GR1001372B - Αναστολή της προσκόλλησης λεμφοκυττάρων στο αγγειακό ενδοθήλιο με την χρησιμοποίηση μιάς αλληλεπίδρασης νέου υποδοχέα εξωκυτταρικής μήτρας-προσδέτη. - Google Patents

Αναστολή της προσκόλλησης λεμφοκυττάρων στο αγγειακό ενδοθήλιο με την χρησιμοποίηση μιάς αλληλεπίδρασης νέου υποδοχέα εξωκυτταρικής μήτρας-προσδέτη.

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Publication number
GR1001372B
GR1001372B GR930100041A GR930100041A GR1001372B GR 1001372 B GR1001372 B GR 1001372B GR 930100041 A GR930100041 A GR 930100041A GR 930100041 A GR930100041 A GR 930100041A GR 1001372 B GR1001372 B GR 1001372B
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GR
Greece
Prior art keywords
present
receptor
specific
extracellular matrix
vascular endothelium
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GR930100041A
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English (en)
Inventor
Elizabeth Wayner
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Hutchinson Fred Cancer Res
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23591680&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GR1001372(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hutchinson Fred Cancer Res filed Critical Hutchinson Fred Cancer Res
Publication of GR1001372B publication Critical patent/GR1001372B/el

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70546—Integrin superfamily
    • C07K14/7055—Integrin beta1-subunit-containing molecules, e.g. CD29, CD49
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2842—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Detergent Compositions (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

Η παρούσα εφεύρεση αναφέρεται σε μια μέθοδο για την αναστολήτης προσκόλλησης του ενός κυττάρου σε ένα άλλο πουπεριλαμβάνει την παρεμβολή στην αλληλεπίδραση μεταξύ τουυποδοχέα εξωκυτταρικής μήτρας και του προσδέτη του.Η εφεύρεση βασίζεται στην ανακάλυψη ότι ο α4β1 υποδοχέαςεξωκυτταρικής μήτρας προάγει την προσκόλληση τωνλεμφοκυττάρων σε ενδοθηλιακά κύτταρα μέσω της σύνδεσης σε μιακαθορισμένη πεπτιδική αλληλουχία. Πριν από την παρούσαεφεύρεση, δεν είχε ταυτοποιηθεί ο προσδέτης του α4β1υποδοχέα, ούτε ήταν γνωστή η λειτουργία του α4β1 υποδοχέα επίτης λεμφοκυτταριακής προσκόλλησης. Παρεμποδίζοντας τηναλληλεπίδραση μεταξύ α4β1 υποδοχέα και των προσδετών του μετην χρησιμοποίηση αντισωμάτων ή καθορισμένων πεπτιδικώναλληλουχιών, η παρούσα εφεύρεση επιτρέπει, για πρώτη φορά,τηνειδική παρεμβολή στην μετακίνηση των λεμφοκυττάρων μέσααπό το αγγειακό ενδοθήλιο και προς τους ιστούς. Η παρούσαεφεύρεση, επομένως, έχει ιδιαίτερη κλινική χρησιμότητα στηνκαταστολή των άνοσων αποκρίσεων; σε διάφορες ειδικέςενσωματώσεις της εφεύρεσης, η προσκόλληση των λεμφοκυττάρωνστο ενδοθήλιο μπορεί να ανασταλλεί συστηματικά, ή μπορείεναλλακτικά, να εντοπισθεί σε ειδικούς ιστούς ήπεριγεγραμμένες επιφάνειες. Κατά συνέπεια, η παρούσα εφεύρεσηπροβλέπει για την θεραπεία ασθενειών που περιλαμβάνουναυτοάνοσες αποκρίσεις όπως άλλων χρόνιων ή υποτροπιαζουσώνενεργοποιήσεων του άνοσου συστήματος, περιλαμβάνονταςαλλεργία, άσθμα, και χρόνιες φλεγμονώδεις καταστάσεις τουδέρματος.ω
GR930100041A 1989-09-01 1990-08-28 Αναστολή της προσκόλλησης λεμφοκυττάρων στο αγγειακό ενδοθήλιο με την χρησιμοποίηση μιάς αλληλεπίδρασης νέου υποδοχέα εξωκυτταρικής μήτρας-προσδέτη. GR1001372B (el)

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US40238989A 1989-09-01 1989-09-01

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GR1001372B true GR1001372B (el) 1993-10-29

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ID=23591680

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GR900100648A GR1001161B (el) 1989-09-01 1990-08-28 Αναστολη της προσκολλησης των λεμφοκυτταρων στο αγγειακο ενδοθηλιο με τη χρησιμοποιηση μιας αλληλεπιδρασης νεου υποδοχεα εξωκυτταρικης μητρας-προσδετη.
GR930100041A GR1001372B (el) 1989-09-01 1990-08-28 Αναστολή της προσκόλλησης λεμφοκυττάρων στο αγγειακό ενδοθήλιο με την χρησιμοποίηση μιάς αλληλεπίδρασης νέου υποδοχέα εξωκυτταρικής μήτρας-προσδέτη.

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GR900100648A GR1001161B (el) 1989-09-01 1990-08-28 Αναστολη της προσκολλησης των λεμφοκυτταρων στο αγγειακο ενδοθηλιο με τη χρησιμοποιηση μιας αλληλεπιδρασης νεου υποδοχεα εξωκυτταρικης μητρας-προσδετη.

Country Status (19)

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EP (2) EP0489837B2 (el)
JP (1) JP3357359B2 (el)
KR (1) KR100188459B1 (el)
AT (1) ATE253642T1 (el)
AU (1) AU654657B2 (el)
CA (1) CA2065292C (el)
DD (1) DD297562A5 (el)
DE (3) DE122006000044I2 (el)
DK (1) DK0489837T4 (el)
ES (1) ES2210225T5 (el)
FI (2) FI116793B (el)
GR (2) GR1001161B (el)
IE (2) IE20040028A1 (el)
IL (3) IL113261A (el)
LU (1) LU91273I2 (el)
NL (1) NL300240I2 (el)
NZ (1) NZ235131A (el)
PT (1) PT95180A (el)
WO (1) WO1991003252A1 (el)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5730978A (en) * 1989-09-01 1998-03-24 Fred Hutchinson Cancer Research Center Inhibition of lymphocyte adherence with α4β1-specific antibodies
US7238668B1 (en) 1989-09-01 2007-07-03 Fred Hutchinson Cancer Research Center Inhibition of lymphocyte adherence with CS-1-peptides and fragments thereof
US6033665A (en) * 1989-09-27 2000-03-07 Elan Pharmaceuticals, Inc. Compositions and methods for modulating leukocyte adhesion to brain endothelial cells
US5629287A (en) * 1991-01-18 1997-05-13 University College London Depot formulations
US5610148A (en) * 1991-01-18 1997-03-11 University College London Macroscopically oriented cell adhesion protein for wound treatment
AU3420693A (en) * 1991-12-24 1993-07-28 Fred Hutchinson Cancer Research Center Competitive inhibition of high-avidity alpha4-beta1 receptor using tripeptide ldv
DK0626861T4 (da) * 1992-01-13 2004-08-16 Biogen Inc Behandling af astma.
US5871734A (en) * 1992-01-13 1999-02-16 Biogen, Inc. Treatment for asthma with VLA-4 blocking agents
US5932214A (en) 1994-08-11 1999-08-03 Biogen, Inc. Treatment for inflammatory bowel disease with VLA-4 blockers
IL102646A (en) * 1992-07-26 1996-05-14 Yeda Res & Dev Non-peptidic surrogates of the ldv sequence and pharmaceutical compositions comprising them
DK0670735T3 (da) 1992-11-13 1997-07-28 Univ Washington Perifisering af hæmotopoietiske stamceller.
WO1994017828A2 (en) † 1993-02-09 1994-08-18 Biogen, Inc. Treatment for insulin dependent diabetes
EP0689609B2 (en) † 1993-03-18 2005-04-13 N.V. Innogenetics S.A. Process for typing hla-b using specific primers and probes sets
ZA947006B (en) * 1993-09-15 1995-05-02 Univ Emory Method of inhibiting binding of reticulocytes to endothelium by interfering with vla-4/vcam-1 interactions
WO1995015973A1 (en) * 1993-12-06 1995-06-15 Cytel Corporation Cs-1 peptidomimetics, compositions and methods of using the same
US5821231A (en) * 1993-12-06 1998-10-13 Cytel Corporation CS-1 peptidomimetics, compositions and methods of using same
US5770573A (en) * 1993-12-06 1998-06-23 Cytel Corporation CS-1 peptidomimetics, compositions and methods of using the same
US5936065A (en) * 1993-12-06 1999-08-10 Cytel Corporation CS-1 peptidomimetics, compositions and methods of using the same
US7435802B2 (en) 1994-01-25 2008-10-14 Elan Pharaceuticals, Inc. Humanized anti-VLA4 immunoglobulins
EP0804237B8 (en) * 1994-01-25 2006-11-08 Elan Pharmaceuticals, Inc. Humanized antibodies against leukocyte adhesion molecule vla-4
US5840299A (en) * 1994-01-25 1998-11-24 Athena Neurosciences, Inc. Humanized antibodies against leukocyte adhesion molecule VLA-4
FR2724393A1 (fr) * 1994-09-12 1996-03-15 Inst Nat Sante Rech Med Obtention d'un anticorps monoclonal recombinant humanise a partir d'un anticorps monoclonal murin, sa production en cellules d'insecte, et ses utilisations
WO1997035557A1 (en) * 1996-03-22 1997-10-02 Kao Corporation External skin-care composition
US7147851B1 (en) 1996-08-15 2006-12-12 Millennium Pharmaceuticals, Inc. Humanized immunoglobulin reactive with α4β7 integrin
PL215263B1 (pl) 2002-02-25 2013-11-29 Elan Pharm Inc Kompozycja do przewleklego leczenia patologicznego zapalenia i zastosowanie natalizumabu lub jego immunologicznie aktywnego fragmentu do wytwarzania leku
US7125650B2 (en) 2004-07-20 2006-10-24 Roberts David H Method for bump exposing relief image printing plates
UA116189C2 (uk) 2011-05-02 2018-02-26 Мілленніум Фармасьютікалз, Інк. КОМПОЗИЦІЯ АНТИ-α4β7 АНТИТІЛА
DK3311834T3 (da) 2011-05-02 2026-04-20 Millennium Pharmaceuticals Inc Formulering til anti-alfa4beta7-antistof
IT202400002376A1 (it) * 2024-02-05 2025-08-05 Univ Degli Studi Di Brescia Marcatori plasmatici di sindrome di ehlers-danlos ipermobile, disordini nello spettro dell’ipermobilità articolare, osteoartrite, artrite reumatoide e artrite psoriasica

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990008833A1 (en) * 1989-02-02 1990-08-09 Massachusetts Institute Of Technology Expression of recombinant fibronectin in genetically engineered cells

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4578079A (en) * 1982-08-04 1986-03-25 La Jolla Cancer Research Foundation Tetrapeptide

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990008833A1 (en) * 1989-02-02 1990-08-09 Massachusetts Institute Of Technology Expression of recombinant fibronectin in genetically engineered cells

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CELL. vol. 60, 12 January 1990, CAMBRIDGE, NA US pages 53 - 61 J-L. GUAN ET AL. 'LYMPHOID CELLS RECOGNIZE AN ALTERNATIVELY SPLICED SEGMENT OF FIBRONECTIN VIA THE INTEGRIN RECEPTOR ALPHA-4, BETA-1.' *
EXPERIMENTAL CELL RESEARCH vol. 181, no. 2, April 1989, NEW YORK, N.Y., US pages 348 - 361 N-S. LIAO ET AL. 'ADHESION OF LYMPHOID CELLS TO THE CARBOXYL-TERMINAL HEPARIN-BINDING DOMAINS OF FIBRONECTIN.' *
JOURNAL OF BIOLOGICAL CHEMISTRY vol. 262, no. 14, 15 May 1987, BALTIMORE, MD US pages 6886 - 6892 M.J. HUMPHRIES ET AL. 'IDENTIFICATION OF TWO DISTINCT REGIONS OF THE TYPE III CONNECTING SEGMENT OF HUMAN PLASMA FIBRONECTIN THAT PROMOTE CELL TYPE-SPECIFIC ADHESION.' *
THE JOURNAL OF CELL BIOLOGY vol. 109, no. 3, September 1989, NEW YORK, N.Y., US pages 1321 - 1330 E.A. WAYNER ET AL. 'IDENTIFICATION AND CHARACTERIZATION OF THE T LYMPHOCYTE ADHESION RECEPTOR FOR AN ALTERNATIVE CELL ATTACHMENT DOMAIN (CS-1) IN PLASMA FIBRONECTIN.' *

Also Published As

Publication number Publication date
KR100188459B1 (ko) 1999-06-01
PT95180A (pt) 1991-05-22
FI920899A0 (fi) 1992-02-28
DD297562A5 (de) 1992-01-16
GR900100648A (en) 1992-01-20
FI20050941L (fi) 2005-09-21
DE69034116T3 (de) 2014-06-18
DE69034116D1 (de) 2003-12-11
WO1991003252A1 (en) 1991-03-21
FI116793B (fi) 2006-02-28
IE20040028A1 (en) 2004-05-05
KR920703086A (ko) 1992-12-17
ATE253642T1 (de) 2003-11-15
EP1366769A1 (en) 2003-12-03
NZ235131A (en) 1993-03-26
DE122006000044I2 (de) 2011-01-13
NL300240I2 (nl) 2007-03-01
GR1001161B (el) 1993-05-24
DE122006000044I1 (de) 2007-04-19
CA2065292A1 (en) 1991-03-02
JPH05503070A (ja) 1993-05-27
IE903169A1 (en) 1991-03-13
IL95501A (en) 1997-04-15
ES2210225T5 (es) 2014-02-04
DE69034116T2 (de) 2004-08-26
DK0489837T4 (da) 2013-11-18
CA2065292C (en) 2001-05-29
ES2210225T3 (es) 2004-07-01
IL113261A0 (en) 1995-07-31
EP0489837A4 (en) 1993-06-16
JP3357359B2 (ja) 2002-12-16
AU6354290A (en) 1991-04-08
FI118842B (fi) 2008-04-15
EP0489837B1 (en) 2003-11-05
IL113261A (en) 1996-10-16
EP0489837A1 (en) 1992-06-17
EP0489837B2 (en) 2013-11-13
AU654657B2 (en) 1994-11-17
LU91273I2 (fr) 2006-10-10
DK0489837T3 (da) 2004-03-01
NL300240I1 (nl) 2006-10-02

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