FR2856685A1 - Derives de thiazolylpiperidine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent - Google Patents

Derives de thiazolylpiperidine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent

Info

Publication number
FR2856685A1
FR2856685A1 FR0307670A FR0307670A FR2856685A1 FR 2856685 A1 FR2856685 A1 FR 2856685A1 FR 0307670 A FR0307670 A FR 0307670A FR 0307670 A FR0307670 A FR 0307670A FR 2856685 A1 FR2856685 A1 FR 2856685A1
Authority
FR
France
Prior art keywords
processes
preparation
pharmaceutical compositions
compositions containing
thiazolylpiperidine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR0307670A
Other languages
English (en)
Other versions
FR2856685B1 (fr
Inventor
Philippe Guedat
Francois Collonges
Herve Dumas
Jean Yves Ortholand
Jacques Decerprit
Jacques Barbanton
Richard J Foster
Peter Kane
Bernd Wendt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sante SAS
Original Assignee
Merck Sante SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0307670A priority Critical patent/FR2856685B1/fr
Application filed by Merck Sante SAS filed Critical Merck Sante SAS
Priority to US10/561,989 priority patent/US7674803B2/en
Priority to ES04735742T priority patent/ES2323463T3/es
Priority to DE602004020223T priority patent/DE602004020223D1/de
Priority to RU2006101890/04A priority patent/RU2006101890A/ru
Priority to MXPA05013521A priority patent/MXPA05013521A/es
Priority to EP04735742A priority patent/EP1636218B1/fr
Priority to PCT/EP2004/005931 priority patent/WO2005003128A1/fr
Priority to AU2004253649A priority patent/AU2004253649B2/en
Priority to JP2006515818A priority patent/JP4629666B2/ja
Priority to AT04735742T priority patent/ATE426599T1/de
Priority to CNA2004800157394A priority patent/CN1809560A/zh
Priority to BRPI0411721-2A priority patent/BRPI0411721A/pt
Priority to CA2531011A priority patent/CA2531011C/fr
Priority to KR1020057024663A priority patent/KR20060024812A/ko
Priority to TW093117985A priority patent/TW200518751A/zh
Priority to ARP040102230A priority patent/AR044909A1/es
Publication of FR2856685A1 publication Critical patent/FR2856685A1/fr
Application granted granted Critical
Publication of FR2856685B1 publication Critical patent/FR2856685B1/fr
Priority to ZA200600690A priority patent/ZA200600690B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Dérivés de thiazolylpipéridine, leurs procédés de préparation, les compositions pharmaceutiques qui les contiennent et leurs applications dans le traitement des hypertriglycéridémies, des hypercholestérolémies et des dyslipidémies.La présente invention concerne des dérivés de thiazolylpipéridine de formule générale (I) :dans laquelle :• A représente un radical choisi parmi les radicaux a1 et a2 suivants :• G représente une liaison ou un radical divalent choisi parmi les groupements g1, g2 et g3 suivants :• et R1, R2, R2', R3, R4, R5, Y et Z sont tels que définis dans la description.Application des composés de formule (I) au traitement des hypertriglycéridémies, des hypercholestérolémies et des dyslipidémies.
FR0307670A 2003-06-25 2003-06-25 Derives de thiazolylpiperidine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent Expired - Fee Related FR2856685B1 (fr)

Priority Applications (18)

Application Number Priority Date Filing Date Title
FR0307670A FR2856685B1 (fr) 2003-06-25 2003-06-25 Derives de thiazolylpiperidine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
CNA2004800157394A CN1809560A (zh) 2003-06-25 2004-06-02 作为mtp抑制剂的噻唑基哌啶衍生物
DE602004020223T DE602004020223D1 (de) 2003-06-25 2004-06-02 Thiazolylpiperidin derivate als mtp inhibitoren
RU2006101890/04A RU2006101890A (ru) 2003-06-25 2004-06-02 Производные тиазолилпиперидина в качестве ингибиторов мпб
MXPA05013521A MXPA05013521A (es) 2003-06-25 2004-06-02 Derivados de tiazolilpiperidina como inhibidores de mtp.
EP04735742A EP1636218B1 (fr) 2003-06-25 2004-06-02 Derives de la thiazolylpiperidine, inhibiteurs de la mtp
PCT/EP2004/005931 WO2005003128A1 (fr) 2003-06-25 2004-06-02 Derives de la thiazolylpiperidine, inhibiteurs de la mtp
AU2004253649A AU2004253649B2 (en) 2003-06-25 2004-06-02 Thiazolylpiperidine derivatives as MTP inhibitors
JP2006515818A JP4629666B2 (ja) 2003-06-25 2004-06-02 ｍｔｐ阻害剤としてのチアゾリルピペリジン誘導体
CA2531011A CA2531011C (fr) 2003-06-25 2004-06-02 Derives de la thiazolylpiperidine, inhibiteurs de la mtp
US10/561,989 US7674803B2 (en) 2003-06-25 2004-06-02 Thiazolypiperidine derivatives as MTP inhibitors
ES04735742T ES2323463T3 (es) 2003-06-25 2004-06-02 Derivados de tiazolilpiperidina como inhibidores de la mtp.
AT04735742T ATE426599T1 (de) 2003-06-25 2004-06-02 Thiazolylpiperidin derivate als mtp inhibitoren
KR1020057024663A KR20060024812A (ko) 2003-06-25 2004-06-02 Ｍｔｐ 저해제로서의 티아졸일피페리딘 유도체
BRPI0411721-2A BRPI0411721A (pt) 2003-06-25 2004-06-02 derivados de tiazolilpiperidina como inibidores de mtp
TW093117985A TW200518751A (en) 2003-06-25 2004-06-21 Thiazolylpiperidine derivatives, processes for the preparation thereof, pharmaceutical compositions comprising same, and applications thereof in the tre atment of hypertriglyceridaemia, hypercholesterolaemia and dyslipidaemia
ARP040102230A AR044909A1 (es) 2003-06-25 2004-06-25 Derivados de tiazolilpiperidina, procesos para su preparacion, composiciones farmaceuticas que los comprenden y aplicaciones de dichos derivados en el tratamiento de hipertrigliceridemia , hipercolesterolemia y dislipidemia
ZA200600690A ZA200600690B (en) 2003-06-25 2006-01-24 Thiazolylpiperidine derivatives as MTP inhibitors

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0307670A FR2856685B1 (fr) 2003-06-25 2003-06-25 Derives de thiazolylpiperidine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
FR2856685A1 true FR2856685A1 (fr) 2004-12-31
FR2856685B1 FR2856685B1 (fr) 2005-09-23

Family

ID=33515396

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0307670A Expired - Fee Related FR2856685B1 (fr) 2003-06-25 2003-06-25 Derives de thiazolylpiperidine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent

Country Status (18)

Country Link
US (1) US7674803B2 (fr)
EP (1) EP1636218B1 (fr)
JP (1) JP4629666B2 (fr)
KR (1) KR20060024812A (fr)
CN (1) CN1809560A (fr)
AR (1) AR044909A1 (fr)
AT (1) ATE426599T1 (fr)
AU (1) AU2004253649B2 (fr)
BR (1) BRPI0411721A (fr)
CA (1) CA2531011C (fr)
DE (1) DE602004020223D1 (fr)
ES (1) ES2323463T3 (fr)
FR (1) FR2856685B1 (fr)
MX (1) MXPA05013521A (fr)
RU (1) RU2006101890A (fr)
TW (1) TW200518751A (fr)
WO (1) WO2005003128A1 (fr)
ZA (1) ZA200600690B (fr)

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WO2007115805A3 (fr) * 2006-04-05 2008-06-05 European Molecular Biology Lab Embl Inhibiteurs de la kinase aurora
DE102007047735A1 (de) 2007-10-05 2009-04-09 Merck Patent Gmbh Thiazolderivate
EP2009005A4 (fr) * 2006-04-19 2010-06-02 Astellas Pharma Inc Dérivé d'azolecarboxamide
WO2011051244A1 (fr) 2009-10-30 2011-05-05 Bayer Cropscience Ag Dérivés d'hétéroarylpipéridine et d'hétéroarylpipérazine
US8304547B2 (en) 2007-10-24 2012-11-06 Astellas Pharma Inc. Azolecarboxamide compound or salt thereof
CN116113406A (zh) * 2020-07-10 2023-05-12 密歇根大学董事会 Gas41抑制剂及其使用方法

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FR2865733B1 (fr) * 2004-02-04 2007-10-12 Merck Sante Sas Derives de thiazolylimidazole, leurs procedes de preparation, les compositions pharmaceutiques qui les contiennent et leurs applications en medecine
EP1637529A1 (fr) 2004-09-20 2006-03-22 4Sc Ag Nouveaux analogues de piperidin-4-yl-thiazole-carboxamide en tant qu'inhibiteurs de proliferation de lymphocytes T er leurs utilisations
WO2006032322A1 (fr) * 2004-09-20 2006-03-30 4Sc Ag NOUVEAUX INHIBITEURS HÉTÉROCYCLIQUES DU NF-κB
US7601745B2 (en) 2004-09-27 2009-10-13 4Sc Ag Heterocyclic NF-kB inhibitors
US20100267717A1 (en) * 2005-07-29 2010-10-21 4Sc Ag Novel Heterocyclic NF-kB Inhibitors
MY179032A (en) 2004-10-25 2020-10-26 Cancer Research Tech Ltd Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors
TW200738701A (en) 2005-07-26 2007-10-16 Du Pont Fungicidal carboxamides
WO2007016979A2 (fr) * 2005-07-29 2007-02-15 4Sc Ag Nouveaux inhibiteurs heterocycliques de nf-kb
MX2008002061A (es) * 2005-08-18 2008-04-16 Hoffmann La Roche Derivados de tiazolil piperidina utiles como moduladores del receptor h3.
EP1832586A1 (fr) * 2006-03-10 2007-09-12 Oridis Biomed Forschungs- und Entwicklungs GmbH Derivés de thiazole-piperidine pour le traitement des des maladies hepatiques et pancréatiques
EP1834954A1 (fr) * 2006-03-15 2007-09-19 4Sc Ag Thiazoles comme inhibiteurs de NF-kB (inhibiteurs de proteasome)
EA200801838A1 (ru) * 2006-03-15 2009-02-27 4ЭсЦэ АГ НОВЫЕ ГЕТЕРОЦИКЛИЧЕСКИЕ ИНГИБИТОРЫ NF-kB
WO2007125321A2 (fr) 2006-04-25 2007-11-08 Astex Therapeutics Limited Composés pharmaceutiques
WO2008013622A2 (fr) * 2006-07-27 2008-01-31 E. I. Du Pont De Nemours And Company Amides azocycliques fongicides
US9090604B2 (en) 2006-07-27 2015-07-28 E I Du Pont De Nemours And Company Fungicidal azocyclic amides
AR063531A1 (es) * 2006-10-31 2009-01-28 Schering Corp Derivados de anilinopiperazina y composicion farmaceutica
CA2668210C (fr) * 2006-10-31 2013-03-12 Schering Corporation Derives d'anilinopiperazine et leurs methodes d'utilisation
CN101663262B (zh) * 2006-12-01 2014-03-26 百时美施贵宝公司 用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
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CA2703978A1 (fr) * 2007-10-29 2009-05-07 Schering Corporation Derives de la thiazole en tant qu'inhibiteurs de la proteine kinase
US8349870B2 (en) * 2008-01-25 2013-01-08 E I Du Pont De Nemours And Company Fungicidal hetercyclic compounds
BRPI0910837B1 (pt) 2008-04-30 2017-03-07 Bayer Cropscience Ag ésteres e tioésteres tiazol-4-carboxílicos, seus usos, e método e composição para controlar fungos fitopatogênicos prejudiciais
EP2334669B1 (fr) * 2008-10-01 2015-12-23 Bayer Intellectual Property GmbH Thiazoles substitués par un hétérocyclyle comme agent phytosanitaire
AU2009322486A1 (en) 2008-12-02 2010-06-10 E. I. Du Pont De Nemours And Company Fungicidal heterocyclic compounds
JP5642661B2 (ja) * 2009-03-05 2014-12-17 塩野義製薬株式会社 Ｎｐｙｙ５受容体拮抗作用を有するピペリジンおよびピロリジン誘導体
EP2272846A1 (fr) * 2009-06-23 2011-01-12 Bayer CropScience AG Dérivés de thiazolylpipéridine en tant que fongicide
EP2464643A1 (fr) * 2009-08-12 2012-06-20 Syngenta Participations AG Hétérocycles microbicides
WO2011051243A1 (fr) 2009-10-29 2011-05-05 Bayer Cropscience Ag Combinaisons de composé actif
US8629286B2 (en) * 2009-12-22 2014-01-14 Syngenta Crop Protection, Llc Pyrazole derivatives
BR112012027762B1 (pt) * 2010-04-28 2018-06-05 Bayer Intellectual Property Gmbh Derivados de cetoheteroarilpiperidina e - piperazina como fungicidas
US8598164B2 (en) 2010-05-06 2013-12-03 Vertex Pharmaceuticals Incorporated Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels
US8815775B2 (en) * 2010-05-18 2014-08-26 Bayer Cropscience Ag Bis(difluoromethyl)pyrazoles as fungicides
WO2012104273A1 (fr) * 2011-02-01 2012-08-09 Bayer Cropscience Ag Dérivés d'hétéroarylpipéridine et d'hétéroarylpipérazine utilisés comme fongicides
MX355907B (es) 2011-02-02 2018-05-04 Vertex Pharma Pirrolopirazina-piperidina espirociclica-amidas como moduladores de canales de ionicos.
BR112013020419A2 (pt) * 2011-02-10 2016-07-12 Syngenta Participations Ag microbicidas derivados de pirazol
JP5940562B2 (ja) * 2011-02-18 2016-06-29 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ イオンチャネルのモジュレーターとしてのクロマン−スピロ環式ピペリジンアミド
MX347982B (es) 2011-03-14 2017-05-22 Vertex Pharma Morfolina-piperidina espirociclica-amidas como moduladores de canales ionicos.
EP2694056B1 (fr) 2011-04-01 2019-10-16 AstraZeneca AB Traitement thérapeutique
PH12014500943A1 (en) 2011-11-30 2014-06-30 Astrazeneca Ab Combination treatment of cancer
AU2013204533B2 (en) 2012-04-17 2017-02-02 Astrazeneca Ab Crystalline forms
WO2015018027A1 (fr) 2013-08-08 2015-02-12 Merck Sharp & Dohme Corp. Antagonistes thiazoles des récepteurs de l'orexine
WO2016086357A1 (fr) 2014-12-02 2016-06-09 Merck Sharp & Dohme Corp. Méthyl oxazoles antagonistes du récepteur d'orexine
EP3573619A4 (fr) * 2017-01-27 2020-10-28 SignalRX Pharmaceuticals, Inc. Thiénopyranones et furanopyranones en tant qu'inhibiteurs de kinase, de bromodomaine et de points de contrôle
MX2019012699A (es) * 2017-04-28 2020-12-11 Texas Childrens Hospital Nanoparticulas dirigidas.
CN111196805A (zh) * 2018-11-17 2020-05-26 曲阜德禄生物科技有限公司 哌啶基噻唑甲酰胺类化合物合成方法与用途
WO2021228123A1 (fr) * 2020-05-12 2021-11-18 北京广为医药科技有限公司 Composé permettant d'ajuster l'activité du récepteur nmda, composition pharmaceutique et utilisation associées
EP4646263A1 (fr) * 2023-01-20 2025-11-12 Allianthera (Suzhou) Biopharmaceutical Co., Ltd. Inhibiteurs de sprk1 et procédés d'utilisation

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WO2003047575A1 (fr) * 2001-12-04 2003-06-12 Glaxo Group Limited Derives de benzamide therapeutiques

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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EP2009005A4 (fr) * 2006-04-19 2010-06-02 Astellas Pharma Inc Dérivé d'azolecarboxamide
US8163746B2 (en) 2006-04-19 2012-04-24 Astellas Pharma Inc. Azolecarboxamide derivative
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US8304547B2 (en) 2007-10-24 2012-11-06 Astellas Pharma Inc. Azolecarboxamide compound or salt thereof
WO2011051244A1 (fr) 2009-10-30 2011-05-05 Bayer Cropscience Ag Dérivés d'hétéroarylpipéridine et d'hétéroarylpipérazine
CN116113406A (zh) * 2020-07-10 2023-05-12 密歇根大学董事会 Gas41抑制剂及其使用方法
EP4178571A4 (fr) * 2020-07-10 2024-07-17 The Regents Of The University Of Michigan Inhibiteurs de gas41 et leurs méthodes d'utilisation

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MXPA05013521A (es) 2006-03-09
ZA200600690B (en) 2007-05-30
EP1636218A1 (fr) 2006-03-22
AU2004253649A1 (en) 2005-01-13
CA2531011C (fr) 2012-10-09
ATE426599T1 (de) 2009-04-15
RU2006101890A (ru) 2007-07-27
FR2856685B1 (fr) 2005-09-23
US7674803B2 (en) 2010-03-09
DE602004020223D1 (de) 2009-05-07
AU2004253649B2 (en) 2009-09-24
CA2531011A1 (fr) 2005-01-13
KR20060024812A (ko) 2006-03-17
EP1636218B1 (fr) 2009-03-25
CN1809560A (zh) 2006-07-26
BRPI0411721A (pt) 2006-05-23
JP2007506651A (ja) 2007-03-22
WO2005003128A1 (fr) 2005-01-13
TW200518751A (en) 2005-06-16
US20070054939A1 (en) 2007-03-08
ES2323463T3 (es) 2009-07-16
AR044909A1 (es) 2005-10-05
JP4629666B2 (ja) 2011-02-09

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