GR3024215T3 - Starburst conjugates - Google Patents

Starburst conjugates

Info

Publication number
GR3024215T3
GR3024215T3 GR970401861T GR970401861T GR3024215T3 GR 3024215 T3 GR3024215 T3 GR 3024215T3 GR 970401861 T GR970401861 T GR 970401861T GR 970401861 T GR970401861 T GR 970401861T GR 3024215 T3 GR3024215 T3 GR 3024215T3
Authority
GR
Greece
Prior art keywords
conjugates
starburst conjugates
starburst
dendrimer
agricutural
Prior art date
Application number
GR970401861T
Other languages
English (en)
Inventor
Donald A Tomalia
Donald A Kaplan
William J Kruper
Roberta C Cheng
Ian A Tomlinson
Michael J Fazio
Larry R Wilson
David M Hedstrand
Original Assignee
Dow Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25407923&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GR3024215(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Dow Chemical Co filed Critical Dow Chemical Co
Publication of GR3024215T3 publication Critical patent/GR3024215T3/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
    • A01N25/10—Macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/595—Polyamides, e.g. nylon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6883—Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy
    • A61K47/6885—Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy the conjugate or the polymer being a starburst, a dendrimer, a cascade
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/48—Polymers modified by chemical after-treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
    • C08G83/002—Dendritic macromolecules
    • C08G83/003—Dendrimers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L101/00—Compositions of unspecified macromolecular compounds
    • C08L101/005—Dendritic macromolecules

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nanotechnology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Environmental Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Polyamides (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Disinfection, Sterilisation Or Deodorisation Of Air (AREA)
GR970401861T 1986-08-18 1997-07-23 Starburst conjugates GR3024215T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US89745586A 1986-08-18 1986-08-18

Publications (1)

Publication Number Publication Date
GR3024215T3 true GR3024215T3 (en) 1997-10-31

Family

ID=25407923

Family Applications (1)

Application Number Title Priority Date Filing Date
GR970401861T GR3024215T3 (en) 1986-08-18 1997-07-23 Starburst conjugates

Country Status (21)

Country Link
EP (1) EP0271180B2 (el)
JP (6) JPH0757735B2 (el)
KR (1) KR970011151B1 (el)
AT (1) ATE89743T1 (el)
AU (2) AU609051B2 (el)
BR (3) BR8707431A (el)
DE (1) DE3786000T3 (el)
DK (1) DK174053B1 (el)
ES (1) ES2054678T5 (el)
FI (2) FI103410B (el)
GR (1) GR3024215T3 (el)
HK (1) HK54396A (el)
HU (2) HU209252B (el)
IE (1) IE61356B1 (el)
IL (1) IL83567A (el)
MX (1) MX169992B (el)
MY (1) MY102878A (el)
NO (1) NO176306C (el)
NZ (1) NZ221484A (el)
WO (3) WO1988001178A1 (el)
ZA (1) ZA876114B (el)

Families Citing this family (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5560929A (en) * 1986-08-18 1996-10-01 The Dow Chemical Company Structured copolymers and their use as absorbents, gels and carriers of metal ions
US5914095A (en) * 1989-04-07 1999-06-22 Salutar, Inc. Polychelants containg amide bonds
DE69022542T2 (de) * 1989-05-26 1996-05-02 Akzo Nobel Nv Chelatierungsmittel zur bindung von metallionen zu proteinen.
US5808003A (en) * 1989-05-26 1998-09-15 Perimmune Holdings, Inc. Polyaminocarboxylate chelators
US5292868A (en) * 1989-05-26 1994-03-08 Akzo N.V. Chelating agents for attaching metal ions to proteins
DE3930674A1 (de) * 1989-09-11 1991-03-21 Diagnostikforschung Inst Bifunktionelle chelatbildner zur komplexierung von tc- und re-isotopen, verfahren zu ihrer herstellung und darstellung von konjugaten daraus sowie deren verwendung in diagnostik und therapie
DE3938992A1 (de) * 1989-11-21 1991-05-23 Schering Ag Kaskadenpolymer-gebundene komplexbildner, deren komplexe und konjugate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
AU642980B2 (en) * 1990-03-21 1993-11-04 Quest International B.V. Ultilization of enzymes
GB9021671D0 (en) * 1990-10-05 1990-11-21 Unilever Plc Delivery of agents
AU641736B2 (en) * 1990-03-21 1993-09-30 Quest International B.V. Delivery of agents
AU642979B2 (en) * 1990-03-21 1993-11-04 Quest International B.V. Utilization and delivery of enzymes
IL99234A (en) * 1990-08-27 1994-05-30 Michigan Molecular Inst Non-cross-linked multi-branch polymers and their preparation
GB9112536D0 (en) * 1991-06-11 1991-07-31 Celltech Ltd Chemical compounds
FR2688508A1 (fr) * 1992-03-13 1993-09-17 Guerbet Sa Nouveau produit de contraste iode, son procede de preparation et son utilisation comme agent de contraste.
US5871713A (en) * 1991-12-04 1999-02-16 Guerbet S.A. Macromolecular polyamine iodine-containing compound, process for its preparation and its use as a contrast agent
CA2125188A1 (fr) * 1991-12-04 1993-06-10 Dominique Meyer Nouveau compose macromoleculaire polyamine iode, son procede de preparation et son utilisation comme agent de contraste
CA2118130A1 (en) 1992-04-14 1993-10-28 Jean M. J. Frechet Dendritic based macromolecules and method of production
US5387617A (en) * 1993-01-22 1995-02-07 The Dow Chemical Company Small cell foams and blends and a process for their preparation
US5898005A (en) * 1993-02-24 1999-04-27 Dade Behring Inc. Rapid detection of analytes with receptors immobilized on soluble submicron particles
US6121056A (en) * 1993-02-24 2000-09-19 Dade Behring Inc. Random detection of antigens with antibodies immobilized on soluble submicron particles
WO1994019693A1 (en) * 1993-02-24 1994-09-01 Baxter Diagnostics Inc. Immobilization of specific binding assay reagents
FR2703055B1 (fr) * 1993-03-22 1995-07-07 Guerbet Sa Nouveaux composés polyiodés, leur préparation et leur utilisation en tant que produits de contraste pour la radiologie .
KR100361933B1 (ko) 1993-09-08 2003-02-14 라 졸라 파마슈티칼 컴파니 화학적으로정의된비중합성결합가플랫폼분자및그것의콘주게이트
US7097839B1 (en) 1993-10-26 2006-08-29 Thomas Jefferson University ST receptor binding compounds and methods of using the same
FI955320A7 (fi) * 1994-03-07 1995-11-24 Univ Michigan Bioaktiivisia ja/tai kohdennettuja dendriimikonjugaatteja
AU750411B2 (en) * 1994-03-07 2002-07-18 Dendritic Nanotechnologies, Inc. Bioactive and/or targeted dendrimer conjugates
GB9407812D0 (en) * 1994-04-20 1994-06-15 Nycomed Salutar Inc Compounds
NL9400880A (nl) * 1994-05-27 1996-01-02 Dsm Nv Samenstelling bestaande uit een dendrimeer en een in het dendrimeer opgesloten actieve stof, een werkwijze voor de bereiding van een dergelijke samenstelling en een werkwijze voor het vrijstellen van de actieve stof.
NL9401886A (nl) * 1994-05-27 1996-01-02 Dsm Nv Samenstelling bestaande uit een dendrimeer en een in het dendrimeer opgesloten actieve stof, een werkwijze voor de bereiding van een dergelijke samenstelling en een werkwijze voor het vrijgeven van de actieve stof.
AUPM623994A0 (en) * 1994-06-15 1994-07-07 Biomolecular Research Institute Limited Antiviral dendrimers
WO1996019240A1 (en) * 1994-12-21 1996-06-27 Novartis Ag Oligonucleotide-dendrimer conjugates
FR2734268B1 (fr) * 1995-05-19 1997-07-04 Centre Nat Rech Scient Nouveaux dendrimeres fonctionnels a terminaisons phosphorees et leur procede de preparation
US6051429A (en) 1995-06-07 2000-04-18 Life Technologies, Inc. Peptide-enhanced cationic lipid transfections
US6083708A (en) * 1995-08-11 2000-07-04 Dade Behring Inc. Polypeptide: dendrimer complexes
US5658574A (en) * 1995-10-13 1997-08-19 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Cleansing compositions with dendrimers as mildness agents
NL1001753C2 (nl) * 1995-11-28 1997-05-30 Dsm Nv Samenstelling omvattende een kunststof en een additief.
DE19625982A1 (de) * 1996-06-28 1998-01-02 Wella Ag Kosmetisches Mittel zur Haarbehandlung mit Dendrimeren
DE69833186T2 (de) * 1997-01-13 2006-09-14 The Dow Chemical Company, Midland Nanoverbundmaterial von dendritischen polymeren
WO1998056427A1 (en) * 1997-06-12 1998-12-17 Mitsubishi Chemical Corporation Novel contrast media
DE19728954C1 (de) * 1997-06-30 1999-04-22 Schering Ag Saccharid-Konjugate, diese enthaltende pharmazeutische Mittel, Verfahren zu ihrer Herstellung und ihre Verwendung
FR2790642A1 (fr) * 1999-03-08 2000-09-15 Aventis Cropscience Sa Nouvelles compositions pesticides et/ou regulatrices de croissance
AU5522600A (en) * 1999-06-29 2001-01-22 Dako A/S Detection using dendrimers bearing labels and probes
BR0013171A (pt) 1999-07-29 2002-05-28 Epix Medical Inc Agentes multimericos para formação de imagem de objetivação através de ligação multi-local
FI19991705A7 (fi) * 1999-08-11 2001-02-12 Neste Chemicals Oy Antimikrobinen hyperhaaroittunut polymeerikoostumus
FR2797563A1 (fr) * 1999-08-18 2001-02-23 Rhodianyl Composes biocides et leur utilisation dans des polymeres thermoplastiques
US6991778B2 (en) * 1999-12-10 2006-01-31 Nitrosci Use of dendrimers polyl-functionalized with nitroxide groups as contrast enhancing agents in MRI imaging of joints and injectable compositions comprising them
DK1268716T3 (da) 2000-04-07 2008-01-02 Shell Int Research Fremgangsmåde til inhibering af gashydrattilstopning af ledninger
US6471968B1 (en) * 2000-05-12 2002-10-29 Regents Of The University Of Michigan Multifunctional nanodevice platform
CU23011A1 (es) * 2000-11-03 2004-12-17 Ct Ingenieria Genetica Biotech Método de obtención de estructuras antigénicas quemétodo de obtención de estructuras antigénicas que potencian la reactividad cruzada específica y su potencian la reactividad cruzada específica y su uso en formulaciones uso en formulaciones
RU2280672C2 (ru) 2001-06-14 2006-07-27 Шелл Интернэшнл Рисерч Маатсхаппий Б.В. Способ солюбилизации асфальтенов в углеводородной смеси и смесь для осуществления способа
TWI221406B (en) 2001-07-30 2004-10-01 Epix Medical Inc Systems and methods for targeted magnetic resonance imaging of the vascular system
GB0209022D0 (en) 2002-04-19 2002-05-29 Imp College Innovations Ltd Compounds
US7696393B2 (en) 2002-09-03 2010-04-13 Shell Oil Company Method and compositions for inhibiting formation of hydrocarbon hydrates
EP1525890A1 (en) 2003-10-02 2005-04-27 Complex Biosystems GmbH Protein-Proteophore complexes
CN1930304B (zh) * 2003-11-21 2016-01-06 Anp技术公司 不对称支化的聚合物缀合物和微阵列检测
BRPI0510093B8 (pt) * 2004-04-20 2022-12-27 Dendritic Nanotechnologies Inc polímeros dendríticos
US7985424B2 (en) 2004-04-20 2011-07-26 Dendritic Nanotechnologies Inc. Dendritic polymers with enhanced amplification and interior functionality
JP5329755B2 (ja) 2004-08-13 2013-10-30 日本曹達株式会社 多分岐ポリマー
US20090104119A1 (en) * 2004-08-25 2009-04-23 Majoros Istvan J Dendrimer Based Compositions And Methods Of Using The Same
DE602005006704D1 (de) 2004-11-08 2008-06-26 Fujifilm Corp Verwendung eines Mittels zur Beseitigung vom Sauerstoff
CN101065466B (zh) 2004-11-24 2013-02-13 国际壳牌研究有限公司 改进含有蜡和其它烃的混合物的流动性的方法
JP2008545621A (ja) * 2005-04-20 2008-12-18 デンドリティック ナノテクノロジーズ，インコーポレイテッド 強化された拡大性と内部官能基性をもった樹枝状ポリマー
US7575687B2 (en) * 2005-08-16 2009-08-18 Ge Osmonics, Inc. Membranes and methods useful for caustic applications
US8436103B2 (en) 2005-09-07 2013-05-07 Nippon Soda Co., Ltd. Star polymer and method of producing the same
WO2007061896A1 (en) 2005-11-17 2007-05-31 Zogenix, Inc. Delivery of viscous formulations by needle-free injection
CN101484488B (zh) 2006-07-11 2012-02-01 日本曹达株式会社 星形聚合物及其制造方法
US20080020043A1 (en) * 2006-07-20 2008-01-24 Marc Gingras Dendrimer-Drug Conjugates
US8268347B1 (en) 2006-10-24 2012-09-18 Aradigm Corporation Dual action, inhaled formulations providing both an immediate and sustained release profile
US8658148B2 (en) 2007-06-22 2014-02-25 Genzyme Corporation Chemically modified dendrimers
KR101176813B1 (ko) 2007-08-31 2012-08-24 닛뽕소다 가부시키가이샤 스타 폴리머의 제조 방법
WO2009151687A2 (en) 2008-03-12 2009-12-17 The Regents Of The University Of Michigan Dendrimer conjugates
AU2009241847B2 (en) 2008-04-28 2014-07-10 Zogenix, Inc. Novel formulations for treatment of migraine
US8889635B2 (en) 2008-09-30 2014-11-18 The Regents Of The University Of Michigan Dendrimer conjugates
WO2010054321A2 (en) 2008-11-07 2010-05-14 The Regents Of The University Of Michigan Methods of treating autoimmune disorders and/or inflammatory disorders
CN102917699A (zh) 2009-10-13 2013-02-06 密执安大学评议会 树枝状聚合物组合物和合成方法
WO2011053605A1 (en) * 2009-10-26 2011-05-05 Dendritic Nanotechnologies, Inc. Peham dendrimers for use in agriculture
US8912323B2 (en) 2009-10-30 2014-12-16 The Regents Of The University Of Michigan Multifunctional small molecules
CN102858367B (zh) 2010-02-26 2014-12-17 国立大学法人长崎大学 抗原或药物递送复合物
US9402911B2 (en) 2011-12-08 2016-08-02 The Regents Of The University Of Michigan Multifunctional small molecules
US9921205B2 (en) 2012-11-13 2018-03-20 Chevron U.S.A. Inc. Method for determining the effectiveness of asphaltene dispersant additives for inhibiting or preventing asphaltene precipitation in a hydrocarbon-containing material subjected to elevated temperature and presssure conditions
GB201405660D0 (en) * 2014-03-28 2014-05-14 Gama Healthcare Ltd A liquid disinfecting composition
KR20180095871A (ko) * 2015-12-16 2018-08-28 프리오스타 피티와이 엘티디 덴드리머 및 그의 배합물
US10907473B2 (en) 2017-11-14 2021-02-02 Chevron U.S.A., Inc. Low volume in-line filtration methods for analyzing hydrocarbon-containing fluid to evaluate asphaltene content and behavior during production operations
CN109287624A (zh) * 2018-10-08 2019-02-01 威海晨源分子新材料有限公司 一种树枝状聚酰胺-胺在农药中的应用
JP2022517193A (ja) 2019-01-03 2022-03-07 アイオンパス， インク． イオンビームイメージングのための組成物および試薬
JP7436838B2 (ja) * 2020-05-20 2024-02-22 藤倉化成株式会社 抗体－デンドリマー複合体を用いるヘモグロビンＡ１ｃの測定方法
CN114292217A (zh) * 2021-12-31 2022-04-08 安源基因科技(上海)有限公司 生物活性交联剂、生物交联物、试剂盒及应用
GB202412414D0 (en) 2024-08-23 2024-10-09 Univ Bradford Methods for treating cancer

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4289872A (en) * 1979-04-06 1981-09-15 Allied Corporation Macromolecular highly branched homogeneous compound based on lysine units
IL64277A0 (en) * 1981-11-11 1982-02-28 Basht Ltd Apparatus for removal of integrated circuits from circuit boards
US4472509A (en) * 1982-06-07 1984-09-18 Gansow Otto A Metal chelate conjugated monoclonal antibodies
GB2122641B (en) * 1982-06-07 1986-08-06 Otto A Gansow Metal chelate conjugated monoclonal antibodies where in the metal is an emitter
US4507466A (en) * 1983-01-07 1985-03-26 The Dow Chemical Corporation Dense star polymers having core, core branches, terminal groups
US4558120A (en) * 1983-01-07 1985-12-10 The Dow Chemical Company Dense star polymer
US4631337A (en) * 1983-01-07 1986-12-23 The Dow Chemical Company Hydrolytically-stable dense star polyamine
US4606907A (en) * 1984-07-02 1986-08-19 The Dow Chemical Company Bone seeking Tc-99m complexes of phosphonate derivatives of polyamidoamines
US4599400A (en) * 1984-12-18 1986-07-08 The Dow Chemical Company Star/comb-branched polyamide
US4694064A (en) * 1986-02-28 1987-09-15 The Dow Chemical Company Rod-shaped dendrimer

Also Published As

Publication number Publication date
FI981807L (fi) 1998-08-24
FI103410B1 (fi) 1999-06-30
BR8707432A (pt) 1988-11-01
HU209252B (en) 1994-04-28
DK205388D0 (da) 1988-04-14
FI105693B (fi) 2000-09-29
HU220205B (hu) 2001-11-28
JPH072840B2 (ja) 1995-01-18
DE3786000T3 (de) 1997-08-21
DE3786000D1 (de) 1993-07-01
HK54396A (en) 1996-04-03
FI881768L (fi) 1988-04-15
FI981807A0 (fi) 1998-08-24
JPH06220190A (ja) 1994-08-09
NO176306B (no) 1994-12-05
KR880701564A (ko) 1988-11-03
KR970011151B1 (ko) 1997-07-07
IE872210L (en) 1988-02-18
AU609051B2 (en) 1991-04-26
DE3786000T2 (de) 1993-09-02
MY102878A (en) 1993-03-31
WO1988001180A1 (en) 1988-02-25
JPH069778A (ja) 1994-01-18
JPS63501876A (ja) 1988-07-28
AU7715987A (en) 1988-03-03
NO881639L (no) 1988-06-15
FI103410B (fi) 1999-06-30
ES2054678T5 (es) 1997-09-16
ATE89743T1 (de) 1993-06-15
HUT55245A (en) 1991-05-28
EP0271180B1 (en) 1993-05-26
DK174053B1 (da) 2002-05-13
NO176306C (no) 1995-03-15
ZA876114B (en) 1989-04-26
JPS63502350A (ja) 1988-09-08
JP2771404B2 (ja) 1998-07-02
AU638153B2 (en) 1993-06-17
EP0271180A1 (en) 1988-06-15
FI881768A0 (fi) 1988-04-15
WO1988001178A1 (en) 1988-02-25
WO1988001179A1 (en) 1988-02-25
DK205388A (da) 1988-06-14
IL83567A (en) 1992-02-16
JPH0757735B2 (ja) 1995-06-21
JPH0757736B2 (ja) 1995-06-21
BR8707433A (pt) 1988-11-01
AU8139191A (en) 1991-10-03
EP0271180B2 (en) 1997-06-18
JPH06219966A (ja) 1994-08-09
JP2848218B2 (ja) 1999-01-20
IL83567A0 (en) 1988-01-31
JPH07108860B2 (ja) 1995-11-22
JPS63501878A (ja) 1988-07-28
BR8707431A (pt) 1988-11-01
IE61356B1 (en) 1994-11-02
MX169992B (es) 1993-08-04
NZ221484A (en) 1991-01-29
ES2054678T3 (es) 1994-08-16
HU9303379D0 (en) 1994-03-28
NO881639D0 (no) 1988-04-15

Similar Documents

Publication Publication Date Title
GR3024215T3 (en) Starburst conjugates
DE68904101D1 (de) Polymerzusammensetzungen.
FI893410L (fi) Tvaerbindbar silylpolymerkomposition.
FI910123A0 (fi) Polymerkomposition foer att avlaegsna syre.
NO891982D0 (no) Polymer-sammensetning.
DE69007311D1 (de) Konjugate.
DE68920021D1 (de) Polymerzusammensetzung.
NO881687L (no) Polymerblanding.
FI893411L (fi) Tvaerbindbar silylpolymerkomposition.
FI883266A0 (fi) 4-aminosubstituerade 1,2-dihydronaftalenderivat.
DE69013711D1 (de) Polymerzusammensetzung.
DE68916717D1 (de) Selbstverlöschende Polymer-Zusammensetzung.
FI880443A7 (fi) Valokovettuva hartsikoostumus.
DE68914047D1 (de) Polymer-Zusammensetzungen.
DE3882313D1 (de) Polymerzusammensetzung.
NO883886D0 (no) Flammehemmende ethylencopolymermateriale.
DE69010556D1 (de) Polyketonpolymerzusammensetzungen.
DE68915561D1 (de) Polymerisierbare Zusammensetzung und Polymer, hergestellt aus dieser.
Lovell et al. Mesolithic Human Remains from the Gangetic Plain: Sarai Nahar Rai
NO905336L (no) Fotonedbrytbar polymersammensetning.