GR1001161B - Αναστολη της προσκολλησης των λεμφοκυτταρων στο αγγειακο ενδοθηλιο με τη χρησιμοποιηση μιας αλληλεπιδρασης νεου υποδοχεα εξωκυτταρικης μητρας-προσδετη. - Google Patents
Αναστολη της προσκολλησης των λεμφοκυτταρων στο αγγειακο ενδοθηλιο με τη χρησιμοποιηση μιας αλληλεπιδρασης νεου υποδοχεα εξωκυτταρικης μητρας-προσδετη.Info
- Publication number
- GR1001161B GR1001161B GR900100648A GR900100648A GR1001161B GR 1001161 B GR1001161 B GR 1001161B GR 900100648 A GR900100648 A GR 900100648A GR 900100648 A GR900100648 A GR 900100648A GR 1001161 B GR1001161 B GR 1001161B
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- Prior art keywords
- present
- receptor
- adhesion
- lymphocytes
- inhibiting
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70546—Integrin superfamily
- C07K14/7055—Integrin beta1-subunit-containing molecules, e.g. CD29, CD49
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2842—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Transplantation (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Detergent Compositions (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
H παρούσα εφεύρεση αναφέρεται σε μια μέθοδο για την αναστολή της προσκόλλησης του ενός κυττάρου σε ένα άλλο που περιλαμβάνει την παρεμβολή στην αλληλεπίδραση μεταξύ του υποδοχέα εξωκυτταρικής μήτρας και του προσδέτη του. Η εφεύρεση βασίζεται στην ανακάλυψη ότι ο α4β1 υποδοχέας εξωκυτταρικής μήτρας προάγει την προσκόλληση των λεμφοκυττάρων σε ενδοθηλιακά κύτταρα μέσω της σύνδεσης σε μια καθορισμένη πεπτιδική αλληλουχία. Πριν από την παρούσα εφέρευση, δεν είχε ταυτοποιηθεί ο προσδέτης του α4β1 υποδοχέα, ούτε ήταν γνωστή η λειτουργία του α4β1 υποδοχέα επί της λεμφοκυτταρικής προσκόλλησης. Παρεμποδίζοντας την αλληλεπίδραση μεταξύ α4β1 υποδοχέα και των προσδετών του με την χρησιμοποίηση αντισωμάτων ή καθορισμένων πεπτιδικών αλληλουχιών, η παρούσα εφεύρεση επιτρέπει, για πρώτη φορά, την ειδική παρεμβολή στην μετακίνηση των λεμφοκυττάρων μέσα από το αγγειακό ενδοθήλιο και προς τους ιστούς. Η παρούσα εφεύρεση, επομένως, έχει ιδιαίτερη κλινική χρησιμότητα στην καταστολή των ανόσων αποκρίσεων; σε διάφορες ειδικές ενσωματώσεις της εφεύρεσης, η προσκόλληση των λεμφοκυττάρων στο ενδοθήλιο μπορεί να ανασταλλεί συστηματικά, ή μπορεί, εναλλακτικά, να εντοπισθεί σε ειδικούς ιστούς ή περιγεγραμμένες επιφάνειες. Κατά συνέπεια, η παρούσα εφεύρεση προβλέπει για την θεραπεία ασθενειών που περιλαμβάνουν αυτοάνοσες αποκρίσεις όπως άλλων χρόνιων ή υποτροπιαζουσών ενεργοποιήσεων του άνοσου συστήματος, περιλαμβάνοντας αλλεργία, άσθμα, και χρόνιες φλεγμονώδεις καταστάσεις του δέρματος. ω
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40238989A | 1989-09-01 | 1989-09-01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GR900100648A GR900100648A (en) | 1992-01-20 |
| GR1001161B true GR1001161B (el) | 1993-05-24 |
Family
ID=23591680
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR900100648A GR1001161B (el) | 1989-09-01 | 1990-08-28 | Αναστολη της προσκολλησης των λεμφοκυτταρων στο αγγειακο ενδοθηλιο με τη χρησιμοποιηση μιας αλληλεπιδρασης νεου υποδοχεα εξωκυτταρικης μητρας-προσδετη. |
| GR930100041A GR1001372B (el) | 1989-09-01 | 1990-08-28 | Αναστολή της προσκόλλησης λεμφοκυττάρων στο αγγειακό ενδοθήλιο με την χρησιμοποίηση μιάς αλληλεπίδρασης νέου υποδοχέα εξωκυτταρικής μήτρας-προσδέτη. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR930100041A GR1001372B (el) | 1989-09-01 | 1990-08-28 | Αναστολή της προσκόλλησης λεμφοκυττάρων στο αγγειακό ενδοθήλιο με την χρησιμοποίηση μιάς αλληλεπίδρασης νέου υποδοχέα εξωκυτταρικής μήτρας-προσδέτη. |
Country Status (19)
| Country | Link |
|---|---|
| EP (2) | EP0489837B2 (el) |
| JP (1) | JP3357359B2 (el) |
| KR (1) | KR100188459B1 (el) |
| AT (1) | ATE253642T1 (el) |
| AU (1) | AU654657B2 (el) |
| CA (1) | CA2065292C (el) |
| DD (1) | DD297562A5 (el) |
| DE (3) | DE122006000044I2 (el) |
| DK (1) | DK0489837T4 (el) |
| ES (1) | ES2210225T5 (el) |
| FI (2) | FI116793B (el) |
| GR (2) | GR1001161B (el) |
| IE (2) | IE20040028A1 (el) |
| IL (3) | IL113261A (el) |
| LU (1) | LU91273I2 (el) |
| NL (1) | NL300240I2 (el) |
| NZ (1) | NZ235131A (el) |
| PT (1) | PT95180A (el) |
| WO (1) | WO1991003252A1 (el) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5730978A (en) * | 1989-09-01 | 1998-03-24 | Fred Hutchinson Cancer Research Center | Inhibition of lymphocyte adherence with α4β1-specific antibodies |
| US7238668B1 (en) | 1989-09-01 | 2007-07-03 | Fred Hutchinson Cancer Research Center | Inhibition of lymphocyte adherence with CS-1-peptides and fragments thereof |
| US6033665A (en) * | 1989-09-27 | 2000-03-07 | Elan Pharmaceuticals, Inc. | Compositions and methods for modulating leukocyte adhesion to brain endothelial cells |
| US5629287A (en) * | 1991-01-18 | 1997-05-13 | University College London | Depot formulations |
| US5610148A (en) * | 1991-01-18 | 1997-03-11 | University College London | Macroscopically oriented cell adhesion protein for wound treatment |
| AU3420693A (en) * | 1991-12-24 | 1993-07-28 | Fred Hutchinson Cancer Research Center | Competitive inhibition of high-avidity alpha4-beta1 receptor using tripeptide ldv |
| DK0626861T4 (da) * | 1992-01-13 | 2004-08-16 | Biogen Inc | Behandling af astma. |
| US5871734A (en) * | 1992-01-13 | 1999-02-16 | Biogen, Inc. | Treatment for asthma with VLA-4 blocking agents |
| US5932214A (en) | 1994-08-11 | 1999-08-03 | Biogen, Inc. | Treatment for inflammatory bowel disease with VLA-4 blockers |
| IL102646A (en) * | 1992-07-26 | 1996-05-14 | Yeda Res & Dev | Non-peptidic surrogates of the ldv sequence and pharmaceutical compositions comprising them |
| DK0670735T3 (da) | 1992-11-13 | 1997-07-28 | Univ Washington | Perifisering af hæmotopoietiske stamceller. |
| WO1994017828A2 (en) † | 1993-02-09 | 1994-08-18 | Biogen, Inc. | Treatment for insulin dependent diabetes |
| EP0689609B2 (en) † | 1993-03-18 | 2005-04-13 | N.V. Innogenetics S.A. | Process for typing hla-b using specific primers and probes sets |
| ZA947006B (en) * | 1993-09-15 | 1995-05-02 | Univ Emory | Method of inhibiting binding of reticulocytes to endothelium by interfering with vla-4/vcam-1 interactions |
| WO1995015973A1 (en) * | 1993-12-06 | 1995-06-15 | Cytel Corporation | Cs-1 peptidomimetics, compositions and methods of using the same |
| US5821231A (en) * | 1993-12-06 | 1998-10-13 | Cytel Corporation | CS-1 peptidomimetics, compositions and methods of using same |
| US5770573A (en) * | 1993-12-06 | 1998-06-23 | Cytel Corporation | CS-1 peptidomimetics, compositions and methods of using the same |
| US5936065A (en) * | 1993-12-06 | 1999-08-10 | Cytel Corporation | CS-1 peptidomimetics, compositions and methods of using the same |
| US7435802B2 (en) | 1994-01-25 | 2008-10-14 | Elan Pharaceuticals, Inc. | Humanized anti-VLA4 immunoglobulins |
| EP0804237B8 (en) * | 1994-01-25 | 2006-11-08 | Elan Pharmaceuticals, Inc. | Humanized antibodies against leukocyte adhesion molecule vla-4 |
| US5840299A (en) * | 1994-01-25 | 1998-11-24 | Athena Neurosciences, Inc. | Humanized antibodies against leukocyte adhesion molecule VLA-4 |
| FR2724393A1 (fr) * | 1994-09-12 | 1996-03-15 | Inst Nat Sante Rech Med | Obtention d'un anticorps monoclonal recombinant humanise a partir d'un anticorps monoclonal murin, sa production en cellules d'insecte, et ses utilisations |
| WO1997035557A1 (en) * | 1996-03-22 | 1997-10-02 | Kao Corporation | External skin-care composition |
| US7147851B1 (en) | 1996-08-15 | 2006-12-12 | Millennium Pharmaceuticals, Inc. | Humanized immunoglobulin reactive with α4β7 integrin |
| PL215263B1 (pl) | 2002-02-25 | 2013-11-29 | Elan Pharm Inc | Kompozycja do przewleklego leczenia patologicznego zapalenia i zastosowanie natalizumabu lub jego immunologicznie aktywnego fragmentu do wytwarzania leku |
| US7125650B2 (en) | 2004-07-20 | 2006-10-24 | Roberts David H | Method for bump exposing relief image printing plates |
| UA116189C2 (uk) | 2011-05-02 | 2018-02-26 | Мілленніум Фармасьютікалз, Інк. | КОМПОЗИЦІЯ АНТИ-α4β7 АНТИТІЛА |
| DK3311834T3 (da) | 2011-05-02 | 2026-04-20 | Millennium Pharmaceuticals Inc | Formulering til anti-alfa4beta7-antistof |
| IT202400002376A1 (it) * | 2024-02-05 | 2025-08-05 | Univ Degli Studi Di Brescia | Marcatori plasmatici di sindrome di ehlers-danlos ipermobile, disordini nello spettro dell’ipermobilità articolare, osteoartrite, artrite reumatoide e artrite psoriasica |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4578079A (en) * | 1982-08-04 | 1986-03-25 | La Jolla Cancer Research Foundation | Tetrapeptide |
| WO1990008833A1 (en) * | 1989-02-02 | 1990-08-09 | Massachusetts Institute Of Technology | Expression of recombinant fibronectin in genetically engineered cells |
-
1990
- 1990-08-27 IL IL11326190A patent/IL113261A/en active IP Right Grant
- 1990-08-27 IL IL95501A patent/IL95501A/xx active IP Right Grant
- 1990-08-28 GR GR900100648A patent/GR1001161B/el not_active IP Right Cessation
- 1990-08-28 GR GR930100041A patent/GR1001372B/el not_active IP Right Cessation
- 1990-08-31 IE IE20040028A patent/IE20040028A1/en not_active IP Right Cessation
- 1990-08-31 KR KR1019920700621A patent/KR100188459B1/ko not_active Expired - Fee Related
- 1990-08-31 EP EP90913598.0A patent/EP0489837B2/en not_active Expired - Lifetime
- 1990-08-31 JP JP51276390A patent/JP3357359B2/ja not_active Expired - Lifetime
- 1990-08-31 DE DE122006000044C patent/DE122006000044I2/de active Active
- 1990-08-31 CA CA002065292A patent/CA2065292C/en not_active Expired - Lifetime
- 1990-08-31 DK DK90913598.0T patent/DK0489837T4/da active
- 1990-08-31 AT AT90913598T patent/ATE253642T1/de active
- 1990-08-31 EP EP20030017578 patent/EP1366769A1/en not_active Withdrawn
- 1990-08-31 NZ NZ235131A patent/NZ235131A/xx unknown
- 1990-08-31 WO PCT/US1990/004978 patent/WO1991003252A1/en not_active Ceased
- 1990-08-31 IE IE316990A patent/IE903169A1/en active IP Right Review Request
- 1990-08-31 DE DE69034116.4T patent/DE69034116T3/de not_active Expired - Lifetime
- 1990-08-31 PT PT95180A patent/PT95180A/pt not_active Application Discontinuation
- 1990-08-31 ES ES90913598.0T patent/ES2210225T5/es not_active Expired - Lifetime
- 1990-08-31 AU AU63542/90A patent/AU654657B2/en not_active Expired
- 1990-08-31 DE DE1990634116 patent/DE122006000044I1/de active Pending
- 1990-09-03 DD DD90343788A patent/DD297562A5/de unknown
-
1992
- 1992-02-28 FI FI920899A patent/FI116793B/fi active IP Right Grant
-
1995
- 1995-04-05 IL IL11326195A patent/IL113261A0/xx unknown
-
2005
- 2005-09-21 FI FI20050941A patent/FI118842B/fi active IP Right Grant
-
2006
- 2006-08-10 LU LU91273C patent/LU91273I2/fr unknown
- 2006-08-11 NL NL300240C patent/NL300240I2/nl unknown
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