GR3023177T3 - Substituted heterocyclic carboxylic acid amide esters, their preparation and their us as medicaments. - Google Patents
Substituted heterocyclic carboxylic acid amide esters, their preparation and their us as medicaments.Info
- Publication number
- GR3023177T3 GR3023177T3 GR970400836T GR970400836T GR3023177T3 GR 3023177 T3 GR3023177 T3 GR 3023177T3 GR 970400836 T GR970400836 T GR 970400836T GR 970400836 T GR970400836 T GR 970400836T GR 3023177 T3 GR3023177 T3 GR 3023177T3
- Authority
- GR
- Greece
- Prior art keywords
- medicaments
- preparation
- carboxylic acid
- acid amide
- substituted heterocyclic
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 2
- 150000002148 esters Chemical class 0.000 title abstract 2
- -1 heterocyclic carboxylic acid Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102000004079 Prolyl Hydroxylases Human genes 0.000 abstract 1
- 108010043005 Prolyl Hydroxylases Proteins 0.000 abstract 1
- 230000036570 collagen biosynthesis Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Quinoline Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4337270A DE4337270A1 (de) | 1993-11-02 | 1993-11-02 | Substituierte heterocyclische Carbonsäureamidester, ihre Herstellung und ihre Verwendung als Arzneimittel |
| DE19944434288 DE4434288A1 (de) | 1994-09-26 | 1994-09-26 | Substituierte heterocyclische Carbonsäureamidester, ihre Herstellung und ihre Verwendung als Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR3023177T3 true GR3023177T3 (en) | 1997-07-30 |
Family
ID=25930886
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR970400836T GR3023177T3 (en) | 1993-11-02 | 1997-04-18 | Substituted heterocyclic carboxylic acid amide esters, their preparation and their us as medicaments. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5658933A (el) |
| EP (1) | EP0650960B1 (el) |
| JP (1) | JPH07224039A (el) |
| KR (1) | KR950014069A (el) |
| CN (1) | CN1084736C (el) |
| AT (1) | ATE149485T1 (el) |
| AU (1) | AU689135B2 (el) |
| CA (1) | CA2134865A1 (el) |
| CZ (1) | CZ287767B6 (el) |
| DE (1) | DE59401923D1 (el) |
| DK (1) | DK0650960T3 (el) |
| ES (1) | ES2101420T3 (el) |
| GR (1) | GR3023177T3 (el) |
| IL (1) | IL111455A0 (el) |
| NO (1) | NO302028B1 (el) |
| NZ (1) | NZ264822A (el) |
| PH (1) | PH31264A (el) |
| PL (1) | PL179687B1 (el) |
| RU (1) | RU2145959C1 (el) |
| TW (1) | TW330202B (el) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6046219A (en) * | 1995-01-20 | 2000-04-04 | Cornell Research Foundation, Inc. | Method for the treatment of conditions mediated by collagen formation together with cell proliferation by application of inhibitors of protein hydroxylation |
| IL135495A (en) * | 1995-09-28 | 2002-12-01 | Hoechst Ag | Intermediate compounds for the preparation of quinoline-converted amines - 2 - carboxylic acid |
| CA2253282A1 (en) * | 1996-04-30 | 1997-11-06 | Hoechst Aktiengesellschaft | 3-alkoxypyridine-2-carboxylic acid amide esters, their preparation and their use as drugs |
| JPH1067674A (ja) * | 1996-06-19 | 1998-03-10 | Advanced Sukin Res Kenkyusho:Kk | 細胞外マトリツクスの異常蓄積抑制剤 |
| DE19746287A1 (de) * | 1997-10-20 | 1999-04-22 | Hoechst Marion Roussel De Gmbh | Substituierte Isochinolin-2-Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel |
| US7183278B1 (en) | 1998-11-04 | 2007-02-27 | Meiji Seika Kaisha, Ltd. | Picolinamide derivative and harmful organism control agent comprising said picolinamide derivative as active component |
| FR2803592A1 (fr) * | 2000-01-06 | 2001-07-13 | Aventis Cropscience Sa | Nouveaux derives de l'acide 3-hydroxypicolinique, leur procede de preparation et compositions fongicides les contenant. |
| AU2001275014A1 (en) * | 2000-05-30 | 2001-12-11 | Neurogen Corporation | Imidazoloisoquinolines |
| DK2298301T3 (en) | 2001-12-06 | 2018-10-01 | Fibrogen Inc | MEDICINALS FOR TREATMENT OF ANEMIA ASSOCIATED WITH Kidney Disease |
| CN101664409A (zh) * | 2001-12-06 | 2010-03-10 | 法布罗根股份有限公司 | 低氧诱导因子(HIF)α的稳定化 |
| EP2295060B1 (en) | 2001-12-06 | 2018-10-31 | Fibrogen, Inc. | Treatment or prevention of ischemic or hypoxic conditions |
| US8124582B2 (en) * | 2002-12-06 | 2012-02-28 | Fibrogen, Inc. | Treatment of diabetes |
| US7618940B2 (en) * | 2002-12-06 | 2009-11-17 | Fibrogen, Inc. | Fat regulation |
| US8614204B2 (en) | 2003-06-06 | 2013-12-24 | Fibrogen, Inc. | Enhanced erythropoiesis and iron metabolism |
| WO2004108681A1 (en) | 2003-06-06 | 2004-12-16 | Fibrogen, Inc. | Nitrogen-containing heteroaryl compounds and their use in increasing endogenous erythropoietin |
| US8703795B2 (en) * | 2005-03-02 | 2014-04-22 | Fibrogen, Inc. | Thienopyridine compounds, and methods of use thereof |
| RU2277085C1 (ru) * | 2005-03-15 | 2006-05-27 | Государственное образовательное учреждение высшего профессионального образования "Воронежский государственный университет" | Способ определения глицина в водном растворе |
| AU2006254897A1 (en) * | 2005-06-06 | 2006-12-14 | Fibrogen, Inc. | Improved treatment for anemia using a HIF-alpha stabilising agent |
| MX2007016160A (es) | 2005-06-15 | 2008-03-07 | Fibrogen Inc | Uso de moduladoers de hif-1 alfa para el tratamiento contra el cancer. |
| BRPI0707302B8 (pt) | 2006-01-27 | 2021-05-25 | Fibrogen Inc | compostos de cianoisoquinolina que atuam no dano tecidual associado com isquemia, hipóxia e anemia, bem como composição farmacêutica que os compreende |
| WO2007098214A1 (en) * | 2006-02-21 | 2007-08-30 | Amgen Inc. | Cinnoline derivatives as phosphodiesterase 10 inhibitors |
| WO2007103554A1 (en) * | 2006-03-08 | 2007-09-13 | Amgen Inc. | Quinoline and isoquinoline derivatives as phosphodiesterase 10 inhibitors |
| BRPI0710527B8 (pt) | 2006-04-04 | 2021-05-25 | Fibrogen Inc | compostos de pirrolo- e tiazolo-piridina e composição farmacêutica que os compreende |
| JO2934B1 (en) * | 2006-06-23 | 2015-09-15 | سميث كلاين بيتشام كوربوريشن | Prolyl hydroxylase inhibitors |
| AU2013231191B2 (en) * | 2006-06-23 | 2015-09-03 | Glaxosmithkline Llc | Prolyl hydroxylase inhibitors |
| PL3357911T3 (pl) | 2006-06-26 | 2022-09-05 | Akebia Therapeutics Inc. | Inhibitory prolilohydroksylazy i sposoby ich użycia |
| JP5352454B2 (ja) * | 2006-06-28 | 2013-11-27 | サノフイ | Cxcr2アンンタゴニスト |
| JP5352455B2 (ja) * | 2006-06-30 | 2013-11-27 | サノフイ | Cxcr2阻害剤 |
| TW200845991A (en) | 2007-01-12 | 2008-12-01 | Smithkline Beecham Corp | N-substituted glycine derivatives: hydroxylase inhibitors |
| US8962530B2 (en) | 2007-06-27 | 2015-02-24 | Regents Of The University Of Colorado | Inflammatory bowel disease therapies |
| JP5649584B2 (ja) | 2008-11-14 | 2015-01-07 | フィブロジェン インコーポレイテッド | Hifヒドロキシラーゼ阻害剤としてのチオクロメン誘導体 |
| RU2528412C2 (ru) * | 2009-02-10 | 2014-09-20 | Янссен Фармацевтика Нв | Хиназолиноны как ингибиторы пролилгидроксилазы |
| RS54010B1 (sr) * | 2009-11-06 | 2015-10-30 | Aerpio Therapeutics Inc. | Inhibitori prolil hidroksilaze |
| RU2436772C2 (ru) * | 2010-01-28 | 2011-12-20 | Закрытое акционерное общество "НПК ЭХО" | 4[(4'-никотиноиламино)бутироиламино]бутановая кислота, проявляющая ноотропную активность, и способ ее получения |
| US8247436B2 (en) | 2010-03-19 | 2012-08-21 | Novartis Ag | Pyridine and pyrazine derivative for the treatment of CF |
| WO2012106472A1 (en) | 2011-02-02 | 2012-08-09 | Fibrogen, Inc. | Naphthyridine derivatives as inhibitors of hypoxia inducible factor (hif) hydroxylase |
| WO2012170439A1 (en) | 2011-06-06 | 2012-12-13 | The Ohio State University | Methods for stabilizing hypoxia inducible factor-2 alpha as a method for treating cancer |
| NO2686520T3 (el) | 2011-06-06 | 2018-03-17 | ||
| WO2013063221A1 (en) | 2011-10-25 | 2013-05-02 | Janssen Pharmaceutica Nv | Meglumine salt formulations of 1-(5,6-dichloro-1h-benzo[d]imidazol-2-yl)-1h-pyrazole-4-carboxylic acid |
| WO2013134660A1 (en) * | 2012-03-09 | 2013-09-12 | Fibrogen, Inc. | 4 -hydroxy- isoquinoline compounds as hif hydroxylase inhibitors |
| US8883823B2 (en) | 2012-07-16 | 2014-11-11 | Fibrogen, Inc. | Crystalline forms of a prolyl hydroxylase inhibitor |
| AU2013290438C1 (en) | 2012-07-16 | 2019-01-03 | Kyntra Bio, Inc. | Crystalline forms of the prolyl hydroxylase inhibitor [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid |
| EP3219706A1 (en) | 2012-07-16 | 2017-09-20 | Fibrogen, Inc. | Process for making isoquinoline compounds |
| AU2014209319B2 (en) | 2013-01-24 | 2018-04-19 | Fibrogen, Inc. | Crystalline forms of {[1-cyano-5-(4-chlorophenoxy)-4-hydroxy-isoquinoline-3-carbonyl]-amino}-acetic acid |
| JP2016521747A (ja) | 2013-06-13 | 2016-07-25 | アケビア セラピューティクス インコーポレイテッドAkebia Therapeutics Inc. | 貧血治療のための組成物及び方法 |
| MY180626A (en) | 2013-11-15 | 2020-12-03 | Akebia Therapeutics Inc | Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid, compositions, and uses thereof |
| EP3240408B1 (en) * | 2014-12-30 | 2020-04-08 | Dow Agrosciences LLC | Picolinamides with fungicidal activity |
| US10150734B2 (en) | 2015-01-23 | 2018-12-11 | Akebia Therapeutics, Inc. | Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof |
| CN106146395B (zh) * | 2015-03-27 | 2019-01-01 | 沈阳三生制药有限责任公司 | 3-羟基吡啶化合物、其制备方法及其制药用途 |
| US11324734B2 (en) | 2015-04-01 | 2022-05-10 | Akebia Therapeutics, Inc. | Compositions and methods for treating anemia |
| US11713298B2 (en) | 2018-05-09 | 2023-08-01 | Akebia Therapeutics, Inc. | Process for preparing 2-[[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino]acetic acid |
| CN113767089B (zh) * | 2019-04-26 | 2024-06-11 | 株式会社钟化 | 伐度司他中间体的制造方法 |
| CN110305143B (zh) * | 2019-07-19 | 2021-03-09 | 济南新科医药科技有限公司 | 一种呋喃[2,3-c]并吡啶衍生物及其制备方法和用途 |
| US11524939B2 (en) | 2019-11-13 | 2022-12-13 | Akebia Therapeutics, Inc. | Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid |
| WO2021117767A1 (ja) | 2019-12-10 | 2021-06-17 | 田辺三菱製薬株式会社 | 含窒素ヘテロアリールカルボキサミド酢酸誘導体の製造方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4015255A1 (de) * | 1990-05-12 | 1991-11-14 | Hoechst Ag | Oxalyl-aminosaeurederivate, verfahren zu ihrer herstellung und ihrer verwendung als arzneimittel zur inhibierung der prolyl-hydroxylase |
| US5192773A (en) * | 1990-07-02 | 1993-03-09 | Vertex Pharmaceuticals, Inc. | Immunosuppressive compounds |
| EP0541042A1 (de) * | 1991-11-05 | 1993-05-12 | Hoechst Aktiengesellschaft | Pyridin-2,4- und 2,5-dicarbonsäureamide und deren Derivate, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel |
| TW352384B (en) * | 1992-03-24 | 1999-02-11 | Hoechst Ag | Sulfonamido- or sulfonamidocarbonylpyridine-2-carboxamides, process for their preparation and their use as pharmaceuticals |
-
1994
- 1994-10-27 AT AT94117017T patent/ATE149485T1/de not_active IP Right Cessation
- 1994-10-27 ES ES94117017T patent/ES2101420T3/es not_active Expired - Lifetime
- 1994-10-27 DE DE59401923T patent/DE59401923D1/de not_active Expired - Fee Related
- 1994-10-27 EP EP94117017A patent/EP0650960B1/de not_active Expired - Lifetime
- 1994-10-27 DK DK94117017.7T patent/DK0650960T3/da active
- 1994-10-28 PL PL94305647A patent/PL179687B1/pl unknown
- 1994-10-28 PH PH49264A patent/PH31264A/en unknown
- 1994-10-30 IL IL11145594A patent/IL111455A0/xx unknown
- 1994-10-31 US US08/332,824 patent/US5658933A/en not_active Expired - Lifetime
- 1994-10-31 NZ NZ264822A patent/NZ264822A/en unknown
- 1994-10-31 AU AU77566/94A patent/AU689135B2/en not_active Ceased
- 1994-11-01 CZ CZ19942682A patent/CZ287767B6/cs not_active IP Right Cessation
- 1994-11-01 NO NO944161A patent/NO302028B1/no not_active IP Right Cessation
- 1994-11-01 RU RU94040163A patent/RU2145959C1/ru active
- 1994-11-01 CA CA002134865A patent/CA2134865A1/en not_active Abandoned
- 1994-11-02 CN CN94117622A patent/CN1084736C/zh not_active Expired - Fee Related
- 1994-11-02 JP JP6292031A patent/JPH07224039A/ja not_active Abandoned
- 1994-11-02 KR KR1019940028870A patent/KR950014069A/ko not_active Ceased
- 1994-12-05 TW TW083111258A patent/TW330202B/zh active
-
1997
- 1997-04-18 GR GR970400836T patent/GR3023177T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1084736C (zh) | 2002-05-15 |
| PL179687B1 (pl) | 2000-10-31 |
| RU94040163A (ru) | 1997-02-20 |
| US5658933A (en) | 1997-08-19 |
| HK1006712A1 (en) | 1999-03-12 |
| KR950014069A (ko) | 1995-06-15 |
| RU2145959C1 (ru) | 2000-02-27 |
| NO944161L (no) | 1995-05-03 |
| EP0650960A1 (de) | 1995-05-03 |
| DK0650960T3 (da) | 1997-09-01 |
| PH31264A (en) | 1998-06-18 |
| CA2134865A1 (en) | 1995-05-03 |
| NO944161D0 (no) | 1994-11-01 |
| AU7756694A (en) | 1995-05-18 |
| DE59401923D1 (de) | 1997-04-10 |
| NO302028B1 (no) | 1998-01-12 |
| CZ268294A3 (en) | 1995-05-17 |
| JPH07224039A (ja) | 1995-08-22 |
| IL111455A0 (en) | 1994-12-29 |
| ES2101420T3 (es) | 1997-07-01 |
| ATE149485T1 (de) | 1997-03-15 |
| TW330202B (en) | 1998-04-21 |
| NZ264822A (en) | 1997-02-24 |
| AU689135B2 (en) | 1998-03-26 |
| PL305647A1 (en) | 1995-05-15 |
| EP0650960B1 (de) | 1997-03-05 |
| CN1107144A (zh) | 1995-08-23 |
| CZ287767B6 (en) | 2001-01-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GR3023177T3 (en) | Substituted heterocyclic carboxylic acid amide esters, their preparation and their us as medicaments. | |
| CY2120B1 (en) | Substituted heterocyclic carboxylic acid amides their preparation and their use as medicaments | |
| HUT70836A (en) | 1-h-indole-3-acetamide spla2 inhibitors, process for producing them and pharmaceutical compositions comprising same compounds | |
| GR3023635T3 (en) | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments. | |
| IL109309A (en) | 1-H-indole-3-acetic acid hydrazide SPLA2 inhibitors and pharmaceutical compositions containing them | |
| HUP9900816A3 (en) | Use of piperidine carboxylic acid derivatives for producing pharmaceutical compositions as inhibitors of rotamase enzyme activity | |
| NZ330216A (en) | Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and use in treatment of atherosclerosis | |
| AU1067895A (en) | Use of carboxylic acid amides as crystallisation inhibitors | |
| NO951147L (no) | Substituerte heterocykliske karboksylsyreamidestere, deres fremstilling og deres anvendelse som legemiddel | |
| EP0518351A3 (en) | Process for the preparation of 2,5-di(phenylamino)terephthalic acids and their dialkylesters in high purity | |
| AU686104B2 (en) | Substituted amidinonaphthyl ester derivatives | |
| HUT58089A (en) | Process for producing 3-(l-pyroglutamyl)-l-thiazolidine-4-carboxylic aci derivatives and pharmaceutical compositions comprising such compounds as active ingredient | |
| MY112414A (en) | Substituted heterocyclic carboxamide esters, their preparation and their use as pharmaceuticals | |
| AU1067995A (en) | Use of carbamide acid esters as crystallisation inhibitors | |
| DE3686876D1 (de) | 4-morpholinyl 1h-indol-derivate, ihre salze, verfahren und zwischenprodukte zur herstellung, verwendung als arzneimittel, sie enthaltende zusammensetzungen. | |
| AU7994294A (en) | Use of phosphonic acid esters as crystallization inhibitors |