptide derivatives having a substituted aspartic acid side chain
CA1340682C (en) * 1989-07-07 1999-07-27 Pierre Lavallee Antiviral peptides having a 2-oxoalkyl amino acid side chain
ATE118785T1 (de) 1989-07-07 1995-03-15 Bio Mega Boehringer Ingelheim Pentapeptidderivate, wirksam gegen herpes, die eine ersetzte asparaginsäureseitenkette enthalten.
US5110799A (en) 1989-07-28 1992-05-05 Merck & Co., Inc. Antiherpetic agents
CA2018801C (en) 1990-06-12 2000-08-22 Pierre Louis Beaulieu Antiherpes peptide derivatives having a 1,4-dioxo c n-terminus
CA2033447C (en) * 1990-12-31 1999-08-31 Robert Deziel Synergistic combination for treating herpes infections

Also Published As

Publication number Publication date
LV10461B (en) 1996-02-20
ZA931745B (en) 1993-09-24
FI944187A7 (fi) 1994-09-12
ATE169931T1 (de) 1998-09-15
HU9402593D0 (en) 1994-11-28
NZ251266A (en) 1996-08-27
MX9301343A (es) 1994-01-31
CZ220994A3 (en) 1995-09-13
CA2131186A1 (en) 1993-09-16
HUT68675A (en) 1995-07-28
NO943345D0 (no) 1994-09-09
DE69320390T2 (de) 1999-02-11
HU211926A9 (en) 1996-01-29
EE9400312A (et) 1996-04-15
JPH0625131A (ja) 1994-02-01
PH30453A (en) 1997-05-28
LT3270B (en) 1995-05-25
SK107794A3 (en) 1995-03-08
DE69320390D1 (de) 1998-09-24
AU3880793A (en) 1993-10-05
BR9306074A (pt) 1997-11-18
SG42995A1 (en) 1997-10-17
RU94040865A (ru) 1996-08-10
IL105001A0 (en) 1993-07-08
EP0560267B1 (en) 1998-08-19
KR950700322A (ko) 1995-01-16
CA2131186C (en) 2000-12-12
EP0560267A1 (en) 1993-09-15
FI944187L (fi) 1994-09-12
FI944187A0 (fi) 1994-09-12
AU671825B2 (en) 1996-09-12
LTIP408A (en) 1994-09-25
WO1993018056A1 (en) 1993-09-16
TW278080B (no) 1996-06-11
LV10461A (lv) 1995-02-20

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