FR2438044A2 - Nouveaux derives de l'alkylene dioxy-1, 2 benzene - Google Patents
Nouveaux derives de l'alkylene dioxy-1, 2 benzeneInfo
- Publication number
- FR2438044A2 FR2438044A2 FR7917586A FR7917586A FR2438044A2 FR 2438044 A2 FR2438044 A2 FR 2438044A2 FR 7917586 A FR7917586 A FR 7917586A FR 7917586 A FR7917586 A FR 7917586A FR 2438044 A2 FR2438044 A2 FR 2438044A2
- Authority
- FR
- France
- Prior art keywords
- carboxamido
- carbamoylamino
- oxygen
- methyl
- intermediates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000000694 effects Effects 0.000 title abstract 4
- 206010002383 Angina Pectoris Diseases 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 title abstract 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 title 2
- DLCYXQODDJUHQL-VOTSOKGWSA-N (e)-3-phenyl-1-piperazin-1-ylprop-2-en-1-one Chemical compound C1CNCCN1C(=O)\C=C\C1=CC=CC=C1 DLCYXQODDJUHQL-VOTSOKGWSA-N 0.000 title 1
- 125000002947 alkylene group Chemical group 0.000 title 1
- -1 Alkylene dioxy benzene Chemical compound 0.000 abstract 9
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 6
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 4
- 229910052760 oxygen Inorganic materials 0.000 abstract 4
- 239000001301 oxygen Substances 0.000 abstract 4
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 2
- 125000005236 alkanoylamino group Chemical group 0.000 abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000005518 carboxamido group Chemical group 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Natural products C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 2
- DLCYXQODDJUHQL-UHFFFAOYSA-N 3-phenyl-1-piperazin-1-ylprop-2-en-1-one Chemical class C1CNCCN1C(=O)C=CC1=CC=CC=C1 DLCYXQODDJUHQL-UHFFFAOYSA-N 0.000 abstract 1
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 abstract 1
- 125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 230000002490 cerebral effect Effects 0.000 abstract 1
- 125000006627 ethoxycarbonylamino group Chemical group 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 230000002093 peripheral effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
- C07D321/02—Seven-membered rings
- C07D321/10—Seven-membered rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/54—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/66—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
A.NOUVEAUX DERIVES DE L'ALKYLENE DIOXY-1,2 BENZENE. B.ILS REPONDENT A LA FORMULE: (CF DESSIN DANS BOPI) DANS LAQUELLE: -R REPRESENTE LE GROUPEMENT -CH OU L'ATOME D'HYDROGENE, AUQUEL LES PARAMETRES X, N REPRESENTENT OX, 2, OX, 1, OX, 3, S, 2, OU -R REPRESENTE LE GROUPEMENT -CH-
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/894,965 US4178442A (en) | 1977-04-19 | 1978-04-10 | Novel cinnamoyles piperazines and homopiperazines, the method of preparing them and their application in therapeutics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2438044A2 true FR2438044A2 (fr) | 1980-04-30 |
| FR2438044B2 FR2438044B2 (fr) | 1982-04-09 |
Family
ID=25403749
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7833468A Granted FR2456738A2 (fr) | 1978-04-10 | 1978-11-27 | Nouvelles cinnamoyles piperazines et homopiperazines, leur procede de preparation et leur application en therapeutique |
| FR7917586A Granted FR2438044A2 (fr) | 1978-04-10 | 1979-07-06 | Nouveaux derives de l'alkylene dioxy-1, 2 benzene |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7833468A Granted FR2456738A2 (fr) | 1978-04-10 | 1978-11-27 | Nouvelles cinnamoyles piperazines et homopiperazines, leur procede de preparation et leur application en therapeutique |
Country Status (3)
| Country | Link |
|---|---|
| FR (2) | FR2456738A2 (fr) |
| LU (1) | LU80680A1 (fr) |
| SE (2) | SE438149B (fr) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2507604A2 (fr) * | 1977-04-19 | 1982-12-17 | Delalande Sa | Nouvelles trimethoxy-3,4,5 cinnamoyle piperazines, leur procede de preparation et leur application en therapeutique |
| EP0943613A4 (fr) * | 1996-11-19 | 2002-07-10 | Kyowa Hakko Kogyo Kk | Composes heterocycliques d'oxygene |
| US6514996B2 (en) | 1995-05-19 | 2003-02-04 | Kyowa Hakko Kogyo Co., Ltd. | Derivatives of benzofuran or benzodioxole |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2497512A2 (fr) * | 1981-01-07 | 1982-07-09 | Delalande Sa | Nouveaux derives de la trimethoxy-3,4,5 cinnamoyl piperazine, leurs sels, leur procede de preparation et leur application en therapeutique |
| DE3407842A1 (de) * | 1983-03-04 | 1984-09-06 | Otsuka Pharmaceutical Co. Ltd., Tokyo | Indanderivate und deren salze, verfahren zu deren herstellung und arzneimittel und antioxidationsmittel, welche diese enthalten |
| US4499100A (en) * | 1983-05-18 | 1985-02-12 | Syntex (U.S.A.) Inc. | Benzodioxanyl-hydroxyethyleneamino-piperidinyl acetanilides, ketones, esters and carbamates which effect immunity and calcium entry and β-blockade |
| US4567264A (en) * | 1983-05-18 | 1986-01-28 | Syntex (U.S.A.) Inc. | Cardioselective aryloxy- and arylthio- hydroxypropylene-piperazinyl acetanilides which affect calcium entry |
| US4558129A (en) * | 1983-05-18 | 1985-12-10 | Syntex (U.S.A.) Inc. | Benzodioxanyl-hydroxyethylene-piperazinyl acetanilides which effect calcium entry and β-blockade |
| DE3407695A1 (de) * | 1984-03-02 | 1985-09-12 | Röhm Pharma GmbH, 6108 Weiterstadt | Pteridinverbindungen mit pharmazeutischer wirksamkeit |
| EP0338906B1 (fr) * | 1988-04-16 | 1994-10-05 | Daicel Chemical Industries, Ltd. | Procédé de moulage d'un substrat formaté pour disque optique et moule pour la mise en oeuvre du procédé |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2396757A2 (fr) * | 1977-07-08 | 1979-02-02 | Ile De France | Nouveaux 2,3-alkylene bis (oxy) benzamides substitues, leurs derives et leurs procedes de preparation |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2267104A1 (en) * | 1974-04-12 | 1975-11-07 | Ferlux Labo Sa | Hypotensive and antiarrhythmic piperazines - 1-(3-phenoxy-2-hydroxy propyl)-4-substd. piperazines |
| GB1521471A (en) * | 1974-06-05 | 1978-08-16 | Randall & Son Ltd J | Token-deposit locks |
| FR2387971A1 (fr) * | 1977-04-19 | 1978-11-17 | Delalande Sa | Nouvelles trimethoxy cinnamoyles piperazines, leur procede de preparation et leur application en therapeutique |
-
1978
- 1978-11-27 FR FR7833468A patent/FR2456738A2/fr active Granted
- 1978-12-20 LU LU80680A patent/LU80680A1/fr unknown
-
1979
- 1979-01-02 SE SE7900020A patent/SE438149B/sv not_active IP Right Cessation
- 1979-07-06 FR FR7917586A patent/FR2438044A2/fr active Granted
- 1979-09-03 SE SE7907312A patent/SE431752B/sv not_active IP Right Cessation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2396757A2 (fr) * | 1977-07-08 | 1979-02-02 | Ile De France | Nouveaux 2,3-alkylene bis (oxy) benzamides substitues, leurs derives et leurs procedes de preparation |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2507604A2 (fr) * | 1977-04-19 | 1982-12-17 | Delalande Sa | Nouvelles trimethoxy-3,4,5 cinnamoyle piperazines, leur procede de preparation et leur application en therapeutique |
| US6514996B2 (en) | 1995-05-19 | 2003-02-04 | Kyowa Hakko Kogyo Co., Ltd. | Derivatives of benzofuran or benzodioxole |
| US6716987B1 (en) | 1995-05-19 | 2004-04-06 | Kyowa Hakko Kogyo Co., Ltd. | Derivatives of benzofuran or benzodioxazole compounds |
| EP0943613A4 (fr) * | 1996-11-19 | 2002-07-10 | Kyowa Hakko Kogyo Kk | Composes heterocycliques d'oxygene |
Also Published As
| Publication number | Publication date |
|---|---|
| SE7900020L (sv) | 1979-10-11 |
| SE438149B (sv) | 1985-04-01 |
| SE7907312L (sv) | 1979-10-11 |
| SE431752B (sv) | 1984-02-27 |
| FR2438044B2 (fr) | 1982-04-09 |
| FR2456738A2 (fr) | 1980-12-12 |
| FR2456738B2 (fr) | 1983-01-14 |
| LU80680A1 (fr) | 1980-07-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TP | Transmission of property |