GR1003575B - Βιομηχανικα ειδη. - Google Patents

Βιομηχανικα ειδη.

Info

Publication number
GR1003575B
GR1003575B GR20000100153A GR2000100153A GR1003575B GR 1003575 B GR1003575 B GR 1003575B GR 20000100153 A GR20000100153 A GR 20000100153A GR 2000100153 A GR2000100153 A GR 2000100153A GR 1003575 B GR1003575 B GR 1003575B
Authority
GR
Greece
Prior art keywords
inhibition
pde5
articles
manufacture
phosphodiesterase
Prior art date
Application number
GR20000100153A
Other languages
English (en)
Other versions
GR20000100153A (el
Inventor
Jeffrey Thomas Emmick
John Steven Whitaker
William Ernest Pullman
Kenneth Michael Ferguson
Original Assignee
Lilly Icos Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22452153&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GR1003575(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Icos Llc filed Critical Lilly Icos Llc
Publication of GR20000100153A publication Critical patent/GR20000100153A/el
Publication of GR1003575B publication Critical patent/GR1003575B/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Pregnancy & Childbirth (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Formation And Processing Of Food Products (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Glass Compositions (AREA)

Abstract

Η παρούσα εφευρεση αναφέρεται σε εξαιρετικά επιλεκτικούς αναστολείς του ενζύμου φωσφοδιεστεράση (PDE) και στη χρήση τους σε φαρμακευτικά βιομηχανικά είδη. Ειδικότερα, η παρούσα εφεύρεση αναφέρεται σε ισχυρούς αναστολείς της εξειδικευμένης για την κυκλική 3',5'-μονοφωσφορική γουανοσίνη φωσφοδιεστεράσης τύπου 5 (PDE5) οι οποίοι όταν ενσωματώνονται σε ένα φαρμακευτικό προϊόν σε μοναδιαίες δόσεις από περίπου 1 έως περίπου 20 mg είναι χρήσιμοι για την αγωγή της γενετήσιας δυσλειτουργίας. Τα ενταύθα περιγραφόμενα βιομηχανικά είδη χαρακτηρίζονται από την επιλεκτική αναστολή της PDE5 και συνεπώς παρέχουν μία ωφέλεια σε θεραπευτικά πεδία όπου επιθυμείται η αναστολή της PDE5, με ελαχιστοποίηση ή εξάλειψη των βλαπτικών παρενεργειών που προκύπτουν από την αναστολή άλλων ενζύμων τύπου φωσφοδιεστεράσης.ΰ
GR20000100153A 1999-04-30 2000-04-26 Βιομηχανικα ειδη. GR1003575B (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13203699P 1999-04-30 1999-04-30

Publications (2)

Publication Number Publication Date
GR20000100153A GR20000100153A (el) 2000-12-29
GR1003575B true GR1003575B (el) 2001-05-14

Family

ID=22452153

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20000100153A GR1003575B (el) 1999-04-30 2000-04-26 Βιομηχανικα ειδη.

Country Status (47)

Country Link
EP (2) EP1173181B3 (el)
JP (2) JP2000336043A (el)
KR (2) KR20010020779A (el)
CN (2) CN1292264A (el)
AT (1) ATE251908T1 (el)
AU (3) AU769946C (el)
BE (1) BE1012957A5 (el)
BR (2) BR0010181A (el)
CA (2) CA2307101C (el)
CH (2) CH692478A5 (el)
CO (1) CO5170493A1 (el)
CZ (1) CZ296534B6 (el)
DE (3) DE60005940T3 (el)
DK (2) DK1173181T6 (el)
DZ (1) DZ3171A1 (el)
EA (2) EA005416B1 (el)
ES (2) ES2187234A1 (el)
FI (1) FI20000976A7 (el)
FR (1) FR2795646B1 (el)
GB (1) GB2351663A (el)
GR (1) GR1003575B (el)
HK (1) HK1041204B (el)
HR (2) HRP20010778B1 (el)
HU (2) HUP0001632A3 (el)
ID (1) ID25704A (el)
IE (1) IE20000315A1 (el)
IL (3) IL135817A0 (el)
IT (1) ITMI20000922A1 (el)
LT (1) LT4758B (el)
LU (1) LU90569B1 (el)
LV (1) LV12560B (el)
MX (2) MXPA00003997A (el)
NL (1) NL1015027C2 (el)
NO (2) NO20002097L (el)
NZ (2) NZ504163A (el)
PE (1) PE20010071A1 (el)
PL (2) PL339897A1 (el)
PT (2) PT1173181E (el)
SE (1) SE0001518L (el)
SG (1) SG98384A1 (el)
SI (2) SI1173181T1 (el)
SK (1) SK285415B6 (el)
SV (1) SV2002000055A (el)
TR (1) TR200001132A2 (el)
UA (1) UA72248C2 (el)
WO (1) WO2000066099A2 (el)
ZA (2) ZA200002058B (el)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ516616A (en) * 1999-08-03 2003-07-25 Lilly Icos Llc Beta-carboline pharmaceutical compositions
DE10010612A1 (de) * 2000-03-03 2001-09-27 Merck Patent Gmbh Verwendung von PDE V-Inhibitoren
JP2004533402A (ja) * 2000-06-08 2004-11-04 リリー アイコス リミテッド ライアビリティ カンパニー Ｐｄｅｖインヒビターとしての四環系ジケトピペラジン化合物
WO2002010166A1 (en) * 2000-08-02 2002-02-07 Lilly Icos Llc Fused heterocyclic derivatives as phosphodiesterase inhibitors
EP1401449B1 (en) * 2001-06-05 2007-04-25 Lilly Icos LLC Tetracyclic compounds as pde5-inhibitors
GB0129274D0 (en) * 2001-12-06 2002-01-23 Pfizer Ltd Novel kit
US20060205733A1 (en) * 2004-08-26 2006-09-14 Encysive Pharmaceuticals Endothelin a receptor antagonists in combination with phosphodiesterase 5 inhibitors and uses thereof
AU2007230716B2 (en) * 2006-03-28 2012-05-03 Javelin Pharmaceuticals, Inc. Formulations of low dose diclofenac and beta-cyclodextrin
US7495024B2 (en) 2006-08-07 2009-02-24 Via Pharmaceuticals, Inc. Phenylalkyl N-hydroxyureas for combating atherosclerotic plaque
DE102007028869A1 (de) 2007-06-22 2008-12-24 Ratiopharm Gmbh Verfahren zur Herstellung eines Arzneimittels enthaltend Tadalafil
DE102009033396A1 (de) 2009-07-16 2011-01-20 Ratiopharm Gmbh Wässrige Lösung und gelatinierte Zusammensetzung umfassend einen Phosphodiesterase-5-Inhibitor sowie diesbezügliche Verfahren und Verwendung
US10610528B2 (en) 2009-12-08 2020-04-07 Intelgenx Corp. Solid oral film dosage forms and methods for making same
US20110136815A1 (en) 2009-12-08 2011-06-09 Horst Zerbe Solid oral film dosage forms and methods for making same
US20110263606A1 (en) * 2010-04-26 2011-10-27 Horst Zerbe Solid oral dosage forms comprising tadalafil
WO2012107090A1 (en) 2011-02-10 2012-08-16 Synthon Bv Granulated composition comprising tadalafil and a disintegrant
WO2012107541A1 (en) 2011-02-10 2012-08-16 Synthon Bv Pharmaceutical composition comprising tadalafil and a cyclodextrin
WO2012107092A1 (en) 2011-02-10 2012-08-16 Synthon Bv Pharmaceutical composition comprising tadalafil and a cyclodextrin
KR102239291B1 (ko) 2013-06-28 2021-04-14 한미약품 주식회사 타다라필 또는 이의 약학적으로 허용가능한 염을 포함하는 저작정 제제
KR20150056443A (ko) 2013-11-15 2015-05-26 한미약품 주식회사 타다라필 및 암로디핀을 포함하는 복합제제
JP2019065006A (ja) 2017-09-29 2019-04-25 ハンミ ファーマシューティカルズ カンパニー リミテッド 生産性及び均一性が改善されたタダラフィルを含む固形製剤、及びその製造方法
KR102894055B1 (ko) * 2018-02-07 2025-12-02 스마와 게엠베하 약학 제형, 약학 제형을 제조하기 위한 방법 및 이를 포함하는 의약

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GB9514465D0 (en) 1995-07-14 1995-09-13 Glaxo Lab Sa Chemical compounds
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WO1999059584A1 (en) * 1998-05-20 1999-11-25 Schering Corporation Combination of phentolamine and cyclic gmp phosphodiesterase inhibitors for the treatment of sexual dysfunction
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WO2000053148A2 (en) * 1999-03-08 2000-09-14 Merck & Co., Inc. Methods and compositions for treating erectile dysfunction
CA2365782A1 (en) * 1999-04-30 2000-11-09 William E. Pullman Treatment of female arousal disorder
US6451807B1 (en) * 1999-04-30 2002-09-17 Lilly Icos, Llc. Methods of treating sexual dysfunction in an individual suffering from a retinal disease, class 1 congestive heart failure, or myocardial infarction using a PDE5 inhibitor

Also Published As

Publication number Publication date
BE1012957A5 (fr) 2001-06-05
CA2307101C (en) 2003-01-28
CA2307101A1 (en) 2000-10-30
AU769946C (en) 2005-01-13
NL1015027C2 (nl) 2001-02-14
HUP0001632A3 (en) 2001-12-28
MXPA00003997A (es) 2002-03-08
LT4758B (lt) 2001-02-26
HUP0001632A2 (hu) 2001-05-28
IL135817A0 (en) 2001-05-20
NO20015275L (no) 2001-12-06
HRP20010778B1 (en) 2005-04-30
AU3012900A (en) 2000-11-02
NO20002097D0 (no) 2000-04-25
WO2000066099A3 (en) 2001-01-18
JP2000336043A (ja) 2000-12-05
SE0001518L (sv) 2000-10-31
PL352629A1 (en) 2003-08-25
EA200000355A2 (ru) 2000-10-30
DK200000677A (da) 2000-10-31
NZ514882A (en) 2003-08-29
JP2002543116A (ja) 2002-12-17
KR100577057B1 (ko) 2006-05-10
WO2000066099A2 (en) 2000-11-09
EP1173181B1 (en) 2003-10-15
DE20007861U1 (de) 2000-08-24
ID25704A (id) 2000-11-02
CA2371684C (en) 2007-10-23
DE10021266A1 (de) 2000-11-16
SV2002000055A (es) 2002-07-03
KR20010020779A (ko) 2001-03-15
TR200001132A3 (tr) 2001-01-22
SI20361A (sl) 2001-04-30
IL146098A (en) 2007-06-03
LV12560B (en) 2001-04-20
HUP0200912A2 (en) 2002-08-28
ATE251908T1 (de) 2003-11-15
HUP0200912A3 (en) 2003-07-28
GB0010199D0 (en) 2000-06-14
IE20000315A1 (en) 2001-03-07
BR0010181A (pt) 2003-02-25
ES2208317T3 (es) 2004-06-16
UA72248C2 (en) 2005-02-15
FR2795646A1 (fr) 2001-01-05
IL146098A0 (en) 2002-07-25
HRP20000243A2 (en) 2001-12-31
SE0001518D0 (sv) 2000-04-26
ITMI20000922A1 (it) 2001-10-26
SG98384A1 (en) 2003-09-19
SK15632001A3 (sk) 2002-02-05
LU90569B1 (fr) 2002-02-27
CZ296534B6 (cs) 2006-04-12
BR0003046A (pt) 2002-07-23
JP4975214B2 (ja) 2012-07-11
AU769946B2 (en) 2004-02-12
TR200001132A2 (tr) 2001-01-22
DE60005940T3 (de) 2015-08-27
AU2004201988A1 (en) 2004-06-10
EP1415652A3 (en) 2004-05-12
CN1292264A (zh) 2001-04-25
SI1173181T1 (en) 2004-04-30
MXPA01010837A (es) 2002-11-07
HU230369B1 (hu) 2016-03-29
AU4490800A (en) 2000-11-17
SK285415B6 (sk) 2007-01-04
ES2208317T7 (es) 2015-09-15
PT1173181E (pt) 2004-02-27
FI20000976L (fi) 2000-10-30
CH1173181H1 (el) 2019-07-15
DE60005940T2 (de) 2004-07-29
NO20002097L (no) 2001-10-26
EP1415652A2 (en) 2004-05-06
GR20000100153A (el) 2000-12-29
HU0200912D0 (en) 2002-04-29
FI20000976A0 (fi) 2000-04-26
NZ504163A (en) 2001-11-30
DZ3171A1 (el) 2000-11-09
CH692478A5 (de) 2002-07-15
PL197813B1 (pl) 2008-04-30
DK1173181T6 (en) 2015-04-27
PT102457A (pt) 2000-11-30
CO5170493A1 (es) 2002-06-27
KR20020008396A (ko) 2002-01-30
CN1196487C (zh) 2005-04-13
CN1384746A (zh) 2002-12-11
PL339897A1 (en) 2000-11-06
HK1041204B (en) 2004-03-05
ZA200108900B (en) 2003-03-26
CZ20013879A3 (cs) 2002-04-17
LT2000035A (lt) 2000-11-27
EP1173181B3 (en) 2015-03-25
EA200000355A3 (ru) 2001-02-26
NL1015027A1 (nl) 2000-10-31
PE20010071A1 (es) 2001-03-22
GB2351663A (en) 2001-01-10
FR2795646B1 (fr) 2002-08-16
ZA200002058B (en) 2000-11-02
EA200101008A1 (ru) 2002-04-25
FI20000976A7 (fi) 2000-10-30
LV12560A (en) 2000-11-20
NO322013B3 (no) 2017-11-06
DE60005940D1 (de) 2003-11-20
ITMI20000922A0 (it) 2000-04-26
CA2371684A1 (en) 2000-11-09
DK1173181T3 (da) 2004-02-16
NO20015275D0 (no) 2001-10-29
EP1173181A2 (en) 2002-01-23
EA005416B1 (ru) 2005-02-24
HU0001632D0 (en) 2000-06-28
HK1041204A1 (en) 2002-07-05
HRP20010778A2 (en) 2002-12-31
ES2187234A1 (es) 2003-05-16
NO322013B1 (no) 2006-08-07

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