FR04C0013I2 - - Google Patents

Info

Publication number
FR04C0013I2
FR04C0013I2 FR04C0013C FR04C0013C FR04C0013I2 FR 04C0013 I2 FR04C0013 I2 FR 04C0013I2 FR 04C0013 C FR04C0013 C FR 04C0013C FR 04C0013 C FR04C0013 C FR 04C0013C FR 04C0013 I2 FR04C0013 I2 FR 04C0013I2
Authority
FR
France
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR04C0013C
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Products Inc
Original Assignee
Pfizer Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21959336&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR04C0013(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Products Inc filed Critical Pfizer Products Inc
Publication of FR04C0013I1 publication Critical patent/FR04C0013I1/fr
Application granted granted Critical
Publication of FR04C0013I2 publication Critical patent/FR04C0013I2/fr
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FR04C0013C 1997-06-11 2004-05-04 Active FR04C0013I2 (th)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4934897P 1997-06-11 1997-06-11
PCT/IB1998/000839 WO1998056802A1 (en) 1997-06-11 1998-05-29 4'-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives

Publications (2)

Publication Number Publication Date
FR04C0013I1 FR04C0013I1 (th) 2004-06-11
FR04C0013I2 true FR04C0013I2 (th) 2005-10-21

Family

ID=21959336

Family Applications (1)

Application Number Title Priority Date Filing Date
FR04C0013C Active FR04C0013I2 (th) 1997-06-11 2004-05-04

Country Status (49)

Country Link
US (4) US6420536B1 (th)
EP (1) EP0988310B9 (th)
JP (2) JP3315704B2 (th)
KR (1) KR100396168B1 (th)
CN (4) CN101691390A (th)
AP (1) AP1231A (th)
AR (1) AR013086A1 (th)
AT (1) ATE251173T1 (th)
AU (1) AU749816B2 (th)
BG (1) BG64391B1 (th)
BR (1) BRPI9810519B8 (th)
CA (1) CA2293823C (th)
CO (1) CO4950611A1 (th)
CZ (1) CZ298556B6 (th)
DE (2) DE122004000018I2 (th)
DK (1) DK0988310T3 (th)
DZ (1) DZ2514A1 (th)
EA (1) EA002441B1 (th)
EG (1) EG24081A (th)
ES (1) ES2205487T3 (th)
FR (1) FR04C0013I2 (th)
GT (1) GT199800077A (th)
HN (1) HN1998000086A (th)
HR (1) HRP980314B1 (th)
HU (2) HU228005B1 (th)
ID (1) ID22992A (th)
IL (1) IL132809A0 (th)
IS (1) IS1998B (th)
LU (1) LU91076I9 (th)
MA (1) MA24564A1 (th)
ME (1) ME00876B (th)
MY (1) MY123354A (th)
NL (1) NL300150I2 (th)
NO (1) NO316911B1 (th)
NZ (2) NZ500660A (th)
OA (1) OA11224A (th)
PA (1) PA8452201A1 (th)
PE (1) PE79699A1 (th)
PL (1) PL191601B1 (th)
PT (1) PT988310E (th)
RS (1) RS49675B (th)
SI (1) SI0988310T1 (th)
SK (1) SK284171B9 (th)
TN (1) TNSN98082A1 (th)
TW (1) TW472060B (th)
UA (1) UA67744C2 (th)
UY (1) UY25040A1 (th)
WO (1) WO1998056802A1 (th)
ZA (1) ZA985017B (th)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
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HN1998000086A (es) 1997-06-11 1999-03-08 Pfizer Prod Inc Derivados de 9 - desofo - 9 aza - 9a - homoeritromicina a - c - 4 sustituidos.
US6339063B1 (en) 1997-09-10 2002-01-15 Merck & Co., Inc. 9a-azalides as veterinary antimicrobial agents
JP2001515865A (ja) * 1997-09-10 2001-09-25 メルク エンド カムパニー インコーポレーテッド 家畜抗菌剤としての９ａ−アザライド
EP1779853A3 (en) * 1997-09-10 2010-01-27 Merial Ltd. 9a-azalides as veterinary antimicrobial agents
AP9801420A0 (en) * 1998-01-02 1998-12-31 Pfizer Prod Inc Novel macrolides.
EP1437360A3 (en) * 1998-08-19 2005-04-06 Pfizer Products Inc. C11 Carbamates of macrolide antibacterials
US6043227A (en) * 1998-08-19 2000-03-28 Pfizer Inc. C11 carbamates of macrolide antibacterials
US6100240A (en) * 1998-10-09 2000-08-08 Pfizer Inc Macrolide derivatives
CA2292359C (en) * 1999-01-28 2004-09-28 Pfizer Products Inc. Novel azalides and methods of making same
UA67842C2 (uk) * 1999-05-18 2004-07-15 Пфайзер Продактс Інк. Кристалічні форми макролідного антибіотика
AP2001002302A0 (en) * 1999-05-24 2001-10-25 Pfizer Prod Inc 13-Methyl erythromycin derivatives.
US6465437B1 (en) 1999-06-30 2002-10-15 Pfizer Inc. Diphosphate salt of a 4″-substituted-9-deoxo-9A-AZA-9A- homoerythromycin derivative and its pharmaceutical composition
MXPA02001897A (es) * 1999-08-24 2002-10-31 Abbott Lab 9a-azalidas con actividad antibacteriana.
US6764996B1 (en) 1999-08-24 2004-07-20 Abbott Laboratories 9a-azalides with antibacterial activity
US6608033B1 (en) 1999-08-27 2003-08-19 Pfizer Inc. Treatment or prevention of coccidiosis
ATE243703T1 (de) 2000-01-27 2003-07-15 Pfizer Prod Inc Antibiotische azalid-zusammensetzungen
PL359861A1 (en) * 2000-04-27 2004-09-06 Pfizer Products Inc. The use of azalide antibiotic compositions for treating or preventing a bacterial or protozoal infection in mammals
BR0209241A (pt) * 2001-04-27 2004-06-15 Pfizer Prod Inc Processo para preparação de derivados de9-deoxo-9a-aza-9a-homoeritromicina a 4-substituida
WO2003011266A2 (en) * 2001-08-01 2003-02-13 Pfizer Products Inc. Azalide antibiotic compositions
EP3738591A3 (en) 2003-03-10 2021-03-24 Merck Sharp & Dohme Corp. Novel antibacterial agents
WO2005030227A1 (en) 2003-09-23 2005-04-07 Enanta Pharmaceuticals, Inc. 9a, 11-3C-BICYCLIC 9a-AZALIDE DERIVATIVES
JP2007512312A (ja) * 2003-11-21 2007-05-17 ファイザー・プロダクツ・インク ワクチンアジュバントとしての抗生物質の使用
CN103450129B (zh) * 2004-03-16 2015-08-12 贝林格尔.英格海姆国际有限公司 吡喃葡萄糖基取代的苯基衍生物、含该化合物的药物、其用途及其制造方法
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7402568B2 (en) 2004-09-29 2008-07-22 Enanta Pharmaceuticals, Inc. Bicyclic 9a-azalide derivatives
US7767797B1 (en) * 2004-09-30 2010-08-03 Synovo Gmbh Macrocyclic compounds and methods of use thereof
US7271155B2 (en) 2005-01-07 2007-09-18 Enanta Pharmaceuticals, Inc. 9A, 11-2C-bicyclic 9a-azalide derivatives
JP2008526948A (ja) * 2005-01-14 2008-07-24 グラクソスミスクライン・イストラジヴァッキ・センタル・ザグレブ・ドルズバ・ゼー・オメイェノ・オドゴヴォルノスティオ 抗マラリア活性を有する９ａ−カルバモイルおよびチオカルバモイルアザライド
US9453042B2 (en) * 2007-10-25 2016-09-27 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
CN107854477A (zh) 2008-10-24 2018-03-30 森普拉制药公司 使用含三唑的大环内酯治疗抗性疾病的方法
US9937194B1 (en) * 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
CN108310000A (zh) 2009-09-10 2018-07-24 森普拉制药公司 治疗疟疾、结核病和mac疾病的方法
US8975386B2 (en) 2010-03-22 2015-03-10 Cempra Pharmaceuticals, Inc. Crystalline forms of a macrolide, and uses therefor
CN102917708B (zh) 2010-05-20 2015-11-25 森普拉制药公司 制备大环内酯和酮内酯及其中间体的方法
KR20180110181A (ko) 2010-09-10 2018-10-08 셈프라 파마슈티컬스, 인크. 질환을 치료하기 위한 수소결합 형성 플루오로 케토라이드
ES2532455T3 (es) * 2010-09-20 2015-03-27 Novartis Tiergesundheit Ag Nuevo procedimiento de preparación de 9-desoxo-9a-aza-9a-homoeritromicina modificada en el C-4'' del anillo de cladinosa por un grupo epóxido
CA2814333A1 (en) * 2010-10-10 2012-04-19 Synovo Gmbh Anti-inflammatory macrolides
CN102993250B (zh) * 2011-07-06 2016-02-10 洛阳惠中兽药有限公司 C-3取代的-9-脱氧-9a-氮杂-9a-高红霉素a衍生物
CN102260306B (zh) * 2011-07-22 2012-07-18 山东鲁抗舍里乐药业有限公司 一种制备泰拉霉素的方法
WO2013013834A1 (en) 2011-07-27 2013-01-31 Farma Grs, D.O.O. New crystalline forms of tulathromycin
SG11201405895UA (en) 2012-03-27 2014-10-30 Cempra Pharmaceuticals Inc Parenteral formulations for administering macrolide antibiotics
CN102786569B (zh) * 2012-09-07 2016-12-07 安徽中升药业有限公司 泰拉霉素中间体及其制备方法与泰拉霉素的制备方法
US9861616B2 (en) 2013-03-14 2018-01-09 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
MX356772B (es) 2013-03-15 2018-06-13 Cempra Pharmaceuticals Inc Procesos convergentes para la preparacion de agentes antibacterianos macrolidos.
EP3027634B1 (en) * 2013-07-31 2018-03-21 Farma GRS, d.o.o. Process for preparation of tulathromycin
CN103497227B (zh) * 2013-09-13 2015-09-30 青岛科技大学 一种泰拉菌素中间体的制备方法
CN104725446B (zh) * 2015-03-26 2017-10-27 宁夏泰瑞制药股份有限公司 一种从泰拉霉素粗品中分离泰拉霉素a和泰拉霉素b的方法
CN104861018A (zh) * 2015-06-17 2015-08-26 瑞普（天津）生物药业有限公司 一种泰拉菌素的制备方法
CN105646617A (zh) * 2016-01-21 2016-06-08 杭州海尔希畜牧科技有限公司 一种制备泰拉霉素的方法
FR3048612B1 (fr) * 2016-03-14 2020-10-02 Septeos Tulathromycine potentialisee
CN106046077B (zh) * 2016-08-04 2019-07-26 湖北美天生物科技股份有限公司 一种泰拉霉素a的合成方法
CN108003207B (zh) 2017-12-19 2019-05-10 海门慧聚药业有限公司 制备泰拉霉素的方法
CN111087433B (zh) * 2018-10-23 2023-03-21 湖北美天生物科技股份有限公司 一种泰拉霉素中间体的制备方法

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SI8110592A8 (en) * 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
US4512982A (en) * 1984-04-13 1985-04-23 Pfizer Inc. 9α-Aza-9α-homoerythromycin compounds, pharmaceutical composition and therapeutic method
CA2064634C (en) * 1991-04-04 1998-08-04 James V. Heck 9-deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and8a-positions
US5226958A (en) * 1991-04-11 1993-07-13 Pacemark, Inc. Sealant for pneumatic inner tubes and tubeless tires
EP0549040A1 (en) * 1991-12-20 1993-06-30 Merck & Co. Inc. Methods of making 4" derivatives of 9-deoxo-8a-aza-8a-alkyl-8a-homoerythromycin A
US5441939A (en) * 1994-03-04 1995-08-15 Pfizer Inc. 3"-desmethoxy derivatives of erythromycin and azithromycin
HN1998000086A (es) * 1997-06-11 1999-03-08 Pfizer Prod Inc Derivados de 9 - desofo - 9 aza - 9a - homoeritromicina a - c - 4 sustituidos.
UA70972C2 (uk) 1998-11-20 2004-11-15 Пфайзер Продактс Інк. 13-членні азаліди і їх застосування як антибіотиків

Also Published As

Publication number Publication date
DE69818665D1 (de) 2003-11-06
CN101691390A (zh) 2010-04-07
EP0988310A1 (en) 2000-03-29
ME00876B (me) 2012-06-20
CA2293823C (en) 2004-02-17
SI0988310T1 (en) 2004-02-29
NO316911B1 (no) 2004-06-21
HN1998000086A (es) 1999-03-08
NZ514871A (en) 2003-08-29
NL300150I2 (nl) 2004-09-01
HRP980314A2 (en) 1999-04-30
WO1998056802A1 (en) 1998-12-17
NL300150I1 (nl) 2004-08-02
EG24081A (en) 2008-05-11
SK284171B6 (sk) 2004-10-05
CZ298556B6 (cs) 2007-11-07
US6777393B2 (en) 2004-08-17
EA199901015A1 (ru) 2000-06-26
JP2000514098A (ja) 2000-10-24
CA2293823A1 (en) 1998-12-17
AP9801255A0 (en) 1998-06-30
PA8452201A1 (es) 2000-05-24
UY25040A1 (es) 2000-09-29
HRP980314B1 (en) 2004-04-30
AP1231A (en) 2003-12-11
AU749816B2 (en) 2002-07-04
CN1243766C (zh) 2006-03-01
MA24564A1 (fr) 1998-12-31
TNSN98082A1 (fr) 2005-03-15
ID22992A (id) 1999-12-23
BRPI9810519B1 (pt) 2012-02-22
DK0988310T3 (da) 2003-12-15
KR20010013632A (ko) 2001-02-26
ES2205487T3 (es) 2004-05-01
HUP0002209A3 (en) 2003-05-28
PE79699A1 (es) 1999-08-25
CN1566129A (zh) 2005-01-19
GT199800077A (es) 1999-12-02
LU91076I2 (fr) 2004-07-05
AU7347598A (en) 1998-12-30
KR100396168B1 (ko) 2003-08-27
HUS1200028I1 (hu) 2016-08-29
UA67744C2 (uk) 2004-07-15
CZ442199A3 (cs) 2000-07-12
DE122004000018I2 (de) 2011-01-13
EP0988310B1 (en) 2003-10-01
HUP0002209A2 (hu) 2000-12-28
CN1172947C (zh) 2004-10-27
BRPI9810519B8 (pt) 2022-11-16
NO996106L (no) 2000-02-10
BG64391B1 (bg) 2004-12-30
NO996106D0 (no) 1999-12-10
DE122004000018I1 (de) 2004-09-30
HK1028048A1 (en) 2001-02-02
YU58699A (th) 2002-08-12
HK1068893A1 (en) 2005-07-29
MY123354A (en) 2006-05-31
EP0988310B9 (en) 2006-03-08
CN1793155B (zh) 2010-05-12
CO4950611A1 (es) 2000-09-01
DE69818665T2 (de) 2004-04-29
SK168399A3 (en) 2000-11-07
OA11224A (en) 2003-07-16
FR04C0013I1 (th) 2004-06-11
IL132809A0 (en) 2001-03-19
JP2002316933A (ja) 2002-10-31
DZ2514A1 (fr) 2003-02-01
US20040180842A1 (en) 2004-09-16
PL191601B1 (pl) 2006-06-30
NZ500660A (en) 2002-03-01
HK1088014A1 (zh) 2006-10-27
EA002441B1 (ru) 2002-04-25
IS1998B (is) 2005-03-15
JP3315704B2 (ja) 2002-08-19
RS49675B (sr) 2007-11-15
US6936592B2 (en) 2005-08-30
US20040023896A1 (en) 2004-02-05
PL337505A1 (en) 2000-08-28
US20020061858A1 (en) 2002-05-23
TW472060B (en) 2002-01-11
CN1793155A (zh) 2006-06-28
PT988310E (pt) 2003-12-31
ATE251173T1 (de) 2003-10-15
HU228005B1 (en) 2012-08-28
ZA985017B (en) 1999-12-17
CN1259136A (zh) 2000-07-05
SK284171B9 (sk) 2005-03-04
US6420536B1 (en) 2002-07-16
BRPI9810519A (pt) 2000-09-19
LU91076I9 (en) 2018-07-02
BG103945A (bg) 2000-07-31
AR013086A1 (es) 2000-12-13
IS5252A (is) 1999-11-16

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