FR2653021A1 - Composition ophtalmique aqueuse liquide a transition de phase liquide-gel. - Google Patents

Composition ophtalmique aqueuse liquide a transition de phase liquide-gel.

Info

Publication number
FR2653021A1
FR2653021A1 FR8913534A FR8913534A FR2653021A1 FR 2653021 A1 FR2653021 A1 FR 2653021A1 FR 8913534 A FR8913534 A FR 8913534A FR 8913534 A FR8913534 A FR 8913534A FR 2653021 A1 FR2653021 A1 FR 2653021A1
Authority
FR
France
Prior art keywords
liquid
phase transition
gel phase
ophthalmic composition
aqueous liquid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
FR8913534A
Other languages
English (en)
Inventor
Chastaing Gilles
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratories Merck Sharp and Dohme Chibret SAS
Organon Pharma UK Ltd
Original Assignee
Laboratories Merck Sharp and Dohme Chibret SAS
Merck Sharp and Dohme Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratories Merck Sharp and Dohme Chibret SAS, Merck Sharp and Dohme Ltd filed Critical Laboratories Merck Sharp and Dohme Chibret SAS
Priority to FR8913534A priority Critical patent/FR2653021A1/fr
Priority to EP90311208A priority patent/EP0424043B1/fr
Priority to DE90311208T priority patent/DE69001739T2/de
Priority to DK90311208.4T priority patent/DK0424043T3/da
Priority to ES90311208T priority patent/ES2055339T3/es
Priority to AT90311208T priority patent/ATE89745T1/de
Priority to CA002027630A priority patent/CA2027630C/fr
Priority to IE371390A priority patent/IE64045B1/en
Priority to JP2276563A priority patent/JP3043795B2/ja
Publication of FR2653021A1 publication Critical patent/FR2653021A1/fr
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne une composition ophtalmique liquide, caractérisée en ce qu'elle comprend au moins un principe actif et un polysaccharide sulfaté ou dérivé de polysaccharide sulfaté en solution aqueuse qui subit une transition de phase liquide-gel lors de l'interaction dudit polysaccharide sulfaté ou d'un de ses dérivés avec les protéines du liquide lacrymal. La présente invention se rapporte également à un procédé de préparation de ladite composition.
FR8913534A 1989-10-17 1989-10-17 Composition ophtalmique aqueuse liquide a transition de phase liquide-gel. Pending FR2653021A1 (fr)

Priority Applications (9)

Application Number Priority Date Filing Date Title
FR8913534A FR2653021A1 (fr) 1989-10-17 1989-10-17 Composition ophtalmique aqueuse liquide a transition de phase liquide-gel.
EP90311208A EP0424043B1 (fr) 1989-10-17 1990-10-12 Composition ophthalmique aqueuse liquide à transition de phase liquide-gel
DE90311208T DE69001739T2 (de) 1989-10-17 1990-10-12 Flüssige, wasserhaltige ophthalmische Zusammensetzung von Flüssig-Gel-Phasenübergangstyp.
DK90311208.4T DK0424043T3 (da) 1989-10-17 1990-10-12 Flydende vandigt ophthalmisk præparat, der overgår fra væske- til gelfase
ES90311208T ES2055339T3 (es) 1989-10-17 1990-10-12 Composicion oftalmica liquido acuosa que presenta una fase de transicion liquido-gel.
AT90311208T ATE89745T1 (de) 1989-10-17 1990-10-12 Fluessige, wasserhaltige ophthalmische zusammensetzung von fluessig-gelphasen¨bergangstyp.
CA002027630A CA2027630C (fr) 1989-10-17 1990-10-15 Vehicule ophtalmique a base de gel proteique
IE371390A IE64045B1 (en) 1989-10-17 1990-10-16 Liquid aqueous ophthalmic composition undergoing liquid-gel phase transition
JP2276563A JP3043795B2 (ja) 1989-10-17 1990-10-17 蛋白質ゲル状眼用賦形剤

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8913534A FR2653021A1 (fr) 1989-10-17 1989-10-17 Composition ophtalmique aqueuse liquide a transition de phase liquide-gel.

Publications (1)

Publication Number Publication Date
FR2653021A1 true FR2653021A1 (fr) 1991-04-19

Family

ID=9386463

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8913534A Pending FR2653021A1 (fr) 1989-10-17 1989-10-17 Composition ophtalmique aqueuse liquide a transition de phase liquide-gel.

Country Status (9)

Country Link
EP (1) EP0424043B1 (fr)
JP (1) JP3043795B2 (fr)
AT (1) ATE89745T1 (fr)
CA (1) CA2027630C (fr)
DE (1) DE69001739T2 (fr)
DK (1) DK0424043T3 (fr)
ES (1) ES2055339T3 (fr)
FR (1) FR2653021A1 (fr)
IE (1) IE64045B1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2594486B2 (ja) * 1991-01-15 1997-03-26 アルコン ラボラトリーズ インコーポレイテッド 局所的眼薬組成物
CA2064160C (fr) * 1991-03-27 1998-08-11 Paul J. T. Missel Emploi de polysaccharides gelifiants combines a des substrats finement divises a action de vecteur des medicaments, dans des compositions ophthalmiques a usage local
US5422116A (en) * 1994-02-18 1995-06-06 Ciba-Geigy Corporation Liquid ophthalmic sustained release delivery system
US6174524B1 (en) 1999-03-26 2001-01-16 Alcon Laboratories, Inc. Gelling ophthalmic compositions containing xanthan gum
US6261547B1 (en) 1998-04-07 2001-07-17 Alcon Manufacturing, Ltd. Gelling ophthalmic compositions containing xanthan gum
PT1225898E (pt) 1999-11-01 2003-10-31 Alcon Inc Composicoes farmaceuticas contendo um farmaco antibiotico de fluoroquinolona e goma xantana
BR0112787B1 (pt) 2000-07-28 2013-03-05 composiÇço de soluÇço topicamente administrÁvel.
PE20020578A1 (es) 2000-10-10 2002-08-14 Upjohn Co Una composicion de antibiotico topico para el tratamiento de infecciones oculares
US7060297B2 (en) 2000-11-06 2006-06-13 Alcon, Inc. Carrageenan viscoelastics for ocular surgery
MXPA04008171A (es) 2002-02-22 2004-11-26 Pharmacia Corp Formulacion oftalmica con sistema de goma.
US20080131454A1 (en) * 2006-12-05 2008-06-05 Marinomed Biotechnologie Gmbh Methods and Compositions for the Treatment of Rhinovirus Infections with Carrageenan
WO2011018800A2 (fr) 2009-08-13 2011-02-17 Fdc Limited Nouvelle solution formant un gel in situ pour l’administration de médicaments par voie oculaire
RS58731B1 (sr) 2014-01-22 2019-06-28 Visufarma B V Kompozicija koja sadrži jota-karagenan protiv virusnog konjuktivitisa
CN107847430B (zh) 2015-07-14 2021-02-02 玛丽诺姆德生物技术股份公司 一种具有抗病毒活性的鼻塞疏通组合物
CN109752557B (zh) * 2017-11-06 2021-06-08 清华大学 检测生物分子间相互作用及其调控因子的成套试剂与应用
DE202022102900U1 (de) 2022-05-25 2023-01-13 Anant Narayanrao Deshpande Tetrahydrocurcumin niosomales in-situ-Gel für okulare Arzneimittelabgabe

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4136173A (en) * 1977-01-31 1979-01-23 American Home Products Corp. Mixed xanthan gum and locust beam gum therapeutic compositions
EP0125759A2 (fr) * 1983-03-17 1984-11-21 Warner Lambert Holland B.V. Composition topique à base d'antibiotiques pour le traitement des muqueuses
US4717713A (en) * 1983-10-31 1988-01-05 Research Corporation Controlled release liquid pharmaceutical
GB2203039A (en) * 1987-03-02 1988-10-12 American Cyanamid Co Ophthalmic local compositions containing acetazolamide
EP0227494B1 (fr) * 1985-10-03 1992-03-04 LABORATOIRES MERCK, SHARP & DOHME-CHIBRET Composition pharmaceutique du type subissant une transition de phase liquide-gel

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3601132A1 (de) * 1986-01-16 1987-07-23 Christian Bannert Verfahren zur behandlung der schleimhaut

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4136173A (en) * 1977-01-31 1979-01-23 American Home Products Corp. Mixed xanthan gum and locust beam gum therapeutic compositions
EP0125759A2 (fr) * 1983-03-17 1984-11-21 Warner Lambert Holland B.V. Composition topique à base d'antibiotiques pour le traitement des muqueuses
US4717713A (en) * 1983-10-31 1988-01-05 Research Corporation Controlled release liquid pharmaceutical
EP0227494B1 (fr) * 1985-10-03 1992-03-04 LABORATOIRES MERCK, SHARP & DOHME-CHIBRET Composition pharmaceutique du type subissant une transition de phase liquide-gel
GB2203039A (en) * 1987-03-02 1988-10-12 American Cyanamid Co Ophthalmic local compositions containing acetazolamide

Also Published As

Publication number Publication date
IE903713A1 (en) 1991-04-24
DK0424043T3 (da) 1993-06-21
EP0424043A1 (fr) 1991-04-24
ES2055339T3 (es) 1994-08-16
ATE89745T1 (de) 1993-06-15
DE69001739D1 (de) 1993-07-01
JP3043795B2 (ja) 2000-05-22
JPH03133936A (ja) 1991-06-07
CA2027630A1 (fr) 1991-04-18
EP0424043B1 (fr) 1993-05-26
IE64045B1 (en) 1995-06-28
CA2027630C (fr) 2001-04-24
DE69001739T2 (de) 1993-11-25

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