GR3014936T3 - A process for the optical resolution of dropropizine. - Google Patents

A process for the optical resolution of dropropizine.

Info

Publication number: GR3014936T3
Authority: GR; Greece
Prior art keywords: optical resolution; dropropizine; carried out; aqueous medium; tartaric acid
Prior art date: 1989-07-20

Application number

GR950400200T

Other languages

English (en)

Inventor

Roberto Giani

Original Assignee

Dompe Farmaceutici Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-07-20

Filing date

1995-02-01

Publication date

1995-05-31

1995-02-01 Application filed by Dompe Farmaceutici Spa filed Critical Dompe Farmaceutici Spa

1995-05-31 Publication of GR3014936T3 publication Critical patent/GR3014936T3/el

Links

230000003287 optical effect Effects 0.000 title abstract 3
PTVWPYVOOKLBCG-UHFFFAOYSA-N 3-(4-phenyl-1-piperazinyl)propane-1,2-diol Chemical compound C1CN(CC(O)CO)CCN1C1=CC=CC=C1 PTVWPYVOOKLBCG-UHFFFAOYSA-N 0.000 title abstract 2
229960004722 dropropizine Drugs 0.000 title abstract 2
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 abstract 1
235000011002 L(+)-tartaric acid Nutrition 0.000 abstract 1
239000001358 L(+)-tartaric acid Substances 0.000 abstract 1
FEWJPZIEWOKRBE-LWMBPPNESA-N L-(+)-Tartaric acid Natural products OC(=O)[C@@H](O)[C@H](O)C(O)=O FEWJPZIEWOKRBE-LWMBPPNESA-N 0.000 abstract 1
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 abstract 1
239000012736 aqueous medium Substances 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B57/00—Separation of optically-active compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Optical Couplings Of Light Guides (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Glass Compositions (AREA)
Prostheses (AREA)
Indole Compounds (AREA)
Semiconductor Lasers (AREA)

GR950400200T 1989-07-20 1995-02-01 A process for the optical resolution of dropropizine. GR3014936T3 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT8921244A IT1231158B (it)	1989-07-20	1989-07-20	Procedimento per la risoluzione ottica della dropropizina.

Publications (1)

Publication Number	Publication Date
GR3014936T3 true GR3014936T3 (en)	1995-05-31

Family

ID=11178946

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
GR91300062T GR910300062T1 (en)	1989-07-20	1991-11-15	A process for the optical resolution of dropropizine
GR950400200T GR3014936T3 (en)	1989-07-20	1995-02-01	A process for the optical resolution of dropropizine.

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
GR91300062T GR910300062T1 (en)	1989-07-20	1991-11-15	A process for the optical resolution of dropropizine

Country Status (11)

Country	Link
US (1)	US5087698A (el)
EP (1)	EP0409044B1 (el)
JP (1)	JP2977237B2 (el)
KR (1)	KR0146047B1 (el)
AT (1)	ATE116975T1 (el)
CA (1)	CA2007385C (el)
DE (2)	DE69015907T2 (el)
ES (1)	ES2019010A6 (el)
GR (2)	GR910300062T1 (el)
IT (1)	IT1231158B (el)
PT (1)	PT92767B (el)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1254452B (it) *	1992-02-14	1995-09-25	Dompe Farmaceutici Spa	N-ossidi ed n,n'-diossidi di 3-(piperazin-1-il)-propan-1,2-dioli
IT1254993B (it) *	1992-06-24	1995-10-11		Procedimento per la preparazione degli enantiomeri della dropropizina
IN187238B (el) *	1995-06-30	2002-03-09	Astra Ab
DE19821039A1 (de) *	1998-05-11	1999-11-18	Bayer Ag	Verfahren zur Herstellung von (S,S)-Benzyl-2,8-diazabicyclo[4.3.0]nonan

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE601394A (el) *
NL275711A (el) *	1962-03-15
US4312877A (en) *	1979-07-09	1982-01-26	Pfizer Inc.	1-(2-Hydroxy-3-n-alkoxypropyl)-4-substituted piperidines, pharmaceutical compositions, thereof and use thereof
US4255426A (en) *	1979-07-09	1981-03-10	Pfizer Inc.	1-(2-Hydroxy-3-n-alkoxypropyl)-4-substituted-piperazines and piperidines
IT1210639B (it) *	1981-02-25	1989-09-14	Menarini Sas	Prodotto: 3(4-fenil1piperazinio-1-il)-1,2-propandiolo 3(teofillin-7-il)-1propansolfonato,utilizzabile in terapia,e relativo procedimento di fabbricazione
IT1203721B (it) *	1983-12-29	1989-02-23	Dompe Farmaceutici Spa	Composti otticamente attivi ad attivita' antitosse e sedativa centrale,procedimento per la preparazione e composizioni che li contengono
NL8801622A (nl) *	1988-06-25	1990-01-16	Stamicarbon	Bereiding van enantiomeren van dropropizine.
IT1217950B (it) *	1988-06-28	1990-03-30	Dott Formenti Ind Chimica E Fa	Sali di (r,s) 3 (4 fenil 1 piperazinil) 1,2 propandtolo
IT1226570B (it) *	1988-08-01	1991-01-24	Bidachem Spa	Procedimento di preparazione della levo- e destro-dropropizina

1989
- 1989-07-20 IT IT8921244A patent/IT1231158B/it active
- 1989-12-29 ES ES8904429A patent/ES2019010A6/es not_active Expired - Fee Related
- 1989-12-29 PT PT92767A patent/PT92767B/pt not_active IP Right Cessation
1990
- 1990-01-09 CA CA002007385A patent/CA2007385C/en not_active Expired - Lifetime
- 1990-01-11 KR KR1019900000286A patent/KR0146047B1/ko not_active Expired - Lifetime
- 1990-07-10 EP EP90113123A patent/EP0409044B1/en not_active Expired - Lifetime
- 1990-07-10 DE DE69015907T patent/DE69015907T2/de not_active Expired - Lifetime
- 1990-07-10 AT AT90113123T patent/ATE116975T1/de not_active IP Right Cessation
- 1990-07-10 DE DE199090113123T patent/DE409044T1/de active Pending
- 1990-07-19 US US07/553,796 patent/US5087698A/en not_active Expired - Lifetime
- 1990-07-19 JP JP2192817A patent/JP2977237B2/ja not_active Expired - Lifetime
1991
- 1991-11-15 GR GR91300062T patent/GR910300062T1/el unknown
1995
- 1995-02-01 GR GR950400200T patent/GR3014936T3/el unknown

Also Published As

Publication number	Publication date
DE69015907D1 (de)	1995-02-23
EP0409044A3 (en)	1991-05-29
HK1006309A1 (en)	1999-02-19
ATE116975T1 (de)	1995-01-15
CA2007385A1 (en)	1991-01-20
CA2007385C (en)	1997-12-30
IT8921244A0 (it)	1989-07-20
JP2977237B2 (ja)	1999-11-15
DE69015907T2 (de)	1995-05-24
KR0146047B1 (ko)	1998-08-17
JPH0381270A (ja)	1991-04-05
EP0409044B1 (en)	1995-01-11
PT92767A (pt)	1991-03-20
IT1231158B (it)	1991-11-19
KR910002745A (ko)	1991-02-26
DE409044T1 (de)	1991-07-25
PT92767B (pt)	1995-11-30
US5087698A (en)	1992-02-11
ES2019010A6 (es)	1991-05-16
GR910300062T1 (en)	1991-11-15
EP0409044A2 (en)	1991-01-23

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